JP2011503089A5 - - Google Patents

Info

Publication number

JP2011503089A5

JP2011503089A5 JP2010533210A JP2010533210A JP2011503089A5 JP 2011503089 A5 JP2011503089 A5 JP 2011503089A5 JP 2010533210 A JP2010533210 A JP 2010533210A JP 2010533210 A JP2010533210 A JP 2010533210A JP 2011503089 A5 JP2011503089 A5 JP 2011503089A5

Authority

JP

Japan

Prior art keywords

thiophene

chloro

propyl

carboxylic acid

hydroxy

Prior art date

2008-11-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 claims 10
• 125000000217 alkyl group Chemical group 0.000 claims 3
• 125000003342 alkenyl group Chemical group 0.000 claims 2
• 125000004432 carbon atom Chemical group C* 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• ODNPRAJSASAODF-XRXFAXGQSA-N 5-[3-[(1r,2r,3r,5r)-5-chloro-2-dec-1-enyl-3-hydroxycyclopentyl]propyl]thiophene-2-carboxylic acid Chemical compound CCCCCCCCC=C[C@H]1[C@H](O)C[C@@H](Cl)[C@@H]1CCCC1=CC=C(C(O)=O)S1 ODNPRAJSASAODF-XRXFAXGQSA-N 0.000 claims 1
• GQOMGAMVIAXXDU-BRSBDYLESA-N 5-[3-[(1r,2r,3r,5r)-5-chloro-2-hept-1-enyl-3-hydroxycyclopentyl]propyl]thiophene-2-carboxylic acid Chemical compound CCCCCC=C[C@H]1[C@H](O)C[C@@H](Cl)[C@@H]1CCCC1=CC=C(C(O)=O)S1 GQOMGAMVIAXXDU-BRSBDYLESA-N 0.000 claims 1
• UEFCCMGZVPNKFG-BRSBDYLESA-N 5-[3-[(1r,2r,3r,5r)-5-chloro-2-heptyl-3-hydroxycyclopentyl]propyl]thiophene-2-carboxylic acid Chemical compound CCCCCCC[C@H]1[C@H](O)C[C@@H](Cl)[C@@H]1CCCC1=CC=C(C(O)=O)S1 UEFCCMGZVPNKFG-BRSBDYLESA-N 0.000 claims 1
• MNRCJCDBASMYFZ-QBPKDAKJSA-N 5-[3-[(1r,2r,3r,5r)-5-chloro-2-hexyl-3-hydroxycyclopentyl]propyl]thiophene-2-carboxylic acid Chemical compound CCCCCC[C@H]1[C@H](O)C[C@@H](Cl)[C@@H]1CCCC1=CC=C(C(O)=O)S1 MNRCJCDBASMYFZ-QBPKDAKJSA-N 0.000 claims 1
• BFMIXIZGHNEHAY-BRSBDYLESA-N 5-[3-[(1r,2r,3r,5r)-5-chloro-3-hydroxy-2-(7-hydroxyhept-1-enyl)cyclopentyl]propyl]thiophene-2-carboxylic acid Chemical compound OCCCCCC=C[C@H]1[C@H](O)C[C@@H](Cl)[C@@H]1CCCC1=CC=C(C(O)=O)S1 BFMIXIZGHNEHAY-BRSBDYLESA-N 0.000 claims 1
• HNXYEYUUZZSFBR-BRSBDYLESA-N 5-[3-[(1r,2r,3r,5r)-5-chloro-3-hydroxy-2-(7-hydroxyheptyl)cyclopentyl]propyl]thiophene-2-carboxylic acid Chemical compound OCCCCCCC[C@H]1[C@H](O)C[C@@H](Cl)[C@@H]1CCCC1=CC=C(C(O)=O)S1 HNXYEYUUZZSFBR-BRSBDYLESA-N 0.000 claims 1
• JLMAVYSIVKNKDO-NCXUSEDFSA-N 5-[3-[(1r,2r,3r,5r)-5-chloro-3-hydroxy-2-(8-hydroxyoct-1-enyl)cyclopentyl]propyl]thiophene-2-carboxylic acid Chemical compound OCCCCCCC=C[C@H]1[C@H](O)C[C@@H](Cl)[C@@H]1CCCC1=CC=C(C(O)=O)S1 JLMAVYSIVKNKDO-NCXUSEDFSA-N 0.000 claims 1
