JP2011513501A5 - - Google Patents
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- Publication number
- JP2011513501A5 JP2011513501A5 JP2010550880A JP2010550880A JP2011513501A5 JP 2011513501 A5 JP2011513501 A5 JP 2011513501A5 JP 2010550880 A JP2010550880 A JP 2010550880A JP 2010550880 A JP2010550880 A JP 2010550880A JP 2011513501 A5 JP2011513501 A5 JP 2011513501A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical formulation
- menadione
- maintain
- water
- sufficient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- MJVAVZPDRWSRRC-UHFFFAOYSA-N Menadione Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1 MJVAVZPDRWSRRC-UHFFFAOYSA-N 0.000 claims 22
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 235000012711 vitamin K3 Nutrition 0.000 claims 11
- 239000011652 vitamin K3 Substances 0.000 claims 11
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 9
- 229940041603 vitamin k 3 Drugs 0.000 claims 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 6
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims 4
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims 4
- 210000003491 skin Anatomy 0.000 claims 4
- JVTIXNMXDLQEJE-UHFFFAOYSA-N 2-decanoyloxypropyl decanoate 2-octanoyloxypropyl octanoate Chemical compound C(CCCCCCC)(=O)OCC(C)OC(CCCCCCC)=O.C(=O)(CCCCCCCCC)OCC(C)OC(=O)CCCCCCCCC JVTIXNMXDLQEJE-UHFFFAOYSA-N 0.000 claims 3
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 claims 3
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 3
- 229940075510 carbopol 981 Drugs 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 229940031578 diisopropyl adipate Drugs 0.000 claims 3
- 230000003472 neutralizing effect Effects 0.000 claims 3
- KSCKTBJJRVPGKM-UHFFFAOYSA-N octan-1-olate;titanium(4+) Chemical compound [Ti+4].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-] KSCKTBJJRVPGKM-UHFFFAOYSA-N 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 239000003755 preservative agent Substances 0.000 claims 3
- 230000002335 preservative effect Effects 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 210000002615 epidermis Anatomy 0.000 claims 2
- 239000003349 gelling agent Substances 0.000 claims 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims 2
- 229960002216 methylparaben Drugs 0.000 claims 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 2
- 229920000058 polyacrylate Polymers 0.000 claims 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims 2
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims 2
- 229960003415 propylparaben Drugs 0.000 claims 2
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims 2
- 102000009465 Growth Factor Receptors Human genes 0.000 claims 1
- 108010009202 Growth Factor Receptors Proteins 0.000 claims 1
- 238000011123 anti-EGFR therapy Methods 0.000 claims 1
- 230000002421 anti-septic effect Effects 0.000 claims 1
- 235000019445 benzyl alcohol Nutrition 0.000 claims 1
- 239000000306 component Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 229940121647 egfr inhibitor Drugs 0.000 claims 1
- 229940116977 epidermal growth factor Drugs 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 235000019441 ethanol Nutrition 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6921808P | 2008-03-13 | 2008-03-13 | |
| US20493909P | 2009-01-13 | 2009-01-13 | |
