JP2011506607A5 - - Google Patents
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- Publication number
- JP2011506607A5 JP2011506607A5 JP2010539470A JP2010539470A JP2011506607A5 JP 2011506607 A5 JP2011506607 A5 JP 2011506607A5 JP 2010539470 A JP2010539470 A JP 2010539470A JP 2010539470 A JP2010539470 A JP 2010539470A JP 2011506607 A5 JP2011506607 A5 JP 2011506607A5
- Authority
- JP
- Japan
- Prior art keywords
- formulated
- dipyridamole
- unit dosage
- pharmaceutical composition
- dosage form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 claims description 66
- 229960002768 dipyridamole Drugs 0.000 claims description 65
- 239000008194 pharmaceutical composition Substances 0.000 claims description 62
- 239000002552 dosage form Substances 0.000 claims description 58
- 239000003246 corticosteroid Substances 0.000 claims description 52
- 229960005205 prednisolone Drugs 0.000 claims description 52
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims description 52
- 238000013270 controlled release Methods 0.000 claims description 40
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims description 32
- 238000004090 dissolution Methods 0.000 claims description 16
- 239000011324 bead Substances 0.000 claims description 14
- 239000011248 coating agent Substances 0.000 claims description 14
- 238000000576 coating method Methods 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 13
- 238000009472 formulation Methods 0.000 claims description 12
- 238000000338 in vitro Methods 0.000 claims description 12
- 239000002253 acid Substances 0.000 claims description 8
- 239000012738 dissolution medium Substances 0.000 claims description 8
- 239000002609 medium Substances 0.000 claims description 8
- 239000008363 phosphate buffer Substances 0.000 claims description 8
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 5
- VHRSUDSXCMQTMA-PJHHCJLFSA-N 6alpha-methylprednisolone Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)CO)CC[C@H]21 VHRSUDSXCMQTMA-PJHHCJLFSA-N 0.000 claims description 4
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims description 4
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 4
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 4
- 238000010521 absorption reaction Methods 0.000 claims description 4
- 229960002537 betamethasone Drugs 0.000 claims description 4
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 claims description 4
- 229960004436 budesonide Drugs 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 229960002714 fluticasone Drugs 0.000 claims description 4
- MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 claims description 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 4
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims description 4
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims description 4
- 230000000495 immunoinflammatory effect Effects 0.000 claims description 4
- 229960004584 methylprednisolone Drugs 0.000 claims description 4
- 229960004618 prednisone Drugs 0.000 claims description 4
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 4
- 235000002906 tartaric acid Nutrition 0.000 claims description 4
- 239000011975 tartaric acid Substances 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 2
- 238000011903 nutritional therapy Methods 0.000 claims description 2
- 229940095064 tartrate Drugs 0.000 claims description 2
- 229920003134 Eudragit® polymer Polymers 0.000 claims 4
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 4
- 229960001145 deflazacort Drugs 0.000 claims 1
