JP2011506490A5 - - Google Patents
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- JP2011506490A5 JP2011506490A5 JP2010538278A JP2010538278A JP2011506490A5 JP 2011506490 A5 JP2011506490 A5 JP 2011506490A5 JP 2010538278 A JP2010538278 A JP 2010538278A JP 2010538278 A JP2010538278 A JP 2010538278A JP 2011506490 A5 JP2011506490 A5 JP 2011506490A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- optionally
- group
- alkyloxy
- heteroalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 41
- 125000006710 (C2-C12) alkenyl group Chemical group 0.000 claims description 34
- 125000000217 alkyl group Chemical group 0.000 claims description 33
- 125000003545 alkoxy group Chemical group 0.000 claims description 30
- 125000005133 alkynyloxy group Chemical group 0.000 claims description 28
- 125000003118 aryl group Chemical group 0.000 claims description 28
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 28
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 28
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 28
- 125000001072 heteroaryl group Chemical group 0.000 claims description 28
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims description 28
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 28
- 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims description 26
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 22
- 125000005843 halogen group Chemical group 0.000 claims description 22
- 229910052736 halogen Inorganic materials 0.000 claims description 21
- 150000002367 halogens Chemical class 0.000 claims description 21
- 125000000000 cycloalkoxy group Chemical group 0.000 claims description 20
- 125000002252 acyl group Chemical group 0.000 claims description 16
- 125000003302 alkenyloxy group Chemical group 0.000 claims description 16
- 125000003282 alkyl amino group Chemical group 0.000 claims description 16
- 125000004104 aryloxy group Chemical group 0.000 claims description 16
- 125000004465 cycloalkenyloxy group Chemical group 0.000 claims description 16
- 125000005553 heteroaryloxy group Chemical group 0.000 claims description 16
- 229940002612 prodrug Drugs 0.000 claims description 7
- 239000000651 prodrug Substances 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 7
- 125000004429 atom Chemical group 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 150000002366 halogen compounds Chemical class 0.000 claims 1
- 0 CC(C)(*)c(cc1*)ccc1N(*)C(C(*)*C(*)c1c(*)c(*)c(*)c(*)c1*)=O Chemical compound CC(C)(*)c(cc1*)ccc1N(*)C(C(*)*C(*)c1c(*)c(*)c(*)c(*)c1*)=O 0.000 description 4
- 125000000304 alkynyl group Chemical group 0.000 description 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1613407P | 2007-12-21 | 2007-12-21 | |
| US61/016,134 | 2007-12-21 | ||
| PCT/AU2008/001868 WO2009079692A1 (en) | 2007-12-21 | 2008-12-19 | Halogenated analogues of anti-fibrotic agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015079433A Division JP6063985B2 (ja) | 2007-12-21 | 2015-04-08 | 抗線維症剤のハロゲン化類似体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011506490A JP2011506490A (ja) | 2011-03-03 |
| JP2011506490A5 true JP2011506490A5 (https=) | 2012-02-16 |
| JP5730578B2 JP5730578B2 (ja) | 2015-06-10 |
Family
ID=40800565
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010538278A Active JP5730578B2 (ja) | 2007-12-21 | 2008-12-19 | 抗線維症剤のハロゲン化類似体 |
