CN102317778B - 测定和表征人体液中微泡的新方法 - Google Patents

测定和表征人体液中微泡的新方法 Download PDF

Info

Publication number
CN102317778B
CN102317778B CN200980111452.4A CN200980111452A CN102317778B CN 102317778 B CN102317778 B CN 102317778B CN 200980111452 A CN200980111452 A CN 200980111452A CN 102317778 B CN102317778 B CN 102317778B
Authority
CN
China
Prior art keywords
exosomes
tumor
plasma
allochthon
body fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200980111452.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN102317778A (zh
Inventor
S·法伊斯
M·洛戈齐
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Waisomix Co ltd
Original Assignee
Hansabiomed OU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hansabiomed OU filed Critical Hansabiomed OU
Publication of CN102317778A publication Critical patent/CN102317778A/zh
Application granted granted Critical
Publication of CN102317778B publication Critical patent/CN102317778B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G01N33/567Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds utilising isolate of tissue or organ as binding agent
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • G01N33/56988HIV or HTLV
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5751Immunoassay; Biospecific binding assay; Materials therefor for cancer of the skin, e.g. melanoma
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08RNA viruses
    • G01N2333/15Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
    • G01N2333/155Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
    • G01N2333/16HIV-1, HIV-2
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08RNA viruses
    • G01N2333/18Togaviridae; Flaviviridae
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2828Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
CN200980111452.4A 2008-01-25 2009-01-26 测定和表征人体液中微泡的新方法 Expired - Fee Related CN102317778B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6252808P 2008-01-25 2008-01-25
US61/062528 2008-01-25
US12/321,412 US8617806B2 (en) 2008-01-25 2009-01-21 Method to measure and characterize microvesicles in the human body fluids
US12/321412 2009-01-21
PCT/EE2009/000002 WO2009092386A2 (en) 2008-01-25 2009-01-26 A new method to measure and characterize microvesicles in the human body fluids

Publications (2)

Publication Number Publication Date
CN102317778A CN102317778A (zh) 2012-01-11
CN102317778B true CN102317778B (zh) 2015-05-13

Family

ID=41064551

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980111452.4A Expired - Fee Related CN102317778B (zh) 2008-01-25 2009-01-26 测定和表征人体液中微泡的新方法

Country Status (12)

