JP2011505143A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011505143A5 JP2011505143A5 JP2010536157A JP2010536157A JP2011505143A5 JP 2011505143 A5 JP2011505143 A5 JP 2011505143A5 JP 2010536157 A JP2010536157 A JP 2010536157A JP 2010536157 A JP2010536157 A JP 2010536157A JP 2011505143 A5 JP2011505143 A5 JP 2011505143A5
- Authority
- JP
- Japan
- Prior art keywords
- mir
- hsa
- prec
- lung cancer
- gene product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091070501 miRNA Proteins 0.000 claims 44
- 238000000034 method Methods 0.000 claims 30
- 108090000623 proteins and genes Proteins 0.000 claims 25
- 239000000523 sample Substances 0.000 claims 18
- 208000020816 lung neoplasm Diseases 0.000 claims 17
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 16
- 201000005202 lung cancer Diseases 0.000 claims 16
- 239000011886 peripheral blood Substances 0.000 claims 10
- 210000005259 peripheral blood Anatomy 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 239000000090 biomarker Substances 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 8
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 5
- 108091069085 Homo sapiens miR-126 stem-loop Proteins 0.000 claims 4
- 210000004369 blood Anatomy 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 239000013068 control sample Substances 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 238000010837 poor prognosis Methods 0.000 claims 2
- 238000011127 radiochemotherapy Methods 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 108091069002 Homo sapiens miR-145 stem-loop Proteins 0.000 claims 1
- 108091068997 Homo sapiens miR-152 stem-loop Proteins 0.000 claims 1
- 108091067995 Homo sapiens miR-192 stem-loop Proteins 0.000 claims 1
- 108091067982 Homo sapiens miR-197 stem-loop Proteins 0.000 claims 1
- 108091092296 Homo sapiens miR-202 stem-loop Proteins 0.000 claims 1
- 108091067008 Homo sapiens miR-342 stem-loop Proteins 0.000 claims 1
- 108091063565 Homo sapiens miR-532 stem-loop Proteins 0.000 claims 1
- 108091061636 Homo sapiens miR-630 stem-loop Proteins 0.000 claims 1
- 108091061623 Homo sapiens miR-636 stem-loop Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 201000005249 lung adenocarcinoma Diseases 0.000 claims 1
- 201000005243 lung squamous cell carcinoma Diseases 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US486307P | 2007-11-30 | 2007-11-30 | |
| PCT/US2008/084821 WO2009070653A1 (en) | 2007-11-30 | 2008-11-26 | Microrna expression profiling and targeting in peripheral blood in lung cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011505143A JP2011505143A (ja) | 2011-02-24 |
| JP2011505143A5 true JP2011505143A5 (enExample) | 2012-01-19 |
Family
ID=40678971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010536157A Pending JP2011505143A (ja) | 2007-11-30 | 2008-11-26 | マイクロｒｎａ発現プロファイリング及び肺癌における末梢血ターゲティング |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20100323357A1 (enExample) |
| EP (1) | EP2225396A4 (enExample) |
| JP (1) | JP2011505143A (enExample) |
| CN (1) | CN101918594A (enExample) |
| AU (1) | AU2008329755A1 (enExample) |
| CA (1) | CA2707157A1 (enExample) |
| IL (1) | IL206079A0 (enExample) |
| WO (1) | WO2009070653A1 (enExample) |
Families Citing this family (119)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103820562B (zh) | 2005-08-01 | 2015-05-13 | 俄亥俄州立大学研究基金会 | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 |
| CA2621441C (en) | 2005-09-12 | 2014-05-20 | The Ohio State University Research Foundation | Compositions and methods for the diagnosis and therapy of bcl2-associated cancers |
| EP2484782B1 (en) | 2006-01-05 | 2015-11-18 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers |
| CN101384273B (zh) | 2006-01-05 | 2013-07-10 | 俄亥俄州立大学研究基金会 | 胰腺内分泌和腺泡肿瘤中的微小rna表达异常 |
| EP2502630B1 (en) | 2006-01-05 | 2015-03-11 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer |
| EP2369013A1 (en) | 2006-03-20 | 2011-09-28 | The Ohio State University Research Foundation | Micro-RNA fingerprints during human megakaryocytopoiesis |
| CA2663027A1 (en) | 2006-09-19 | 2008-08-14 | The Ohio State University Research Foundation | Tcl1 expression in chronic lymphocytic leukemia (cll) regulated by mir-29 and mir-181 |
| US8252538B2 (en) | 2006-11-01 | 2012-08-28 | The Ohio State University | MicroRNA expression signature for predicting survival and metastases in hepatocellular carcinoma |