• QJKBBTPYPVOIKG-NCXUSEDFSA-N 5-[3-[(1r,2r,3r,5r)-5-chloro-3-hydroxy-2-(8-hydroxyoctyl)cyclopentyl]propyl]thiophene-2-carboxylic acid Chemical compound OCCCCCCCC[C@H]1[C@H](O)C[C@@H](Cl)[C@@H]1CCCC1=CC=C(C(O)=O)S1 QJKBBTPYPVOIKG-NCXUSEDFSA-N 0.000 claims 1
• KFHGHVRQPZAHFB-IDIOOTERSA-N 5-[3-[(1r,2r,3r,5r)-5-chloro-3-hydroxy-2-[(e,3r)-3-hydroxyoct-1-enyl]cyclopentyl]propyl]thiophene-2-carboxylic acid Chemical compound CCCCC[C@@H](O)\C=C\[C@H]1[C@H](O)C[C@@H](Cl)[C@@H]1CCCC1=CC=C(C(O)=O)S1 KFHGHVRQPZAHFB-IDIOOTERSA-N 0.000 claims 1
• KFHGHVRQPZAHFB-YXUOESJXSA-N 5-[3-[(1r,2r,3r,5r)-5-chloro-3-hydroxy-2-[(e,3s)-3-hydroxyoct-1-enyl]cyclopentyl]propyl]thiophene-2-carboxylic acid Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H](Cl)[C@@H]1CCCC1=CC=C(C(O)=O)S1 KFHGHVRQPZAHFB-YXUOESJXSA-N 0.000 claims 1
• YBXGWWJKUQBHMV-UAFMIMERSA-N 5-[3-[(1r,2r,3r,5r)-5-chloro-3-hydroxy-2-non-1-enylcyclopentyl]propyl]thiophene-2-carboxylic acid Chemical compound CCCCCCCC=C[C@H]1[C@H](O)C[C@@H](Cl)[C@@H]1CCCC1=CC=C(C(O)=O)S1 YBXGWWJKUQBHMV-UAFMIMERSA-N 0.000 claims 1
• VOSAZQWIEFWQDH-UAFMIMERSA-N 5-[3-[(1r,2r,3r,5r)-5-chloro-3-hydroxy-2-nonylcyclopentyl]propyl]thiophene-2-carboxylic acid Chemical compound CCCCCCCCC[C@H]1[C@H](O)C[C@@H](Cl)[C@@H]1CCCC1=CC=C(C(O)=O)S1 VOSAZQWIEFWQDH-UAFMIMERSA-N 0.000 claims 1
• YQEIMGWXMUBJFG-NCXUSEDFSA-N 5-[3-[(1r,2r,3r,5r)-5-chloro-3-hydroxy-2-oct-7-enylcyclopentyl]propyl]thiophene-2-carboxylic acid Chemical compound C=CCCCCCC[C@H]1[C@H](O)C[C@@H](Cl)[C@@H]1CCCC1=CC=C(C(O)=O)S1 YQEIMGWXMUBJFG-NCXUSEDFSA-N 0.000 claims 1
• WFAKLIBGIZQNAN-NCXUSEDFSA-N 5-[3-[(1r,2r,3r,5r)-5-chloro-3-hydroxy-2-octylcyclopentyl]propyl]thiophene-2-carboxylic acid Chemical compound CCCCCCCC[C@H]1[C@H](O)C[C@@H](Cl)[C@@H]1CCCC1=CC=C(C(O)=O)S1 WFAKLIBGIZQNAN-NCXUSEDFSA-N 0.000 claims 1
• FUDHERGUBLWRPR-KLHDSHLOSA-N 5-[3-[(1r,2r,3r,5r)-5-chloro-3-hydroxy-2-pent-1-enylcyclopentyl]propyl]thiophene-2-carboxylic acid Chemical compound CCCC=C[C@H]1[C@H](O)C[C@@H](Cl)[C@@H]1CCCC1=CC=C(C(O)=O)S1 FUDHERGUBLWRPR-KLHDSHLOSA-N 0.000 claims 1
• PLMYBWCKKMBKMA-KLHDSHLOSA-N 5-[3-[(1r,2r,3r,5r)-5-chloro-3-hydroxy-2-pentylcyclopentyl]propyl]thiophene-2-carboxylic acid Chemical compound CCCCC[C@H]1[C@H](O)C[C@@H](Cl)[C@@H]1CCCC1=CC=C(C(O)=O)S1 PLMYBWCKKMBKMA-KLHDSHLOSA-N 0.000 claims 1
• 208000010412 Glaucoma Diseases 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• 230000004410 intraocular pressure Effects 0.000 claims 1
• 239000007788 liquid Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1