JP2011510309A5 - - Google Patents
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- Publication number
- JP2011510309A5 JP2011510309A5 JP2010543379A JP2010543379A JP2011510309A5 JP 2011510309 A5 JP2011510309 A5 JP 2011510309A5 JP 2010543379 A JP2010543379 A JP 2010543379A JP 2010543379 A JP2010543379 A JP 2010543379A JP 2011510309 A5 JP2011510309 A5 JP 2011510309A5
- Authority
- JP
- Japan
- Prior art keywords
- exosome
- sample
- exosomes
- body fluid
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000001808 exosome Anatomy 0.000 claims 24
- 238000000034 method Methods 0.000 claims 19
- 210000001124 body fluid Anatomy 0.000 claims 12
- 239000010839 body fluid Substances 0.000 claims 12
- 239000000523 sample Substances 0.000 claims 12
- 238000001514 detection method Methods 0.000 claims 9
- 210000005260 human cell Anatomy 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 102000004190 Enzymes Human genes 0.000 claims 5
- 108090000790 Enzymes Proteins 0.000 claims 5
- 239000000758 substrate Substances 0.000 claims 4
- 239000012530 fluid Substances 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 2
- 239000012678 infectious agent Substances 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000002458 infectious effect Effects 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 206010003445 Ascites Diseases 0.000 claims 1
- 102100025222 CD63 antigen Human genes 0.000 claims 1
- 102000003727 Caveolin 1 Human genes 0.000 claims 1
- 108090000026 Caveolin 1 Proteins 0.000 claims 1
- 101000934368 Homo sapiens CD63 antigen Proteins 0.000 claims 1
- 102000029797 Prion Human genes 0.000 claims 1
- 108091000054 Prion Proteins 0.000 claims 1
- 108010067390 Viral Proteins Proteins 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 239000013610 patient sample Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6252808P | 2008-01-25 | 2008-01-25 | |
| US61/062,528 | 2008-01-25 | ||
| US12/321,412 US8617806B2 (en) | 2008-01-25 | 2009-01-21 | Method to measure and characterize microvesicles in the human body fluids |
| US12/321.412 | 2009-01-21 | ||
| PCT/EE2009/000002 WO2009092386A2 (en) | 2008-01-25 | 2009-01-26 | A new method to measure and characterize microvesicles in the human body fluids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011510309A JP2011510309A (ja) | 2011-03-31 |
| JP2011510309A5 true JP2011510309A5 (https=) | 2012-02-16 |
| JP5583600B2 JP5583600B2 (ja) | 2014-09-03 |
Family
ID=41064551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010543379A Expired - Fee Related JP5583600B2 (ja) | 2008-01-25 | 2009-01-26 | ヒト体液中の微小胞を測定し、特徴付けるための新規な方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8617806B2 (https=) |
| EP (1) | EP2245458B1 (https=) |
| JP (1) | JP5583600B2 (https=) |
| CN (1) | CN102317778B (https=) |
| AU (1) | AU2009207927B2 (https=) |
| BR (1) | BRPI0906683B8 (https=) |
| CA (1) | CA2713196C (https=) |
| ES (1) | ES2613670T3 (https=) |
| MX (1) | MX2010008164A (https=) |
| PL (1) | PL2245458T3 (https=) |
| RU (1) | RU2520741C2 (https=) |
| WO (1) | WO2009092386A2 (https=) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100255514A1 (en) | 2007-08-16 | 2010-10-07 | The Royal Institution For The Advancement Of Learning/Mcgill University | Tumor cell-derived microvesicles |