Country Link
US (1) US8617806B2 (https=)
EP (1) EP2245458B1 (https=)
JP (1) JP5583600B2 (https=)
CN (1) CN102317778B (https=)
AU (1) AU2009207927B2 (https=)
BR (1) BRPI0906683B8 (https=)
CA (1) CA2713196C (https=)
ES (1) ES2613670T3 (https=)
MX (1) MX2010008164A (https=)
PL (1) PL2245458T3 (https=)
RU (1) RU2520741C2 (https=)
WO (1) WO2009092386A2 (https=)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2733672C (en) 2007-08-16 2018-09-11 The Royal Institution For The Advancement Of Learning/Mcgill University Tumor cell-derived microvesicles
US20100255514A1 (en) 2007-08-16 2010-10-07 The Royal Institution For The Advancement Of Learning/Mcgill University Tumor cell-derived microvesicles
KR101810799B1 (ko) * 2008-02-01 2017-12-19 더 제너럴 하스피탈 코포레이션 의학적 질환 및 병태의 진단, 예후, 및 치료에 있어서 미세소포체의 용도
US10545149B2 (en) * 2008-10-06 2020-01-28 Morehouse School Of Medicine Detection of HIV-related proteins in urine
US9487837B2 (en) * 2008-10-06 2016-11-08 Morehouse School Of Medicine Exosome-mediated diagnosis of hepatitis virus infections and diseases
US7888035B2 (en) 2008-10-30 2011-02-15 Caris Mpi, Inc. Methods for assessing RNA patterns
WO2010056337A2 (en) 2008-11-12 2010-05-20 Caris Mpi, Inc. Methods and systems of using exosomes for determining phenotypes
US20130029339A1 (en) 2009-09-09 2013-01-31 The General Hospital Corporation Use of microvesicles in analyzing kras mutations
EP2475988B1 (en) 2009-09-09 2018-11-14 The General Hospital Corporation Use of microvesicles in analyzing nucleic acid profiles
CA2782284A1 (en) * 2009-11-30 2011-06-03 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Methods and systems for isolating, storing, and analyzing vesicles
EP2542696B1 (en) * 2010-03-01 2016-09-28 Caris Life Sciences Switzerland Holdings GmbH Biomarkers for theranostics
JP2013526852A (ja) 2010-04-06 2013-06-27 カリス ライフ サイエンシズ ルクセンブルク ホールディングス 疾患に対する循環バイオマーカー
ES2624284T3 (es) 2010-07-07 2017-07-13 Aethlon Medical Inc Métodos para cuantificar exosomas
WO2012031008A2 (en) 2010-08-31 2012-03-08 The General Hospital Corporation Cancer-related biological materials in microvesicles
AU2011316477A1 (en) * 2010-10-11 2013-05-02 Medsaic Pty Ltd Assay for disease detection
CA2817111C (en) 2010-11-10 2019-03-05 Exosome Diagnostics, Inc. Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom
FR2973029B1 (fr) * 2011-03-23 2013-04-26 Centre Nat Rech Scient Complexes metalliques dinucleaires greffes, et leur utilisation en tant que capteurs de microparticules cellulaires
WO2012135844A2 (en) * 2011-04-01 2012-10-04 Cornell University Circulating exosomes as diagnostic/prognostic indicators and therapeutic targets of melanoma and other cancers
WO2012162563A2 (en) * 2011-05-24 2012-11-29 The Regents Of The University Of California Method for exosomal biomarker detection by electric field-induced release and measurement
KR20140067001A (ko) * 2011-08-08 2014-06-03 카리스 라이프 사이언스 룩셈부르크 홀딩스, 에스.에이.알.엘. 생물지표 조성물 및 방법
JP6029112B2 (ja) * 2011-12-22 2016-11-24 テオリアサイエンス株式会社 エクソソームの分析方法、エクソソーム分析用試薬およびエクソソーム分析装置
EP2889623B1 (en) 2012-08-24 2017-10-04 The University of Tokyo Exosome analysis method, exosome analysis apparatus, and use of exosome electrophoresis chip
KR101933620B1 (ko) * 2012-09-18 2018-12-28 삼성전자주식회사 소포를 검출하기 위한 조성물, 키트 및 이를 이용하여 소포를 분석하는 방법
US9480714B2 (en) 2012-11-13 2016-11-01 Allan Yang Wu Methods and systems for processing exosomes
CA2904181A1 (en) 2013-03-13 2014-10-09 Anahit Aghvanyan Sandwich immunoassay comprising anchoring reagent
