JP2011516410A5 - - Google Patents

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Publication number
JP2011516410A5
JP2011516410A5 JP2010548040A JP2010548040A JP2011516410A5 JP 2011516410 A5 JP2011516410 A5 JP 2011516410A5 JP 2010548040 A JP2010548040 A JP 2010548040A JP 2010548040 A JP2010548040 A JP 2010548040A JP 2011516410 A5 JP2011516410 A5 JP 2011516410A5
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JP
Japan
Prior art keywords
fibrosis
modified
compound according
compound
sugar
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JP2010548040A
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English (en)
Japanese (ja)
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JP6033527B2 (ja
JP2011516410A (ja
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Priority claimed from EP20080003570 external-priority patent/EP2096171A1/en
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Publication of JP2011516410A5 publication Critical patent/JP2011516410A5/ja
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JP2010548040A 2008-02-27 2009-02-26 診断および治療のためのミクロＲＮＡ（ｍｉＲＮＡ）および下流標的 Active JP6033527B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US3183508P 2008-02-27 2008-02-27
US61/031,835 2008-02-27
EP20080003570 EP2096171A1 (en) 2008-02-27 2008-02-27 MicroRNA (miRNA) and down-stream targets for diagnostic and therapeutic purposes
EP08003570.2 2008-02-27
US3334008P 2008-03-03 2008-03-03
US61/033,340 2008-03-03
EPPCT/EP2009/051986 2009-02-19
PCT/EP2009/051986 WO2009106477A1 (en) 2008-02-27 2009-02-19 Microrna (mirna) and down-stream targets for diagnostic and therapeutic purposes
PCT/EP2009/001590 WO2009106367A1 (en) 2008-02-27 2009-02-26 Microrna (mirna) and downstream targets for diagnostic and therapeutic purposes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014246185A Division JP2015107971A (ja) 2008-02-27 2014-12-04 診断および治療のためのミクロＲＮＡ（ｍｉＲＮＡ）および下流標的

Publications (3)

Publication Number Publication Date
JP2011516410A JP2011516410A (ja) 2011-05-26
JP2011516410A5 true JP2011516410A5 (https=) 2013-01-17
JP6033527B2 JP6033527B2 (ja) 2016-11-30

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ID=39639202

Family Applications (2)

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JP2010548040A Active JP6033527B2 (ja) 2008-02-27 2009-02-26 診断および治療のためのミクロＲＮＡ（ｍｉＲＮＡ）および下流標的
JP2014246185A Pending JP2015107971A (ja) 2008-02-27 2014-12-04 診断および治療のためのミクロＲＮＡ（ｍｉＲＮＡ）および下流標的

Family Applications After (1)

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JP2014246185A Pending JP2015107971A (ja) 2008-02-27 2014-12-04 診断および治療のためのミクロＲＮＡ（ｍｉＲＮＡ）および下流標的

Country Status (23)

Country Link
US (10) US8236777B2 (https=)
EP (3) EP2096171A1 (https=)
JP (2) JP6033527B2 (https=)
KR (1) KR101697482B1 (https=)
CN (1) CN102027113B (https=)
AU (1) AU2009218704C1 (https=)
BR (1) BRPI0907565B1 (https=)
CA (2) CA3123067A1 (https=)
CY (1) CY1114426T1 (https=)
DK (1) DK2260101T3 (https=)
EA (1) EA020335B1 (https=)
ES (1) ES2436885T3 (https=)
HR (1) HRP20130766T1 (https=)
IL (1) IL207704A (https=)
ME (1) ME01600B (https=)
MX (2) MX336299B (https=)
MY (1) MY159454A (https=)
NZ (1) NZ588185A (https=)
PL (1) PL2260101T3 (https=)
PT (1) PT2260101E (https=)
SI (1) SI2260101T1 (https=)
UA (1) UA100727C2 (https=)
WO (2) WO2009106477A1 (https=)

