JP2011515073A5 - - Google Patents
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- JP2011515073A5 JP2011515073A5 JP2010547002A JP2010547002A JP2011515073A5 JP 2011515073 A5 JP2011515073 A5 JP 2011515073A5 JP 2010547002 A JP2010547002 A JP 2010547002A JP 2010547002 A JP2010547002 A JP 2010547002A JP 2011515073 A5 JP2011515073 A5 JP 2011515073A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- variable region
- chain comprises
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 30
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 18
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 18
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 17
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 17
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 239000002157 polynucleotide Substances 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 5
- 101000867983 Homo sapiens C5a anaphylatoxin chemotactic receptor 1 Proteins 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 210000000440 neutrophil Anatomy 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 2
- 230000002134 immunopathologic effect Effects 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 230000009460 calcium influx Effects 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 230000005012 migration Effects 0.000 claims 1
- 238000013508 migration Methods 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6653908P | 2008-02-20 | 2008-02-20 | |
| US61/066,539 | 2008-02-20 | ||
| PCT/AU2009/000184 WO2009103113A1 (en) | 2008-02-20 | 2009-02-19 | HUMANIZED ANTI-C5aR ANTIBODIES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014092573A Division JP6034826B2 (ja) | 2008-02-20 | 2014-04-28 | ヒト化抗Ｃ５ａＲ抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011515073A JP2011515073A (ja) | 2011-05-19 |
| JP2011515073A5 true JP2011515073A5 (enExample) | 2012-04-05 |
Family
ID=40984994
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010547002A Pending JP2011515073A (ja) | 2008-02-20 | 2009-02-19 | ヒト化抗Ｃ５ａＲ抗体 |
| JP2014092573A Expired - Fee Related JP6034826B2 (ja) | 2008-02-20 | 2014-04-28 | ヒト化抗Ｃ５ａＲ抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014092573A Expired - Fee Related JP6034826B2 (ja) | 2008-02-20 | 2014-04-28 | ヒト化抗Ｃ５ａＲ抗体 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US8268972B2 (enExample) |
| EP (2) | EP2254911B1 (enExample) |
| JP (2) | JP2011515073A (enExample) |
| KR (1) | KR20100117120A (enExample) |
| CN (2) | CN104193824A (enExample) |
| AU (1) | AU2009217224B2 (enExample) |
| BR (1) | BRPI0907532A2 (enExample) |
| CA (1) | CA2714296A1 (enExample) |
| ES (1) | ES2562627T3 (enExample) |
| IL (1) | IL207217A (enExample) |
| MX (1) | MX2010009190A (enExample) |
| RU (1) | RU2010138612A (enExample) |
| WO (1) | WO2009103113A1 (enExample) |
| ZA (1) | ZA201005348B (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2371861T3 (da) | 2002-01-25 | 2017-11-20 | Novo Nordisk As | Monoklonale antistoffer mod ekstracellulære løkker af C5aR |
| EP2051997B1 (en) * | 2006-08-22 | 2015-03-18 | G2 Inflammation Pty Ltd | Anti-c5ar antibodies with improved properties |
| CN104193824A (zh) | 2008-02-20 | 2014-12-10 | G2炎症私人有限公司 | 人源化抗-C5aR抗体 |
| TW201022288A (en) | 2008-06-30 | 2010-06-16 | Novo Nordisk As | Anti-human interleukin-20 antibodies |
| WO2010035012A1 (en) * | 2008-09-26 | 2010-04-01 | Ucb Pharma S.A. | Biological products |
| US8454956B2 (en) | 2009-08-31 | 2013-06-04 | National Cheng Kung University | Methods for treating rheumatoid arthritis and osteoporosis with anti-IL-20 antibodies |
| CN107693791B (zh) * | 2010-02-26 | 2022-06-07 | 诺沃—诺迪斯克有限公司 | 包含稳定抗体的组合物 |
| CA2976671C (en) | 2010-03-01 | 2021-01-12 | Bayer Healthcare Llc | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
| US20130136733A1 (en) | 2010-05-28 | 2013-05-30 | Novo Nordisk A/S | Stable Multi-Dose Compositions Comprising an Antibody and a Preservative |
| EP2468295A1 (en) | 2010-12-21 | 2012-06-27 | Affiris AG | Vaccines based on peptides of the complement protein C5a |