WO2014159662A1 (en) 2013-03-13 2014-10-02 University Of Miami Method for isolation and purification of microvesicles from cell culture supernatants and biological fluids
US12558316B2 (en) 2013-03-13 2026-02-24 University Of Miami Methods and compositions for the treatment of epidermolysis bullosa
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
JP6210004B2 (ja) * 2013-04-09 2017-10-11 株式会社Jvcケンウッド 試料分析用デバイス及びエクソソームの捕捉方法
JPWO2015029979A1 (ja) * 2013-08-30 2017-03-02 国立大学法人 東京大学 エキソソームの分析方法、エキソソーム分析チップ、及びエキソソーム分析装置
WO2015045666A1 (ja) 2013-09-25 2015-04-02 国立大学法人東京大学 流体デバイス、エキソソームの分析方法、生体分子分析方法及び生体分子検出方法
JP6255035B2 (ja) * 2013-11-06 2017-12-27 Jsr株式会社 分離方法、検出方法、シグナル測定方法、疾患の判定方法、疾患治療薬の薬効評価方法、キット及び液状組成物
JP6638917B2 (ja) 2013-12-06 2020-02-05 国立大学法人 東京大学 バルブ、流体制御構造、流体デバイス及びバルブの製造方法
EP3143401A4 (en) 2014-05-15 2017-10-11 Meso Scale Technologies, LLC Improved assay methods
WO2015185730A2 (en) * 2014-06-06 2015-12-10 Hansabiomed Ou Exosomal biomarkers
RU2556825C1 (ru) * 2014-09-15 2015-07-20 Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) Способ получения экзосом из крови
US20160320390A1 (en) * 2015-05-01 2016-11-03 Morehouse School Of Medicine Compositions and methods for capturing exosomes
EP3299816A4 (en) * 2015-05-20 2018-10-03 JSR Corporation Separation method, detection method, signal measurement method, disease determination method, drug efficacy assessment method, kit, liquid composition, and specimen diluent
CA2988771A1 (en) 2015-06-09 2016-12-15 The Board Of Regents Of The University Of Texas System Diagnostic test for early stage cancer
JP6606916B2 (ja) 2015-08-21 2019-11-20 株式会社Jvcケンウッド エクソソームの捕捉方法
GB201518466D0 (en) * 2015-10-19 2015-12-02 Cizzle Biotechnology Ltd Use
CN106093412A (zh) * 2016-06-28 2016-11-09 叶瑞东 一种多肽分子在制备诊断急性脑梗死后微出血的试剂盒中的应用
WO2018070479A1 (ja) * 2016-10-13 2018-04-19 合同会社みらか中央研究所 細胞外小胞の回収方法
RU2682721C2 (ru) * 2016-11-17 2019-03-21 Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) Биологический микрочип для обнаружения опухолевых экзосом в сыворотке крови человека для диагностики колоректального рака
JP6797427B2 (ja) * 2017-01-12 2020-12-09 テオリアサイエンス株式会社 被検者が膵臓癌に罹患している可能性を試験する方法
CN106906294A (zh) * 2017-03-31 2017-06-30 浙江大学 一种胞外囊泡/脂质体的定量方法
CN107144688B (zh) * 2017-04-07 2018-09-11 浙江大学 Cd19阳性外泌体作为分子标记在制备肿瘤诊断试剂盒中的应用及试剂盒
EP3647786B1 (en) 2017-05-29 2023-03-08 National University Corporation Kobe University Base material for manufacturing sensor for analyzing detection target, sensor for analyzing detection target, method for analyzing detection target
DE102017005543A1 (de) * 2017-06-13 2018-12-13 Forschungszentrum Jülich GmbH Verfahren zum Nachweis von Extrazellulären Vesikeln in einer Probe
CN107907689A (zh) * 2017-10-10 2018-04-13 北京大学 外泌体蛋白cd5l的检测方法
KR101968046B1 (ko) * 2018-07-19 2019-04-11 (주) 바이오인프라생명과학 암의 조기 진단을 위한 복합 바이오마커
JP6677284B2 (ja) * 2018-10-09 2020-04-08 凸版印刷株式会社 分析対象物の検出方法及びラテラルフロー用テストストリップ
CN120098057A (zh) 2019-03-01 2025-06-06 中尺度技术有限责任公司 用于免疫方法的被电化学发光标记的探针、使用这类探针的方法和包含这类探针的试剂盒
CN109991427A (zh) * 2019-04-08 2019-07-09 王延博 一种用于检测血清中外泌体表面蛋白标志物的试剂盒
CN110095604B (zh) * 2019-04-12 2022-03-18 南方医科大学南方医院 Caveolin-1蛋白阳性外泌体作为非小细胞肺癌诊断标志物的应用
CN114127561A (zh) * 2019-05-24 2022-03-01 索尔生物公司 使用开关样结合反应的亲和分离系统和方法
CN115176163B (zh) * 2019-11-29 2026-03-24 富士胶片和光纯药株式会社 辅助阿尔茨海默型痴呆症或轻度认知障碍的诊断的方法、生物标志物、试剂盒及装置
CN111537725A (zh) * 2020-05-29 2020-08-14 武汉大学 高效定量检测细胞外囊泡中pd-1水平的方法、elisa试剂盒及使用方法
DE102021208893B3 (de) 2021-08-13 2022-11-17 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Isolieren von Analyten unterschiedlicher Analyt-Klassen

