JP2011501962A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011501962A5 JP2011501962A5 JP2010532219A JP2010532219A JP2011501962A5 JP 2011501962 A5 JP2011501962 A5 JP 2011501962A5 JP 2010532219 A JP2010532219 A JP 2010532219A JP 2010532219 A JP2010532219 A JP 2010532219A JP 2011501962 A5 JP2011501962 A5 JP 2011501962A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- nucleobase
- modified
- compound
- liver cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 19
- 201000007270 liver cancer Diseases 0.000 claims 6
- 208000014018 liver neoplasm Diseases 0.000 claims 6
- 239000002777 nucleoside Substances 0.000 claims 4
- 210000002966 serum Anatomy 0.000 claims 4
- 108091034117 Oligonucleotide Proteins 0.000 claims 3
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 3
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 108010063628 acarboxyprothrombin Proteins 0.000 claims 2
- 102000013529 alpha-Fetoproteins Human genes 0.000 claims 2
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 230000004083 survival effect Effects 0.000 claims 2
- KVGZZAHHUNAVKZ-UHFFFAOYSA-N 1,4-Dioxin Chemical group O1C=COC=C1 KVGZZAHHUNAVKZ-UHFFFAOYSA-N 0.000 claims 1
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 claims 1
- LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical group CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 claims 1
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims 1
- HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 claims 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
- 239000005511 L01XE05 - Sorafenib Substances 0.000 claims 1
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims 1
- 238000011374 additional therapy Methods 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 229960004562 carboplatin Drugs 0.000 claims 1
- 190000008236 carboplatin Chemical compound 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 229960004679 doxorubicin Drugs 0.000 claims 1
- 229960001904 epirubicin Drugs 0.000 claims 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 1
- 229960005420 etoposide Drugs 0.000 claims 1
- 229960002949 fluorouracil Drugs 0.000 claims 1
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 1
- 229960005277 gemcitabine Drugs 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 229960004768 irinotecan Drugs 0.000 claims 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000003835 nucleoside group Chemical group 0.000 claims 1
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 1
- 229960001756 oxaliplatin Drugs 0.000 claims 1
- 229960003787 sorafenib Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98323107P | 2007-10-29 | 2007-10-29 | |
| US60/983,231 | 2007-10-29 | ||
| PCT/US2008/081645 WO2009058907A2 (en) | 2007-10-29 | 2008-10-29 | Targeting micrornas for the treatment of liver cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011501962A JP2011501962A (ja) | 2011-01-20 |
| JP2011501962A5 true JP2011501962A5 (https=) | 2012-05-10 |
| JP5535076B2 JP5535076B2 (ja) | 2014-07-02 |
Family
ID=40524369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010532219A Active JP5535076B2 (ja) | 2007-10-29 | 2008-10-29 | 肝臓癌を治療するための標的化ミクロｒｎａ |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US8211867B2 (https=) |
