JP2011510120A5 - - Google Patents
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- JP2011510120A5 JP2011510120A5 JP2010542410A JP2010542410A JP2011510120A5 JP 2011510120 A5 JP2011510120 A5 JP 2011510120A5 JP 2010542410 A JP2010542410 A JP 2010542410A JP 2010542410 A JP2010542410 A JP 2010542410A JP 2011510120 A5 JP2011510120 A5 JP 2011510120A5
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- 125000000524 functional group Chemical group 0.000 claims description 80
- 229920000765 poly(2-oxazolines) Polymers 0.000 claims description 60
- 150000001412 amines Chemical class 0.000 claims description 18
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 14
- 150000002148 esters Chemical class 0.000 claims description 14
- -1 ketal Chemical class 0.000 claims description 14
- 125000005647 linker group Chemical group 0.000 claims description 13
- 150000001540 azides Chemical class 0.000 claims description 12
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 claims description 9
- 150000001345 alkine derivatives Chemical class 0.000 claims description 9
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims description 9
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 claims description 9
- 150000002576 ketones Chemical class 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- HAXFWIACAGNFHA-UHFFFAOYSA-N aldrithiol Chemical compound C=1C=CC=NC=1SSC1=CC=CC=N1 HAXFWIACAGNFHA-UHFFFAOYSA-N 0.000 claims description 7
- FZFAMSAMCHXGEF-UHFFFAOYSA-N chloro formate Chemical class ClOC=O FZFAMSAMCHXGEF-UHFFFAOYSA-N 0.000 claims description 7
- 230000008685 targeting Effects 0.000 claims description 7
- 230000001225 therapeutic effect Effects 0.000 claims description 7
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 6
- 125000002947 alkylene group Chemical group 0.000 claims description 5
- 150000003923 2,5-pyrrolediones Chemical class 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 229920001400 block copolymer Polymers 0.000 claims description 4
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 4
- 230000000977 initiatory effect Effects 0.000 claims description 4
- 229920005604 random copolymer Polymers 0.000 claims description 4
- 125000003342 alkenyl group Chemical group 0.000 claims description 3
- 150000001298 alcohols Chemical class 0.000 claims description 2
- 150000002019 disulfides Chemical class 0.000 claims description 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 6
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 5
- SYNHCENRCUAUNM-UHFFFAOYSA-N Nitrogen mustard N-oxide hydrochloride Chemical compound Cl.ClCC[N+]([O-])(C)CCCl SYNHCENRCUAUNM-UHFFFAOYSA-N 0.000 claims 5
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000012038 nucleophile Substances 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 description 6
- 125000005677 ethinylene group Chemical group [*:2]C#C[*:1] 0.000 description 4
- 150000001299 aldehydes Chemical class 0.000 description 3
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 108010072041 arginyl-glycyl-aspartic acid Proteins 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide group Chemical group [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- AOGYCOYQMAVAFD-UHFFFAOYSA-N chlorocarbonic acid Chemical class OC(Cl)=O AOGYCOYQMAVAFD-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- ZBKFYXZXZJPWNQ-UHFFFAOYSA-N isothiocyanate group Chemical group [N-]=C=S ZBKFYXZXZJPWNQ-UHFFFAOYSA-N 0.000 description 1