| CN103555825B (zh) | 2007-01-31 | 2015-09-30 | 俄亥俄州立大学研究基金会 | 用于急性髓细胞白血病(aml)的诊断、预后和治疗的基于微rna的方法和组合物 |
| CN101711287B (zh) | 2007-06-08 | 2016-04-27 | 由卫生与公众服务部代表的美利坚合众国政府 | 确定肝细胞癌亚型和检测肝癌干细胞的方法 |
| AU2008266014B2 (en) | 2007-06-15 | 2013-06-06 | The Ohio State University Research Foundation | Oncogenic ALL-1 fusion proteins for targeting drosha-mediated microRNA processing |
| CN101809169B (zh) | 2007-07-31 | 2013-07-17 | 俄亥俄州立大学研究基金会 | 通过靶向dnmt3a和dnmt3b恢复甲基化的方法 |
| EP2173908B1 (en) | 2007-08-03 | 2016-01-06 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncrnas |
| CA2926831A1 (en) | 2007-08-22 | 2009-02-26 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias |
| WO2009044899A1 (ja) * | 2007-10-03 | 2009-04-09 | Kyowa Hakko Kirin Co., Ltd. | 細胞の増殖を制御する核酸 |
| CA2703707A1 (en) | 2007-10-26 | 2009-04-30 | The Ohio State University Research Foundation | Methods for identifying fragile histidine triad (fhit) interaction and uses thereof |
| CA2727633A1 (en) | 2008-06-11 | 2009-12-17 | Xin W. Wang | Use of mir-26 family as a predictive marker for hepatocellular carcinoma and responsiveness to therapy |
| CN102308004A (zh) | 2008-10-30 | 2012-01-04 | 卡里斯生命科学卢森堡控股有限责任公司 | 评价rna图案的方法 |
| CA2743211A1 (en) | 2008-11-12 | 2010-05-20 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Methods and systems of using exosomes for determining phenotypes |
| CN101475984A (zh) | 2008-12-15 | 2009-07-08 | 江苏命码生物科技有限公司 | 一种非小细胞肺癌检测标记物及其检测方法、相关生物芯片和试剂盒 |
| SG173042A1 (en) * | 2009-01-19 | 2011-08-29 | Sistemic Scotland Ltd | Methods employing non-coding rna expression assays |
| EP2336353A1 (en) | 2009-12-17 | 2011-06-22 | febit holding GmbH | miRNA fingerprints in the diagnosis of diseases |
| CN102387816B (zh) * | 2009-07-09 | 2014-07-09 | 中国医学科学院肿瘤研究所 | 两个microRNA分子在肺癌预后及药物制备中的用途 |
| CN102725632A (zh) * | 2009-08-28 | 2012-10-10 | 奥斯瑞根公司 | 肺病的miRNA生物标志物 |
| WO2011029903A1 (en) * | 2009-09-10 | 2011-03-17 | Flemming Velin | Method for the preparation of micro-rna and its therapeutic application |
| CN102858997B (zh) * | 2009-11-02 | 2014-06-18 | 新加坡科技研究局 | 用于监测细胞状态和用于永生间充质干细胞的方法 |
| ES2597554T3 (es) | 2009-11-04 | 2017-01-19 | Diamir, Llc | Métodos de utilización de micro-ARN de fluidos corporales para el diagnóstico y control del deterioro cognitivo leve |
| EP2504452A4 (en) | 2009-11-23 | 2014-06-11 | Univ Ohio State Res Found | MATERIALS AND METHODS FOR INFLUENCING GROWTH, MIGRATION AND INVASION OF TUMOR CELLS |
| EP2518158B1 (en) | 2009-12-24 | 2016-09-14 | Micromedmark Biotech Co., Ltd | Pancreatic cancer markers and detecting methods |
| EP2341145A1 (en) * | 2009-12-30 | 2011-07-06 | febit holding GmbH | miRNA fingerprint in the diagnosis of diseases |
| CN101804208A (zh) * | 2010-02-26 | 2010-08-18 | 南京医科大学 | miR-451在制备治疗非小细胞肺癌药物的应用 |
| US9128101B2 (en) | 2010-03-01 | 2015-09-08 | Caris Life Sciences Switzerland Holdings Gmbh | Biomarkers for theranostics |
| WO2011127219A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings | Circulating biomarkers for disease |
| EP3124623B1 (en) * | 2010-04-20 | 2018-03-28 | Hummingbird Diagnostics GmbH | Complex mirna sets as novel biomarkers for an acute coronary syndrome |
| CN103648505B (zh) | 2010-11-12 | 2016-09-28 | 俄亥俄州立大学研究基金会 | 与微rna-21、错配修复和结肠直肠癌相关的材料和方法 |
| BR112013011942A2 (pt) | 2010-11-15 | 2016-11-01 | Univ Michigan | formulação, forma de dosagem de droga para administração transmucosa oral, sistema transmucoso de fornecimento de droga, método de tratamento e profilaxia de uma doença ou distúrbio, método de tratamento, formulação, método para tratamento ou prevenção de carcinoma de célula escamosa de cabeça e pescoço (hnscc), método para quimioprevenção de um câncer oral ou condição pré-cancerosa, método para aumentar a concentração de uma composição de retinida, método de tratamento e profilaxia de uma doença ou condição, método de ratamento de um sujeito apresentando uma condição médica sintomática, método de tratamento de um câncer oral ou condição pré-cancerosa num paciente, método para fazer um sistema de fornecimento de droga bucal, método para aumentar a liberação e permeação de uma composição de retinida. |
| EP2505663A1 (en) | 2011-03-30 | 2012-10-03 | IFOM Fondazione Istituto Firc di Oncologia Molecolare | A method to identify asymptomatic high-risk individuals with early stage lung cancer by means of detecting miRNAs in biologic fluids |
