JP2011511071A5 - - Google Patents
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- Publication number
- JP2011511071A5 JP2011511071A5 JP2010545878A JP2010545878A JP2011511071A5 JP 2011511071 A5 JP2011511071 A5 JP 2011511071A5 JP 2010545878 A JP2010545878 A JP 2010545878A JP 2010545878 A JP2010545878 A JP 2010545878A JP 2011511071 A5 JP2011511071 A5 JP 2011511071A5
- Authority
- JP
- Japan
- Prior art keywords
- treatment
- picoplatin
- patient
- amrubicin
- lung cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 claims description 90
- 238000011282 treatment Methods 0.000 claims description 77
- IIMIOEBMYPRQGU-UHFFFAOYSA-L picoplatin Chemical compound N.[Cl-].[Cl-].[Pt+2].CC1=CC=CC=N1 IIMIOEBMYPRQGU-UHFFFAOYSA-L 0.000 claims description 66
- 229950005566 picoplatin Drugs 0.000 claims description 66
- 229960002550 amrubicin Drugs 0.000 claims description 46
- VJZITPJGSQKZMX-XDPRQOKASA-N amrubicin Chemical compound O([C@H]1C[C@](CC2=C(O)C=3C(=O)C4=CC=CC=C4C(=O)C=3C(O)=C21)(N)C(=O)C)[C@H]1C[C@H](O)[C@H](O)CO1 VJZITPJGSQKZMX-XDPRQOKASA-N 0.000 claims description 46
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 35
- 201000005202 lung cancer Diseases 0.000 claims description 35
- 208000020816 lung neoplasm Diseases 0.000 claims description 35
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 20
- 206010041067 Small cell lung cancer Diseases 0.000 claims description 19
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 19
- 208000000587 small cell lung carcinoma Diseases 0.000 claims description 19
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 19
- 238000009093 first-line therapy Methods 0.000 claims description 15
- 238000011221 initial treatment Methods 0.000 claims description 14
- 238000002560 therapeutic procedure Methods 0.000 claims description 14
- 238000001959 radiotherapy Methods 0.000 claims description 12
- 238000001990 intravenous administration Methods 0.000 claims description 11
- 229910052697 platinum Inorganic materials 0.000 claims description 10
- 230000001093 anti-cancer Effects 0.000 claims description 9
- 230000000750 progressive effect Effects 0.000 claims description 8
- 239000002552 dosage form Substances 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 238000011396 initial chemotherapy Methods 0.000 claims description 6
- 230000003319 supportive effect Effects 0.000 claims description 6
- 239000002246 antineoplastic agent Substances 0.000 claims description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 238000002512 chemotherapy Methods 0.000 claims description 4
- 238000001802 infusion Methods 0.000 claims description 4
- 239000000644 isotonic solution Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 229940127089 cytotoxic agent Drugs 0.000 claims description 3
- 238000002651 drug therapy Methods 0.000 claims description 3
- 238000011287 therapeutic dose Methods 0.000 claims description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- 208000000059 Dyspnea Diseases 0.000 claims description 2
- 206010013975 Dyspnoeas Diseases 0.000 claims description 2
- 102000001554 Hemoglobins Human genes 0.000 claims description 2
- 108010054147 Hemoglobins Proteins 0.000 claims description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 2
- VLSOAXRVHARBEQ-UHFFFAOYSA-N [4-fluoro-2-(hydroxymethyl)phenyl]methanol Chemical compound OCC1=CC=C(F)C=C1CO VLSOAXRVHARBEQ-UHFFFAOYSA-N 0.000 claims description 2
- 230000000202 analgesic effect Effects 0.000 claims description 2
- 208000007502 anemia Diseases 0.000 claims description 2
- 230000003474 anti-emetic effect Effects 0.000 claims description 2
- 239000002111 antiemetic agent Substances 0.000 claims description 2
- 239000008365 aqueous carrier Substances 0.000 claims description 2
- 229960004562 carboplatin Drugs 0.000 claims description 2
- 190000008236 carboplatin Chemical compound 0.000 claims description 2
- 230000000973 chemotherapeutic effect Effects 0.000 claims description 2
- 229960004316 cisplatin Drugs 0.000 claims description 2