- 150000002540 isothiocyanates Chemical class 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2068408P | 2008-01-11 | 2008-01-11 | |
| US61/020,684 | 2008-01-11 | ||
| US2933708P | 2008-02-16 | 2008-02-16 | |
| US61/029,337 | 2008-02-16 | ||
| PCT/US2009/030762 WO2009089542A2 (en) | 2008-01-11 | 2009-01-12 | Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011510120A JP2011510120A (ja) | 2011-03-31 |
| JP2011510120A5 true JP2011510120A5 (https=) | 2013-06-27 |
| JP5514736B2 JP5514736B2 (ja) | 2014-06-04 |
Family
ID=40853790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010542410A Active JP5514736B2 (ja) | 2008-01-11 | 2009-01-12 | ポリオキサゾリン共重合体の多機能形態およびそれを含む薬物組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8110651B2 (https=) |
| EP (3) | EP3042922B1 (https=) |
| JP (1) | JP5514736B2 (https=) |
| KR (1) | KR101486449B1 (https=) |
| CN (1) | CN101959934B (https=) |
| DK (1) | DK3042922T3 (https=) |
| WO (1) | WO2009089542A2 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8101706B2 (en) | 2008-01-11 | 2012-01-24 | Serina Therapeutics, Inc. | Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same |
| JP5514736B2 (ja) | 2008-01-11 | 2014-06-04 | セリナ・セラピユーテイツクス・インコーポレーテツド | ポリオキサゾリン共重合体の多機能形態およびそれを含む薬物組成物 |
| US8883211B2 (en) * | 2008-07-10 | 2014-11-11 | Serina Therapeutics, Inc. | Polyoxazolines with inert terminating groups, polyoxazolines prepared from protected initiating groups and related compounds |
| CN103429268B (zh) * | 2011-01-04 | 2015-11-25 | 本德尔分析控股有限公司 | 从亲电活化的聚噁唑啉衍生的经交联的聚合物和植入物 |
| CN102731791B (zh) * | 2011-04-13 | 2016-04-13 | 北京大学 | 温度敏感型嵌段共聚物及其水凝胶和其用途 |
| US8383093B1 (en) * | 2011-11-01 | 2013-02-26 | Serina Therapeutics, Inc. | Subcutaneous delivery of poly(oxazoline) conjugates |
| US20140271527A1 (en) * | 2011-11-01 | 2014-09-18 | Serina Therapeutics, Inc. | Subcutaneous delivery of polymer conjugates of therapeutic agents |
| CN104024306B (zh) * | 2012-01-02 | 2017-06-13 | 根特大学 | 聚噁唑啉聚合物及其制备方法、这些聚合物的结合物及其医疗用途 |
| JP6178399B2 (ja) | 2012-03-16 | 2017-08-09 | ベンデル アナリティカル ホールディング ビー．ブイ．Ｂｅｎｄｅｒ Ａｎａｌｙｔｉｃａｌ Ｈｏｌｄｉｎｇ Ｂ．Ｖ． | 求核的に活性化したポリオキサゾリンに由来する架橋ポリマー及び医療製品 |
| MX366404B (es) | 2012-11-15 | 2019-07-08 | Apellis Pharmaceuticals Inc | Analogos de compstatina de celula reactiva, de acción prolongada u objetivos y composiciones y metodos relacionados. |
| CN106715533B (zh) * | 2014-07-31 | 2020-03-13 | 塞瑞纳治疗公司 | 聚恶唑啉抗体药物结合物 |
| AU2015321646B2 (en) | 2014-09-26 | 2017-11-30 | Alcon Inc. | Polymerizable polysiloxanes with hydrophilic substituents |
| CA2963057C (en) | 2014-10-06 | 2023-08-01 | Gatt Technologies B.V. | Tissue-adhesive porous haemostatic product |
| US11903994B2 (en) | 2015-10-07 | 2024-02-20 | Apellis Pharmaceuticals, Inc. | Dosing regimens |
| CN105418911A (zh) * | 2015-12-29 | 2016-03-23 | 南京工业大学 | 一种聚(2-r-2-噁唑啉)嵌段聚(肌氨酸)双亲性嵌段共聚物的制备方法 |
| IL269844B2 (en) | 2017-04-07 | 2025-01-01 | Apellis Pharmaceuticals Inc | Dosage regimens and related compositions and methods |