| EP2668288B1 (en) * | 2011-01-28 | 2016-01-20 | Comprehensive Biomarker Center GmbH | Complex mirna sets as novel biomarkers for lung diseases |
| IT1406866B1 (it) * | 2011-02-07 | 2014-03-14 | Fond Irccs Istituto Naz Dei Tumori | Procedimento ed apparecchiatura per identificare individui a rischio di tumore polmonare e/o per diagnosticare un tumore polmonare, nonché composizione e metodo per ridurre o eliminare il rischio di tumore polmonare |
| HUE045731T2 (hu) | 2011-02-07 | 2020-01-28 | Gabriella Sozzi | Mikro-RNS biomarkerek tüdõtumor diagnosztizálásához és/vagy kockázatának azonosításához |
| IT1403685B1 (it) * | 2011-02-07 | 2013-10-31 | Fond Irccs Istituto Naz Dei Tumori | Procedimento ed apparecchiatura per identificare individui a rischio di tumore polmonare e/o per diagnosticare un tumore polmonare, nonche' composizione e metodo per ridurre o eliminare il rischio di tumore polmonare. |
| CA2828772A1 (en) | 2011-03-07 | 2012-09-13 | The Ohio State University | Mutator activity induced by microrna-155 (mir-155) links inflammation and cancer |
| WO2012140234A1 (en) | 2011-04-13 | 2012-10-18 | Vib Vzw | Modulation of mirna in diseases with aberrant angiogenesis |
| EP2699666B1 (en) | 2011-04-18 | 2016-10-05 | DiamiR, LLC | miRNA-BASED UNIVERSAL SCREENING TEST (UST) |
| KR101938548B1 (ko) * | 2011-06-23 | 2019-01-15 | (주)아모레퍼시픽 | 마이크로 ｒｎａ를 포함하는 색소형성유전자 발현조절용 조성물 |
| BR112014012288A2 (pt) * | 2011-11-22 | 2017-05-23 | Intermune Inc | métodos para diagnosticar e tratar fibrose pulmonar idiopática |
| CA2859430A1 (en) | 2011-12-13 | 2013-06-20 | Ohio State Innovation Foundation | Methods and compositions related to mir-21 and mir-29a, exosome inhibition, and cancer metastasis |
| ES2886147T3 (es) * | 2011-12-22 | 2021-12-16 | Interna Tech B V | MiARN para el tratamiento del cáncer de cabeza y de cuello |
| US8859202B2 (en) | 2012-01-20 | 2014-10-14 | The Ohio State University | Breast cancer biomarker signatures for invasiveness and prognosis |
| EP2857521A4 (en) * | 2012-05-31 | 2015-12-30 | Takeda Pharmaceutical | METHOD FOR ASSESSING ENDOMETRIOSIS |
| CN102757965B (zh) * | 2012-06-21 | 2014-09-24 | 中国人民解放军第四军医大学 | 血清microRNA分子标志物及其应用 |
| ES2921623T3 (es) | 2012-11-26 | 2022-08-30 | Modernatx Inc | ARN modificado terminalmente |
| EP2931319B1 (en) | 2012-12-13 | 2019-08-21 | ModernaTX, Inc. | Modified nucleic acid molecules and uses thereof |
| JP2016504050A (ja) | 2013-01-17 | 2016-02-12 | モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 細胞表現型の改変のためのシグナルセンサーポリヌクレオチド |
| CN104342439B (zh) * | 2013-07-23 | 2017-06-23 | 中国科学院遗传与发育生物学研究所 | miR‑7及其应用 |
| JP6930832B2 (ja) | 2013-11-18 | 2021-09-01 | ディアミール, エルエルシーDiamir, Llc | パーキンソン病（ＰＤ）の検出およびモニタリングのための、体液からのｍｉＲＮＡを使用する方法 |
| CN122038564A (zh) * | 2014-01-05 | 2026-05-15 | G·索兹 | 使用mirna比率确定肺癌 |
| CN103865928B (zh) * | 2014-03-03 | 2016-04-13 | 吉林大学 | 可检测感染弓形虫的标识性mmu-miR-511-5p |
| KR20250005392A (ko) | 2014-06-18 | 2025-01-09 | 도레이 카부시키가이샤 | 폐암의 검출 키트 또는 디바이스 및 검출 방법 |
| WO2016025867A1 (en) * | 2014-08-15 | 2016-02-18 | Affymetrix, Inc. | Robust detection of nucleic acids in situ |
| WO2016077125A1 (en) | 2014-11-10 | 2016-05-19 | Moderna Therapeutics, Inc. | Alternative nucleic acid molecules containing reduced uracil content and uses thereof |
| CN105412944A (zh) * | 2015-12-09 | 2016-03-23 | 上海大学 | miR-451a细胞在非小细胞肺癌中的作用 |
| US10975436B2 (en) | 2016-01-05 | 2021-04-13 | Diamir, Llc | Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders |
| EP3405579A1 (en) | 2016-01-22 | 2018-11-28 | Modernatx, Inc. | Messenger ribonucleic acids for the production of intracellular binding polypeptides and methods of use thereof |
| US11149313B2 (en) | 2016-03-21 | 2021-10-19 | Diamir, Llc | Methods of using miRNAs from bodily fluids for detection and differentiation of neurodegenerative diseases |
| EP3443001B1 (en) | 2016-04-11 | 2025-04-30 | Obsidian Therapeutics, Inc. | REGULATED BIOCIRCUIT SYSTEMS |
| DK3458083T5 (da) | 2016-05-18 | 2024-10-21 | Modernatx Inc | Polynukleotider, der koder for interleukin-12 (il12), og anvendelser heraf |
| WO2017218704A1 (en) | 2016-06-14 | 2017-12-21 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| WO2017221744A1 (ja) * | 2016-06-24 | 2017-12-28 | 国立大学法人名古屋大学 | 肺がん検査用の情報を提供する方法、肺がんの検査方法、肺がんの検査装置、肺がんの検査装置のプログラム及び記録媒体、並びに肺がん検査用のｍｉＲＮＡ測定用キット |