| EP (1) | EP2217248B1 (https=) |
| JP (1) | JP5535076B2 (https=) |
| CN (1) | CN101980712B (https=) |
| AU (1) | AU2008318778B2 (https=) |
| CA (1) | CA2704043C (https=) |
| IL (1) | IL205307A (https=) |
| WO (1) | WO2009058907A2 (https=) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2857881A1 (en) | 2004-11-12 | 2006-12-28 | Asuragen, Inc. | Methods and compositions involving mirna and mirna inhibitor molecules |
| WO2006138145A1 (en) | 2005-06-14 | 2006-12-28 | Northwestern University | Nucleic acid functionalized nanoparticles for therapeutic applications |
| EP2487258B1 (en) | 2006-01-05 | 2014-10-01 | The Ohio State University Research Foundation | MicroRNA-based methods for the diagnosis of colon, pancreas and stomach cancer |
| ES2446362T3 (es) | 2006-03-20 | 2014-03-07 | The Ohio State University Research Foundation | Huellas de microARN durante megacariocipoyesis humana |
| US8507200B2 (en) | 2007-02-09 | 2013-08-13 | Northwestern University | Particles for detecting intracellular targets |
| JP2010535473A (ja) | 2007-08-03 | 2010-11-25 | ズィ、オハイオウ、ステイト、ユーニヴァーサティ、リサーチ、ファウンデイシャン | ｎｃＲＮＡをコードする超保存領域 |
| EP2217248B1 (en) | 2007-10-29 | 2016-11-30 | Regulus Therapeutics Inc. | Targeting micrornas for the treatment of liver cancer |
| WO2009108853A1 (en) * | 2008-02-28 | 2009-09-03 | The Ohio State University Research Foundation | MicroRNA-BASED METHODS AND COMPOSITIONS FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF GASTRIC CANCER |
| US8258111B2 (en) | 2008-05-08 | 2012-09-04 | The Johns Hopkins University | Compositions and methods related to miRNA modulation of neovascularization or angiogenesis |
| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
| WO2011017456A2 (en) * | 2009-08-04 | 2011-02-10 | Northwestern University | Localized delivery of nanoparticles for therapeutic and diagnostic applications |
| US8916533B2 (en) | 2009-11-23 | 2014-12-23 | The Ohio State University | Materials and methods useful for affecting tumor cell growth, migration and invasion |
| WO2011066312A1 (en) * | 2009-11-25 | 2011-06-03 | Elitech Holding B.V. | Minor groove binder (mgb)-oligonucleotide mirna antagonists |
| WO2011076141A1 (en) * | 2009-12-24 | 2011-06-30 | Fudan University | Diagnostic kits comprising microrna biomarkers and methods for diagnosis of hepatocellular cancer |
| CN101831427B (zh) * | 2010-04-01 | 2012-07-18 | 清华大学深圳研究生院 | 一种预防肿瘤复发和抑制肿瘤生长的寡聚核酸及其应用 |
| RU2585491C2 (ru) * | 2010-06-04 | 2016-05-27 | Борд Оф Риджентс, Зе Юниверсити Оф Техас Систем | Регуляция метаболизма с помощью mir-378 |
| CN103189511B (zh) * | 2010-07-12 | 2016-10-12 | 国立大学法人鸟取大学 | 利用siRNA导入的新型hiPSC制作法 |
| JP5931897B2 (ja) | 2010-11-12 | 2016-06-08 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイションＴｈｅ Ｏｈｉｏ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | マイクロｒｎａ−２１、ミスマッチ修復および結腸直腸癌に関連する物質および方法 |
| CA2817982C (en) | 2010-11-15 | 2020-06-30 | The Regents Of The University Of Michigan | Controlled release mucoadhesive systems |
| CN102140471B (zh) * | 2011-01-10 | 2013-11-20 | 清华大学深圳研究生院 | 一种抑制肿瘤生长的寡聚核酸及其应用 |
| CN102125696B (zh) * | 2011-01-11 | 2013-06-12 | 清华大学深圳研究生院 | 抑制肿瘤生长及血管生成的寡聚核酸组合物及其应用 |
| JP2014506791A (ja) | 2011-02-03 | 2014-03-20 | マーナ セラピューティクス インコーポレイテッド | ｍｉＲ−３４の合成模倣体 |
