CN102317778B - 测定和表征人体液中微泡的新方法 - Google Patents
测定和表征人体液中微泡的新方法 Download PDFInfo
- Publication number
- CN102317778B CN102317778B CN200980111452.4A CN200980111452A CN102317778B CN 102317778 B CN102317778 B CN 102317778B CN 200980111452 A CN200980111452 A CN 200980111452A CN 102317778 B CN102317778 B CN 102317778B
- Authority
- CN
- China
- Prior art keywords
- exosomes
- tumor
- plasma
- allochthon
- body fluid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
- G01N33/567—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds utilising isolate of tissue or organ as binding agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
- G01N33/56988—HIV or HTLV
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5751—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the skin, e.g. melanoma
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
- G01N2333/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
- G01N2333/16—HIV-1, HIV-2
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/18—Togaviridae; Flaviviridae
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2828—Prion diseases
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6252808P | 2008-01-25 | 2008-01-25 | |
| US61/062528 | 2008-01-25 | ||
| US12/321,412 US8617806B2 (en) | 2008-01-25 | 2009-01-21 | Method to measure and characterize microvesicles in the human body fluids |
| US12/321412 | 2009-01-21 | ||
| PCT/EE2009/000002 WO2009092386A2 (en) | 2008-01-25 | 2009-01-26 | A new method to measure and characterize microvesicles in the human body fluids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102317778A CN102317778A (zh) | 2012-01-11 |
| CN102317778B true CN102317778B (zh) | 2015-05-13 |
Family
ID=41064551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200980111452.4A Expired - Fee Related CN102317778B (zh) | 2008-01-25 | 2009-01-26 | 测定和表征人体液中微泡的新方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8617806B2 (https=) |
| EP (1) | EP2245458B1 (https=) |
| JP (1) | JP5583600B2 (https=) |
| CN (1) | CN102317778B (https=) |
| AU (1) | AU2009207927B2 (https=) |
| BR (1) | BRPI0906683B8 (https=) |
| CA (1) | CA2713196C (https=) |
| ES (1) | ES2613670T3 (https=) |
| MX (1) | MX2010008164A (https=) |
| PL (1) | PL2245458T3 (https=) |
| RU (1) | RU2520741C2 (https=) |
| WO (1) | WO2009092386A2 (https=) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2733672C (en) | 2007-08-16 | 2018-09-11 | The Royal Institution For The Advancement Of Learning/Mcgill University | Tumor cell-derived microvesicles |
| US20100255514A1 (en) | 2007-08-16 | 2010-10-07 | The Royal Institution For The Advancement Of Learning/Mcgill University | Tumor cell-derived microvesicles |
| KR101810799B1 (ko) * | 2008-02-01 | 2017-12-19 | 더 제너럴 하스피탈 코포레이션 | 의학적 질환 및 병태의 진단, 예후, 및 치료에 있어서 미세소포체의 용도 |
| US10545149B2 (en) * | 2008-10-06 | 2020-01-28 | Morehouse School Of Medicine | Detection of HIV-related proteins in urine |
| US9487837B2 (en) * | 2008-10-06 | 2016-11-08 | Morehouse School Of Medicine | Exosome-mediated diagnosis of hepatitis virus infections and diseases |
| US7888035B2 (en) | 2008-10-30 | 2011-02-15 | Caris Mpi, Inc. | Methods for assessing RNA patterns |
| WO2010056337A2 (en) | 2008-11-12 | 2010-05-20 | Caris Mpi, Inc. | Methods and systems of using exosomes for determining phenotypes |
| US20130029339A1 (en) | 2009-09-09 | 2013-01-31 | The General Hospital Corporation | Use of microvesicles in analyzing kras mutations |
| EP2475988B1 (en) | 2009-09-09 | 2018-11-14 | The General Hospital Corporation | Use of microvesicles in analyzing nucleic acid profiles |