| WO2018002812A1 (en) | 2016-06-29 | 2018-01-04 | Crispr Therapeutics Ag | Materials and methods for treatment of myotonic dystrophy type 1 (dm1) and other related disorders |
| US11564997B2 (en) | 2016-06-29 | 2023-01-31 | Crispr Therapeutics Ag | Materials and methods for treatment of friedreich ataxia and other related disorders |
| US11174469B2 (en) | 2016-06-29 | 2021-11-16 | Crispr Therapeutics Ag | Materials and methods for treatment of Amyotrophic Lateral Sclerosis (ALS) and other related disorders |
| CA3029132A1 (en) | 2016-07-06 | 2018-01-11 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of pain related disorders |
| US11459587B2 (en) | 2016-07-06 | 2022-10-04 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of pain related disorders |
| EP3532070A1 (en) | 2016-10-26 | 2019-09-04 | Modernatx, Inc. | Messenger ribonucleic acids for enhancing immune responses and methods of use thereof |
| US11583504B2 (en) | 2016-11-08 | 2023-02-21 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| CN107058480B (zh) * | 2016-12-14 | 2018-07-13 | 河北医科大学第四医院（河北省肿瘤医院） | 用于诊断肺腺癌的长链非编码rna标志物 |
| EP3576780A1 (en) | 2017-02-01 | 2019-12-11 | Modernatx, Inc. | Immunomodulatory therapeutic mrna compositions encoding activating oncogene mutation peptides |
| US20200216857A1 (en) | 2017-02-22 | 2020-07-09 | Crispr Therapeutics Ag | Materials and methods for treatment of spinocerebellar ataxia type 2 (sca2) and other spinocerebellar ataxia type 2 protein (atxn2) gene related conditions or disorders |
| EP3585807A1 (en) | 2017-02-22 | 2020-01-01 | CRISPR Therapeutics AG | Materials and methods for treatment of early onset parkinson's disease (park1) and other synuclein, alpha (snca) gene related conditions or disorders |
| EP3585899A1 (en) | 2017-02-22 | 2020-01-01 | CRISPR Therapeutics AG | Materials and methods for treatment of primary hyperoxaluria type 1 (ph1) and other alanine-glyoxylate aminotransferase (agxt) gene related conditions or disorders |
| CN119351474A (zh) | 2017-02-22 | 2025-01-24 | 克里斯珀医疗股份公司 | 用于基因编辑的组合物和方法 |
| EP3585898A1 (en) | 2017-02-22 | 2020-01-01 | CRISPR Therapeutics AG | Materials and methods for treatment of spinocerebellar ataxia type 1 (sca1) and other spinocerebellar ataxia type 1 protein (atxn1) gene related conditions or disorders |
| US20200131498A1 (en) | 2017-06-14 | 2020-04-30 | Modernatx, Inc. | Polynucleotides encoding methylmalonyl-coa mutase |
| EP4464797A3 (en) | 2017-06-29 | 2025-02-26 | Toray Industries, Inc. | Kit, device, and method for detecting lung cancer |
| US10781487B2 (en) | 2017-07-24 | 2020-09-22 | Diamir, Llc | miRNA-based methods for detecting and monitoring aging |
| WO2019046809A1 (en) | 2017-08-31 | 2019-03-07 | Modernatx, Inc. | METHODS OF MANUFACTURING LIPID NANOPARTICLES |
| WO2019102381A1 (en) | 2017-11-21 | 2019-05-31 | Casebia Therapeutics Llp | Materials and methods for treatment of autosomal dominant retinitis pigmentosa |
| EP3728594A1 (en) | 2017-12-21 | 2020-10-28 | CRISPR Therapeutics AG | Materials and methods for treatment of usher syndrome type 2a |
| EP3728595A1 (en) | 2017-12-21 | 2020-10-28 | CRISPR Therapeutics AG | Materials and methods for treatment of usher syndrome type 2a and/or non-syndromic autosomal recessive retinitis pigmentosa (arrp) |
| US20190314291A1 (en) | 2018-01-30 | 2019-10-17 | Modernatx, Inc. | Compositions and methods for delivery of agents to immune cells |
| EP3773745A1 (en) | 2018-04-11 | 2021-02-17 | ModernaTX, Inc. | Messenger rna comprising functional rna elements |
| US20220403001A1 (en) | 2018-06-12 | 2022-12-22 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
| WO2020061457A1 (en) | 2018-09-20 | 2020-03-26 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| WO2020086742A1 (en) | 2018-10-24 | 2020-04-30 | Obsidian Therapeutics, Inc. | Er tunable protein regulation |
| MX2021009245A (es) | 2019-01-31 | 2021-11-12 | Modernatx Inc | Metodos de preparacion de nanoparticulas lipidicas. |
| KR20210149251A (ko) | 2019-03-08 | 2021-12-08 | 옵시디안 테라퓨틱스, 인크. | 조율가능한 조절을 위한 인간 탄산 무수화효소 2 조성물 및 방법 |
| WO2020263883A1 (en) | 2019-06-24 | 2020-12-30 | Modernatx, Inc. | Endonuclease-resistant messenger rna and uses thereof |