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003063690A2 (en) * 2002-01-31 2003-08-07 Baylor College Of Medicine Secreted caveolin as a marker for prostate cancer
CA2453198A1 (en) * 2004-01-07 2005-07-07 Wei-Ping Min Quantification and generation of immune suppressive exosomes

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH081438B2 (ja) * 1986-05-13 1996-01-10 三洋化成工業株式会社 酵素免疫測定法
EP1004664A1 (en) * 1998-11-24 2000-05-31 Institut National De La Sante Et De La Recherche Medicale (Inserm) Compositions and methods using lactadherin or variants thereof
GB9927320D0 (en) * 1999-11-18 2000-01-12 Chiron Spa Exosome separation
US6812023B1 (en) * 2000-04-27 2004-11-02 Anosys, Inc. Methods of producing membrane vesicles
US20040241176A1 (en) * 2000-04-27 2004-12-02 Ap Cells. Inc. Method of producing membrane vesicles
US7442777B2 (en) * 2000-11-29 2008-10-28 Arius Research Inc. Cytotoxicity mediation of cells evidencing surface expression of CD63
US20030190602A1 (en) * 2001-03-12 2003-10-09 Monogen, Inc. Cell-based detection and differentiation of disease states
JP2005237234A (ja) * 2004-02-25 2005-09-08 Japan Science & Technology Agency カベオリン抗原とその用途
WO2007127464A2 (en) * 2006-04-28 2007-11-08 University Of Iowa Research Foundation Methods and compounds to modulate parvovirus transduction of mammalian cells or to alter virus infection, method to identify a viral receptor or co-receptor
US20120058492A1 (en) * 2008-01-25 2012-03-08 Hansabiomed Ou Method and a Kit To Detect Malignant Tumors and Provide a Prognosis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003063690A2 (en) * 2002-01-31 2003-08-07 Baylor College Of Medicine Secreted caveolin as a marker for prostate cancer
CA2453198A1 (en) * 2004-01-07 2005-07-07 Wei-Ping Min Quantification and generation of immune suppressive exosomes

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
B cell-derived exosomes can present allergen peptides and activate allergen-specific T cells to proliferate and produce TH2-like cytokines;Charlotte Admyre et al.;《J ALLERGY CLIN IMMUNOL》;20070917;第120卷(第6期);1418-1424 *
Caveolin_1与泌尿系肿瘤研究进展;沈在雄 等;《国际泌尿系统杂志》;20061130;第26卷(第6期);806-809 *
Identification and Characterization of Microvesicles Secreted by 3T3-L1 Adipocytes_ Redox- and Hormone-Dependent Induction of Milk Fat Globule-Epidermal Growth Factor 8-Associated Microvesicles;Naohito Aoki et al.;《Endocrinology》;20070503;第148卷(第8期);3850-3862 *
malignant effusions and immunogenic tumour-derived exospmes;Fabrice Andre et al.;《Mechanisms of disease》;20020727;第360卷;295-305 *
purification,characterization and biological significance of tumor-derived exosomes;KENICHIRO KOGA et al.;《ANTICANCER RESEARCH》;20051130;第25卷;3703-3707 *

