DK3042922T3 - MULTIFUNCTIONAL FORMS OF POLYOXAZOLINE COLPOLYMERS AND PHARMACEUTICAL COMPOSITIONS INCLUDING THE SAME - Google Patents
MULTIFUNCTIONAL FORMS OF POLYOXAZOLINE COLPOLYMERS AND PHARMACEUTICAL COMPOSITIONS INCLUDING THE SAME Download PDFInfo
- Publication number
- DK3042922T3 DK3042922T3 DK16154587.6T DK16154587T DK3042922T3 DK 3042922 T3 DK3042922 T3 DK 3042922T3 DK 16154587 T DK16154587 T DK 16154587T DK 3042922 T3 DK3042922 T3 DK 3042922T3
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- Prior art keywords
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- substituted
- carboxylic acid
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Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/02—Polyamines
- C08G73/0233—Polyamines derived from (poly)oxazolines, (poly)oxazines or having pendant acyl groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/02—Polyamines
- C08G73/028—Polyamidoamines
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2068408P | 2008-01-11 | 2008-01-11 | |
| US2933708P | 2008-02-16 | 2008-02-16 | |
| EP13181892.4A EP2669313B1 (en) | 2008-01-11 | 2009-01-12 | Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3042922T3 true DK3042922T3 (en) | 2017-10-23 |
Family
ID=40853790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16154587.6T DK3042922T3 (en) | 2008-01-11 | 2009-01-12 | MULTIFUNCTIONAL FORMS OF POLYOXAZOLINE COLPOLYMERS AND PHARMACEUTICAL COMPOSITIONS INCLUDING THE SAME |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8110651B2 (https=) |
| EP (3) | EP3042922B1 (https=) |
| JP (1) | JP5514736B2 (https=) |
| KR (1) | KR101486449B1 (https=) |
| CN (1) | CN101959934B (https=) |
| DK (1) | DK3042922T3 (https=) |
| WO (1) | WO2009089542A2 (https=) |
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| US8101706B2 (en) | 2008-01-11 | 2012-01-24 | Serina Therapeutics, Inc. | Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same |
| US8110651B2 (en) | 2008-01-11 | 2012-02-07 | Serina Therapeutics, Inc. | Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same |
| JP5642673B2 (ja) * | 2008-07-10 | 2014-12-17 | セリナ・セラピユーテイツクス・インコーポレーテツド | 不活性末端基を有するポリオキサゾリン類、保護された開始基から調製されるポリオキサゾリン類及び関連化合物 |
| RU2593755C2 (ru) * | 2011-01-04 | 2016-08-10 | Бендер Аналитикал Холдинг Б.В. | Сшитые полимеры и имплантаты, произведенные из электрофильно активированного полиоксазолина |
| CN102731791B (zh) * | 2011-04-13 | 2016-04-13 | 北京大学 | 温度敏感型嵌段共聚物及其水凝胶和其用途 |
| US20140271527A1 (en) * | 2011-11-01 | 2014-09-18 | Serina Therapeutics, Inc. | Subcutaneous delivery of polymer conjugates of therapeutic agents |
| US8383093B1 (en) * | 2011-11-01 | 2013-02-26 | Serina Therapeutics, Inc. | Subcutaneous delivery of poly(oxazoline) conjugates |
| EP2800773B1 (en) * | 2012-01-02 | 2017-12-13 | Universiteit Gent | Polyoxazoline polymers and methods for their preparation, conjugates of these polymers and medical uses thereof |
| US9416228B2 (en) | 2012-03-16 | 2016-08-16 | Bender Analytical Holding B.V. | Cross-linked polymers and medical products derived from nucleophilically activated polyoxazoline |
| ES2879430T3 (es) | 2012-11-15 | 2021-11-22 | Apellis Pharmaceuticals Inc | Análogos de compstatina de acción prolongada y composiciones y métodos relacionados |
| US10071168B2 (en) | 2014-07-31 | 2018-09-11 | Serina Therapeutics, Inc. | Polyoxazoline antibody drug conjugates |
| NZ728772A (en) | 2014-09-26 | 2018-10-26 | Novartis Ag | Polymerizable polysiloxanes with hydrophilic substituents |
| BR112017006943B1 (pt) | 2014-10-06 | 2020-12-01 | Gatt Technologies B.V | produto hemostático poroso adesivo de tecido |
| EP3359555B1 (en) | 2015-10-07 | 2023-12-20 | Apellis Pharmaceuticals, Inc. | Dosing regimens |
| CN105418911A (zh) * | 2015-12-29 | 2016-03-23 | 南京工业大学 | 一种聚(2-r-2-噁唑啉)嵌段聚(肌氨酸)双亲性嵌段共聚物的制备方法 |
| JP2020516607A (ja) | 2017-04-07 | 2020-06-11 | アペリス・ファーマシューティカルズ・インコーポレイテッドＡｐｅｌｌｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 投与レジメンならびに関連組成物および方法 |
