JP2005530763A5 - - Google Patents
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- Publication number
- JP2005530763A5 JP2005530763A5 JP2004502949A JP2004502949A JP2005530763A5 JP 2005530763 A5 JP2005530763 A5 JP 2005530763A5 JP 2004502949 A JP2004502949 A JP 2004502949A JP 2004502949 A JP2004502949 A JP 2004502949A JP 2005530763 A5 JP2005530763 A5 JP 2005530763A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- alkyl
- group
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 53
- 125000003118 aryl group Chemical group 0.000 claims description 32
- 125000001072 heteroaryl group Chemical group 0.000 claims description 32
- -1 C (O) NH 2 Chemical class 0.000 claims description 24
- 229910052739 hydrogen Inorganic materials 0.000 claims description 24
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims description 22
- 229910052736 halogen Inorganic materials 0.000 claims description 20
- 150000002367 halogens Chemical class 0.000 claims description 20
- 150000001875 compounds Chemical class 0.000 claims description 19
- 229910052757 nitrogen Inorganic materials 0.000 claims description 18
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 18
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 16
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims description 11
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 11
- 125000003545 alkoxy group Chemical group 0.000 claims description 11
- 150000003973 alkyl amines Chemical class 0.000 claims description 11
- 150000004982 aromatic amines Chemical class 0.000 claims description 11
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 11
- 150000002148 esters Chemical class 0.000 claims description 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 11
- 229940124530 sulfonamide Drugs 0.000 claims description 11
- 150000003456 sulfonamides Chemical class 0.000 claims description 11
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 10
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
- 150000003949 imides Chemical class 0.000 claims description 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 5
- 150000002576 ketones Chemical class 0.000 claims description 5
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 4
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 14
- 125000004122 cyclic group Chemical group 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 102000004257 Potassium Channel Human genes 0.000 claims 2
- 108020001213 potassium channel Proteins 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- 108091082572 SK family Proteins 0.000 claims 1
- 102000003734 Voltage-Gated Potassium Channels Human genes 0.000 claims 1
- 108090000013 Voltage-Gated Potassium Channels Proteins 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 0 *CCC*1C(C(CCC*CCCC2)C2C(NC2C(*)CCCCCCCC2)I)NC2C1CCCCCC2 Chemical compound *CCC*1C(C(CCC*CCCC2)C2C(NC2C(*)CCCCCCCC2)I)NC2C1CCCCCC2 0.000 description 8
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38036702P | 2002-05-13 | 2002-05-13 | |
| PCT/US2003/015225 WO2003094861A2 (en) | 2002-05-13 | 2003-05-13 | Bis-benzimidazoles and related compounds as potassium channel modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005530763A JP2005530763A (ja) | 2005-10-13 |
| JP2005530763A5 true JP2005530763A5 (https=) | 2006-06-29 |
Family
ID=29420615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004502949A Pending JP2005530763A (ja) | 2002-05-13 | 2003-05-13 | カリウム・チャネル調節物質としてのビス−ベンズイミダゾール及び関連化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US7132439B2 (https=) |