| CN103459598B (zh) | 2011-02-03 | 2016-08-10 | 米尔纳医疗股份有限公司 | Mir-124的合成模拟物 |
| US8420617B2 (en) | 2011-03-11 | 2013-04-16 | Biocell Laboratories | Multiantivirus compound, composition and method for treatment of virus diseases |
| CN102178959B (zh) * | 2011-03-15 | 2013-10-23 | 清华大学深圳研究生院 | 抑制肺转移肿瘤生长的siRNA及其寡聚核酸组合与应用 |
| WO2012145374A1 (en) * | 2011-04-19 | 2012-10-26 | Regulus Therapeutics Inc. | TARGETING miR-378 FAMILY MEMBERS FOR THE TREATMENT OF METABOLIC DISORDERS |
| EP3211082B1 (en) * | 2011-04-25 | 2021-02-17 | Sanofi | Microrna compounds and methods for modulating mir-21 activity |
| EP2705157B1 (en) * | 2011-05-06 | 2017-02-01 | New England Biolabs, Inc. | Ligation enhancement |
| US9889209B2 (en) | 2011-09-14 | 2018-02-13 | Northwestern University | Nanoconjugates able to cross the blood-brain barrier |
| AU2012323924A1 (en) | 2011-10-14 | 2014-05-29 | The Ohio State University | Methods and materials related to ovarian cancer |
| CA2859430A1 (en) * | 2011-12-13 | 2013-06-20 | Ohio State Innovation Foundation | Methods and compositions related to mir-21 and mir-29a, exosome inhibition, and cancer metastasis |
| US8859202B2 (en) | 2012-01-20 | 2014-10-14 | The Ohio State University | Breast cancer biomarker signatures for invasiveness and prognosis |
| PE20142404A1 (es) | 2012-04-25 | 2015-02-02 | Regulus Therapeutics Inc | Compuestos de microarn y metodos de modulacion de la actividad de mir-21 |
| JP2014027898A (ja) * | 2012-07-31 | 2014-02-13 | Yamaguchi Univ | 肝細胞がん発症リスクの判定方法 |
| UA116639C2 (uk) | 2012-10-09 | 2018-04-25 | Рег'Юлес Терап'Ютікс Інк. | Способи лікування синдрому альпорта |
| US9994846B2 (en) | 2013-10-25 | 2018-06-12 | Regulus Therapeutics Inc. | MicroRNA compounds and methods for modulating miR-21 activity |
| JP6527516B2 (ja) | 2013-12-03 | 2019-06-05 | ノースウェスタン ユニバーシティ | リポソーム粒子、前述のものを作製する方法及びその使用 |
| AU2015269412B2 (en) | 2014-06-04 | 2020-03-12 | Exicure Operating Company | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
| KR20170078843A (ko) | 2014-11-21 | 2017-07-07 | 노오쓰웨스턴 유니버시티 | 구형 핵산 나노입자 접합체의 서열 특이적 세포 흡수 |
| EP3337900B1 (en) * | 2015-08-20 | 2021-04-07 | Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE | Methods and compositions to treat liver diseases and conditions |
| EP3446432A1 (en) | 2016-04-20 | 2019-02-27 | Convida Wireless, LLC | Configurable reference signals |
| KR102153077B1 (ko) | 2016-04-20 | 2020-09-07 | 콘비다 와이어리스, 엘엘씨 | 다운링크 동기화 |
| JP6837492B2 (ja) | 2016-04-20 | 2021-03-03 | コンヴィーダ ワイヤレス， エルエルシー | 新しい無線における物理チャネル |
| KR102106581B1 (ko) | 2016-04-20 | 2020-05-04 | 콘비다 와이어리스, 엘엘씨 | 시스템 정보 프로비저닝 및 경량 접속 시그널링 |
| US10524244B2 (en) | 2016-05-11 | 2019-12-31 | Convida Wireless, Llc | Radio PDCCH to facilitate numerology operations |
| KR102166986B1 (ko) | 2016-06-15 | 2020-10-16 | 콘비다 와이어리스, 엘엘씨 | 그랜트리스 동작들 |
| US10631319B2 (en) | 2016-06-15 | 2020-04-21 | Convida Wireless, Llc | Grant-less uplink transmission for new radio |
| WO2017218794A1 (en) | 2016-06-15 | 2017-12-21 | Convida Wireless, Llc | Upload control signaling for new radio |
| KR20240006080A (ko) | 2016-08-11 | 2024-01-12 | 인터디지탈 패튼 홀딩스, 인크 | 뉴 라디오를 위한 유연한 프레임 구조에서의 빔포밍 스위핑 및 트레이닝 |