| JP5769417B2 (ja) | 2007-08-16 | 2015-08-26 | ザ ロイヤル インスティチューション フォー ザ アドバンスメント オブ ラーニング/マギル ユニバーシティ | 腫瘍細胞由来微小胞 |
| EP2245199B1 (en) * | 2008-02-01 | 2013-11-13 | The General Hospital Corporation | Use of microvesicles in diagnosis, prognosis and treatment of medical diseases and conditions |
| US9487837B2 (en) * | 2008-10-06 | 2016-11-08 | Morehouse School Of Medicine | Exosome-mediated diagnosis of hepatitis virus infections and diseases |
| US10545149B2 (en) * | 2008-10-06 | 2020-01-28 | Morehouse School Of Medicine | Detection of HIV-related proteins in urine |
| EP2358912B1 (en) | 2008-10-30 | 2016-10-12 | Caris Life Sciences Switzerland Holdings GmbH | Methods for assessing rna patterns |
| GB2463401B (en) | 2008-11-12 | 2014-01-29 | Caris Life Sciences Luxembourg Holdings S A R L | Characterizing prostate disorders by analysis of microvesicles |
| WO2011109440A1 (en) * | 2010-03-01 | 2011-09-09 | Caris Life Sciences Luxembourg Holdings | Biomarkers for theranostics |
| EP2475989A4 (en) | 2009-09-09 | 2013-02-27 | Gen Hospital Corp | USE OF MICROVESICLES IN THE ANALYSIS OF KRAS MUTATIONS |
| WO2011031877A1 (en) | 2009-09-09 | 2011-03-17 | The General Hospital Corporation | Use of microvesicles in analyzing nucleic acid profiles |
| CA2782284A1 (en) * | 2009-11-30 | 2011-06-03 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Methods and systems for isolating, storing, and analyzing vesicles |
| WO2011127219A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings | Circulating biomarkers for disease |
| WO2012006476A2 (en) | 2010-07-07 | 2012-01-12 | Aethlon Medical, Inc. | Methods and compositions for quantifying exosomes |
| US20140045915A1 (en) | 2010-08-31 | 2014-02-13 | The General Hospital Corporation | Cancer-related biological materials in microvesicles |
| WO2012048372A1 (en) * | 2010-10-11 | 2012-04-19 | Medsaic Pty Ltd | Assay for disease detection |
| JP6219721B2 (ja) | 2010-11-10 | 2017-10-25 | エキソソーム ダイアグノスティックス インコーポレイテッド | 核酸含有粒子の単離および該粒子からの核酸の抽出のための方法 |
| FR2973029B1 (fr) * | 2011-03-23 | 2013-04-26 | Centre Nat Rech Scient | Complexes metalliques dinucleaires greffes, et leur utilisation en tant que capteurs de microparticules cellulaires |
| WO2012135844A2 (en) * | 2011-04-01 | 2012-10-04 | Cornell University | Circulating exosomes as diagnostic/prognostic indicators and therapeutic targets of melanoma and other cancers |
| EP2715351B1 (en) * | 2011-05-24 | 2016-10-19 | The Regents of The University of California | Method for exosomal biomarker detection by electric field-induced release and measurement |
| CN103874770A (zh) * | 2011-08-08 | 2014-06-18 | 卡里斯生命科学卢森堡控股有限责任公司 | 生物标志物组合物和方法 |
| US11391741B2 (en) * | 2011-12-22 | 2022-07-19 | Theoria Science Inc. | Method of exosome analysis, reagent for exosome analysis, and analyzer for exosome |
| WO2014030590A1 (ja) * | 2012-08-24 | 2014-02-27 | 国立大学法人東京大学 | エキソソームの分析方法、エキソソーム分析装置、抗体-エキソソーム複合体、及びエキソソーム電気泳動チップ |
| KR101933620B1 (ko) * | 2012-09-18 | 2018-12-28 | 삼성전자주식회사 | 소포를 검출하기 위한 조성물, 키트 및 이를 이용하여 소포를 분석하는 방법 |
| US9480714B2 (en) | 2012-11-13 | 2016-11-01 | Allan Yang Wu | Methods and systems for processing exosomes |
| CA2904181A1 (en) | 2013-03-13 | 2014-10-09 | Anahit Aghvanyan | Sandwich immunoassay comprising anchoring reagent |
