CO6280480A2 - Ciclopentanos sustituidos que tienen actividad prostaglandina - Google Patents
Ciclopentanos sustituidos que tienen actividad prostaglandinaInfo
- Publication number
- CO6280480A2 CO6280480A2 CO10066597A CO10066597A CO6280480A2 CO 6280480 A2 CO6280480 A2 CO 6280480A2 CO 10066597 A CO10066597 A CO 10066597A CO 10066597 A CO10066597 A CO 10066597A CO 6280480 A2 CO6280480 A2 CO 6280480A2
- Authority
- CO
- Colombia
- Prior art keywords
- fractions
- compound
- formula
- cyclopentans
- prostaglandina
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D333/40—Thiophene-2-carboxylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Medicinal Preparation (AREA)
Abstract
Se divulgan en esta especificación compuestos que tienen una fórmula:Se divulgan así mismo métodos terapéuticos, medicamentos y composiciones relacionados con ellos.1.- Un compuesto que tiene una fórmulaen donde R es H, o R consta de: 1) C1-6 alquilo o fenilo, y 2) de 0 a 2 fracciones -OH, Y es -CI, -F, -CN, o-CF3; y X consta de: 1) alquilo lineal o alquenilo que tiene de 4 a 10 átomos de carbono, y 2) de 0 a 3 fracciones -OH.2.- El compuesto de la reivindicación 1 en donde X consta de: 1) alquilo lineal o alquenilo que tiene de 4 a 10 átomos de carbono, y 2) de 0 a 1 fracciones -OH.3.- El compuesto de la reivindicación 1, que tiene una fórmula:en donde una línea de marcas entrecortadas indica la presencia o ausencia de un enlace, una línea ondulada indica una configuración cis o trans;R1 es -H, o -OH;R2 es -CH2CH3, -CH2CH2OH, o -CH=CH2;T es 0, 1, 2, 3, 4, o 5.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98684907P | 2007-11-09 | 2007-11-09 | |
| US12/265,062 US9006464B2 (en) | 2007-11-09 | 2008-11-05 | Substituted cyclopentanes having prostaglandin activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6280480A2 true CO6280480A2 (es) | 2011-05-20 |
Family
ID=40524829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO10066597A CO6280480A2 (es) | 2007-11-09 | 2010-06-02 | Ciclopentanos sustituidos que tienen actividad prostaglandina |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9006464B2 (es) |
| EP (1) | EP2217581B1 (es) |
| JP (1) | JP2011503089A (es) |
| KR (1) | KR20100101097A (es) |
| CN (2) | CN102977048A (es) |
| AR (1) | AR069228A1 (es) |
| AU (1) | AU2008324793B2 (es) |
| BR (1) | BRPI0818902A2 (es) |
| CA (1) | CA2705150C (es) |
| CL (1) | CL2008003332A1 (es) |
| CO (1) | CO6280480A2 (es) |
| DK (1) | DK2217581T3 (es) |
| ES (1) | ES2432058T3 (es) |
| IL (1) | IL205604A (es) |
| MX (1) | MX2010005105A (es) |
| NZ (1) | NZ585517A (es) |
| RU (1) | RU2481339C2 (es) |
| TW (1) | TWI411438B (es) |
| UA (1) | UA99840C2 (es) |
| WO (1) | WO2009061811A1 (es) |
| ZA (1) | ZA201003304B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7799336B2 (en) | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
| US8673341B2 (en) * | 2004-04-30 | 2014-03-18 | Allergan, Inc. | Intraocular pressure reduction with intracameral bimatoprost implants |
| US7993634B2 (en) | 2004-04-30 | 2011-08-09 | Allergan, Inc. | Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods |
| US9498457B2 (en) | 2004-04-30 | 2016-11-22 | Allergan, Inc. | Hypotensive prostamide-containing biodegradable intraocular implants and related implants |
| US8722097B2 (en) | 2004-04-30 | 2014-05-13 | Allergan, Inc. | Oil-in-water method for making polymeric implants containing a hypotensive lipid |
| US20100247606A1 (en) * | 2009-03-25 | 2010-09-30 | Allergan, Inc. | Intraocular sustained release drug delivery systems and methods for treating ocular conditions |
| WO2020263115A1 (ru) | 2019-06-28 | 2020-12-30 | Общество С Ограниченной Ответственностью "Регеус" | Средство для усиления роста волос |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7012A (en) * | 1850-01-15 | Improvement in mowing-machines | ||
| IE37602B1 (en) * | 1971-05-11 | 1977-08-31 | Ici Ltd | Cyclopentane derivatives |
| JPS5623984B2 (es) * | 1973-04-19 | 1981-06-03 | ||