| JP2015079433A Active JP6063985B2 (ja) | 2007-12-21 | 2015-04-08 | 抗線維症剤のハロゲン化類似体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015079433A Active JP6063985B2 (ja) | 2007-12-21 | 2015-04-08 | 抗線維症剤のハロゲン化類似体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8624056B2 (https=) |
| EP (2) | EP3045170B1 (https=) |
| JP (2) | JP5730578B2 (https=) |
| KR (2) | KR20160017139A (https=) |
| CN (2) | CN102164887A (https=) |
| AU (1) | AU2008341010B2 (https=) |
| CA (1) | CA2709937C (https=) |
| MX (2) | MX372721B (https=) |
| NZ (1) | NZ584613A (https=) |
| SG (1) | SG10201506526QA (https=) |
| WO (1) | WO2009079692A1 (https=) |
| ZA (1) | ZA201003376B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX352516B (es) | 2006-07-05 | 2017-04-06 | Fibrotech Therapeutics Pty Ltd | Compuestos terapeuticos. |
| CA2709937C (en) | 2007-12-21 | 2016-03-22 | Fibrotech Therapeutics Pty Ltd | Halogenated analogues of anti-fibrotic agents |
| CN102574843B (zh) | 2009-10-22 | 2015-06-17 | 法博太科制药有限公司 | 抗纤维化剂的稠环类似物 |
| NZ609144A (en) * | 2010-11-24 | 2014-08-29 | Occurx Pty Ltd | Methods of treating eye diseases associated with inflammation and vascular proliferation |
| CN110201144B (zh) * | 2013-03-15 | 2024-01-02 | 得克萨斯州大学系统董事会 | 用Nutlin-3a和肽抑制肺纤维化 |
| WO2015080943A1 (en) * | 2013-11-26 | 2015-06-04 | Yale University | Novel cell-penetrating compositions and methods using same |
| JP6533997B2 (ja) * | 2014-12-26 | 2019-06-26 | 株式会社ヤクルト本社 | Ｚｎｆ１４３阻害活性を有する化合物およびその利用 |
| JP7185631B2 (ja) | 2017-02-03 | 2022-12-07 | サータ セラピューティクス プロプライエタリー リミテッド | 抗線維化化合物 |
| CN110357789B (zh) * | 2018-04-11 | 2022-09-30 | 华东理工大学 | 作为dhodh抑制剂的n-取代丙烯酰胺衍生物及其制备和用途 |
| BR112023018314A2 (pt) * | 2021-03-17 | 2023-10-31 | Occurx Pty Ltd | Compostos para o tratamento de distúrbios e sais e polimorfos dos mesmos |
| CN116730977A (zh) * | 2022-03-04 | 2023-09-12 | 华东理工大学 | 新型芳基杂环类化合物及其制备方法和用途 |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5640710B2 (https=) | 1973-01-18 | 1981-09-22 | ||
| JPS5830302B2 (ja) * | 1974-04-16 | 1983-06-28 | キツセイヤクヒンコウギヨウ カブシキガイシヤ | シンキホウコウゾクカルボンサンアミドユウドウタイ ノ セイゾウホウホウ |
| GB1484413A (en) * | 1974-04-18 | 1977-09-01 | Kissei Pharmaceutical | Aromatic amidocarboxylic acid derivatives |
| JPS5848545B2 (ja) | 1974-04-18 | 1983-10-28 | キツセイヤクヒンコウギヨウ カブシキガイシヤ | シンキホウコウゾクカルボンサンアミドユウドウタイ ノ セイゾウホウホウ |
| JPS511440A (ja) * | 1974-04-18 | 1976-01-08 | Kissei Pharmaceutical | Shinkihokozokukarubonsanjudotai no seizohoho |
| JPS5576852A (en) | 1978-12-01 | 1980-06-10 | Hisamitsu Pharmaceut Co Inc | Novel derivative of anthranilic acid |
| JPS5817186B2 (ja) | 1981-01-23 | 1983-04-05 | キツセイ薬品工業株式会社 | 新規芳香族カルボン酸誘導体の製造方法 |
| JPS5838244A (ja) * | 1981-09-01 | 1983-03-05 | Kissei Pharmaceut Co Ltd | 核置換シンナモイルアントラニル酸塩およびその製造方法 |
| US4587356A (en) * | 1981-09-01 | 1986-05-06 | Kissei Pharmaceutical Co., Ltd. | Process for the production of nuclear substituted cinnamoylanthranilic acid derivatives |
| JPS6019754A (ja) | 1983-07-14 | 1985-01-31 | Kissei Pharmaceut Co Ltd | 芳香族カルボン酸アミド誘導体の製造方法 |
| JPS60152454A (ja) | 1984-01-18 | 1985-08-10 | Terumo Corp | アミド誘導体およびこれを有効成分として含有する５−リポキシゲナ−ゼ作用阻害剤 |
| JPH07116029B2 (ja) * | 1989-04-04 | 1995-12-13 | キッセイ薬品工業株式会社 | トラニラスト水溶液製剤 |
| ES2100943T3 (es) * | 1990-02-08 | 1997-07-01 | Eisai Co Ltd | Derivado de bencenosulfonamida. |
| US5248825A (en) * | 1990-09-20 | 1993-09-28 | Merrell Dow Pharmaceuticals Inc. | Calcium uptake inhibitors |