| US10114015B2 (en) | 2013-03-13 | 2018-10-30 | Meso Scale Technologies, Llc. | Assay methods |
| CN105209881B (zh) | 2013-03-13 | 2021-01-22 | 迈阿密大学 | 从细胞培养上清液和生物流体分离并纯化微泡的方法 |
| US12558316B2 (en) | 2013-03-13 | 2026-02-24 | University Of Miami | Methods and compositions for the treatment of epidermolysis bullosa |
| JP6210004B2 (ja) | 2013-04-09 | 2017-10-11 | 株式会社Jvcケンウッド | 試料分析用デバイス及びエクソソームの捕捉方法 |
| WO2015029979A1 (ja) * | 2013-08-30 | 2015-03-05 | 国立大学法人東京大学 | エキソソームの分析方法、エキソソーム分析チップ、及びエキソソーム分析装置 |
| JPWO2015045666A1 (ja) | 2013-09-25 | 2017-03-09 | 国立大学法人 東京大学 | 流体デバイス、エキソソームの分析方法、生体分子分析方法及び生体分子検出方法 |
| US10139402B2 (en) | 2013-11-06 | 2018-11-27 | Jsr Corporation | Separation method, detection method, signal measurement method, method for determining disease, method for evaluating drug efficacy of disease treatment drug, kit, and liquid composition |
| EP3078889B1 (en) | 2013-12-06 | 2019-09-18 | The University of Tokyo | Valve, fluid-controlling structure, fluid device, and method for manufacturing valve |
| WO2015175856A1 (en) * | 2014-05-15 | 2015-11-19 | Meso Scale Technologies, Llc. | Improved assay methods |
| WO2015185730A2 (en) * | 2014-06-06 | 2015-12-10 | Hansabiomed Ou | Exosomal biomarkers |
| RU2556825C1 (ru) * | 2014-09-15 | 2015-07-20 | Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) | Способ получения экзосом из крови |
| US20160320390A1 (en) * | 2015-05-01 | 2016-11-03 | Morehouse School Of Medicine | Compositions and methods for capturing exosomes |
| WO2016186215A1 (ja) * | 2015-05-20 | 2016-11-24 | Jsr株式会社 | 分離方法、検出方法、シグナル測定方法、疾患の判定方法、薬効評価方法、キット、液状組成物及び検体希釈液 |
| WO2016201064A1 (en) | 2015-06-09 | 2016-12-15 | The Board Of Regents Of The University Of Texas System | Diagnostic test for early stage cancer |
| JP6606916B2 (ja) | 2015-08-21 | 2019-11-20 | 株式会社Jvcケンウッド | エクソソームの捕捉方法 |
| GB201518466D0 (en) * | 2015-10-19 | 2015-12-02 | Cizzle Biotechnology Ltd | Use |
| CN106093412A (zh) * | 2016-06-28 | 2016-11-09 | 叶瑞东 | 一种多肽分子在制备诊断急性脑梗死后微出血的试剂盒中的应用 |
| WO2018070479A1 (ja) * | 2016-10-13 | 2018-04-19 | 合同会社みらか中央研究所 | 細胞外小胞の回収方法 |
| RU2682721C2 (ru) * | 2016-11-17 | 2019-03-21 | Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) | Биологический микрочип для обнаружения опухолевых экзосом в сыворотке крови человека для диагностики колоректального рака |
| CN110462404B (zh) * | 2017-01-12 | 2023-06-02 | 理论科学株式会社 | 测试受试者患有胰腺癌的可能性的方法 |
| CN106906294A (zh) * | 2017-03-31 | 2017-06-30 | 浙江大学 | 一种胞外囊泡/脂质体的定量方法 |
| CN107144688B (zh) * | 2017-04-07 | 2018-09-11 | 浙江大学 | Cd19阳性外泌体作为分子标记在制备肿瘤诊断试剂盒中的应用及试剂盒 |
| JP6573351B2 (ja) | 2017-05-29 | 2019-09-11 | 国立大学法人神戸大学 | 検出対象の分析用センサ作製用基材、検出対象の分析用センサ、及び検出対象の分析法 |
| DE102017005543A1 (de) * | 2017-06-13 | 2018-12-13 | Forschungszentrum Jülich GmbH | Verfahren zum Nachweis von Extrazellulären Vesikeln in einer Probe |
| CN107907689A (zh) * | 2017-10-10 | 2018-04-13 | 北京大学 | 外泌体蛋白cd5l的检测方法 |
| KR101968046B1 (ko) * | 2018-07-19 | 2019-04-11 | (주) 바이오인프라생명과학 | 암의 조기 진단을 위한 복합 바이오마커 |
| JP6677284B2 (ja) * | 2018-10-09 | 2020-04-08 | 凸版印刷株式会社 | 分析対象物の検出方法及びラテラルフロー用テストストリップ |
| AU2020232954B2 (en) | 2019-03-01 | 2026-01-15 | Meso Scale Technologies, Llc. | Electrochemiluminescent labeled probes for use in immunoassay methods, methods using such and kits comprising same |
