JP2011509287A5 - - Google Patents
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- Publication number
- JP2011509287A5 JP2011509287A5 JP2010541885A JP2010541885A JP2011509287A5 JP 2011509287 A5 JP2011509287 A5 JP 2011509287A5 JP 2010541885 A JP2010541885 A JP 2010541885A JP 2010541885 A JP2010541885 A JP 2010541885A JP 2011509287 A5 JP2011509287 A5 JP 2011509287A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- peptide
- polysaccharide
- oil
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 28
- 108090000765 processed proteins & peptides Proteins 0.000 claims 26
- 235000018102 proteins Nutrition 0.000 claims 26
- 102000004169 proteins and genes Human genes 0.000 claims 26
- 108090000623 proteins and genes Proteins 0.000 claims 26
- 150000004676 glycans Chemical class 0.000 claims 20
- 229920001282 polysaccharide Polymers 0.000 claims 20
- 239000005017 polysaccharide Substances 0.000 claims 20
- 239000003921 oil Substances 0.000 claims 18
- 235000019198 oils Nutrition 0.000 claims 18
- 239000002105 nanoparticle Substances 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 239000000377 silicon dioxide Substances 0.000 claims 14
- 238000000034 method Methods 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 101710172711 Structural protein Proteins 0.000 claims 4
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 4
- 238000002844 melting Methods 0.000 claims 4
- 230000008018 melting Effects 0.000 claims 4
- 102000003390 tumor necrosis factor Human genes 0.000 claims 4
- 230000005661 hydrophobic surface Effects 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 2
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 2
- 102000055006 Calcitonin Human genes 0.000 claims 2
- 108060001064 Calcitonin Proteins 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 2
- 108010035532 Collagen Proteins 0.000 claims 2
- 102000016911 Deoxyribonucleases Human genes 0.000 claims 2
- 108010053770 Deoxyribonucleases Proteins 0.000 claims 2
- 102000016942 Elastin Human genes 0.000 claims 2
- 108010014258 Elastin Proteins 0.000 claims 2
- 108010049003 Fibrinogen Proteins 0.000 claims 2
- 102000008946 Fibrinogen Human genes 0.000 claims 2
- 102000018997 Growth Hormone Human genes 0.000 claims 2
- 108010051696 Growth Hormone Proteins 0.000 claims 2
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 2
- 102000006992 Interferon-alpha Human genes 0.000 claims 2
- 108010047761 Interferon-alpha Proteins 0.000 claims 2
- 108090000467 Interferon-beta Proteins 0.000 claims 2
- 102000003996 Interferon-beta Human genes 0.000 claims 2
- 108010074328 Interferon-gamma Proteins 0.000 claims 2
- 102000008070 Interferon-gamma Human genes 0.000 claims 2
- 102000011782 Keratins Human genes 0.000 claims 2
- 108010076876 Keratins Proteins 0.000 claims 2
- 102000006382 Ribonucleases Human genes 0.000 claims 2
- 108010083644 Ribonucleases Proteins 0.000 claims 2
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 claims 2
- 229960004015 calcitonin Drugs 0.000 claims 2
- 229920001436 collagen Polymers 0.000 claims 2
- 229920002549 elastin Polymers 0.000 claims 2
- 230000010437 erythropoiesis Effects 0.000 claims 2
- 229940012952 fibrinogen Drugs 0.000 claims 2
- 239000000122 growth hormone Substances 0.000 claims 2
- 229960003130 interferon gamma Drugs 0.000 claims 2
- 229960001388 interferon-beta Drugs 0.000 claims 2
- 238000002156 mixing Methods 0.000 claims 2
- 239000013618 particulate matter Substances 0.000 claims 2
- 230000001737 promoting effect Effects 0.000 claims 2