| US20220387628A1 (en) | 2019-06-24 | 2022-12-08 | Modernatx, Inc. | Messenger rna comprising functional rna elements and uses thereof |
| WO2021046451A1 (en) | 2019-09-06 | 2021-03-11 | Obsidian Therapeutics, Inc. | Compositions and methods for dhfr tunable protein regulation |
| CN116133652A (zh) | 2020-01-31 | 2023-05-16 | 摩登纳特斯有限公司 | 制备脂质纳米粒子的方法 |
| CN111218513B (zh) * | 2020-04-24 | 2020-08-14 | 上海思路迪医学检验所有限公司 | 一种用于肺癌早期诊断的外周血胞外囊泡microRNA生物标志物及其用途 |
| CN113969261B (zh) * | 2020-07-06 | 2024-04-09 | 苏州市立医院(北区) | 三步法快速测定中性粒细胞趋化的方法 |
| CN116710079A (zh) | 2020-07-24 | 2023-09-05 | 斯特兰德生物科技公司 | 包含经修饰的核苷酸的脂质纳米颗粒 |
| TW202220637A (zh) | 2020-08-06 | 2022-06-01 | 美商現代公司 | 製備脂質奈米顆粒之方法 |
| CN112301130B (zh) * | 2020-11-12 | 2021-11-30 | 苏州京脉生物科技有限公司 | 一种肺癌早期检测的标志物、试剂盒及方法 |
| CN112410402A (zh) * | 2020-11-12 | 2021-02-26 | 麦凯(上海)生物科技有限公司 | 一种游离rna助沉剂 |
| AU2022205679A1 (en) | 2021-01-08 | 2023-07-06 | Strand Therapeutics Inc. | Expression constructs and uses thereof |
| CN112760381B (zh) * | 2021-02-08 | 2022-11-01 | 复旦大学附属中山医院 | 一种检测肺腺癌预后的miRNA试剂盒 |
| EP4334446A1 (en) | 2021-05-03 | 2024-03-13 | CureVac SE | Improved nucleic acid sequence for cell type specific expression |
| US12037616B2 (en) | 2022-03-01 | 2024-07-16 | Crispr Therapeutics Ag | Methods and compositions for treating angiopoietin-like 3 (ANGPTL3) related conditions |
| IL316186A (en) | 2022-04-26 | 2024-12-01 | Strand Therapeutics Inc | Lipid nanoparticles containing Venezuelan equine encephalitis (VEE) replicon and uses thereof |
| WO2024026487A1 (en) | 2022-07-29 | 2024-02-01 | Modernatx, Inc. | Lipid nanoparticle compositions comprising phospholipid derivatives and related uses |
| EP4561546A1 (en) | 2022-07-29 | 2025-06-04 | ModernaTX, Inc. | Lipid nanoparticle compositions comprising surface lipid derivatives and related uses |
| WO2024026475A1 (en) | 2022-07-29 | 2024-02-01 | Modernatx, Inc. | Compositions for delivery to hematopoietic stem and progenitor cells (hspcs) and related uses |
| KR20260006623A (ko) | 2023-04-28 | 2026-01-13 | 센젠 센신 바이오테크놀로지 컴퍼니 리미티드 | 변형된 전달 담체 및 이의 용도 |
| WO2024259373A1 (en) | 2023-06-14 | 2024-12-19 | Modernatx, Inc. | Compounds and compositions for delivery of therapeutic agents |
| WO2025160381A1 (en) | 2024-01-26 | 2025-07-31 | Modernatx, Inc. | Methods of preparing lipid nanoparticles |
| WO2025166202A1 (en) | 2024-01-31 | 2025-08-07 | Modernatx, Inc. | Lipid nanoparticle compositions comprising sialic acid derivatives and the uses thereof |
Family Cites Families (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4196265A (en) * | 1977-06-15 | 1980-04-01 | The Wistar Institute | Method of producing antibodies |
| US5015568A (en) * | 1986-07-09 | 1991-05-14 | The Wistar Institute | Diagnostic methods for detecting lymphomas in humans |
| US5202429A (en) * | 1986-07-09 | 1993-04-13 | The Wistar Institute | DNA molecules having human BCL-2 gene sequences |
| US5198338A (en) * | 1989-05-31 | 1993-03-30 | Temple University | Molecular probing for human t-cell leukemia and lymphoma |
| WO1993012136A1 (en) * | 1991-12-11 | 1993-06-24 | Thomas Jefferson University | Detection and treatment of acute leukemias resulting from chromosome abnormalities in the all-1 region |
| US6040140A (en) * | 1991-12-11 | 2000-03-21 | Thomas Jefferson University | Methods for screening and treating leukemias resulting from all-1 region chromosome abnormalities |
| US5633135A (en) * | 1991-12-11 | 1997-05-27 | Thomas Jefferson University | Chimeric nucleic acids and proteins resulting from ALL-1 region chromosome abnormalities |
| PT667920E (pt) * | 1992-10-29 | 2003-06-30 | Univ Jefferson | Metodos de deteccao de micrometasteses do cancro da prostata |
| US7175995B1 (en) * | 1994-10-27 | 2007-02-13 | Thomas Jefferson University | TCL-1 protein and related methods |
| US5985598A (en) * | 1994-10-27 | 1999-11-16 | Thomas Jefferson University | TCL-1 gene and protein and related methods and compositions |
| US6242212B1 (en) * | 1996-02-09 | 2001-06-05 | Thomas Jefferson University | Fragile histidine triad (FHIT) nucleic acids and methods of producing FHIT proteins |
| US5928884A (en) * | 1996-02-09 | 1999-07-27 | Croce; Carlo M. | FHIT proteins and nucleic acids and methods based thereon |
| US6187536B1 (en) * | 1997-02-18 | 2001-02-13 | Thomas Jefferson University | Methods of identifying and detecting pancreatic cancer |