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EP2302055B1 (en) 2004-11-12 2014-08-27 Asuragen, Inc. Methods and compositions involving miRNA and miRNA inhibitor molecules
EP2096171A1 (en) 2008-02-27 2009-09-02 Julius-Maximilians-Universität Würzburg MicroRNA (miRNA) and down-stream targets for diagnostic and therapeutic purposes
US20110190372A1 (en) * 2009-08-07 2011-08-04 New York University Compositions and methods for treating inflammatory disorders
CN102038959B (zh) * 2009-10-26 2012-12-19 中国科学院上海生命科学研究院 let-7/miR-98家族在制备治疗FAS基因相关疾病的药物中的应用
WO2011126842A2 (en) * 2010-03-30 2011-10-13 Regulus Therapeutics Inc. Targeting micrornas for the treatment of cardiac disorders
US20130150256A1 (en) 2010-06-11 2013-06-13 Jane Synnergren Novel micrornas for the detection and isolation of human embryonic stem cell-derived cardiac cell types
WO2012012716A2 (en) 2010-07-23 2012-01-26 Regulus Therapeutics, Inc. Targeting micrornas for the treatment of fibrosis
KR20140004646A (ko) * 2010-12-15 2014-01-13 미라젠 세러퓨틱스 잠금 뉴클레오티드를 포함하는 마이크로rna 억제제
HUE031595T2 (en) * 2011-04-25 2017-07-28 Regulus Therapeutics Inc Micro RNA Compounds s Methods for Modulating Mir-21 Activity
EP2753696B1 (en) * 2011-09-06 2017-11-22 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. The mirna-212/132 family as a therapeutic target
KR20140091688A (ko) 2011-10-06 2014-07-22 미라젠 세러퓨틱스 인코포레이티드 마이크로rna 조절에 의한 전신 에너지 항상성의 제어
EP2592145A1 (en) * 2011-11-11 2013-05-15 Medizinische Hochschule Hannover Medicament for the treatment of cardiac disease
JP2015504307A (ja) * 2011-11-22 2015-02-12 インターミューン， インコーポレイテッド 特発性肺線維症を診断および治療する方法
AU2012352265B2 (en) * 2011-12-13 2017-02-16 Ohio State Innovation Foundation Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis
JP2015518475A (ja) * 2012-04-10 2015-07-02 インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラルシェルシェ メディカル）Ｉｎｓｅｒｍ（Ｉｎｓｔｉｔｕｔ Ｎａｔｉｏｎａｌ Ｄｅｌａ Ｓａｎｔｅ Ｅｔｄｅ Ｌａ Ｒｅｃｈｅｒｃｈｅ Ｍｅｄｉｃａｌｅ） 非アルコール性脂肪性肝炎の治療方法
EA030211B1 (ru) 2012-04-25 2018-07-31 Регьюлэс Терапьютикс Инк. Соединения на основе микрорнк и способы модулирования активности mir-21
CN107236735B (zh) 2012-06-21 2019-11-08 米拉根医疗股份有限公司 包含锁核酸基序的基于寡核苷酸的抑制剂
CA2782942C (en) 2012-07-12 2019-08-27 Canadian Blood Services Method for inducing immune tolerance using polymer-modified antigenic leukocytes
UA116639C2 (uk) * 2012-10-09 2018-04-25 Рег'Юлес Терап'Ютікс Інк. Способи лікування синдрому альпорта
DK3019176T3 (da) 2013-07-12 2020-06-22 Canadian Blood Services Anvendelse af acellulære pro-inflammatoriske sammensætninger og fremgangsmåde til fremstilling heraf
US9994846B2 (en) 2013-10-25 2018-06-12 Regulus Therapeutics Inc. MicroRNA compounds and methods for modulating miR-21 activity
WO2015086828A1 (en) * 2013-12-12 2015-06-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the prevention and treatment of diabetic cardiomyopathy using mir-424/322
WO2016004538A1 (en) 2014-07-10 2016-01-14 Canadian Blood Services Combination therapy of a cellular pro-tolerogenic and pro-inflammatory preparations for modulating the immune system
US9376681B2 (en) * 2014-09-08 2016-06-28 MiRagen Therapeutics, Inc. miR-29 mimics and uses thereof
EP3247716A4 (en) 2015-01-20 2018-10-17 Miragen Therapeutics, Inc. Mir-92 inhibitors and uses thereof
CN106924757B (zh) * 2015-12-31 2020-07-24 中国科学院遗传与发育生物学研究所 miR-449c-5p及其拟似物在制备治疗和预防心脏瓣膜疾病产品中的应用
CN107034216A (zh) * 2016-02-04 2017-08-11 中国科学技术大学 miRancer分子的设计与应用
KR101835018B1 (ko) 2016-03-03 2018-03-06 고려대학교 산학협력단 엑소좀 또는 엑소좀 유래 리보핵산을 포함하는 간섬유증 예방 또는 치료용 조성물
US11236337B2 (en) 2016-11-01 2022-02-01 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
US11667916B2 (en) 2017-09-08 2023-06-06 Korea University Research And Business Foundation Composition for preventing or treating liver fibrosis, containing exosome or exosome-derived ribonucleic acid
CN107858419A (zh) * 2017-11-10 2018-03-30 青岛大学 miRNA的应用、应用其的产品及检测方法
KR102746742B1 (ko) 2018-05-25 2024-12-26 (주)바이오니아 엠피레귤린 유전자 특이적 이중가닥 올리고뉴클레오티드 및 이를 포함하는 섬유증 관련 질환 및 호흡기 관련 질환 예방 및 치료용 조성물
CN109498642A (zh) * 2018-12-21 2019-03-22 复旦大学附属中山医院 一种柯萨奇b3病毒感染导致的心脏微血管病变的靶向治疗药物
WO2021205032A1 (en) 2020-04-09 2021-10-14 Technische Universität München Targeted delivery of an inhibitor of mir-21 to macrophages for the treatment of pulmonary fibrosis
WO2021262919A2 (en) 2020-06-26 2021-12-30 The Research Foundation For The State University Of New York 5-halouracil-modified micrornas and their use in the treatment of cancer
US20230302139A1 (en) * 2020-07-31 2023-09-28 University Of Florida Research Foundation, Incorporated Targeted rna degradation allows precision repurposing of protein-targeted small molecule medicines to rna
EP4301856A2 (en) * 2021-03-05 2024-01-10 ProQR Therapeutics II B.V. Antisense oligonucleotides for use in the treatment of corneal dystrophies
KR102549208B1 (ko) * 2021-04-08 2023-06-30 연세대학교 산학협력단 심혈관 질환과 관련된 LncRNA 및 이의 용도
CN118667869B (zh) * 2024-07-10 2025-06-27 中国水稻研究所 水稻氮素利用基因nu4在调控水稻生长中的应用