- FBHSPRKOSMHSIF-GRMWVWQJSA-N deflazacort Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(C)=N[C@@]3(C(=O)COC(=O)C)[C@@]1(C)C[C@@H]2O FBHSPRKOSMHSIF-GRMWVWQJSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 230000035764 nutrition Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 30
- 229920003139 Eudragit® L 100 Polymers 0.000 description 2
- 229920003141 Eudragit® S 100 Polymers 0.000 description 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1430707P | 2007-12-17 | 2007-12-17 | |
| PCT/US2008/013805 WO2009078998A1 (en) | 2007-12-17 | 2008-12-17 | Therapeutic regimens for the treatment of immunoinflammatory disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011506607A JP2011506607A (ja) | 2011-03-03 |
| JP2011506607A5 true JP2011506607A5 (enExample) | 2012-02-09 |
Family
ID=40795828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010539470A Pending JP2011506607A (ja) | 2007-12-17 | 2008-12-17 | 免疫炎症性障害の処置のための治療法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20110189293A1 (enExample) |
| EP (1) | EP2231129A4 (enExample) |
| JP (1) | JP2011506607A (enExample) |
| KR (1) | KR20100121601A (enExample) |
| CN (1) | CN101938996A (enExample) |
| AU (1) | AU2008338980A1 (enExample) |
| CA (1) | CA2709561A1 (enExample) |
| IL (1) | IL206435A0 (enExample) |
| MX (1) | MX2010006724A (enExample) |
| NZ (1) | NZ586332A (enExample) |
| WO (1) | WO2009078998A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0808537D0 (en) * | 2008-05-12 | 2008-06-18 | Archimedes Dev Ltd | Compositions |
| GB201202433D0 (en) * | 2012-02-13 | 2012-03-28 | Diurnal Ltd | Controlled drug release |
| CA2975000A1 (en) * | 2015-01-28 | 2016-08-04 | Realinn Life Science Limited | Compounds for enhancing ppar.gamma. expression and nuclear translocation and therapeutic use thereof |
| CN106994128A (zh) * | 2016-01-26 | 2017-08-01 | 上海普瑞得生物技术有限公司 | 17-α羟孕酮化合物在预防和治疗中性粒细胞炎症疾病中的应用 |
| US11896719B2 (en) | 2022-01-24 | 2024-02-13 | Calliditas Therapeutics Ab | Pharmaceutical compositions |
| EP4427752A1 (en) * | 2023-03-09 | 2024-09-11 | Fundacion Instituto De Investigacion Sanitaria Fundacion Jimenez Diaz | Dipyridamole as a novel therapy for muscular myogenesis disorders and inflammatory arthritis |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3031450A (en) * | 1959-04-30 | 1962-04-24 | Thomae Gmbh Dr K | Substituted pyrimido-[5, 4-d]-pyrimidines |
| AU496759B2 (en) * | 1972-12-27 | 1978-10-26 | Schering Aktiengesellschaft | New pregnan-21-oic derivatives |
| US4034087A (en) * | 1973-12-17 | 1977-07-05 | The Regents Of The University Of Michigan | Pharmaceutical composition and process of treatment |
| US4107306A (en) * | 1973-01-16 | 1978-08-15 | The Regents Of The University Of Michigan | Process for treating proliferative skin disease |
| US3934036A (en) * | 1975-01-23 | 1976-01-20 | Kyorin Seiyaku Kabushiki Kaisha | N-benzenesulfonyl-β-alanine hydrazide useful as an immunosuppressive agent |
| EP0005911B1 (en) * | 1978-05-26 | 1982-02-17 | Imperial Chemical Industries Plc | Analgesic 6-acylaminotetrahydro-1,3,5-triazine-2,4-dione derivatives, pharmaceutical compositions thereof, and process for their manufacture |
| FR2470599A1 (fr) * | 1979-12-07 | 1981-06-12 | Panoz Donald | Perfectionnements apportes aux procedes de preparation de formes galeniques a action retard et a liberation programmee et formes galeniques de medicaments ainsi obtenus |
| DE3000979A1 (de) * | 1980-01-12 | 1981-07-23 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue dipyridamol-retardformen und verfahren zu ihrer herstellung |