| WO1998045480A1 (en) * | 1997-04-04 | 1998-10-15 | The Texas A & M University System | Noninvasive detection of colonic biomarkers using fecal messenger rna |
| WO2000003685A2 (en) * | 1998-07-20 | 2000-01-27 | Thomas Jefferson University | Nitrilase homologs |
| AU5128999A (en) * | 1998-07-24 | 2000-02-14 | Yeda Research And Development Co. Ltd. | Prevention of metastasis with 5-aza-2'-deoxycytidine |
| US7141417B1 (en) * | 1999-02-25 | 2006-11-28 | Thomas Jefferson University | Compositions, kits, and methods relating to the human FEZ1 gene, a novel tumor suppressor gene |
| EP1276879A4 (en) * | 2000-04-11 | 2004-12-22 | Univ Jefferson | MUIR-TORRE-LIKE SYNDROME IN Fhit-DEFECTIVE MICE |
| US20020086331A1 (en) * | 2000-05-16 | 2002-07-04 | Carlo Croce | Crystal structure of worm NitFhit reveals that a Nit tetramer binds two Fhit dimers |
| US7060811B2 (en) * | 2000-10-13 | 2006-06-13 | Board Of Regents, The University Of Texas System | WWOX: a tumor suppressor gene mutated in multiple cancers |
| US20040033502A1 (en) * | 2001-03-28 | 2004-02-19 | Amanda Williams | Gene expression profiles in esophageal tissue |
| CA2462144C (en) * | 2001-09-28 | 2016-09-20 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Micro-rna molecules |
| US7371736B2 (en) * | 2001-11-07 | 2008-05-13 | The Board Of Trustees Of The University Of Arkansas | Gene expression profiling based identification of DKK1 as a potential therapeutic targets for controlling bone loss |
| GB0128898D0 (en) * | 2001-12-03 | 2002-01-23 | Biotech Res Ventures Pte Ltd | Materials and methods relating to the stabilization and activation of a tumour suppressor protein |
| CN1649613A (zh) * | 2002-04-08 | 2005-08-03 | 赛弗根生物系统股份有限公司 | 肝细胞癌血清生物标记 |
| EP1499182B1 (en) * | 2002-04-29 | 2009-10-28 | Thomas Jefferson University | Human chronic lymphocytic leukemia modeled in mouse by targeted tcl1 expression |
| JP2005528115A (ja) * | 2002-05-31 | 2005-09-22 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | 幹細胞および癌幹細胞を同定および単離する方法 |
| CA2501602A1 (en) * | 2002-10-11 | 2004-04-22 | Thomas Jefferson University | Novel tumor suppressor gene and compositions and methods for making and using the same |
| JP4939055B2 (ja) * | 2002-11-13 | 2012-05-23 | トマス ジェファソン ユニバーシティ | 癌の診断および治療のための組成物および方法 |
| WO2004071464A2 (en) * | 2003-02-12 | 2004-08-26 | Johns Hopkins University School Of Medicine | Diagnostic application of differentially-expressed genes in lympho-hematopoietic stem cells |
| WO2006031210A1 (en) * | 2003-05-29 | 2006-03-23 | Board Of Regents, The University Of Texas Systems | Jabi as a prognostic marker and a therapeutic target for human cancer |
| US20050037362A1 (en) * | 2003-08-11 | 2005-02-17 | Eppendorf Array Technologies, S.A. | Detection and quantification of siRNA on microarrays |
| CN1890382A (zh) * | 2003-09-24 | 2007-01-03 | 肿瘤疗法科学股份有限公司 | 检测、诊断和治疗肝细胞癌(hcc)的方法 |
| US20050164252A1 (en) * | 2003-12-04 | 2005-07-28 | Yeung Wah Hin A. | Methods using non-genic sequences for the detection, modification and treatment of any disease or improvement of functions of a cell |
| CA2554818A1 (en) * | 2004-02-09 | 2005-08-25 | Thomas Jefferson University | Diagnosis and treatment of cancers with microrna located in or near cancer-associated chromosomal features |
| WO2005111211A2 (en) * | 2004-05-14 | 2005-11-24 | Rosetta Genomics Ltd. | Micronas and uses thereof |
| EP2290073A3 (en) * | 2004-05-28 | 2011-08-31 | Asuragen, Inc. | Methods and compositions involving microRNA |
| US7635563B2 (en) * | 2004-06-30 | 2009-12-22 | Massachusetts Institute Of Technology | High throughput methods relating to microRNA expression analysis |
| US20060037088A1 (en) * | 2004-08-13 | 2006-02-16 | Shulin Li | Gene expression levels as predictors of chemoradiation response of cancer |
| US7642348B2 (en) * | 2004-10-04 | 2010-01-05 | Rosetta Genomics Ltd | Prostate cancer-related nucleic acids |
| FR2877350B1 (fr) * | 2004-11-03 | 2010-08-27 | Centre Nat Rech Scient | IDENTIFICATION ET UTILISATION DE miRNAs IMPLIQUES DANS LA DIFFERENCIATION DE CELLULES ISSUES D'UNE LEUCEMIE MYELOIDE |
| CA2857878A1 (en) * | 2004-11-12 | 2006-12-28 | Asuragen, Inc. | Methods and compositions involving mirna and mirna inhibitor molecules |
| WO2006066158A2 (en) * | 2004-12-14 | 2006-06-22 | Alnylam Pharmaceuticals, Inc. | Rnai modulation of mll-af4 and uses thereof |