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims 1
- 229920000310 Alpha glucan Polymers 0.000 claims 1
- 229920000945 Amylopectin Polymers 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- 229920002498 Beta-glucan Polymers 0.000 claims 1
- 229920002101 Chitin Polymers 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- 229920002527 Glycogen Polymers 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 235000009697 arginine Nutrition 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 238000007580 dry-mixing Methods 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 229940096919 glycogen Drugs 0.000 claims 1
- 235000014304 histidine Nutrition 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
- 235000018977 lysine Nutrition 0.000 claims 1
- 239000011236 particulate material Substances 0.000 claims 1
- 239000000813 peptide hormone Substances 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 1
- 239000008158 vegetable oil Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL188647A IL188647A0 (en) | 2008-01-08 | 2008-01-08 | Adaptable structured drug and supplements administration system (for oral and/or transdermal applications) |
| IL188647 | 2008-01-08 | ||
| US8029508P | 2008-07-14 | 2008-07-14 | |
| US61/080,295 | 2008-07-14 | ||
| PCT/IL2009/000036 WO2009087633A2 (en) | 2008-01-08 | 2009-01-08 | Methods and compositions for oral administration of protein and peptide therapeutic agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011509287A JP2011509287A (ja) | 2011-03-24 |
| JP2011509287A5 true JP2011509287A5 (https=) | 2012-03-01 |
| JP5432183B2 JP5432183B2 (ja) | 2014-03-05 |
Family
ID=40326402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010541885A Expired - Fee Related JP5432183B2 (ja) | 2008-01-08 | 2009-01-08 | タンパク質およびペプチドの治療薬の経口投与に関する方法および組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US8936786B2 (https=) |
| EP (2) | EP2231123B1 (https=) |
| JP (1) | JP5432183B2 (https=) |
| KR (1) | KR101588066B1 (https=) |
| AU (2) | AU2009203529B2 (https=) |
| BR (1) | BRPI0906866A2 (https=) |
| CA (2) | CA2711556A1 (https=) |
| DK (2) | DK2254590T3 (https=) |
| EA (1) | EA018461B1 (https=) |
| ES (2) | ES2397061T3 (https=) |
| IL (3) | IL188647A0 (https=) |
| MX (1) | MX2010007462A (https=) |
| NZ (1) | NZ586374A (https=) |
| WO (2) | WO2009087633A2 (https=) |
| ZA (1) | ZA201004480B (https=) |
Families Citing this family (22)
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| JP2521295Y2 (ja) | 1991-11-13 | 1996-12-25 | シーケーディ株式会社 | 流体混合器 |
| IL188647A0 (en) * | 2008-01-08 | 2008-11-03 | Orina Gribova | Adaptable structured drug and supplements administration system (for oral and/or transdermal applications) |
| CN102099011B (zh) * | 2009-07-09 | 2016-06-01 | 奥莎迪药品管理有限公司 | 基质载体组合物、方法及用途 |
| MX367097B (es) * | 2011-05-02 | 2019-08-05 | Millennium Pharm Inc | FORMULACION PARA ANTICUERPO ANTI-A4ß7. |
| US9603907B2 (en) | 2012-02-01 | 2017-03-28 | Protalix Ltd. | Dry powder formulations of dNase I |
| WO2014031837A1 (en) * | 2012-08-22 | 2014-02-27 | The Regents Of The University Of California | Compositions and methods for enhancing sialic acid levels in tissue |
| CN113842362A (zh) | 2012-11-14 | 2021-12-28 | 格雷斯公司 | 含有生物活性材料与无序无机氧化物的组合物 |
| WO2014118774A1 (en) * | 2013-01-29 | 2014-08-07 | Oshadi Drug Administration Ltd. | Pharmaceutical compositions for oral treatment of diabetes |
| ES2502691B1 (es) * | 2013-09-25 | 2015-07-07 | Sani-Red, S.L. | Método de conservación y estabilización de proteínas, aplicable para desarrollos industriales de formulaciones de productos sanitarios, farmacéuticos y cosméticos |