| BG36086A1 (en) * | 1982-01-19 | 1984-09-14 | Glbov | Method for inducing interferon |
| US4879119A (en) * | 1984-02-21 | 1989-11-07 | Yamanouchi Pharmaceutical Co., Ltd. | Patch |
| JPS60174716A (ja) * | 1984-02-21 | 1985-09-09 | Yamanouchi Pharmaceut Co Ltd | パツチ剤 |
| US4554271A (en) * | 1984-02-24 | 1985-11-19 | The Upjohn Company | Use of high doses of derivatives of 6α-methylprednisolone for the acute treatment of stroke syndrome |
| DE3627423A1 (de) * | 1986-08-13 | 1988-02-18 | Thomae Gmbh Dr K | Arzneimittel enthaltend dipyridamol oder mopidamol und o-acetylsalicylsaeure bzw. deren physiologisch vertraegliche salze, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung der thrombusbildung |
| AU618517B2 (en) * | 1986-12-23 | 1992-01-02 | Eugene J. Van Scott | Additives enhancing topical actions of therapeutic agents |
| US5668116A (en) * | 1987-03-19 | 1997-09-16 | Anthropharm Pty. Limited | Anti-inflammatory compounds and compositions |
| US5242921A (en) * | 1988-04-27 | 1993-09-07 | Yale University | Compositions and methods for treating cutaneous hyperproliferative disorders |
| US5270047A (en) * | 1991-11-21 | 1993-12-14 | Kauffman Raymond F | Local delivery of dipyridamole for the treatment of proliferative diseases |
| US5474765A (en) * | 1992-03-23 | 1995-12-12 | Ut Sw Medical Ctr At Dallas | Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells |
| EG20321A (en) * | 1993-07-21 | 1998-10-31 | Otsuka Pharma Co Ltd | Medical material and process for producing the same |
| US5428040A (en) * | 1993-08-31 | 1995-06-27 | The Du Pont Merck Pharmaceutical Company | Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents |
| DE4430128A1 (de) * | 1994-08-25 | 1996-02-29 | Hoechst Ag | Kombinationspräparat mit immunsuppressiven, kardiovaskulären und cerebralen Wirkungen |
| FR2732223B1 (fr) * | 1995-03-30 | 1997-06-13 | Sanofi Sa | Composition pharmaceutique pour administration transdermique |
| AU5772196A (en) * | 1995-05-19 | 1996-11-29 | Chiroscience Limited | 3,4-disubstituted-phenylsulphonamides and their therapeutic use |
| US6265427B1 (en) * | 1995-06-07 | 2001-07-24 | The Proctor & Gamble Company | Pharmaceutical composition for the method of treating leukemia |
| US6235706B1 (en) * | 1996-09-18 | 2001-05-22 | Merck & Co., Inc. | Combination therapy for reducing the risks associated with cardiovascular disease |
| US5958926A (en) * | 1996-11-01 | 1999-09-28 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
| US6331543B1 (en) * | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
| US5874437A (en) * | 1996-11-01 | 1999-02-23 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
| US5792476A (en) * | 1996-12-19 | 1998-08-11 | Abigo Medical Ab | Sustained release glucocorticoid pharmaceutical composition |
| US6054487A (en) * | 1997-03-18 | 2000-04-25 | Basf Aktiengesellschaft | Methods and compositions for modulating responsiveness to corticosteroids |
| KR20010013413A (ko) * | 1997-06-05 | 2001-02-26 | 피터 지. 스트링거 | 혈전성 질환의 치료 방법 |
| US20030077229A1 (en) * | 1997-10-01 | 2003-04-24 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing cardiovascular or renal drugs |
| US6372254B1 (en) * | 1998-04-02 | 2002-04-16 | Impax Pharmaceuticals Inc. | Press coated, pulsatile drug delivery system suitable for oral administration |
| US6602521B1 (en) * | 1998-09-29 | 2003-08-05 | Impax Pharmaceuticals, Inc. | Multiplex drug delivery system suitable for oral administration |