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims description 2
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims description 2
- 229960003957 dexamethasone Drugs 0.000 claims description 2
- 239000008101 lactose Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000003369 serotonin 5-HT3 receptor antagonist Substances 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 239000002131 composite material Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000003002 pH adjusting agent Substances 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 241000282412 Homo Species 0.000 description 1
- 238000009094 second-line therapy Methods 0.000 description 1
- 238000009095 third-line therapy Methods 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2736008P | 2008-02-08 | 2008-02-08 | |
| US2738708P | 2008-02-08 | 2008-02-08 | |
| US2738208P | 2008-02-08 | 2008-02-08 | |
| PCT/US2009/000750 WO2009099634A2 (en) | 2008-02-08 | 2009-02-06 | Picoplatin and amrubicin to treat lung cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011511071A JP2011511071A (ja) | 2011-04-07 |
| JP2011511071A5 true JP2011511071A5 (enExample) | 2013-04-11 |
Family
ID=40952402
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010545878A Withdrawn JP2011511071A (ja) | 2008-02-08 | 2009-02-06 | 肺癌を治療するためのピコプラチンおよびアムルビシン |
| JP2010545885A Withdrawn JP2011511074A (ja) | 2008-02-08 | 2009-02-06 | 結腸直腸癌を治療するためのピコプラチンおよびセツキシマブの使用 |
| JP2010545883A Withdrawn JP2011511072A (ja) | 2008-02-08 | 2009-02-06 | 結腸直腸癌を治療するためのピコプラチンおよびベバシツマブの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010545885A Withdrawn JP2011511074A (ja) | 2008-02-08 | 2009-02-06 | 結腸直腸癌を治療するためのピコプラチンおよびセツキシマブの使用 |
| JP2010545883A Withdrawn JP2011511072A (ja) | 2008-02-08 | 2009-02-06 | 結腸直腸癌を治療するためのピコプラチンおよびベバシツマブの使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20110053879A1 (enExample) |
| EP (3) | EP2244714A4 (enExample) |
| JP (3) | JP2011511071A (enExample) |
| CN (3) | CN101998851A (enExample) |
| AU (3) | AU2009210734A1 (enExample) |
| CA (3) | CA2715329A1 (enExample) |
| WO (3) | WO2009099634A2 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0011903D0 (en) * | 2000-05-18 | 2000-07-05 | Astrazeneca Ab | Combination chemotherapy |
| US8168662B1 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8168661B2 (en) * | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8178564B2 (en) | 2006-11-06 | 2012-05-15 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8173686B2 (en) | 2006-11-06 | 2012-05-08 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US20110033528A1 (en) * | 2009-08-05 | 2011-02-10 | Poniard Pharmaceuticals, Inc. | Stabilized picoplatin oral dosage form |
| KR20090109130A (ko) * | 2007-02-09 | 2009-10-19 | 포니아드 파마슈티칼즈, 인크. | 캡슐화된 피코플라틴 |
| TW200916094A (en) * | 2007-06-27 | 2009-04-16 | Poniard Pharmaceuticals Inc | Stabilized picoplatin dosage form |
| WO2009011861A1 (en) * | 2007-07-16 | 2009-01-22 | Poniard Pharmaceuticals, Inc. | Oral formulations for picoplatin |
| CN101998851A (zh) * | 2008-02-08 | 2011-03-30 | 帕纳德制药公司 | 吡铂和西妥昔单抗治疗结直肠癌的用途 |
| ES2354922B1 (es) * | 2009-09-02 | 2012-02-07 | Fundacion Institut De Recerca De L'hospital Universitari Vall D'hebron | Marcadores para la selección de terapias personalizadas para el tratamiento del c�?ncer. |
| US9217032B2 (en) | 2010-01-08 | 2015-12-22 | Les Laboratoires Servier | Methods for treating colorectal cancer |
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| JP2013521338A (ja) * | 2010-03-05 | 2013-06-10 | ポニアード ファーマシューティカルズ， インコーポレイテッド | 小細胞肺癌を治療するための方法 |
| US20150071912A1 (en) | 2010-03-24 | 2015-03-12 | Centre National De La Recherche Scientifique (Cnrs) | Prophylaxis of colorectal and gastrointestinal cancer |
| US9205086B2 (en) | 2010-04-19 | 2015-12-08 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of a Hsp90 inhibitory compounds and a EGFR inhibitor |
| WO2011133521A2 (en) * | 2010-04-19 | 2011-10-27 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of a hsp90 inhibitory compounds and a vegf inhibitor |