| EP (1) | EP1511744A4 (https=) |
| JP (1) | JP2005530763A (https=) |
| AU (1) | AU2003230401A1 (https=) |
| WO (1) | WO2003094861A2 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7777051B2 (en) * | 2003-05-13 | 2010-08-17 | Icagen, Inc. | Asymmetric benzimidazoles and related compounds as potassium channel modulators |
| CA2561895A1 (en) | 2004-04-13 | 2005-10-27 | Icagen, Inc. | Polycyclic pyrimidines as potassium ion channel modulators |
| CA2561831A1 (en) | 2004-04-13 | 2005-12-22 | Icagen, Inc. | Polycyclic pyrazines as potassium ion channel modulators |
| CA2561718A1 (en) * | 2004-04-13 | 2005-10-27 | Icagen, Inc. | Polycyclic pyridines as potassium ion channel modulators |
| ATE396977T1 (de) | 2004-08-05 | 2008-06-15 | Neurosearch As | 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit |
| EP1838306B1 (en) | 2005-01-11 | 2010-11-17 | NeuroSearch A/S | Novel 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels |
| TWI375673B (en) | 2005-04-11 | 2012-11-01 | Abbott Lab | 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors |
| US7728026B2 (en) | 2005-04-11 | 2010-06-01 | Abbott Laboratories, Inc. | 2-substituted-1 h-benzimidazile-4-carboxamides are PARP inhibitors |
| JP5162465B2 (ja) | 2005-11-15 | 2013-03-13 | アボット・ラボラトリーズ | 置換１ｈ−ベンズイミダゾール−４−カルボキサミド類は強力なｐａｒｐ阻害薬である |
| MX2008014004A (es) | 2006-05-02 | 2008-11-12 | Abbott Lab | 1h-benzimidazol-4-carboxamidas sustituidas son inhibidores de parp potentes. |
| US8067613B2 (en) | 2007-07-16 | 2011-11-29 | Abbott Laboratories | Benzimidazole poly(ADP ribose)polymerase inhibitors |
| WO2010083199A1 (en) | 2009-01-19 | 2010-07-22 | Abbott Laboratories | Benzthiazole inhibitors of poly(adp-ribose)polymerase |
| WO2012020725A1 (ja) * | 2010-08-10 | 2012-02-16 | 塩野義製薬株式会社 | Ｎｐｙ ｙ５受容体拮抗作用を有するヘテロ環誘導体 |
| TW201217387A (en) | 2010-09-15 | 2012-05-01 | Hoffmann La Roche | Azabenzothiazole compounds, compositions and methods of use |
| US20120087981A1 (en) | 2010-10-11 | 2012-04-12 | Xiandong Wang | Skin Engaging Member Comprising Encapsulated Actives |
| US20130042482A1 (en) | 2011-08-16 | 2013-02-21 | Valerie Jean Bradford | Skin Engaging Member Comprising An Anti-Irritation Agent |
| WO2014047355A1 (en) | 2012-09-19 | 2014-03-27 | Denervx LLC | Cooled microwave denervation |
| BR112015006847B1 (pt) | 2012-09-28 | 2020-02-04 | Gillette Co | um elemento auxiliar de barbeamento ou depilação de contato com a pele que compreende ao menos uma substância sensibilizante termicamente resiliente |
| CA2882090C (en) | 2012-09-28 | 2018-07-10 | The Gillette Company | A skin engaging member comprising at least one thermally resilient sensate |
| KR20150039551A (ko) * | 2013-10-02 | 2015-04-10 | 제이에스알 가부시끼가이샤 | 경화성 조성물, 경화막 및 그의 형성 방법, 그리고 화합물 |
| US10390881B2 (en) | 2013-10-25 | 2019-08-27 | Denervx LLC | Cooled microwave denervation catheter with insertion feature |
| US20150209107A1 (en) | 2014-01-24 | 2015-07-30 | Denervx LLC | Cooled microwave denervation catheter configuration |
| US20150272847A1 (en) | 2014-03-26 | 2015-10-01 | The Gillette Company | Skin Engaging Shaving Aid Comprising A Thermally Resilient Sensate And A TRPA1 Receptor Inhibitor |
| US20150273711A1 (en) | 2014-03-26 | 2015-10-01 | The Gillette Company | Razor Comprising A Molded Shaving Aid Composition Comprising A Thermally Resilient Sensate |
| AU2015249706A1 (en) | 2014-04-23 | 2016-11-03 | The Procter & Gamble Company | Cyclohexanecarboxamide with cooling properties |