| DK0657422T3 (da) * | 1993-12-09 | 1998-10-12 | Ono Pharmaceutical Co | Naphthyloxyeddikesyrederivater som PEG2-agonister og -antagonister |
| KR19990082523A (ko) | 1996-02-15 | 1999-11-25 | 간자와 무츠와 | 혈관생성 억제제 |
| JPH09278653A (ja) | 1996-04-05 | 1997-10-28 | Santen Pharmaceut Co Ltd | 網膜疾患治療剤 |
| DE19624155A1 (de) | 1996-06-18 | 1998-01-08 | Hoechst Ag | Substituierte Benzoesäurederivate, Verfahren zu ihrer Herstellung und die Anwendung der Verbindungen zur Behandlung von Krankheiten |
| JPH10259129A (ja) | 1997-01-16 | 1998-09-29 | Kissei Pharmaceut Co Ltd | 血管新生阻害剤 |
| FR2759368B1 (fr) * | 1997-02-10 | 2001-06-01 | Galderma Rech Dermatologique | Composes biaromatiques, compositions les contenant et utilisations |
| JPH10306024A (ja) * | 1997-03-07 | 1998-11-17 | Kissei Pharmaceut Co Ltd | 糸球体疾患の予防および治療剤 |
| JPH10330254A (ja) | 1997-04-01 | 1998-12-15 | Kissei Pharmaceut Co Ltd | 翼状片の進行および術後の再発抑制剤 |
| US6127392A (en) * | 1997-08-05 | 2000-10-03 | American Home Products Corporation | Anthranilic acid analogs |
| DE19935219A1 (de) * | 1999-07-27 | 2001-02-01 | Boehringer Ingelheim Pharma | Carbonsäureamide, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Herstellung |
| US6646009B2 (en) * | 2001-02-28 | 2003-11-11 | Temple University — Of Commonwealth System of Higher Education | N-(aryl)-2-arylethenesulfonamides and therapeutic uses thereof |
| US7429593B2 (en) * | 2001-09-14 | 2008-09-30 | Shionogi & Co., Ltd. | Utilities of amide compounds |
| JP4851671B2 (ja) | 2001-10-11 | 2012-01-11 | ニチバン株式会社 | トラニラスト経皮吸収貼付剤およびその製造方法 |
| JP2005518371A (ja) | 2001-12-10 | 2005-06-23 | アムジエン・インコーポレーテツド | バニロイド受容体リガンド及び治療に於けるこれらの使用 |
| IL162533A0 (en) * | 2001-12-19 | 2005-11-20 | Atherogenics Inc | Chalcone derivatives and their use to treat diseases |
| EP1466891A1 (en) * | 2001-12-27 | 2004-10-13 | Taisho Pharmaceutical Co., Ltd | Carboxylic acid derivative |
| US7351719B2 (en) * | 2002-10-31 | 2008-04-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds |
| DE10254872A1 (de) * | 2002-11-25 | 2004-06-03 | Symrise Gmbh & Co. Kg | Anthranilsäureamide und deren Derivate als kosmetische und pharmazeutische Wirkstoffe |
| US7250444B2 (en) * | 2003-08-11 | 2007-07-31 | Pfizer Inc. | Pyrrole-based HMG-CoA reductase inhibitors |
| GB0319126D0 (en) * | 2003-08-14 | 2003-09-17 | Smithkline Beecham Corp | Chemical compounds |
| DE10346913A1 (de) | 2003-10-09 | 2005-05-04 | Merck Patent Gmbh | Acylhydrazonderivate |
| US7592373B2 (en) * | 2003-12-23 | 2009-09-22 | Boehringer Ingelheim International Gmbh | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds |
| DE102004030987A1 (de) * | 2004-06-26 | 2006-01-12 | Merck Patent Gmbh | Ortho-substituierte (3-Hydroxyphenyl)-essigsäure-benzyliden-hydrazide |
| US7671077B2 (en) * | 2004-07-19 | 2010-03-02 | Leu-Fen Hou Lin | Neuroprotective small organic molecules, compositions and uses related thereto |
| JP2008518957A (ja) * | 2004-11-04 | 2008-06-05 | メルク エンド カムパニー インコーポレーテッド | ナイアシン受容体作動薬、そのような化合物を含んでいる組成物及び治療方法 |
| US20100041756A1 (en) | 2004-11-17 | 2010-02-18 | Michael Lionel Selley | method of modulating b cell functioning |
| WO2006057922A2 (en) * | 2004-11-23 | 2006-06-01 | Merck & Co., Inc. | Niacin receptor agonists, compositions containing such compounds and methods of treatment |
| ITMI20050261A1 (it) | 2005-02-21 | 2006-08-22 | Carlo Ghisalberti | Analoghi strutturali di avenatramidi loro uso in composizioni utili nel trattamento di disordini dermatologici |