| CA2782284A1 (en) * | 2009-11-30 | 2011-06-03 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Methods and systems for isolating, storing, and analyzing vesicles |
| EP2542696B1 (en) * | 2010-03-01 | 2016-09-28 | Caris Life Sciences Switzerland Holdings GmbH | Biomarkers for theranostics |
| JP2013526852A (ja) | 2010-04-06 | 2013-06-27 | カリス ライフ サイエンシズ ルクセンブルク ホールディングス | 疾患に対する循環バイオマーカー |
| ES2624284T3 (es) | 2010-07-07 | 2017-07-13 | Aethlon Medical Inc | Métodos para cuantificar exosomas |
| WO2012031008A2 (en) | 2010-08-31 | 2012-03-08 | The General Hospital Corporation | Cancer-related biological materials in microvesicles |
| AU2011316477A1 (en) * | 2010-10-11 | 2013-05-02 | Medsaic Pty Ltd | Assay for disease detection |
| CA2817111C (en) | 2010-11-10 | 2019-03-05 | Exosome Diagnostics, Inc. | Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom |
| FR2973029B1 (fr) * | 2011-03-23 | 2013-04-26 | Centre Nat Rech Scient | Complexes metalliques dinucleaires greffes, et leur utilisation en tant que capteurs de microparticules cellulaires |
| WO2012135844A2 (en) * | 2011-04-01 | 2012-10-04 | Cornell University | Circulating exosomes as diagnostic/prognostic indicators and therapeutic targets of melanoma and other cancers |
| WO2012162563A2 (en) * | 2011-05-24 | 2012-11-29 | The Regents Of The University Of California | Method for exosomal biomarker detection by electric field-induced release and measurement |
| KR20140067001A (ko) * | 2011-08-08 | 2014-06-03 | 카리스 라이프 사이언스 룩셈부르크 홀딩스, 에스.에이.알.엘. | 생물지표 조성물 및 방법 |
| JP6029112B2 (ja) * | 2011-12-22 | 2016-11-24 | テオリアサイエンス株式会社 | エクソソームの分析方法、エクソソーム分析用試薬およびエクソソーム分析装置 |
| EP2889623B1 (en) | 2012-08-24 | 2017-10-04 | The University of Tokyo | Exosome analysis method, exosome analysis apparatus, and use of exosome electrophoresis chip |
| KR101933620B1 (ko) * | 2012-09-18 | 2018-12-28 | 삼성전자주식회사 | 소포를 검출하기 위한 조성물, 키트 및 이를 이용하여 소포를 분석하는 방법 |
| US9480714B2 (en) | 2012-11-13 | 2016-11-01 | Allan Yang Wu | Methods and systems for processing exosomes |
| CA2904181A1 (en) | 2013-03-13 | 2014-10-09 | Anahit Aghvanyan | Sandwich immunoassay comprising anchoring reagent |
| WO2014159662A1 (en) | 2013-03-13 | 2014-10-02 | University Of Miami | Method for isolation and purification of microvesicles from cell culture supernatants and biological fluids |
| US12558316B2 (en) | 2013-03-13 | 2026-02-24 | University Of Miami | Methods and compositions for the treatment of epidermolysis bullosa |
| US10114015B2 (en) | 2013-03-13 | 2018-10-30 | Meso Scale Technologies, Llc. | Assay methods |
| JP6210004B2 (ja) * | 2013-04-09 | 2017-10-11 | 株式会社Jvcケンウッド | 試料分析用デバイス及びエクソソームの捕捉方法 |
| JPWO2015029979A1 (ja) * | 2013-08-30 | 2017-03-02 | 国立大学法人 東京大学 | エキソソームの分析方法、エキソソーム分析チップ、及びエキソソーム分析装置 |
| WO2015045666A1 (ja) | 2013-09-25 | 2015-04-02 | 国立大学法人東京大学 | 流体デバイス、エキソソームの分析方法、生体分子分析方法及び生体分子検出方法 |
| JP6255035B2 (ja) * | 2013-11-06 | 2017-12-27 | Jsr株式会社 | 分離方法、検出方法、シグナル測定方法、疾患の判定方法、疾患治療薬の薬効評価方法、キット及び液状組成物 |
| JP6638917B2 (ja) | 2013-12-06 | 2020-02-05 | 国立大学法人 東京大学 | バルブ、流体制御構造、流体デバイス及びバルブの製造方法 |
| EP3143401A4 (en) | 2014-05-15 | 2017-10-11 | Meso Scale Technologies, LLC | Improved assay methods |
| WO2015185730A2 (en) * | 2014-06-06 | 2015-12-10 | Hansabiomed Ou | Exosomal biomarkers |
| RU2556825C1 (ru) * | 2014-09-15 | 2015-07-20 | Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) | Способ получения экзосом из крови |
| US20160320390A1 (en) * | 2015-05-01 | 2016-11-03 | Morehouse School Of Medicine | Compositions and methods for capturing exosomes |