| AU2015353904B2 (en) | 2014-11-26 | 2018-12-20 | The Gillette Company Llc | A skin engaging member comprising ethylene vinyl acetate |
| US20170334082A1 (en) | 2016-05-18 | 2017-11-23 | The Gillette Company Llc | Skin Engaging Member Comprising Ethylene Vinyl Acetate |
| WO2018022014A1 (en) | 2016-07-26 | 2018-02-01 | Hewlett-Packard Development Company, L.P. | Microfluidic device with manifold |
| US20180117780A1 (en) | 2016-11-03 | 2018-05-03 | The Gillette Company Llc | Skin engaging member comprising ethylene vinyl acetate |
| US10898425B2 (en) | 2016-11-17 | 2021-01-26 | The Gillette Company Llc | Skin engaging member comprising ethylene vinyl acetate and a fragrance |
| ES2885179T3 (es) * | 2017-08-23 | 2021-12-13 | Acesion Pharma Aps | Derivados de bencimidazol útiles como inhibidores del canal de potasio |
| KR102134268B1 (ko) * | 2017-11-08 | 2020-07-15 | 삼성에스디아이 주식회사 | 모노머, 중합체, 유기막 조성물 및 패턴 형성 방법 |
| WO2019099777A2 (en) * | 2017-11-17 | 2019-05-23 | The Scripps Research Institute | Bis-benzimidazole compounds and methods of using same |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3250780A (en) * | 1962-05-21 | 1966-05-10 | Union Oil Co | Bis-benzoxazolythyl sulfide |
| US3314894A (en) * | 1962-11-30 | 1967-04-18 | American Polymer And Chemical | Scintillators, compounds useful therein, and method of making the same |
| FR1488286A (fr) * | 1966-04-01 | 1967-07-13 | Chimetron Sarl | Bis (benzimidazolyl-2) pyridines |
| US3621076A (en) * | 1969-08-11 | 1971-11-16 | Walter F De Winter | Block polyheterocyclic polyimide elastomers having high thermal resistance |
| SU1348335A1 (ru) * | 1986-03-07 | 1987-10-30 | Московская сельскохозяйственная академия им.К.А.Тимирязева | Способ получени 3-азинилиндолов |
| US5760230A (en) * | 1996-10-11 | 1998-06-02 | Bayer Aktiengesellschaft | 4, 4'-bridged bis-2, 4-diaminoquinazolines |
| US5739127A (en) * | 1996-11-08 | 1998-04-14 | Bayer Aktiengesellschaft | 2,4'-bridged bis-2,4-diaminoquinazolines |
| US5922794A (en) * | 1997-03-26 | 1999-07-13 | General Electric Company | Compositions stabilized with tertiary amine oxides |
| AU1608399A (en) * | 1997-11-26 | 1999-06-15 | Axys Pharmaceuticals, Inc. | Substituted amidinoaryl derivatives and their use as anticoagulants |
| US6194447B1 (en) * | 1998-07-02 | 2001-02-27 | Neurosearch A/S | Bis (benzimidazole) derivatives serving as potassium blocking agents |
| EP1091942B1 (en) | 1998-07-02 | 2005-03-30 | Neurosearch A/S | Potassium channel blocking agents |
| FR2818128B1 (fr) * | 2000-12-18 | 2004-04-02 | Oreal | Compositions cosmetiques antisolaires a base d'un melange synergetique de filtres et utilisations |
| FR2833164B1 (fr) * | 2001-12-07 | 2004-07-16 | Oreal | Compositions cosmetiques antisolaires a base d'un melange synergique de filtres et utilisations |
| AU2003271548A1 (en) | 2002-10-13 | 2004-05-04 | Neurosearch A/S | Use of skca channel blocking drugs for combating parkinson's disease |
| WO2006097441A1 (en) | 2005-03-14 | 2006-09-21 | Neurosearch A/S | Potassium channel modulating agents and their medical use |
-
2003
- 2003-05-13 EP EP03724584A patent/EP1511744A4/en not_active Withdrawn
- 2003-05-13 AU AU2003230401A patent/AU2003230401A1/en not_active Abandoned
- 2003-05-13 US US10/437,732 patent/US7132439B2/en not_active Expired - Fee Related
- 2003-05-13 JP JP2004502949A patent/JP2005530763A/ja active Pending
- 2003-05-13 WO PCT/US2003/015225 patent/WO2003094861A2/en not_active Ceased
-
2006
- 2006-09-29 US US11/540,772 patent/US7482373B2/en not_active Expired - Fee Related
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