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| KR102418550B1 (ko) * | 2015-11-03 | 2022-07-06 | 삼성전자주식회사 | 포토 레지스트 패턴 형성 방법 및 이를 이용한 반도체 장치 제조 방법 |
| WO2017141262A1 (en) * | 2016-02-19 | 2017-08-24 | Indian Institute Of Technology, Bombay | Orally administrable pharmaceutical preparation containing protein |
| CN109819650A (zh) * | 2017-09-25 | 2019-05-28 | 春布里泽·格奥尔基·格奥尔基耶维奇 | 具有抗病毒和抗细菌活性的热稳定组合物及其用途 |
| IT201800007947A1 (it) * | 2018-08-07 | 2020-02-07 | Vetagro Int Srl | Metodo per preparare una composizione di aminoacidi per consentire la corrispondenza dei singoli fabbisogni di amminoacidi ad un soggetto in base all'età, al genere, all'attività fisica e alla genetica |
| EP3952900A1 (en) * | 2019-04-11 | 2022-02-16 | R.P. Scherer Technologies, LLC | Formulation for oral delivery of proteins, peptides and small molecules with poor permeability |
| US20220296683A1 (en) * | 2019-09-20 | 2022-09-22 | University College Dublin | Oral delivery system |
| PL3937983T3 (pl) | 2019-12-17 | 2025-08-11 | 9286-3620 Québec Inc. | Doustne systemy dostarczania oparte na tworzących się in situ koacerwatach białko/polisacharyd |
| EP4096698A1 (en) | 2020-01-28 | 2022-12-07 | Genentech, Inc. | Il15/il15r alpha heterodimeric fc-fusion proteins for the treatment of cancer |
| KR20230051164A (ko) | 2020-07-15 | 2023-04-17 | 샤바르 리서치 어소시에이츠 엘엘씨 | 급성 통증의 치료 및 속쓰림의 중증도 및/또는 위험의 감소를 위한 이부프로펜 및 파모티딘으로 구성된 단위 경구 투여 조성물 |
| US20240315972A1 (en) | 2021-07-12 | 2024-09-26 | Zidkiyahu Simenhaus | Protein containing bio-active compositions comprising cellulose microparticle carriers |
| JP2025519656A (ja) | 2022-06-13 | 2025-06-26 | ビー．エー．アイ． ラボラトリーズ， エルエルシー | インターロイキン－１３結合環状オリゴペプチドおよびその使用方法 |
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| EP2012817A2 (en) * | 2006-04-12 | 2009-01-14 | Biodel, Inc. | Rapid acting and long acting insulin combination formulations |
| IL188647A0 (en) * | 2008-01-08 | 2008-11-03 | Orina Gribova | Adaptable structured drug and supplements administration system (for oral and/or transdermal applications) |
| CN102099011B (zh) * | 2009-07-09 | 2016-06-01 | 奥莎迪药品管理有限公司 | 基质载体组合物、方法及用途 |
-
2008
- 2008-01-08 IL IL188647A patent/IL188647A0/en unknown
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2009
- 2009-01-08 ES ES09700655T patent/ES2397061T3/es active Active
- 2009-01-08 CA CA2711556A patent/CA2711556A1/en not_active Abandoned
- 2009-01-08 WO PCT/IL2009/000036 patent/WO2009087633A2/en not_active Ceased
- 2009-01-08 KR KR1020107016634A patent/KR101588066B1/ko not_active Expired - Fee Related
- 2009-01-08 US US12/811,871 patent/US8936786B2/en not_active Expired - Fee Related
- 2009-01-08 AU AU2009203529A patent/AU2009203529B2/en not_active Ceased
- 2009-01-08 NZ NZ586374A patent/NZ586374A/en not_active IP Right Cessation
- 2009-01-08 US US12/811,859 patent/US20100278922A1/en not_active Abandoned
- 2009-01-08 DK DK09700655.5T patent/DK2254590T3/da active
- 2009-01-08 WO PCT/IL2009/000037 patent/WO2009087634A2/en not_active Ceased
- 2009-01-08 MX MX2010007462A patent/MX2010007462A/es active IP Right Grant
- 2009-01-08 DK DK09701269.4T patent/DK2231123T3/da active
- 2009-01-08 BR BRPI0906866-0A patent/BRPI0906866A2/pt not_active Application Discontinuation
- 2009-01-08 EP EP09701269A patent/EP2231123B1/en not_active Not-in-force
- 2009-01-08 EP EP09700655A patent/EP2254590B1/en not_active Not-in-force
- 2009-01-08 AU AU2009203530A patent/AU2009203530B2/en not_active Ceased
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