| RU2616881C2 (ru) | 2011-06-06 | 2017-04-18 | Ново Нордиск А/С | Терапевтические антитела |
| US9221904B2 (en) | 2012-07-19 | 2015-12-29 | National Cheng Kung University | Treatment of osteoarthritis using IL-20 antagonists |
| US8852588B2 (en) | 2012-08-07 | 2014-10-07 | National Cheng Kung University | Treating allergic airway disorders using anti-IL-20 receptor antibodies |
| US8603470B1 (en) | 2012-08-07 | 2013-12-10 | National Cheng Kung University | Use of IL-20 antagonists for treating liver diseases |
| US9592297B2 (en) | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations |
| US8613919B1 (en) | 2012-08-31 | 2013-12-24 | Bayer Healthcare, Llc | High concentration antibody and protein formulations |
| GB201220242D0 (en) * | 2012-11-09 | 2012-12-26 | Fusion Antibodies Ltd | Antibody |
| TWI682941B (zh) | 2013-02-01 | 2020-01-21 | 美商再生元醫藥公司 | 含嵌合恆定區之抗體 |
| US20160060351A1 (en) * | 2013-05-08 | 2016-03-03 | Novo Nordisk A/S | Use of C5AR Antagonists |
| TWI701042B (zh) | 2014-03-19 | 2020-08-11 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
| BR112016025751A2 (pt) * | 2014-05-05 | 2018-01-16 | Regeneron Pharma | roedor, e, métodos para fabricar um roedor e um camundongo humanizados e para identificar um composto capaz de modular a ativação de complemento |
| HRP20250552T1 (hr) | 2014-11-17 | 2025-08-15 | Regeneron Pharmaceuticals, Inc. | Postupci za liječenje tumora upotrebom cd3xcd20 bispecifičnog antitijela |
| JP2018503368A (ja) * | 2014-12-18 | 2018-02-08 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｃｄｃを誘発する抗体を決定するためのアッセイ法および方法 |
| WO2016161010A2 (en) | 2015-03-30 | 2016-10-06 | Regeneron Pharmaceuticals, Inc. | Heavy chain constant regions with reduced binding to fc gamma receptors |
| IL292798A (en) | 2015-05-04 | 2022-07-01 | Cytomx Therapeutics Inc | Anti-cd166 antibodies, activatable anti-cd166 antibodies, preparations containing them and their uses |
| CN106957366B (zh) * | 2016-01-12 | 2022-02-01 | 上海昀怡健康科技发展有限公司 | 一种C5aR抗体及其制备方法和应用 |
| SG11201908744PA (en) * | 2017-03-23 | 2019-10-30 | Univ Pennsylvania | Anti-c5a antibodies and uses thereof |
| KR20200027971A (ko) * | 2017-07-14 | 2020-03-13 | 싸이톰스 테라퓨틱스, 인크. | 항-cd166 항체 및 이의 용도 |
| KR102355755B1 (ko) * | 2017-12-14 | 2022-02-08 | 코카 크롬 인더스트리 컴퍼니 리미티드 | 냉각롤 및 그것을 사용한 열가소성 수지 시트의 제조 방법 |
| WO2019236820A1 (en) * | 2018-06-07 | 2019-12-12 | Chemocentryx, Inc. | Dosing and effect of c5a antagonist with anca-associated vasculitis |
| KR20210054528A (ko) | 2018-08-31 | 2021-05-13 | 리제너론 파아마슈티컬스, 인크. | Cd3/c20 이중특이적 항체에 대한 사이토카인 방출 증후군을 경감시키는 투약 전략 |
| CN109439662B (zh) * | 2018-11-15 | 2020-09-01 | 北京大学第三医院 | 用于C5aR1基因敲除的sgRNA、载体以及构建方法和检测方法 |
| MX2021011040A (es) * | 2019-03-14 | 2021-12-10 | Morphosys Ag | Anticuerpos dirigidos contra c5ar. |
| TWI869528B (zh) | 2020-01-13 | 2025-01-11 | 美商威特拉公司 | C5ar1抗體分子及其用途 |
| JP2024502863A (ja) | 2021-01-13 | 2024-01-23 | ビステラ， インコーポレイテッド | ヒト化補体５ａ受容体１抗体及びその使用方法 |
| CN121152813A (zh) * | 2023-03-23 | 2025-12-16 | 恺兴生命科技(上海)有限公司 | 细胞免疫疗法的组合物和方法 |
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| NL154598B (nl) * | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3817827A (en) | 1972-03-30 | 1974-06-18 | Scott Paper Co | Soft absorbent fibrous webs containing elastomeric bonding material and formed by creping and embossing |
| US4098876A (en) * | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
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| US4568649A (en) | 1983-02-22 | 1986-02-04 | Immunex Corporation | Immediate ligand detection assay |
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| EP0832981A1 (en) | 1987-02-17 | 1998-04-01 | Pharming B.V. | DNA sequences to target proteins to the mammary gland for efficient secretion |
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| DE69029036T2 (de) | 1989-06-29 | 1997-05-22 | Medarex Inc | Bispezifische reagenzien für die aids-therapie |