| US9141756B1 (en) | 2010-07-20 | 2015-09-22 | University Of Southern California | Multi-scale complex systems transdisciplinary analysis of response to therapy |
| US8709419B2 (en) * | 2010-08-17 | 2014-04-29 | Hoffmann-La Roche, Inc. | Combination therapy |
| US8962804B2 (en) * | 2010-10-08 | 2015-02-24 | City Of Hope | Meditopes and meditope-binding antibodies and uses thereof |
| CL2011000273A1 (es) | 2011-02-08 | 2011-06-17 | Univ Pontificia Catolica Chile | Uso de un inhibidor de la enzima fosfohidrolasa de acido fosfatidico (pap) o combinacion de inhibidores, en que el inhibidor es d(+) propranolol, y la combinacion es mezcla racemica de propranolol o d(+) propranolol junto con desipramina, para preparar un medicamento util en el tratamiento del cancer. |
| AU2012332424A1 (en) | 2011-11-02 | 2014-06-05 | Synta Pharmaceuticals Corp. | Combination therapy of Hsp90 inhibitors with platinum-containing agents |
| JP2014532712A (ja) | 2011-11-02 | 2014-12-08 | シンタ ファーマシューティカルズ コーポレーション | トポイソメラーゼｉ阻害剤とｈｓｐ９０阻害剤の組合せを使用する癌療法 |
| AU2012339679A1 (en) | 2011-11-14 | 2014-06-12 | Synta Pharmaceuticals Corp. | Combination therapy of Hsp90 inhibitors with BRAF inhibitors |
| EP2617421A1 (en) | 2012-01-20 | 2013-07-24 | Isofol Medical AB | Tetrahydrofolates in combination with EGFR-inhibitors in the use of treating cancer |
| WO2013130625A1 (en) * | 2012-02-27 | 2013-09-06 | Basil Rigas | Phospho-ester derivatives and uses thereof |
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| ES2942585T3 (es) * | 2012-04-26 | 2023-06-02 | Stichting Vumc | Biomarcadores |
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| MY186099A (en) * | 2012-05-31 | 2021-06-22 | Genentech Inc | Methods of treating cancer using pd-l1 axis binding antagonists and vegf antagonists |
| BR112015009134A2 (pt) * | 2012-10-25 | 2017-07-04 | Glaxosmithkline Llc | combinação |
| CA2982169A1 (en) | 2015-04-10 | 2016-10-13 | Applied Proteomics, Inc. | Protein biomarker panels for detecting colorectal cancer and advanced adenoma |
| CN108136023B (zh) * | 2015-08-12 | 2021-07-27 | 北卡罗莱纳州立大学 | 血小板膜包覆的药物递送系统 |
| WO2021007512A1 (en) * | 2019-07-11 | 2021-01-14 | Emory University | Platinum-based chemotherapy, mast binding agents, glucocorticoid receptor (gr) binding agents, and/or hsp90 binding agents for uses in treating cancer |
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2009
- 2009-02-06 CN CN2009801110152A patent/CN101998851A/zh active Pending
- 2009-02-06 WO PCT/US2009/000750 patent/WO2009099634A2/en not_active Ceased
- 2009-02-06 WO PCT/US2009/000773 patent/WO2009099651A1/en not_active Ceased
- 2009-02-06 CN CN2009801097586A patent/CN102006875A/zh active Pending
- 2009-02-06 JP JP2010545878A patent/JP2011511071A/ja not_active Withdrawn
- 2009-02-06 CA CA2715329A patent/CA2715329A1/en not_active Abandoned
- 2009-02-06 US US12/866,710 patent/US20110053879A1/en not_active Abandoned
- 2009-02-06 AU AU2009210734A patent/AU2009210734A1/en not_active Abandoned
- 2009-02-06 CN CN2009801101399A patent/CN102014624A/zh active Pending
- 2009-02-06 EP EP09708527A patent/EP2244714A4/en not_active Withdrawn
- 2009-02-06 EP EP09708387A patent/EP2249827A4/en not_active Withdrawn
- 2009-02-06 CA CA2715353A patent/CA2715353A1/en not_active Abandoned
- 2009-02-06 AU AU2009210656A patent/AU2009210656A1/en not_active Abandoned
- 2009-02-06 JP JP2010545885A patent/JP2011511074A/ja not_active Withdrawn
- 2009-02-06 EP EP09708292A patent/EP2249644A4/en not_active Withdrawn
- 2009-02-06 US US12/866,702 patent/US20110052580A1/en not_active Abandoned
- 2009-02-06 JP JP2010545883A patent/JP2011511072A/ja not_active Withdrawn
- 2009-02-06 AU AU2009210654A patent/AU2009210654A1/en not_active Abandoned
- 2009-02-06 WO PCT/US2009/000770 patent/WO2009099649A1/en not_active Ceased
- 2009-02-06 US US12/866,706 patent/US20110052581A1/en not_active Abandoned
- 2009-02-06 CA CA2715348A patent/CA2715348A1/en not_active Abandoned
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