| EP3299816A4 (en) * | 2015-05-20 | 2018-10-03 | JSR Corporation | Separation method, detection method, signal measurement method, disease determination method, drug efficacy assessment method, kit, liquid composition, and specimen diluent |
| CA2988771A1 (en) | 2015-06-09 | 2016-12-15 | The Board Of Regents Of The University Of Texas System | Diagnostic test for early stage cancer |
| JP6606916B2 (ja) | 2015-08-21 | 2019-11-20 | 株式会社Jvcケンウッド | エクソソームの捕捉方法 |
| GB201518466D0 (en) * | 2015-10-19 | 2015-12-02 | Cizzle Biotechnology Ltd | Use |
| CN106093412A (zh) * | 2016-06-28 | 2016-11-09 | 叶瑞东 | 一种多肽分子在制备诊断急性脑梗死后微出血的试剂盒中的应用 |
| WO2018070479A1 (ja) * | 2016-10-13 | 2018-04-19 | 合同会社みらか中央研究所 | 細胞外小胞の回収方法 |
| RU2682721C2 (ru) * | 2016-11-17 | 2019-03-21 | Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) | Биологический микрочип для обнаружения опухолевых экзосом в сыворотке крови человека для диагностики колоректального рака |
| JP6797427B2 (ja) * | 2017-01-12 | 2020-12-09 | テオリアサイエンス株式会社 | 被検者が膵臓癌に罹患している可能性を試験する方法 |
| CN106906294A (zh) * | 2017-03-31 | 2017-06-30 | 浙江大学 | 一种胞外囊泡/脂质体的定量方法 |
| CN107144688B (zh) * | 2017-04-07 | 2018-09-11 | 浙江大学 | Cd19阳性外泌体作为分子标记在制备肿瘤诊断试剂盒中的应用及试剂盒 |
| EP3647786B1 (en) | 2017-05-29 | 2023-03-08 | National University Corporation Kobe University | Base material for manufacturing sensor for analyzing detection target, sensor for analyzing detection target, method for analyzing detection target |
| DE102017005543A1 (de) * | 2017-06-13 | 2018-12-13 | Forschungszentrum Jülich GmbH | Verfahren zum Nachweis von Extrazellulären Vesikeln in einer Probe |
| CN107907689A (zh) * | 2017-10-10 | 2018-04-13 | 北京大学 | 外泌体蛋白cd5l的检测方法 |
| KR101968046B1 (ko) * | 2018-07-19 | 2019-04-11 | (주) 바이오인프라생명과학 | 암의 조기 진단을 위한 복합 바이오마커 |
| JP6677284B2 (ja) * | 2018-10-09 | 2020-04-08 | 凸版印刷株式会社 | 分析対象物の検出方法及びラテラルフロー用テストストリップ |
| CN120098057A (zh) | 2019-03-01 | 2025-06-06 | 中尺度技术有限责任公司 | 用于免疫方法的被电化学发光标记的探针、使用这类探针的方法和包含这类探针的试剂盒 |
| CN109991427A (zh) * | 2019-04-08 | 2019-07-09 | 王延博 | 一种用于检测血清中外泌体表面蛋白标志物的试剂盒 |
| CN110095604B (zh) * | 2019-04-12 | 2022-03-18 | 南方医科大学南方医院 | Caveolin-1蛋白阳性外泌体作为非小细胞肺癌诊断标志物的应用 |
| CN114127561A (zh) * | 2019-05-24 | 2022-03-01 | 索尔生物公司 | 使用开关样结合反应的亲和分离系统和方法 |
| CN115176163B (zh) * | 2019-11-29 | 2026-03-24 | 富士胶片和光纯药株式会社 | 辅助阿尔茨海默型痴呆症或轻度认知障碍的诊断的方法、生物标志物、试剂盒及装置 |
| CN111537725A (zh) * | 2020-05-29 | 2020-08-14 | 武汉大学 | 高效定量检测细胞外囊泡中pd-1水平的方法、elisa试剂盒及使用方法 |
| DE102021208893B3 (de) | 2021-08-13 | 2022-11-17 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Isolieren von Analyten unterschiedlicher Analyt-Klassen |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003063690A2 (en) * | 2002-01-31 | 2003-08-07 | Baylor College Of Medicine | Secreted caveolin as a marker for prostate cancer |
| CA2453198A1 (en) * | 2004-01-07 | 2005-07-07 | Wei-Ping Min | Quantification and generation of immune suppressive exosomes |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH081438B2 (ja) * | 1986-05-13 | 1996-01-10 | 三洋化成工業株式会社 | 酵素免疫測定法 |
| EP1004664A1 (en) * | 1998-11-24 | 2000-05-31 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Compositions and methods using lactadherin or variants thereof |
| GB9927320D0 (en) * | 1999-11-18 | 2000-01-12 | Chiron Spa | Exosome separation |
| US6812023B1 (en) * | 2000-04-27 | 2004-11-02 | Anosys, Inc. | Methods of producing membrane vesicles |
| US20040241176A1 (en) * | 2000-04-27 | 2004-12-02 | Ap Cells. Inc. | Method of producing membrane vesicles |
| US7442777B2 (en) * | 2000-11-29 | 2008-10-28 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD63 |