| US20070099196A1 (en) * | 2004-12-29 | 2007-05-03 | Sakari Kauppinen | Novel oligonucleotide compositions and probe sequences useful for detection and analysis of micrornas and their target mRNAs |
| JP2008528003A (ja) * | 2005-01-25 | 2008-07-31 | ロゼッタ インファーマティックス エルエルシー | 小ｒｎａ分子の定量方法 |
| US20070065840A1 (en) * | 2005-03-23 | 2007-03-22 | Irena Naguibneva | Novel oligonucleotide compositions and probe sequences useful for detection and analysis of microRNAS and their target mRNAS |
| US20070054287A1 (en) * | 2005-05-31 | 2007-03-08 | Applera Corporation | Method for identifying medically important cell populations using micro rna as tissue specific biomarkers |
| US20070065844A1 (en) * | 2005-06-08 | 2007-03-22 | Massachusetts Institute Of Technology | Solution-based methods for RNA expression profiling |
| EP1919512B1 (en) * | 2005-08-10 | 2014-11-12 | Alnylam Pharmaceuticals Inc. | Chemically modified oligonucleotides for use in modulating micro rna and uses thereof |
| CA2621441C (en) * | 2005-09-12 | 2014-05-20 | The Ohio State University Research Foundation | Compositions and methods for the diagnosis and therapy of bcl2-associated cancers |
| US20070092882A1 (en) * | 2005-10-21 | 2007-04-26 | Hui Wang | Analysis of microRNA |
| US7390792B2 (en) * | 2005-12-15 | 2008-06-24 | Board Of Regents, The University Of Texas System | MicroRNA1 therapies |
| CN101384273B (zh) * | 2006-01-05 | 2013-07-10 | 俄亥俄州立大学研究基金会 | 胰腺内分泌和腺泡肿瘤中的微小rna表达异常 |
| EP2502630B1 (en) * | 2006-01-05 | 2015-03-11 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer |
| CA2650026C (en) * | 2006-04-24 | 2013-01-22 | The Ohio State University Research Foundation | Pre-b cell proliferation and lymphoblastic leukemia/high-grade lymphoma in mir155 transgenic mice |
| CA2663878A1 (en) * | 2006-09-19 | 2008-03-27 | Asuragen, Inc. | Mir-200 regulated genes and pathways as targets for therapeutic intervention |
| CA2663027A1 (en) * | 2006-09-19 | 2008-08-14 | The Ohio State University Research Foundation | Tcl1 expression in chronic lymphocytic leukemia (cll) regulated by mir-29 and mir-181 |
| WO2008036765A2 (en) * | 2006-09-19 | 2008-03-27 | Asuragen, Inc. | Micrornas differentially expressed in pancreatic diseases and uses thereof |
| JP2010510964A (ja) * | 2006-09-19 | 2010-04-08 | アシュラジェン インコーポレイテッド | 治療的介入の標的としての、ｍｉＲ−１５、ｍｉＲ−２６、ｍｉＲ−３１、ｍｉＲ−１４５、ｍｉＲ−１４７、ｍｉＲ−１８８、ｍｉＲ−２１５、ｍｉＲ−２１６、ｍｉＲ−３３１、ｍｍｕ−ｍｉＲ−２９２−３ｐによって調節される遺伝子および経路 |
| US8252538B2 (en) * | 2006-11-01 | 2012-08-28 | The Ohio State University | MicroRNA expression signature for predicting survival and metastases in hepatocellular carcinoma |
| US8293684B2 (en) * | 2006-11-29 | 2012-10-23 | Exiqon | Locked nucleic acid reagents for labelling nucleic acids |
| WO2008070082A2 (en) * | 2006-12-04 | 2008-06-12 | The Johns Hopkins University | Stem-progenitor cell specific micro-ribonucleic acids and uses thereof |
| WO2008073920A2 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Mir-21 regulated genes and pathways as targets for therapeutic intervention |
| CA2671299A1 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Functions and targets of let-7 micro rnas |
| CN101622348A (zh) * | 2006-12-08 | 2010-01-06 | 奥斯瑞根公司 | 作为治疗性干预靶标的miR-20调节的基因和途径 |
| WO2008073919A2 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Mir-20 regulated genes and pathways as targets for therapeutic intervention |
| US20090175827A1 (en) * | 2006-12-29 | 2009-07-09 | Byrom Mike W | miR-16 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
| CN103555825B (zh) * | 2007-01-31 | 2015-09-30 | 俄亥俄州立大学研究基金会 | 用于急性髓细胞白血病(aml)的诊断、预后和治疗的基于微rna的方法和组合物 |
| ATE553196T1 (de) * | 2007-02-27 | 2012-04-15 | Rosetta Genomics Ltd | Zusammensetzung und verfahren zur modulation von zellproliferation und zelltod |
| JP5331714B2 (ja) * | 2007-03-16 | 2013-10-30 | コヴァルクス・アーゲー | タンパク質複合体をターゲティングする薬物候補の直接質量分析 |
| WO2008136971A1 (en) * | 2007-04-30 | 2008-11-13 | The Ohio State University Research Foundation | Methods for differentiating pancreatic cancer from normal pancreatic function and/or chronic pancreatitis |
| US20090005336A1 (en) * | 2007-05-08 | 2009-01-01 | Zhiguo Wang | Use of the microRNA miR-1 for the treatment, prevention, and diagnosis of cardiac conditions |
| US20090131354A1 (en) * | 2007-05-22 | 2009-05-21 | Bader Andreas G | miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