| US6677326B2 (en) * | 1999-03-15 | 2004-01-13 | Arakis, Ltd. | Corticosteroid formulation comprising less than 2.5 mg prednisolone for once daily administration |
| US6383471B1 (en) * | 1999-04-06 | 2002-05-07 | Lipocine, Inc. | Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
| EP1225901A2 (en) * | 1999-09-21 | 2002-07-31 | Emory University | Uses and compositions for treating platelet-related disorders using anagrelide |
| EP1233768A1 (en) * | 1999-11-15 | 2002-08-28 | Smithkline Beecham | Carvedilol methanesulfonate |
| US20010007083A1 (en) * | 1999-12-29 | 2001-07-05 | Roorda Wouter E. | Device and active component for inhibiting formation of thrombus-inflammatory cell matrix |
| EP1370211A4 (en) * | 2001-03-02 | 2005-02-09 | Bristol Myers Squibb Co | SIMULTANEOUS ADMINISTRATION OF MELANOCORTIN RECEPTOR AGONISTS AND A PHOSPHODIESTERASE HEMMER FOR THE TREATMENT OF DISEASES RELATED TO CYCLIC AMP |
| US6960357B2 (en) * | 2001-05-25 | 2005-11-01 | Mistral Pharma Inc. | Chemical delivery device |
| ES2330837T3 (es) * | 2001-07-09 | 2009-12-16 | Combinatorx, Incorporated | Combinaciones para el tratamiento de trastornos inflamatorios. |
| GB0119848D0 (en) * | 2001-08-15 | 2001-10-10 | Univ Sheffield | Delayed and sustained drug release |
| DE60239558D1 (de) * | 2001-10-05 | 2011-05-05 | Zalicus Inc | Kombinationen für die behandlung von immun-entzündlichen erkrankungen |
| US20040180812A1 (en) * | 2002-12-13 | 2004-09-16 | Technology Center | Methods of treating and preventing proliferative disease |
| WO2004060354A1 (en) * | 2002-12-31 | 2004-07-22 | Augsburger Larry L | Methods for making pharmaceutical dosage forms containing active cushioning components |
| US20050058688A1 (en) * | 2003-02-22 | 2005-03-17 | Lars Boerger | Device for the treatment and prevention of disease, and methods related thereto |
| JP4532868B2 (ja) * | 2003-09-22 | 2010-08-25 | キヤノン株式会社 | 放射線画像処理装置 |
| TW200517114A (en) * | 2003-10-15 | 2005-06-01 | Combinatorx Inc | Methods and reagents for the treatment of immunoinflammatory disorders |
| EP1999626A4 (en) * | 2006-01-26 | 2009-11-25 | Combinatorx Inc | METHODS, COMPOSITIONS AND NEEDS FOR TREATING MUSCULOSKELETAL DISORDERS AND SYMPTOMS ASSOCIATED THEREWITH |
| AU2007211101B2 (en) * | 2006-01-27 | 2013-05-02 | Adare Pharmaceuticals, Inc. | Drug delivery systems comprising weakly basic drugs and organic acids |
| CA2644889A1 (en) * | 2006-03-07 | 2007-09-13 | Combinatorx, Incorporated | Compositions and methods for the treatment of immunoinflammatory disorders |
| US20090075955A1 (en) * | 2007-09-19 | 2009-03-19 | Combinatorx, Inc. | Therapeutic regimens for the treatment of immunoinflammatory disorders |
-
2008
- 2008-12-17 CA CA2709561A patent/CA2709561A1/en not_active Abandoned
- 2008-12-17 EP EP08861473A patent/EP2231129A4/en not_active Withdrawn
- 2008-12-17 US US12/808,477 patent/US20110189293A1/en not_active Abandoned
- 2008-12-17 CN CN2008801264669A patent/CN101938996A/zh active Pending
- 2008-12-17 NZ NZ586332A patent/NZ586332A/en not_active IP Right Cessation
- 2008-12-17 MX MX2010006724A patent/MX2010006724A/es not_active Application Discontinuation
- 2008-12-17 JP JP2010539470A patent/JP2011506607A/ja active Pending
- 2008-12-17 KR KR1020107015745A patent/KR20100121601A/ko not_active Withdrawn
- 2008-12-17 WO PCT/US2008/013805 patent/WO2009078998A1/en not_active Ceased
- 2008-12-17 AU AU2008338980A patent/AU2008338980A1/en not_active Abandoned
-
2010
- 2010-06-17 IL IL206435A patent/IL206435A0/en unknown
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