Also Published As

Publication number Publication date
US8617806B2 (en) 2013-12-31
PL2245458T3 (pl) 2017-08-31
WO2009092386A2 (en) 2009-07-30
MX2010008164A (es) 2010-11-25
US20090220944A1 (en) 2009-09-03
BRPI0906683A2 (pt) 2017-08-22
JP5583600B2 (ja) 2014-09-03
BRPI0906683B1 (pt) 2021-03-02
AU2009207927A1 (en) 2009-07-30
CA2713196A1 (en) 2009-07-30
JP2011510309A (ja) 2011-03-31
RU2010135526A (ru) 2012-02-27
EP2245458B1 (en) 2016-10-26
WO2009092386A8 (en) 2010-10-14
AU2009207927B2 (en) 2015-04-09
ES2613670T3 (es) 2017-05-25
CA2713196C (en) 2014-06-17
EP2245458A2 (en) 2010-11-03
CN102317778A (zh) 2012-01-11
WO2009092386A3 (en) 2009-09-17
BRPI0906683B8 (pt) 2021-07-27
RU2520741C2 (ru) 2014-06-27

Similar Documents

Publication Publication Date Title
CN102317778B (zh) 测定和表征人体液中微泡的新方法
Vargas et al. Syncytin proteins incorporated in placenta exosomes are important for cell uptake and show variation in abundance in serum exosomes from patients with preeclampsia
Bergmann et al. Tumor‐derived microvesicles in sera of patients with head and neck cancer and their role in tumor progression
Boukouris et al. Exosomes in bodily fluids are a highly stable resource of disease biomarkers
EP3111212B1 (en) Methods and compositions for isolating exosomes
Frisullo et al. Regulatory T cells fail to suppress CD4+ T‐bet+ T cells in relapsing multiple sclerosis patients
Santegoets et al. Expression profiling of immune inhibitory Siglecs and their ligands in patients with glioma
US20160370265A1 (en) Method for isolating exosomes
US20100279315A1 (en) Improved method for prenatal diagnosis
CN102301236A (zh) 方法
US11561223B2 (en) Method and system for identifying membrane proteins on extracellular vesicles
US11460472B2 (en) Quantitative assay for heat shock proteins 70 (Hsp70) protein in body fluids
JP2022530351A (ja) 疾患および障害の検出のために細胞外小胞を使用する方法および組成物
WO2020218121A1 (ja) 癌を検出する方法および検出試薬
Nazarova et al. Colorectal cancer diagnostics via detection of tissue-specific extracellular nano-vesicles
US20140302526A1 (en) Zap-70 detection in chronic lymphocytic leukemia
Mourtzikou et al. Colorectal Cancer CTCs Detection Using Two FCM Protocol Approaches.
Stanzer et al. Resistance to apoptosis and expansion of regulatory T cells in relation to the detection of circulating tumor cells in patients with metastatic epithelial cancer
Eroğlu Characterization of Functional and Molecular Properties of Circulating Extracellular Vesicles of Childhood Idiopathic Nephrotic Syndrome Patients
Alzahrani Assessing basophil activation in allergic disease by the measurement of the unique marker basogranulin: Release into cell supernatants and biological fluids, and alterations in intracellular and membrane expression
Ham The role of breast cancer derived-exosomes in the tumour micro-environment
Kuai et al. Th17/Treg cell imbalance in patients with early esophageal squamous cell carcinoma
Shen et al. Co-Enrichment of Proteins in Extracellular Vesicles
Lim Targeting the Oligomannose Biomarker Present on Distinct Subsets of Non-Hodgkin Lymphomas
Paolini et al. Exploiting exosomes for differential diagnosis of multiple myeloma and monoclonal gammopathy of undetermined significance

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
TR01 Transfer of patent right

Effective date of registration: 20170418

Address after: Italy Siena

Patentee after: Transomex Siena

Address before: Tallinn

Patentee before: HANSABIOMED Ou

TR01 Transfer of patent right
CP01 Change in the name or title of a patent holder

Address after: Italy Siena

Patentee after: Waisomix Co.,Ltd.

Address before: Italy Siena

Patentee before: Transomex Siena

CP01 Change in the name or title of a patent holder
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20150513

Termination date: 20220126

CF01 Termination of patent right due to non-payment of annual fee