| US20090099034A1 (en) * | 2007-06-07 | 2009-04-16 | Wisconsin Alumni Research Foundation | Reagents and Methods for miRNA Expression Analysis and Identification of Cancer Biomarkers |
| AU2008266014B2 (en) * | 2007-06-15 | 2013-06-06 | The Ohio State University Research Foundation | Oncogenic ALL-1 fusion proteins for targeting drosha-mediated microRNA processing |
| EP2173908B1 (en) * | 2007-08-03 | 2016-01-06 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncrnas |
| US20090061424A1 (en) * | 2007-08-30 | 2009-03-05 | Sigma-Aldrich Company | Universal ligation array for analyzing gene expression or genomic variations |
| US20090123933A1 (en) * | 2007-11-12 | 2009-05-14 | Wake Forest University Health Sciences | Microrna biomarkers in lupus |
| WO2009070805A2 (en) * | 2007-12-01 | 2009-06-04 | Asuragen, Inc. | Mir-124 regulated genes and pathways as targets for therapeutic intervention |
| WO2009086156A2 (en) * | 2007-12-21 | 2009-07-09 | Asuragen, Inc. | Mir-10 regulated genes and pathways as targets for therapeutic intervention |
-
2008
- 2008-11-26 CN CN2008801238895A patent/CN101918594A/zh active Pending
- 2008-11-26 US US12/745,327 patent/US20100323357A1/en not_active Abandoned
- 2008-11-26 WO PCT/US2008/084821 patent/WO2009070653A1/en not_active Ceased
- 2008-11-26 CA CA2707157A patent/CA2707157A1/en not_active Abandoned
- 2008-11-26 JP JP2010536157A patent/JP2011505143A/ja active Pending
- 2008-11-26 EP EP08853294A patent/EP2225396A4/en not_active Withdrawn
- 2008-11-26 AU AU2008329755A patent/AU2008329755A1/en not_active Abandoned
-
2010
- 2010-05-30 IL IL206079A patent/IL206079A0/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Li et al. | Salivary extracellular MicroRNAs for early detection and prognostication of esophageal cancer: a clinical study | |
| Lu et al. | Two plasma microRNA panels for diagnosis and subtype discrimination of lung cancer | |
| Vargas et al. | Biomarker development in the precision medicine era: lung cancer as a case study | |
| Liu et al. | A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis | |
| Chen et al. | Prognostic fifteen-gene signature for early stage pancreatic ductal adenocarcinoma | |
| Yin et al. | NGS-based profiling reveals a critical contributing role of somatic D-loop mtDNA mutations in HBV-related hepatocarcinogenesis | |
| Naito et al. | Prognostic impact of circulating tumor cells in patients with small cell lung cancer | |
| Sanfiorenzo et al. | Two panels of plasma microRNAs as non-invasive biomarkers for prediction of recurrence in resectable NSCLC | |
| Duffy et al. | Tumor markers in pancreatic cancer: a European Group on Tumor Markers (EGTM) status report | |
| Chundong et al. | Molecular diagnosis of MACC1 status in lung adenocarcinoma by immunohistochemical analysis | |
| Crisafulli et al. | Whole exome sequencing analysis of urine trans-renal tumour DNA in metastatic colorectal cancer patients | |
| JP2020530290A5 (enExample) | ||
| Zhong et al. | Discovery and validation of extracellular vesicle‐associated miRNAs as noninvasive detection biomarkers for early‐stage non‐small‐cell lung cancer | |
| Jantus-Lewintre et al. | Update on biomarkers for the detection of lung cancer | |
| Wang et al. | Methylation markers for small cell lung cancer in peripheral blood leukocyte DNA | |
| JP2023545017A (ja) | 肺がんの検出及び治療のための方法 | |
| Hmmier et al. | Proteomic analysis of bronchoalveolar lavage fluid (BALF) from lung cancer patients using label-free mass spectrometry | |
| CN107541565B (zh) | 宿主外周血单个核细胞和t细胞的癌症dna甲基化标志物 | |
| Bibikova et al. | Liquid biopsy for early detection of lung cancer | |
| Ancin et al. | The correlation of serum sPD-1 and sPD-L1 levels with clinical, pathological characteristics and lymph node metastasis in nonsmall cell lung cancer patients | |
| Wang et al. | Current and emerging applications of liquid biopsy in pan-cancer | |
| Wu et al. | CPEB4 and IRF4 expression in peripheral mononuclear cells are potential prognostic factors for advanced lung cancer | |
| JP2019122412A (ja) | Ｍｉｒｎａ比率を使用する肺がん決定 | |
| Peng et al. | The mSHOX2 is capable of assessing the therapeutic effect and predicting the prognosis of stage IV lung cancer | |
| Deng et al. | Circulating tumor cells in gastric cancer: developments and clinical applications |