| DE102018000650A1 (de) * | 2018-01-27 | 2019-08-01 | Friedrich-Schiller-Universität Jena | Verfahren zur Bestimmung von Verunreinigungen in Polyalkylenethern oder Polyalkylenaminen und dessen Verwendung |
| EP3829577A4 (en) * | 2018-07-27 | 2022-12-21 | Serina Therapeutics, Inc. | CLEAVABLE CONJUGATES OF CATECHOL COMPOUNDS AND WATER-SOLUBLE POLYMERS AND METHODS OF TREATMENT THEREOF |
| US12485181B2 (en) | 2019-06-28 | 2025-12-02 | Serina Therapeutics (Al), Inc. | Polyoxazoline-drug conjugates with novel pharmacokinetic properties |
| CN113354811B (zh) * | 2020-02-19 | 2024-05-07 | 华东理工大学 | 一种侧链含有氨基和/或羟基的噁唑啉聚合物，其制备方法及应用 |
| CN112661961B (zh) * | 2020-12-28 | 2022-05-06 | 中国科学院长春应用化学研究所 | 两亲性聚噁唑啉共聚物、其制备方法及应用 |
| US12233132B2 (en) | 2021-02-09 | 2025-02-25 | Serina Therapeutics, Inc. | Polyoxazoline-lipid conjugates and lipid nanoparticles and pharmaceutical compositions including same |
| US20240398940A1 (en) | 2021-09-03 | 2024-12-05 | CureVac SE | Novel lipid nanoparticles for delivery of nucleic acids |
| US20240398933A1 (en) | 2021-09-03 | 2024-12-05 | CureVac SE | Novel lipid nanoparticles for delivery of nucleic acids comprising phosphatidylserine |
| KR20230044782A (ko) | 2021-09-27 | 2023-04-04 | 삼성전자주식회사 | 패치 안테나를 포함하는 안테나 구조 및 이를 포함하는 전자 장치 |
| EP4422698A1 (en) | 2021-10-29 | 2024-09-04 | CureVac SE | Improved circular rna for expressing therapeutic proteins |
| US20250099614A1 (en) | 2022-01-28 | 2025-03-27 | CureVac SE | Nucleic acid encoded transcription factor inhibitors |
| WO2024184500A1 (en) | 2023-03-08 | 2024-09-12 | CureVac SE | Novel lipid nanoparticle formulations for delivery of nucleic acids |
| WO2024230934A1 (en) | 2023-05-11 | 2024-11-14 | CureVac SE | Therapeutic nucleic acid for the treatment of ophthalmic diseases |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4709039A (en) * | 1986-03-21 | 1987-11-24 | The Dow Chemical Company | Vinyloxazoline monomer and preparation thereof |
| JPH075686B2 (ja) | 1988-08-22 | 1995-01-25 | フューズド・コンタクツ・オブ・シカゴ・インコーポレイテッド | 改善された気体透過コンタクトレンズを作るための組成 |
| US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
| US5130126A (en) | 1990-07-09 | 1992-07-14 | Nippon Oil & Fats Co., Ltd. | Polymer-drug conjugate and a method of producing it |
| US5416071A (en) | 1991-03-12 | 1995-05-16 | Takeda Chemical Industries, Ltd. | Water-soluble composition for sustained-release containing epo and hyaluronic acid |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US5635571A (en) * | 1995-06-30 | 1997-06-03 | Cornell Research Foundation, Inc. | Polymerizable macromonomers and polymers prepared therefrom |
| US6753165B1 (en) | 1999-01-14 | 2004-06-22 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
| ES2297889T3 (es) | 1997-07-14 | 2008-05-01 | Bolder Biotechnology, Inc. | Derivados de hormona de crecimiento y proteinas relacionadas. |
| JO2291B1 (en) | 1999-07-02 | 2005-09-12 | اف . هوفمان لاروش ايه جي | Erythropoietin derivatives |
| CZ299516B6 (cs) | 1999-07-02 | 2008-08-20 | F. Hoffmann-La Roche Ag | Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem |
| DE19936014C2 (de) | 1999-08-04 | 2003-04-03 | Zf Lemfoerder Metallwaren Ag | Gummilager mit axialer Dämpfung |
| WO2001076639A2 (en) | 2000-04-06 | 2001-10-18 | Pharmacia Corporation | Chemically-modified myelopoietin conjugates |