| US20030190602A1 (en) * | 2001-03-12 | 2003-10-09 | Monogen, Inc. | Cell-based detection and differentiation of disease states |
| JP2005237234A (ja) * | 2004-02-25 | 2005-09-08 | Japan Science & Technology Agency | カベオリン抗原とその用途 |
| WO2007127464A2 (en) * | 2006-04-28 | 2007-11-08 | University Of Iowa Research Foundation | Methods and compounds to modulate parvovirus transduction of mammalian cells or to alter virus infection, method to identify a viral receptor or co-receptor |
| US20120058492A1 (en) * | 2008-01-25 | 2012-03-08 | Hansabiomed Ou | Method and a Kit To Detect Malignant Tumors and Provide a Prognosis |
-
2009
- 2009-01-21 US US12/321,412 patent/US8617806B2/en not_active Expired - Fee Related
- 2009-01-26 WO PCT/EE2009/000002 patent/WO2009092386A2/en not_active Ceased
- 2009-01-26 BR BRPI0906683A patent/BRPI0906683B8/pt not_active IP Right Cessation
- 2009-01-26 PL PL09704302T patent/PL2245458T3/pl unknown
- 2009-01-26 CN CN200980111452.4A patent/CN102317778B/zh not_active Expired - Fee Related
- 2009-01-26 JP JP2010543379A patent/JP5583600B2/ja not_active Expired - Fee Related
- 2009-01-26 ES ES09704302.0T patent/ES2613670T3/es active Active
- 2009-01-26 CA CA2713196A patent/CA2713196C/en not_active Expired - Fee Related
- 2009-01-26 EP EP09704302.0A patent/EP2245458B1/en not_active Not-in-force
- 2009-01-26 AU AU2009207927A patent/AU2009207927B2/en not_active Ceased
- 2009-01-26 MX MX2010008164A patent/MX2010008164A/es active IP Right Grant
- 2009-01-26 RU RU2010135526/15A patent/RU2520741C2/ru active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003063690A2 (en) * | 2002-01-31 | 2003-08-07 | Baylor College Of Medicine | Secreted caveolin as a marker for prostate cancer |
| CA2453198A1 (en) * | 2004-01-07 | 2005-07-07 | Wei-Ping Min | Quantification and generation of immune suppressive exosomes |
Non-Patent Citations (5)
| Title |
|---|
| B cell-derived exosomes can present allergen peptides and activate allergen-specific T cells to proliferate and produce TH2-like cytokines;Charlotte Admyre et al.;《J ALLERGY CLIN IMMUNOL》;20070917;第120卷(第6期);1418-1424 * |
| Caveolin_1与泌尿系肿瘤研究进展;沈在雄 等;《国际泌尿系统杂志》;20061130;第26卷(第6期);806-809 * |
| Identification and Characterization of Microvesicles Secreted by 3T3-L1 Adipocytes_ Redox- and Hormone-Dependent Induction of Milk Fat Globule-Epidermal Growth Factor 8-Associated Microvesicles;Naohito Aoki et al.;《Endocrinology》;20070503;第148卷(第8期);3850-3862 * |
| malignant effusions and immunogenic tumour-derived exospmes;Fabrice Andre et al.;《Mechanisms of disease》;20020727;第360卷;295-305 * |
| purification,characterization and biological significance of tumor-derived exosomes;KENICHIRO KOGA et al.;《ANTICANCER RESEARCH》;20051130;第25卷;3703-3707 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US8617806B2 (en) | 2013-12-31 |
| PL2245458T3 (pl) | 2017-08-31 |
| WO2009092386A2 (en) | 2009-07-30 |
| MX2010008164A (es) | 2010-11-25 |
| US20090220944A1 (en) | 2009-09-03 |
| BRPI0906683A2 (pt) | 2017-08-22 |
| JP5583600B2 (ja) | 2014-09-03 |
| BRPI0906683B1 (pt) | 2021-03-02 |
| AU2009207927A1 (en) | 2009-07-30 |
| CA2713196A1 (en) | 2009-07-30 |
| JP2011510309A (ja) | 2011-03-31 |
| RU2010135526A (ru) | 2012-02-27 |
| EP2245458B1 (en) | 2016-10-26 |
| WO2009092386A8 (en) | 2010-10-14 |
| AU2009207927B2 (en) | 2015-04-09 |
| ES2613670T3 (es) | 2017-05-25 |
| CA2713196C (en) | 2014-06-17 |
| EP2245458A2 (en) | 2010-11-03 |
| CN102317778A (zh) | 2012-01-11 |
| WO2009092386A3 (en) | 2009-09-17 |
| BRPI0906683B8 (pt) | 2021-07-27 |
| RU2520741C2 (ru) | 2014-06-27 |
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