| CN109991427A (zh) * | 2019-04-08 | 2019-07-09 | 王延博 | 一种用于检测血清中外泌体表面蛋白标志物的试剂盒 |
| CN110095604B (zh) * | 2019-04-12 | 2022-03-18 | 南方医科大学南方医院 | Caveolin-1蛋白阳性外泌体作为非小细胞肺癌诊断标志物的应用 |
| WO2020241999A1 (ko) * | 2019-05-24 | 2020-12-03 | 고려대학교 세종산학협력단 | 스위치 성 부착반응을 이용한 친화 분리 시스템 및 방법 |
| EP4067906A4 (en) * | 2019-11-29 | 2023-04-26 | FUJIFILM Wako Pure Chemical Corporation | METHODS TO AID THE DIAGNOSIS OF ALZHEIMER'S DISEASE OR MILD COGNITIVE IMPAIRMENT, BIOMARKERS, REAGENT KIT AND DEVICE |
| CN111537725A (zh) * | 2020-05-29 | 2020-08-14 | 武汉大学 | 高效定量检测细胞外囊泡中pd-1水平的方法、elisa试剂盒及使用方法 |
| DE102021208893B3 (de) | 2021-08-13 | 2022-11-17 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Isolieren von Analyten unterschiedlicher Analyt-Klassen |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH081438B2 (ja) * | 1986-05-13 | 1996-01-10 | 三洋化成工業株式会社 | 酵素免疫測定法 |
| EP1004664A1 (en) * | 1998-11-24 | 2000-05-31 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Compositions and methods using lactadherin or variants thereof |
| GB9927320D0 (en) * | 1999-11-18 | 2000-01-12 | Chiron Spa | Exosome separation |
| US20040241176A1 (en) * | 2000-04-27 | 2004-12-02 | Ap Cells. Inc. | Method of producing membrane vesicles |
| US6812023B1 (en) * | 2000-04-27 | 2004-11-02 | Anosys, Inc. | Methods of producing membrane vesicles |
| US7442777B2 (en) * | 2000-11-29 | 2008-10-28 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD63 |
| US20030190602A1 (en) * | 2001-03-12 | 2003-10-09 | Monogen, Inc. | Cell-based detection and differentiation of disease states |
| AU2003214944A1 (en) | 2002-01-31 | 2003-09-02 | Baylor College Of Medicine | Secreted caveolin as a marker for prostate cancer |
| CA2453198A1 (en) * | 2004-01-07 | 2005-07-07 | Wei-Ping Min | Quantification and generation of immune suppressive exosomes |
| JP2005237234A (ja) * | 2004-02-25 | 2005-09-08 | Japan Science & Technology Agency | カベオリン抗原とその用途 |
| AU2007243184A1 (en) * | 2006-04-28 | 2007-11-08 | University Of Iowa Research Foundation | Methods and compounds to modulate parvovirus transduction of mammalian cells or to alter virus infection, method to identify a viral receptor or co-receptor |
| US20120058492A1 (en) * | 2008-01-25 | 2012-03-08 | Hansabiomed Ou | Method and a Kit To Detect Malignant Tumors and Provide a Prognosis |
-
2009
- 2009-01-21 US US12/321,412 patent/US8617806B2/en not_active Expired - Fee Related
- 2009-01-26 WO PCT/EE2009/000002 patent/WO2009092386A2/en not_active Ceased
- 2009-01-26 BR BRPI0906683A patent/BRPI0906683B8/pt not_active IP Right Cessation
- 2009-01-26 PL PL09704302T patent/PL2245458T3/pl unknown
- 2009-01-26 ES ES09704302.0T patent/ES2613670T3/es active Active
- 2009-01-26 RU RU2010135526/15A patent/RU2520741C2/ru active
- 2009-01-26 AU AU2009207927A patent/AU2009207927B2/en not_active Ceased
- 2009-01-26 CA CA2713196A patent/CA2713196C/en not_active Expired - Fee Related
- 2009-01-26 JP JP2010543379A patent/JP5583600B2/ja not_active Expired - Fee Related
- 2009-01-26 EP EP09704302.0A patent/EP2245458B1/en not_active Not-in-force
- 2009-01-26 CN CN200980111452.4A patent/CN102317778B/zh not_active Expired - Fee Related
- 2009-01-26 MX MX2010008164A patent/MX2010008164A/es active IP Right Grant
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