| US4065472A (en) * | 1975-09-29 | 1977-12-27 | Pfizer Inc. | 5-(2-Carboxythiophen-5-yl)-16-aryloxy-α-tetranor-ω-tetranorprostaglandins |
| GB1563201A (en) * | 1975-11-05 | 1980-03-19 | Shell Int Research | Preparation of herbicidally acitve alanine derivatives |
| US5698598A (en) * | 1995-08-04 | 1997-12-16 | Allergan | EP2 -receptor agonists as agents for lowering intraocular pressure |
| US5877211A (en) * | 1997-11-21 | 1999-03-02 | Allergan | EP2 receptor agonists as neuroprotective agents for the eye |
| WO2000038667A2 (en) * | 1998-12-24 | 2000-07-06 | Alcon Laboratories, Inc. | Prostaglandin e agonists for treatment of glaucoma |
| US7091231B2 (en) * | 2004-12-10 | 2006-08-15 | Allergan, Inc. | 12-Aryl prostaglandin analogs |
| US7427685B2 (en) * | 2005-12-06 | 2008-09-23 | Allergan, Inc. | Therapeutic substituted cyclopentanes |
| US7585895B2 (en) * | 2005-12-06 | 2009-09-08 | Allergan, Inc. | Therapeutic substituted cyclopentanes |
| US7439372B2 (en) * | 2006-05-03 | 2008-10-21 | Allergan, Inc. | Therapeutic compounds |
| US7960431B2 (en) * | 2007-02-01 | 2011-06-14 | Allergan, Inc. | Thiophenyl prostaglandin derivatives for treating glaucoma and ocular hypertension |
-
2008
- 2008-11-05 CA CA2705150A patent/CA2705150C/en not_active Expired - Fee Related
- 2008-11-05 AU AU2008324793A patent/AU2008324793B2/en not_active Ceased
- 2008-11-05 ES ES08848280T patent/ES2432058T3/es active Active
- 2008-11-05 US US12/265,062 patent/US9006464B2/en active Active
- 2008-11-05 DK DK08848280T patent/DK2217581T3/da active
- 2008-11-05 JP JP2010533210A patent/JP2011503089A/ja not_active Ceased
- 2008-11-05 MX MX2010005105A patent/MX2010005105A/es active IP Right Grant
- 2008-11-05 WO PCT/US2008/082469 patent/WO2009061811A1/en active Application Filing
- 2008-11-05 CN CN2012104400409A patent/CN102977048A/zh active Pending
- 2008-11-05 UA UAA201007073A patent/UA99840C2/ru unknown
- 2008-11-05 KR KR1020107012599A patent/KR20100101097A/ko not_active Application Discontinuation
- 2008-11-05 NZ NZ58551708A patent/NZ585517A/xx not_active IP Right Cessation
- 2008-11-05 EP EP20080848280 patent/EP2217581B1/en not_active Not-in-force
- 2008-11-05 CN CN2008801227890A patent/CN101952261B/zh not_active Expired - Fee Related
- 2008-11-05 BR BRPI0818902 patent/BRPI0818902A2/pt not_active IP Right Cessation
- 2008-11-05 RU RU2010122681/04A patent/RU2481339C2/ru not_active IP Right Cessation
- 2008-11-07 AR ARP080104883 patent/AR069228A1/es not_active Application Discontinuation
- 2008-11-07 CL CL2008003332A patent/CL2008003332A1/es unknown
- 2008-11-07 TW TW97143230A patent/TWI411438B/zh not_active IP Right Cessation
-
2010
- 2010-05-06 IL IL205604A patent/IL205604A/en not_active IP Right Cessation
- 2010-05-11 ZA ZA2010/03304A patent/ZA201003304B/en unknown
- 2010-06-02 CO CO10066597A patent/CO6280480A2/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008324793B2 (en) | 2013-12-05 |
| CL2008003332A1 (es) | 2011-08-12 |
| TWI411438B (zh) | 2013-10-11 |
| ZA201003304B (en) | 2014-03-26 |
| AR069228A1 (es) | 2010-01-06 |
| AU2008324793A1 (en) | 2009-05-14 |
| US9006464B2 (en) | 2015-04-14 |
| IL205604A (en) | 2014-06-30 |
| IL205604A0 (en) | 2010-11-30 |
| ES2432058T3 (es) | 2013-11-29 |
| CA2705150C (en) | 2016-06-14 |
| CN102977048A (zh) | 2013-03-20 |
| CA2705150A1 (en) | 2009-05-14 |
| DK2217581T3 (da) | 2013-10-21 |
| UA99840C2 (ru) | 2012-10-10 |
| BRPI0818902A2 (pt) | 2015-05-12 |
| RU2010122681A (ru) | 2011-12-20 |
| US20090124676A1 (en) | 2009-05-14 |
| CN101952261A (zh) | 2011-01-19 |
| TW200934500A (en) | 2009-08-16 |
| WO2009061811A8 (en) | 2009-07-02 |
| EP2217581B1 (en) | 2013-07-31 |
| KR20100101097A (ko) | 2010-09-16 |
| JP2011503089A (ja) | 2011-01-27 |
| EP2217581A1 (en) | 2010-08-18 |
| CN101952261B (zh) | 2013-06-12 |
| MX2010005105A (es) | 2010-05-27 |
| RU2481339C2 (ru) | 2013-05-10 |
| NZ585517A (en) | 2012-08-31 |
| WO2009061811A1 (en) | 2009-05-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Application granted |