AR069228A1 - Compuesto del acido ciclopentil sustituido tiofen-2-carboxilico, su uso para la preparacion de un medicamento util para el tratamiento de glaucoma y composicion farmaceutica que lo comprende - Google Patents
Compuesto del acido ciclopentil sustituido tiofen-2-carboxilico, su uso para la preparacion de un medicamento util para el tratamiento de glaucoma y composicion farmaceutica que lo comprendeInfo
- Publication number
- AR069228A1 AR069228A1 ARP080104883A AR069228A1 AR 069228 A1 AR069228 A1 AR 069228A1 AR P080104883 A ARP080104883 A AR P080104883A AR 069228 A1 AR069228 A1 AR 069228A1
- Authority
- AR
- Argentina
- Prior art keywords
- glaucoma
- preparation
- treatment
- pharmaceutical composition
- cyclopentil
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D333/40—Thiophene-2-carboxylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Medicinal Preparation (AREA)
Abstract
Compuesto del ácido ciclopentil sustituido tiofen-2-carboxílico que posee la formula: (1) en donde R es H, o R consta de: 1) alquilo C1-6 o fenilo, y 2) de 0 a 2 fracciones de -OH; Y es -Cl, -F, -CN, o -CF3 y X consta de: 1) alquilo lineal o alquenilo que posee de 4 a 10 átomos de carbono, y 2) de 0 a 3 grupos -OH. Uso de dicho compuesto para la preparacion de un medicamento util para el tratamiento de glaucoma. Composicion farmacéutica que comprende un líquido aceptable desde el punto de vista oftalmologico que comprende dicho compuesto junto con un excipiente aceptable desde el punto de vista oftalmologico.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98684907P | 2007-11-09 | 2007-11-09 | |
| US12/265,062 US9006464B2 (en) | 2007-11-09 | 2008-11-05 | Substituted cyclopentanes having prostaglandin activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR069228A1 true AR069228A1 (es) | 2010-01-06 |
Family
ID=40524829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080104883 AR069228A1 (es) | 2007-11-09 | 2008-11-07 | Compuesto del acido ciclopentil sustituido tiofen-2-carboxilico, su uso para la preparacion de un medicamento util para el tratamiento de glaucoma y composicion farmaceutica que lo comprende |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9006464B2 (es) |
| EP (1) | EP2217581B1 (es) |
| JP (1) | JP2011503089A (es) |
| KR (1) | KR20100101097A (es) |
| CN (2) | CN101952261B (es) |
| AR (1) | AR069228A1 (es) |
| AU (1) | AU2008324793B2 (es) |
| BR (1) | BRPI0818902A2 (es) |
| CA (1) | CA2705150C (es) |
| CL (1) | CL2008003332A1 (es) |
| CO (1) | CO6280480A2 (es) |
| DK (1) | DK2217581T3 (es) |
| ES (1) | ES2432058T3 (es) |
| IL (1) | IL205604A (es) |
| MX (1) | MX2010005105A (es) |
| NZ (1) | NZ585517A (es) |
| RU (1) | RU2481339C2 (es) |
| TW (1) | TWI411438B (es) |
| UA (1) | UA99840C2 (es) |
| WO (1) | WO2009061811A1 (es) |
| ZA (1) | ZA201003304B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8673341B2 (en) | 2004-04-30 | 2014-03-18 | Allergan, Inc. | Intraocular pressure reduction with intracameral bimatoprost implants |
| US9498457B2 (en) | 2004-04-30 | 2016-11-22 | Allergan, Inc. | Hypotensive prostamide-containing biodegradable intraocular implants and related implants |
| US7799336B2 (en) | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
| US7993634B2 (en) | 2004-04-30 | 2011-08-09 | Allergan, Inc. | Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods |
| US8722097B2 (en) | 2004-04-30 | 2014-05-13 | Allergan, Inc. | Oil-in-water method for making polymeric implants containing a hypotensive lipid |
| US20100247606A1 (en) * | 2009-03-25 | 2010-09-30 | Allergan, Inc. | Intraocular sustained release drug delivery systems and methods for treating ocular conditions |
| EP3991734A4 (en) | 2019-06-28 | 2023-03-01 | Gurus BioPharm Inc. | AGENT FOR ENHANCING HAIR GROWTH |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7012A (en) * | 1850-01-15 | Improvement in mowing-machines | ||
| IE37602B1 (en) * | 1971-05-11 | 1977-08-31 | Ici Ltd | Cyclopentane derivatives |