| KR20030057529A (ko) | 2000-09-08 | 2003-07-04 | 그리폰 테라퓨틱스, 인코포레이티드 | 합성 적혈구생성 자극 단백질 |
| WO2002032957A1 (en) | 2000-10-16 | 2002-04-25 | Chugai Seiyaku Kabushiki Kaisha | Peg-modified erythropoietin |
| US6759496B2 (en) * | 2000-12-18 | 2004-07-06 | Bausch & Lomb Incorporated | Poly(2-oxazoline) biomedical devices |
| AU2002233230B2 (en) | 2000-12-20 | 2007-02-01 | F. Hoffmann-La Roche Ag | Erythropoietin conjugates |
| KR100401296B1 (ko) | 2000-12-27 | 2003-10-11 | 드림바이오젠 주식회사 | 수식물질에 의해 수식된 단백질 변이체 및 이것의 제조방법 |
| US7077939B1 (en) | 2001-06-18 | 2006-07-18 | The Texas A&M University System | Method and apparatus for nanoparticle transport and detection |
| US6908963B2 (en) | 2001-10-09 | 2005-06-21 | Nektar Therapeutics Al, Corporation | Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith |
| US7125843B2 (en) | 2001-10-19 | 2006-10-24 | Neose Technologies, Inc. | Glycoconjugates including more than one peptide |
| JP3984541B2 (ja) * | 2001-12-26 | 2007-10-03 | 財団法人川村理化学研究所 | 星型ポリオキサゾリンからなる粒子およびその製造方法 |
| WO2003066069A1 (en) | 2002-02-01 | 2003-08-14 | Intradigm Corporation | Polymers for delivering peptides and small molecules in vivo |
| EP1344810A1 (en) | 2002-03-13 | 2003-09-17 | Infineum International Limited | Fuel additive compositions for diesel engine equipped with a particulate trap |
| US7074755B2 (en) | 2003-05-17 | 2006-07-11 | Centocor, Inc. | Erythropoietin conjugate compounds with extended half-lives |
| CA2527665A1 (en) | 2003-05-30 | 2004-12-16 | Centocor, Inc. | Formation of novel erythropoietin conjugates using transglutaminase |
| PT1512736T (pt) | 2003-09-05 | 2018-05-29 | Infineum Int Ltd | Composições estabilizadas de aditivos para gasóleo |
| US8057821B2 (en) * | 2004-11-03 | 2011-11-15 | Egen, Inc. | Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof |
| EP2399893B1 (en) | 2004-12-22 | 2018-08-15 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
| WO2007010552A2 (en) | 2005-03-17 | 2007-01-25 | Serum Institute Of India Limited | N- terminal peg conjugate of erythropoietin |
| EP2134181A4 (en) | 2007-02-28 | 2011-09-28 | Serina Therapeutics Inc | ACTIVATED POLYOXAZOLINES AND COMPOSITION COMPRISING THE SAME |
| JP5514736B2 (ja) * | 2008-01-11 | 2014-06-04 | セリナ・セラピユーテイツクス・インコーポレーテツド | ポリオキサゾリン共重合体の多機能形態およびそれを含む薬物組成物 |
| US8101706B2 (en) * | 2008-01-11 | 2012-01-24 | Serina Therapeutics, Inc. | Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same |
-
2009
- 2009-01-12 JP JP2010542410A patent/JP5514736B2/ja active Active
- 2009-01-12 US US12/744,472 patent/US8110651B2/en active Active
- 2009-01-12 WO PCT/US2009/030762 patent/WO2009089542A2/en not_active Ceased
- 2009-01-12 EP EP16154587.6A patent/EP3042922B1/en active Active
- 2009-01-12 EP EP09701187.8A patent/EP2235090B1/en active Active
- 2009-01-12 KR KR1020107017208A patent/KR101486449B1/ko active Active
- 2009-01-12 CN CN2009801062765A patent/CN101959934B/zh active Active
- 2009-01-12 DK DK16154587.6T patent/DK3042922T3/en active
- 2009-01-12 EP EP13181892.4A patent/EP2669313B1/en active Active
-
2012
- 2012-02-06 US US13/367,128 patent/US9169354B2/en active Active
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