| US11364304B2 (en) | 2016-08-25 | 2022-06-21 | Northwestern University | Crosslinked micellar spherical nucleic acids |
| US11584932B2 (en) | 2016-11-01 | 2023-02-21 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
| US11236337B2 (en) | 2016-11-01 | 2022-02-01 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
| WO2018097947A2 (en) | 2016-11-03 | 2018-05-31 | Convida Wireless, Llc | Reference signals and control channels in nr |
| EP4035659A1 (en) | 2016-11-29 | 2022-08-03 | PureTech LYT, Inc. | Exosomes for delivery of therapeutic agents |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
| WO2020068251A1 (en) | 2018-09-27 | 2020-04-02 | Convida Wireless, Llc | Sub-band operations in unlicensed spectrums of new radio |
| CN109880907A (zh) * | 2019-03-26 | 2019-06-14 | 中国人民解放军第八一医院 | 一种肝癌细胞侵袭转移的分子机制研究方法 |
| WO2021262919A2 (en) | 2020-06-26 | 2021-12-30 | The Research Foundation For The State University Of New York | 5-halouracil-modified micrornas and their use in the treatment of cancer |
| CA3234547A1 (en) * | 2021-10-08 | 2023-04-13 | Regulus Therapeutics Inc. | Methods and compositions for treatment of polycystic kidney disease |
| WO2025104709A1 (en) * | 2023-11-17 | 2025-05-22 | Biorchestra Co., Ltd. | Microrna-378a-3p antisense oligonucleotides and uses thereof |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4334165B2 (ja) | 2001-07-13 | 2009-09-30 | コニカミノルタホールディングス株式会社 | 静電潜像現像用トナーと画像形成方法及び画像形成装置 |
| EP2390331B1 (en) * | 2001-09-28 | 2018-04-25 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | MicroRNA molecules |
| AU2003216255A1 (en) * | 2002-02-20 | 2003-09-09 | Ribozyme Pharmaceuticals, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF MDR P-GLYCOPROTEIN GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| JP4369691B2 (ja) | 2003-06-26 | 2009-11-25 | 株式会社Ｉｄｘ | マイクロ波化学反応装置 |
| US7683036B2 (en) * | 2003-07-31 | 2010-03-23 | Regulus Therapeutics Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding RNAs |
| JP2007501617A (ja) * | 2003-08-07 | 2007-02-01 | ジーン ロジック インコーポレイテッド | 初代ラット肝細胞毒性モデリング |
| JP3959722B2 (ja) | 2003-10-15 | 2007-08-15 | 住友金属工業株式会社 | 線材コイルの冷却装置 |
| EP2295604B1 (en) * | 2004-02-09 | 2015-04-08 | Thomas Jefferson University | Diagnosis and treatment of cancers with microRNA located in or near cancer-associated chromosomal features |
| US20050182005A1 (en) * | 2004-02-13 | 2005-08-18 | Tuschl Thomas H. | Anti-microRNA oligonucleotide molecules |
| EP2290071B1 (en) * | 2004-05-28 | 2014-12-31 | Asuragen, Inc. | Methods and compositions involving microRNA |
| US7635563B2 (en) * | 2004-06-30 | 2009-12-22 | Massachusetts Institute Of Technology | High throughput methods relating to microRNA expression analysis |
| EP1791567B1 (en) * | 2004-08-10 | 2015-07-29 | Alnylam Pharmaceuticals Inc. | Chemically modified oligonucleotides |
| CA2857881A1 (en) | 2004-11-12 | 2006-12-28 | Asuragen, Inc. | Methods and compositions involving mirna and mirna inhibitor molecules |
| CN1800388A (zh) | 2005-01-07 | 2006-07-12 | 中国人民解放军军事医学科学院放射医学研究所 | 八种人源miRNA |
| EP1874936B1 (en) * | 2005-04-19 | 2013-10-30 | BASF Plant Science GmbH | Improved methods controlling gene expression |
| US20070065844A1 (en) * | 2005-06-08 | 2007-03-22 | Massachusetts Institute Of Technology | Solution-based methods for RNA expression profiling |