| PCT/US2009/037041 WO2009114745A1 (en) | 2008-03-13 | 2009-03-13 | Formulations of vitamin k analogs for topical use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014218037A Division JP2015042658A (ja) | 2008-03-13 | 2014-10-27 | 局所使用のためのビタミンｋ類似体製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011513501A JP2011513501A (ja) | 2011-04-28 |
| JP2011513501A5 true JP2011513501A5 (enExample) | 2013-05-09 |
Family
ID=40677542
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010550880A Pending JP2011513501A (ja) | 2008-03-13 | 2009-03-13 | 局所使用のためのビタミンｋ類似体製剤 |
| JP2014218037A Pending JP2015042658A (ja) | 2008-03-13 | 2014-10-27 | 局所使用のためのビタミンｋ類似体製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014218037A Pending JP2015042658A (ja) | 2008-03-13 | 2014-10-27 | 局所使用のためのビタミンｋ類似体製剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8815953B2 (enExample) |
| EP (1) | EP2265255A1 (enExample) |
| JP (2) | JP2011513501A (enExample) |
| KR (1) | KR20110004382A (enExample) |
| AU (1) | AU2009223158B2 (enExample) |
| CA (1) | CA2718262A1 (enExample) |
| WO (1) | WO2009114745A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100010100A1 (en) * | 2008-07-09 | 2010-01-14 | Hinman Andrew W | Dermatological compositions with anti-aging and skin even-toning properties |
| WO2010014361A1 (en) * | 2008-07-30 | 2010-02-04 | Edison Pharmaceuticals, Inc. | Naphthoquinone compositions with anti-aging, anti- inflammatory and skin even-toning properties |
| AU2010292439A1 (en) * | 2009-09-14 | 2012-04-12 | Nestec S.A. | Nutritional compositions including exogenous vitamin K2 |
| ITPD20100090A1 (it) * | 2010-03-22 | 2011-09-23 | Sanitas Farmaceutici S R L | Formulazione topica per il trattamento di eruzioni cutanee, in particolare conseguenti a trattamenti con farmaci anti egfr |
| EP2601168A4 (en) * | 2010-08-06 | 2013-12-04 | Ampere Life Sciences Inc | TREATMENT OF MITOCHONDRIAL DISEASES BY VITAMIN K |
| JP5062922B2 (ja) | 2011-02-14 | 2012-10-31 | 株式会社Ｊ−オイルミルズ | 皮膚コラーゲン産生促進剤 |
| US9421297B2 (en) | 2014-04-02 | 2016-08-23 | Adhezion Biomedical, Llc | Sterilized compositions of cyanoacrylate monomers and naphthoquinone 2,3-oxides |
| WO2019072877A1 (en) | 2017-10-10 | 2019-04-18 | Capsugel Belgium Nv | GETTING MULTIPARTICULAR COMPOSITIONS |
| TW201927292A (zh) | 2017-12-13 | 2019-07-16 | 大陸商上海小午醫藥科技有限公司 | 一種用於預防或治療與ｅｇｆｒ被抑制相關疾病的方法 |
| AU2019254237B2 (en) | 2018-04-16 | 2025-01-30 | Onquality Pharmaceuticals China Ltd. | Method for preventing or treating side effects of cancer therapy |
| WO2020067663A1 (ko) * | 2018-09-28 | 2020-04-02 | 주식회사 엘지생활건강 | 피부 턴오버 촉진 및 멜라닌 배출 촉진용 조성물 |
| KR20230110821A (ko) * | 2019-04-17 | 2023-07-25 | 아조라 테라퓨틱스 인코포레이티드 | 염증성 피부 질환을 치료하기 위한 국소 조성물 및방법 |
| WO2023119230A1 (en) | 2021-12-22 | 2023-06-29 | L'oreal | Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use |
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-
2009
- 2009-03-12 US US12/381,467 patent/US8815953B2/en active Active
- 2009-03-13 CA CA2718262A patent/CA2718262A1/en not_active Abandoned
- 2009-03-13 KR KR1020107022900A patent/KR20110004382A/ko not_active Ceased
- 2009-03-13 JP JP2010550880A patent/JP2011513501A/ja active Pending
- 2009-03-13 AU AU2009223158A patent/AU2009223158B2/en not_active Ceased
- 2009-03-13 EP EP09718881A patent/EP2265255A1/en not_active Withdrawn
- 2009-03-13 WO PCT/US2009/037041 patent/WO2009114745A1/en not_active Ceased
-
2014
- 2014-07-21 US US14/336,876 patent/US20140336268A1/en not_active Abandoned
- 2014-10-27 JP JP2014218037A patent/JP2015042658A/ja active Pending
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