JP2011507856A - 整形外科状態の治療のための抗コネキシンポリヌクレオチド、ペプチド、または抗体の使用 - Google Patents

整形外科状態の治療のための抗コネキシンポリヌクレオチド、ペプチド、または抗体の使用 Download PDF

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JP2011507856A
JP2011507856A JP2010539512A JP2010539512A JP2011507856A JP 2011507856 A JP2011507856 A JP 2011507856A JP 2010539512 A JP2010539512 A JP 2010539512A JP 2010539512 A JP2010539512 A JP 2010539512A JP 2011507856 A JP2011507856 A JP 2011507856A
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connexin
composition
agent
polynucleotide
agents
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JP2011507856A5 (OSRAM
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デイビッド エル. ベッカー,
コリン アール. グリーン,
ブラッドフォード ジェイ. ダフト,
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コーダ セラピューティクス, インコーポレイテッド
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications
    • C12N2320/31Combination therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP2010539512A 2007-12-21 2008-12-22 整形外科状態の治療のための抗コネキシンポリヌクレオチド、ペプチド、または抗体の使用 Withdrawn JP2011507856A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US866007P 2007-12-21 2007-12-21
PCT/US2008/014020 WO2009085269A2 (en) 2007-12-21 2008-12-22 Use of anti-connexin polynucleotides, peptides or antibodies for the treatment of orthopedic conditions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014124291A Division JP2014169330A (ja) 2007-12-21 2014-06-17 整形外科状態の治療のための抗コネキシンポリヌクレオチド、ペプチド、または抗体の使用

Publications (2)

Publication Number Publication Date
JP2011507856A true JP2011507856A (ja) 2011-03-10
JP2011507856A5 JP2011507856A5 (OSRAM) 2013-04-25

Family

ID=40824954

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2010539512A Withdrawn JP2011507856A (ja) 2007-12-21 2008-12-22 整形外科状態の治療のための抗コネキシンポリヌクレオチド、ペプチド、または抗体の使用
JP2014124291A Withdrawn JP2014169330A (ja) 2007-12-21 2014-06-17 整形外科状態の治療のための抗コネキシンポリヌクレオチド、ペプチド、または抗体の使用
JP2016169310A Pending JP2017025076A (ja) 2007-12-21 2016-08-31 整形外科状態の治療のための抗コネキシンポリヌクレオチド、ペプチド、または抗体の使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2014124291A Withdrawn JP2014169330A (ja) 2007-12-21 2014-06-17 整形外科状態の治療のための抗コネキシンポリヌクレオチド、ペプチド、または抗体の使用
JP2016169310A Pending JP2017025076A (ja) 2007-12-21 2016-08-31 整形外科状態の治療のための抗コネキシンポリヌクレオチド、ペプチド、または抗体の使用

Country Status (6)

Country Link
US (1) US20110217313A1 (OSRAM)
EP (1) EP2238250B1 (OSRAM)
JP (3) JP2011507856A (OSRAM)
AU (1) AU2008343840A1 (OSRAM)
CA (1) CA2710375A1 (OSRAM)
WO (1) WO2009085269A2 (OSRAM)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006257283A1 (en) 2005-02-03 2006-12-21 Coda Therapeutics Limited Anti-connexin compounds and uses thereof
JP2011507857A (ja) 2007-12-21 2011-03-10 コーダ セラピューティクス, インコーポレイテッド 線維症性の状態の処置のためのコネキシン43の阻害剤の使用
JP6185937B2 (ja) 2012-03-01 2017-08-23 ファーストストリング・リサーチ・インコーポレイテッドFirststring Research,Inc. アルファコネキシンc末端(act)ペプチド含有局所用ゲル剤
JP2015513905A (ja) 2012-03-27 2015-05-18 コーダ セラピューティクス, インコーポレイテッド カドヘリン調節に基づく組成物および処置
US10465188B2 (en) 2014-08-22 2019-11-05 Auckland Uniservices Limited Channel modulators
CN109414475A (zh) * 2016-05-03 2019-03-01 奥克兰大学 新型肽和肽模拟物
WO2018199777A1 (en) 2017-04-28 2018-11-01 Auckland Uniservices Limited Methods of treatment and novel constructs
CN116710474A (zh) 2020-10-22 2023-09-05 撒凯尔生物公司 肽制剂及其眼科用途
WO2022103636A1 (en) * 2020-11-16 2022-05-19 Orcosa Inc. Improved use of cannabinoids in the treatment of alzheimer's disease
US11672761B2 (en) 2020-11-16 2023-06-13 Orcosa Inc. Rapidly infusing platform and compositions for therapeutic treatment in humans