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| WO1994011026A2 (en) | 1992-11-13 | 1994-05-26 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human b lymphocyte restricted differentiation antigen for treatment of b cell lymphoma |
| US5514555A (en) | 1993-03-12 | 1996-05-07 | Center For Blood Research, Inc. | Assays and therapeutic methods based on lymphocyte chemoattractants |
| US5480974A (en) | 1993-06-18 | 1996-01-02 | The Scripps Research Institute | Antibodies to human C5a receptor |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
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| JPH08109200A (ja) | 1994-08-19 | 1996-04-30 | Takeda Chem Ind Ltd | 抗Ｃ５ａレセプター抗体、その製造法および用途 |
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| TWI327597B (en) | 2001-08-01 | 2010-07-21 | Centocor Inc | Anti-tnf antibodies, compositions, methods and uses |
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| RU2377253C2 (ru) | 2002-12-02 | 2009-12-27 | Амген Фремонт,Инк. | Антитела, специфичные к фактору некроза опухолей, и их применение |
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| CN1997384A (zh) * | 2004-03-26 | 2007-07-11 | 普罗米克斯有限公司 | 使用补体C5a受体调节剂治疗神经系统病症 |
| MX2007011064A (es) | 2005-03-23 | 2008-02-19 | Genmab As | Anticuerpos contra cd38 para tratamiento de mieloma multiple. |
| US7649951B2 (en) | 2006-08-16 | 2010-01-19 | Harris Corporation | System and method for communicating data using symbol-based randomized orthogonal frequency division multiplexing (OFDM) with applied frequency domain spreading |
| EP2051997B1 (en) | 2006-08-22 | 2015-03-18 | G2 Inflammation Pty Ltd | Anti-c5ar antibodies with improved properties |
| JP2010501165A (ja) | 2006-08-22 | 2010-01-21 | ジーツー インフラメイション プロプライエタリー リミテッド | 抗体の作製方法 |
| WO2008030564A2 (en) | 2006-09-08 | 2008-03-13 | Verenium Corporation | Aglycosylated antibodies and methods of making and using those antibodies |
| JP5314033B2 (ja) | 2007-10-22 | 2013-10-16 | メルク セローノ ソシエテ アノニム | 突然変異ＩｇＧＦｃフラグメントと融合した単一ＩＦＮ−ベータ |
| CN104193824A (zh) | 2008-02-20 | 2014-12-10 | G2炎症私人有限公司 | 人源化抗-C5aR抗体 |
| WO2010000864A1 (en) | 2008-07-04 | 2010-01-07 | Novo Nordisk A/S | Method for producing monoclonal antibodies |
| CN107693791B (zh) | 2010-02-26 | 2022-06-07 | 诺沃—诺迪斯克有限公司 | 包含稳定抗体的组合物 |
| US20130136733A1 (en) | 2010-05-28 | 2013-05-30 | Novo Nordisk A/S | Stable Multi-Dose Compositions Comprising an Antibody and a Preservative |
-
2009
- 2009-02-19 CN CN201410315627.6A patent/CN104193824A/zh not_active Withdrawn
- 2009-02-19 EP EP09713373.0A patent/EP2254911B1/en not_active Not-in-force
- 2009-02-19 JP JP2010547002A patent/JP2011515073A/ja active Pending
- 2009-02-19 CA CA2714296A patent/CA2714296A1/en not_active Abandoned
- 2009-02-19 WO PCT/AU2009/000184 patent/WO2009103113A1/en not_active Ceased
- 2009-02-19 EP EP14177321.8A patent/EP2826791A3/en not_active Withdrawn
- 2009-02-19 ES ES09713373.0T patent/ES2562627T3/es active Active
- 2009-02-19 RU RU2010138612/10A patent/RU2010138612A/ru not_active Application Discontinuation
- 2009-02-19 MX MX2010009190A patent/MX2010009190A/es active IP Right Grant
- 2009-02-19 KR KR1020107020742A patent/KR20100117120A/ko not_active Ceased
- 2009-02-19 AU AU2009217224A patent/AU2009217224B2/en not_active Ceased
- 2009-02-19 BR BRPI0907532-1A patent/BRPI0907532A2/pt not_active Application Discontinuation
- 2009-02-19 US US12/866,009 patent/US8268972B2/en not_active Expired - Fee Related
- 2009-02-19 CN CN200980105691.9A patent/CN101970494B/zh not_active Expired - Fee Related
-
2010
- 2010-07-26 IL IL207217A patent/IL207217A/en not_active IP Right Cessation
- 2010-07-27 ZA ZA2010/05348A patent/ZA201005348B/en unknown
-
2012
- 2012-08-20 US US13/590,016 patent/US8361468B2/en not_active Expired - Fee Related
- 2012-12-19 US US13/720,685 patent/US8808701B2/en not_active Expired - Fee Related
-
2014
- 2014-04-28 JP JP2014092573A patent/JP6034826B2/ja not_active Expired - Fee Related
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