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JP2006519008A (ja) * 2003-02-10 2006-08-24 独立行政法人産業技術総合研究所 哺乳動物細胞の調節
ATE443765T1 (de) 2003-03-21 2009-10-15 Santaris Pharma As Analoga kurzer interferierender rna (sirna)
WO2005049022A2 (en) * 2003-11-17 2005-06-02 Novartis Ag Use of dipeptidyl peptidase iv inhibitors
JP5697297B2 (ja) 2004-05-14 2015-04-08 ロゼッタ ジノミクス リミテッド マイクロｎａｓおよびその使用
WO2006053014A2 (en) * 2004-11-09 2006-05-18 Baylor College Of Medicine Selective inhibition of rock1 in cardiac therapy
US20070213292A1 (en) * 2005-08-10 2007-09-13 The Rockefeller University Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof
EP2007888A2 (en) 2006-04-03 2008-12-31 Santaris Pharma A/S Pharmaceutical composition comprising anti-mirna antisense oligonucleotides
EP2208798B1 (de) 2006-10-09 2013-08-07 Medizinische Hochschule Hannover MicroRNA (miRNA) zur Diagnose und Therapie von Herzerkrankungen
AU2007333107A1 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. miR-21 regulated genes and pathways as targets for therapeutic intervention
WO2009058818A2 (en) 2007-10-29 2009-05-07 The Board Of Regents Of The University Of Texas System Compositions comprising a micro-rna and methods of their use in regulating cardiac remodeling
EP2096171A1 (en) 2008-02-27 2009-09-02 Julius-Maximilians-Universität Würzburg MicroRNA (miRNA) and down-stream targets for diagnostic and therapeutic purposes

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