| DE102018000650A1 (de) * | 2018-01-27 | 2019-08-01 | Friedrich-Schiller-Universität Jena | Verfahren zur Bestimmung von Verunreinigungen in Polyalkylenethern oder Polyalkylenaminen und dessen Verwendung |
| JP7614086B2 (ja) * | 2018-07-27 | 2025-01-15 | セリナ・セラピユーテイツクス・インコーポレーテツド | カテコール化合物と水溶性ポリマーの切断可能なコンジュゲート及びそれらを使用する治療方法 |
| US12485181B2 (en) | 2019-06-28 | 2025-12-02 | Serina Therapeutics (Al), Inc. | Polyoxazoline-drug conjugates with novel pharmacokinetic properties |
| CN113354811B (zh) * | 2020-02-19 | 2024-05-07 | 华东理工大学 | 一种侧链含有氨基和/或羟基的噁唑啉聚合物，其制备方法及应用 |
| CN112661961B (zh) * | 2020-12-28 | 2022-05-06 | 中国科学院长春应用化学研究所 | 两亲性聚噁唑啉共聚物、其制备方法及应用 |
| CN117098558A (zh) | 2021-02-09 | 2023-11-21 | 塞瑞纳治疗公司 | 聚噁唑啉-脂质缀合物及包含其的脂质纳米颗粒和药物组合物 |
| WO2023031392A2 (en) | 2021-09-03 | 2023-03-09 | CureVac SE | Novel lipid nanoparticles for delivery of nucleic acids comprising phosphatidylserine |
| MX2024002726A (es) | 2021-09-03 | 2024-03-20 | CureVac SE | Nuevas nanoparticulas lipidicas para la administracion de acidos nucleicos. |
| KR20230044782A (ko) | 2021-09-27 | 2023-04-04 | 삼성전자주식회사 | 패치 안테나를 포함하는 안테나 구조 및 이를 포함하는 전자 장치 |
| WO2023073228A1 (en) | 2021-10-29 | 2023-05-04 | CureVac SE | Improved circular rna for expressing therapeutic proteins |
| US20250099614A1 (en) | 2022-01-28 | 2025-03-27 | CureVac SE | Nucleic acid encoded transcription factor inhibitors |
| KR20250153298A (ko) | 2023-03-08 | 2025-10-24 | 큐어백 에스이 | 핵산 전달을 위한 신규의 지질 나노입자 제형 |
| WO2024230934A1 (en) | 2023-05-11 | 2024-11-14 | CureVac SE | Therapeutic nucleic acid for the treatment of ophthalmic diseases |
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| US4709039A (en) | 1986-03-21 | 1987-11-24 | The Dow Chemical Company | Vinyloxazoline monomer and preparation thereof |
| WO1990002144A1 (en) | 1988-08-22 | 1990-03-08 | Fused Kontacts Of Chicago, Inc. | Compositions for making improved gas permeable contact lenses |
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| WO2007010552A2 (en) | 2005-03-17 | 2007-01-25 | Serum Institute Of India Limited | N- terminal peg conjugate of erythropoietin |
| KR101508621B1 (ko) | 2007-02-28 | 2015-04-07 | 세리나 쎄라퓨틱스, 인코포레이티드 | 활성화된 폴리옥사졸린 및 이를 포함하는 조성물 |
| US8101706B2 (en) * | 2008-01-11 | 2012-01-24 | Serina Therapeutics, Inc. | Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same |
| US8110651B2 (en) * | 2008-01-11 | 2012-02-07 | Serina Therapeutics, Inc. | Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same |
-
2009
- 2009-01-12 US US12/744,472 patent/US8110651B2/en active Active
- 2009-01-12 EP EP16154587.6A patent/EP3042922B1/en active Active
- 2009-01-12 DK DK16154587.6T patent/DK3042922T3/en active
- 2009-01-12 WO PCT/US2009/030762 patent/WO2009089542A2/en not_active Ceased
- 2009-01-12 EP EP09701187.8A patent/EP2235090B1/en active Active
- 2009-01-12 EP EP13181892.4A patent/EP2669313B1/en active Active
- 2009-01-12 KR KR1020107017208A patent/KR101486449B1/ko active Active
- 2009-01-12 JP JP2010542410A patent/JP5514736B2/ja active Active
- 2009-01-12 CN CN2009801062765A patent/CN101959934B/zh active Active
-
2012
- 2012-02-06 US US13/367,128 patent/US9169354B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2235090B1 (en) | 2013-09-04 |
| CN101959934B (zh) | 2012-12-12 |
| EP2669313B1 (en) | 2016-03-23 |
| EP3042922B1 (en) | 2017-07-19 |
| EP2669313A1 (en) | 2013-12-04 |
| KR101486449B1 (ko) | 2015-01-26 |
| US9169354B2 (en) | 2015-10-27 |
| EP3042922A1 (en) | 2016-07-13 |
| EP2235090A2 (en) | 2010-10-06 |
| KR20110007084A (ko) | 2011-01-21 |
| EP2235090A4 (en) | 2011-10-05 |
| US8110651B2 (en) | 2012-02-07 |
| JP5514736B2 (ja) | 2014-06-04 |
| US20110009594A1 (en) | 2011-01-13 |
| WO2009089542A2 (en) | 2009-07-16 |
| WO2009089542A3 (en) | 2009-10-01 |
| US20120136123A1 (en) | 2012-05-31 |
| CN101959934A (zh) | 2011-01-26 |
| JP2011510120A (ja) | 2011-03-31 |
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