| JP2007073737A (ja) | 2005-09-07 | 2007-03-22 | Toyo Ink Mfg Co Ltd | 複数の導電性回路層を有するプリント配線板並びにその製造方法 |
| DE102005046385B4 (de) | 2005-09-28 | 2012-03-22 | Siemens Ag | Verfahren und Vorrichtung zur Nachbearbeitung eines 3D-Bilddatensatzes, insbesondere für die virtuelle Kolonographie |
| JP2007097429A (ja) * | 2005-09-30 | 2007-04-19 | Mitsubishi Rayon Co Ltd | ｎｏｎ−ｃｏｄｉｎｇＲＮＡの検出データ補正方法 |
| JP4483757B2 (ja) | 2005-09-30 | 2010-06-16 | セイコーエプソン株式会社 | 有機ｅｌ装置及び光学装置 |
| US20070092882A1 (en) * | 2005-10-21 | 2007-04-26 | Hui Wang | Analysis of microRNA |
| EP1966390A1 (en) * | 2005-12-29 | 2008-09-10 | Exiqon A/S | Detection of tissue origin of cancer |
| EP1984499B1 (en) * | 2006-01-27 | 2015-05-27 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for the use in modulation of micrornas |
| WO2007095614A2 (en) * | 2006-02-15 | 2007-08-23 | University Of Louisville Research Foundation, Inc. | Microarray, system, and method for detecting, identifying, and quantitating micro-rnas |
| EP1986697B1 (en) | 2006-02-17 | 2016-06-29 | GE Healthcare Dharmacon, Inc. | Compositions and methods for inhibiting gene silencing by rna interference |
| CA2648132C (en) * | 2006-04-03 | 2019-05-28 | Santaris Pharma A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
| CA2657030A1 (en) * | 2006-07-13 | 2008-01-17 | The Ohio State University Research Foundation, An Instrumentality Of The State Of Ohio | Micro-rna-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases |
| US20080199961A1 (en) * | 2006-08-25 | 2008-08-21 | Avi Biopharma, Inc. | ANTISENSE COMPOSITION AND METHOD FOR INHIBITION OF miRNA BIOGENESIS |
| EP2087135B8 (en) * | 2006-11-01 | 2013-07-24 | The Ohio State University Research Foundation | Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma |
| WO2008073920A2 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Mir-21 regulated genes and pathways as targets for therapeutic intervention |
| JP2009043353A (ja) | 2007-08-09 | 2009-02-26 | Pioneer Electronic Corp | タイトル付与装置、タイトル付与方法、タイトル付与プログラム、および記録媒体 |
| EP2623599B1 (en) * | 2007-10-04 | 2019-01-02 | Roche Innovation Center Copenhagen A/S | Micromirs |
| EP2217248B1 (en) | 2007-10-29 | 2016-11-30 | Regulus Therapeutics Inc. | Targeting micrornas for the treatment of liver cancer |
-
2008
- 2008-10-29 EP EP08844596.0A patent/EP2217248B1/en active Active
- 2008-10-29 AU AU2008318778A patent/AU2008318778B2/en active Active
- 2008-10-29 CA CA2704043A patent/CA2704043C/en active Active
- 2008-10-29 JP JP2010532219A patent/JP5535076B2/ja active Active
- 2008-10-29 CN CN200880121316.9A patent/CN101980712B/zh active Active
- 2008-10-29 US US12/740,211 patent/US8211867B2/en active Active
- 2008-10-29 WO PCT/US2008/081645 patent/WO2009058907A2/en not_active Ceased
-
2010
- 2010-04-25 IL IL205307A patent/IL205307A/en active IP Right Grant
-
2012
- 2012-05-25 US US13/481,105 patent/US8680067B2/en active Active
-
2014
- 2014-01-30 US US14/168,812 patent/US9150857B2/en active Active
-
2015
- 2015-08-24 US US14/833,889 patent/US9506062B2/en not_active Expired - Fee Related
-
2016
- 2016-10-26 US US15/334,422 patent/US9845470B2/en active Active
-
2017
- 2017-11-15 US US15/813,584 patent/US10301627B2/en active Active