Citations (3)

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JP2002535377A (ja) * 1999-01-27 2002-10-22 ユニバーシテイ・カレツジ・ロンドン コネキシンに対するアンチセンスヌクレオチドを含む配合物
WO2006127249A1 (en) * 2005-05-25 2006-11-30 Waddell David D Method and composition for treating osteoarthritis
WO2006134494A2 (en) * 2005-02-03 2006-12-21 Coda Therapeutics Limited Anti-connexin compounds and therapeutic uses thereof

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US4861757A (en) * 1986-11-14 1989-08-29 Institute Of Molecular Biology Wound healing and bone regeneration using PDGF and IGF-I
US5004810A (en) * 1988-09-30 1991-04-02 Schering Corporation Antiviral oligomers
US5166195A (en) * 1990-05-11 1992-11-24 Isis Pharmaceuticals, Inc. Antisense inhibitors of the human immunodeficiency virus phosphorothioate oligonucleotides
GB9206861D0 (en) * 1992-03-28 1992-05-13 Univ Manchester Wound healing and treatment of fibrotic disorders
US6566339B1 (en) * 1995-08-04 2003-05-20 Renovo Limited Pharmaceutical composition
GB2304047A (en) * 1995-08-09 1997-03-12 Univ Manchester Pharmaceutical compositions containing cytokines
EP1486565B1 (en) * 1995-10-11 2007-11-21 Novartis Vaccines and Diagnostics, Inc. Combination of PDGF, KGF, IGF, and IGFBP for wound healing
EP1506775A1 (en) * 1996-07-22 2005-02-16 Renovo Limited Use of sex steroid function modulators to treat wounds and fibrotic disorders
GB9702943D0 (en) * 1997-02-13 1997-04-02 Univ Manchester Wound healing
US6855505B2 (en) * 1998-06-26 2005-02-15 Renovo Limited Method for quantifying TGF-β
GB9903598D0 (en) * 1999-02-18 1999-04-07 Univ Manchester Connective tissue healing
US7250397B2 (en) * 2000-02-23 2007-07-31 Zealand Pharma A/S Antiarrhythmic peptides
JP2005516054A (ja) * 2002-01-29 2005-06-02 ワイス コネキシンヘミチャンネルを調節する組成物及びその方法
AU2005210668A1 (en) * 2004-01-30 2005-08-18 Angiotech International Ag Compositions and methods for treating contracture
US7767710B2 (en) * 2005-05-25 2010-08-03 Calosyn Pharma, Inc. Method for treating osteoarthritis
WO2009085271A2 (en) * 2007-12-21 2009-07-09 Coda Therapeutics, Inc. Use of anti-connexin peptides, alone or in combination with anti-connexin polynucleotides, for the treatment of orthopedic conditions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002535377A (ja) * 1999-01-27 2002-10-22 ユニバーシテイ・カレツジ・ロンドン コネキシンに対するアンチセンスヌクレオチドを含む配合物
WO2006134494A2 (en) * 2005-02-03 2006-12-21 Coda Therapeutics Limited Anti-connexin compounds and therapeutic uses thereof
WO2006127249A1 (en) * 2005-05-25 2006-11-30 Waddell David D Method and composition for treating osteoarthritis

Also Published As

Publication number Publication date
EP2238250B1 (en) 2017-07-19
JP2014169330A (ja) 2014-09-18
US20110217313A1 (en) 2011-09-08
WO2009085269A2 (en) 2009-07-09
WO2009085269A3 (en) 2009-09-24
EP2238250A2 (en) 2010-10-13
AU2008343840A1 (en) 2009-07-09
CA2710375A1 (en) 2009-07-09
JP2017025076A (ja) 2017-02-02

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