| WO2006102645A1 (en) | 2005-03-24 | 2006-09-28 | Janssen Pharmaceutica, N.V. | Biaryl derived amide modulators of vanilloid vr1 receptor |
| BRPI0610349A2 (pt) * | 2005-05-16 | 2010-06-15 | Angiogen Pharmaceuticals Pty L | processos e composições para o tratamento de dor |
| WO2006134013A1 (en) | 2005-06-14 | 2006-12-21 | Symrise Gmbh & Co. Kg | Mixtures comprising anthranilic acid amides and cooling agents as cosmetic and pharmaceutical compositions for alleviating itching |
| WO2007015744A1 (en) | 2005-07-21 | 2007-02-08 | Incyte Corporation | Disubstituted thienyl compounds and their use as pharmaceuticals |
| EP1959915B1 (en) * | 2005-11-30 | 2015-05-13 | Symrise AG | Mixtures comprising anthranilic acid amides and antidandruff agents as cosmetic and pharmaceutical compositions for alleviating itching |
| US20070286892A1 (en) * | 2006-06-13 | 2007-12-13 | Uri Herzberg | Compositions and methods for preventing or reducing postoperative ileus and gastric stasis in mammals |
| ES2462925T3 (es) * | 2006-06-14 | 2014-05-26 | Symrise Ag | Compuestos con efecto antimicrobiano para el tratamiento de fetidez oral |
| MX352516B (es) * | 2006-07-05 | 2017-04-06 | Fibrotech Therapeutics Pty Ltd | Compuestos terapeuticos. |
| KR100832747B1 (ko) | 2006-10-27 | 2008-05-27 | 한국화학연구원 | 아미노피라졸 유도체, 이의 제조 방법 및 이를 함유하는허혈성 질환의 예방 또는 치료용 조성물 |
| WO2008057862A2 (en) | 2006-11-01 | 2008-05-15 | Bristol-Myers Squibb Company | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF |
| EP2030617A1 (en) * | 2007-08-17 | 2009-03-04 | Sygnis Bioscience GmbH & Co. KG | Use of tranilast and derivatives thereof for the therapy of neurological conditions |
| WO2009068557A1 (en) | 2007-11-28 | 2009-06-04 | Neurosearch A/S | Novel phenyl-acetamide and phenyl-propionamide derivatives useful as potassium channel modulators |
| US20090163586A1 (en) | 2007-12-20 | 2009-06-25 | Astrazeneca Ab | Bis-(Sulfonylamino) Derivatives in Therapy 205 |
| CA2709937C (en) | 2007-12-21 | 2016-03-22 | Fibrotech Therapeutics Pty Ltd | Halogenated analogues of anti-fibrotic agents |
| EP2179984A1 (en) * | 2008-10-27 | 2010-04-28 | Congenia S.r.l. | Acrylamido derivatives useful as inhibitors of the mitochondrial permeability transition |
-
2008
- 2008-12-19 CA CA2709937A patent/CA2709937C/en active Active
- 2008-12-19 AU AU2008341010A patent/AU2008341010B2/en active Active
- 2008-12-19 EP EP16156167.5A patent/EP3045170B1/en active Active
- 2008-12-19 KR KR1020167002802A patent/KR20160017139A/ko not_active Ceased
- 2008-12-19 NZ NZ584613A patent/NZ584613A/en unknown
- 2008-12-19 CN CN2008801221536A patent/CN102164887A/zh active Pending
- 2008-12-19 WO PCT/AU2008/001868 patent/WO2009079692A1/en not_active Ceased
- 2008-12-19 MX MX2016000325A patent/MX372721B/es unknown
- 2008-12-19 MX MX2010006787A patent/MX337320B/es active IP Right Grant
- 2008-12-19 JP JP2010538278A patent/JP5730578B2/ja active Active
- 2008-12-19 KR KR1020107011284A patent/KR101593708B1/ko active Active
- 2008-12-19 EP EP08865709.3A patent/EP2220028B1/en active Active
- 2008-12-19 CN CN201710172053.5A patent/CN107162928B/zh active Active
- 2008-12-19 SG SG10201506526QA patent/SG10201506526QA/en unknown
- 2008-12-19 US US12/809,751 patent/US8624056B2/en active Active
-
2010
- 2010-05-13 ZA ZA2010/03376A patent/ZA201003376B/en unknown
-
2015
- 2015-04-08 JP JP2015079433A patent/JP6063985B2/ja active Active