| JPS5623984B2 (es) * | 1973-04-19 | 1981-06-03 | ||
| US4065472A (en) * | 1975-09-29 | 1977-12-27 | Pfizer Inc. | 5-(2-Carboxythiophen-5-yl)-16-aryloxy-α-tetranor-ω-tetranorprostaglandins |
| GB1563201A (en) * | 1975-11-05 | 1980-03-19 | Shell Int Research | Preparation of herbicidally acitve alanine derivatives |
| US5698598A (en) * | 1995-08-04 | 1997-12-16 | Allergan | EP2 -receptor agonists as agents for lowering intraocular pressure |
| US5877211A (en) * | 1997-11-21 | 1999-03-02 | Allergan | EP2 receptor agonists as neuroprotective agents for the eye |
| US6545045B1 (en) * | 1998-12-24 | 2003-04-08 | Alcon Manufacturing, Ltd. | Prostaglandin E agonists for treatment of glaucoma |
| US7091231B2 (en) * | 2004-12-10 | 2006-08-15 | Allergan, Inc. | 12-Aryl prostaglandin analogs |
| US7585895B2 (en) * | 2005-12-06 | 2009-09-08 | Allergan, Inc. | Therapeutic substituted cyclopentanes |
| US7427685B2 (en) | 2005-12-06 | 2008-09-23 | Allergan, Inc. | Therapeutic substituted cyclopentanes |
| US7439372B2 (en) * | 2006-05-03 | 2008-10-21 | Allergan, Inc. | Therapeutic compounds |
| ATE496903T1 (de) | 2007-02-01 | 2011-02-15 | Allergan Inc | Thiophenderivate als medikamente zur behandlung von okularer hypertonie |
-
2008
- 2008-11-05 NZ NZ58551708A patent/NZ585517A/xx not_active IP Right Cessation
- 2008-11-05 MX MX2010005105A patent/MX2010005105A/es active IP Right Grant
- 2008-11-05 DK DK08848280T patent/DK2217581T3/da active
- 2008-11-05 AU AU2008324793A patent/AU2008324793B2/en not_active Ceased
- 2008-11-05 BR BRPI0818902 patent/BRPI0818902A2/pt not_active IP Right Cessation
- 2008-11-05 WO PCT/US2008/082469 patent/WO2009061811A1/en active Application Filing
- 2008-11-05 ES ES08848280T patent/ES2432058T3/es active Active
- 2008-11-05 KR KR1020107012599A patent/KR20100101097A/ko not_active Application Discontinuation
- 2008-11-05 US US12/265,062 patent/US9006464B2/en active Active
- 2008-11-05 CA CA2705150A patent/CA2705150C/en not_active Expired - Fee Related
- 2008-11-05 JP JP2010533210A patent/JP2011503089A/ja not_active Ceased
- 2008-11-05 CN CN2008801227890A patent/CN101952261B/zh not_active Expired - Fee Related
- 2008-11-05 EP EP20080848280 patent/EP2217581B1/en not_active Not-in-force
- 2008-11-05 UA UAA201007073A patent/UA99840C2/ru unknown
- 2008-11-05 CN CN2012104400409A patent/CN102977048A/zh active Pending
- 2008-11-05 RU RU2010122681/04A patent/RU2481339C2/ru not_active IP Right Cessation
- 2008-11-07 TW TW97143230A patent/TWI411438B/zh not_active IP Right Cessation
- 2008-11-07 CL CL2008003332A patent/CL2008003332A1/es unknown
- 2008-11-07 AR ARP080104883 patent/AR069228A1/es not_active Application Discontinuation
-
2010
- 2010-05-06 IL IL205604A patent/IL205604A/en not_active IP Right Cessation
- 2010-05-11 ZA ZA2010/03304A patent/ZA201003304B/en unknown
- 2010-06-02 CO CO10066597A patent/CO6280480A2/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| IL205604A (en) | 2014-06-30 |
| IL205604A0 (en) | 2010-11-30 |
| EP2217581B1 (en) | 2013-07-31 |
| MX2010005105A (es) | 2010-05-27 |
| JP2011503089A (ja) | 2011-01-27 |
| TWI411438B (zh) | 2013-10-11 |
| US9006464B2 (en) | 2015-04-14 |
| WO2009061811A8 (en) | 2009-07-02 |
| DK2217581T3 (da) | 2013-10-21 |
| NZ585517A (en) | 2012-08-31 |
| EP2217581A1 (en) | 2010-08-18 |
| CA2705150A1 (en) | 2009-05-14 |
| BRPI0818902A2 (pt) | 2015-05-12 |
| US20090124676A1 (en) | 2009-05-14 |
| UA99840C2 (ru) | 2012-10-10 |
| WO2009061811A1 (en) | 2009-05-14 |
| TW200934500A (en) | 2009-08-16 |
| CN101952261A (zh) | 2011-01-19 |
| AU2008324793B2 (en) | 2013-12-05 |
| CL2008003332A1 (es) | 2011-08-12 |
| ZA201003304B (en) | 2014-03-26 |
| CA2705150C (en) | 2016-06-14 |
| AU2008324793A1 (en) | 2009-05-14 |
| RU2010122681A (ru) | 2011-12-20 |
| ES2432058T3 (es) | 2013-11-29 |
| CN101952261B (zh) | 2013-06-12 |
| CO6280480A2 (es) | 2011-05-20 |
| KR20100101097A (ko) | 2010-09-16 |
| RU2481339C2 (ru) | 2013-05-10 |
| CN102977048A (zh) | 2013-03-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |