JP2011501952A - 脂質障害およびコレステロール障害を治療するための抗ｐｃｓｋ９および方法 - Google Patents

脂質障害およびコレステロール障害を治療するための抗ｐｃｓｋ９および方法 Download PDF

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JP2011501952A
JP2011501952A JP2010531314A JP2010531314A JP2011501952A JP 2011501952 A JP2011501952 A JP 2011501952A JP 2010531314 A JP2010531314 A JP 2010531314A JP 2010531314 A JP2010531314 A JP 2010531314A JP 2011501952 A JP2011501952 A JP 2011501952A
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hydrochloride
antibody
amino acid
acid sequence
seq
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ジョセフ エー． ヘドリック，
フレデリック ジェイムス ジュニア モンスマ，
タティアナ チャラコバ，
ダイアン ホーレンバーグ，
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Merck Sharp and Dohme LLC
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Schering Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2010531314A 2007-10-26 2008-10-27 脂質障害およびコレステロール障害を治療するための抗ｐｃｓｋ９および方法 Pending JP2011501952A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98292207P 2007-10-26 2007-10-26
PCT/US2008/081311 WO2009055783A2 (en) 2007-10-26 2008-10-27 Anti-pcsk9 and methods for treating lipid and cholesterol disorders

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JP2012284770A Division JP5692867B2 (ja) 2007-10-26 2012-12-27 脂質障害およびコレステロール障害を治療するための抗ｐｃｓｋ９および方法
JP2013147578A Division JP2013213057A (ja) 2007-10-26 2013-07-16 脂質障害およびコレステロール障害を治療するための抗ｐｃｓｋ９および方法

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JP2011501952A true JP2011501952A (ja) 2011-01-20

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JP2010531314A Pending JP2011501952A (ja) 2007-10-26 2008-10-27 脂質障害およびコレステロール障害を治療するための抗ｐｃｓｋ９および方法
JP2012284770A Expired - Fee Related JP5692867B2 (ja) 2007-10-26 2012-12-27 脂質障害およびコレステロール障害を治療するための抗ｐｃｓｋ９および方法
JP2013147578A Pending JP2013213057A (ja) 2007-10-26 2013-07-16 脂質障害およびコレステロール障害を治療するための抗ｐｃｓｋ９および方法

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JP2013147578A Pending JP2013213057A (ja) 2007-10-26 2013-07-16 脂質障害およびコレステロール障害を治療するための抗ｐｃｓｋ９および方法

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US (2) US8598320B2 (enExample)
EP (1) EP2205639B1 (enExample)
JP (3) JP2011501952A (enExample)
KR (1) KR20100091191A (enExample)
CN (1) CN102232088A (enExample)
AU (1) AU2008316587B2 (enExample)
BR (1) BRPI0818765A8 (enExample)
CA (1) CA2703712A1 (enExample)
IL (1) IL205323A0 (enExample)
MX (1) MX2010004454A (enExample)
NZ (1) NZ584902A (enExample)
SG (2) SG188814A1 (enExample)
WO (1) WO2009055783A2 (enExample)

Cited By (12)

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JP2014508142A (ja) * 2011-01-28 2014-04-03 サノフイ Ｐｃｓｋ９に対するヒト抗体を含んでなる医薬組成物
JP2014530188A (ja) * 2011-09-16 2014-11-17 イーライ リリー アンド カンパニー Ｐｃｓｋ９に対する抗体およびその使用
JP2015503905A (ja) * 2011-12-20 2015-02-05 アダエラータ、リミテッド パートナーシップＡｄａｅｒａｔａ， Ｌｉｍｉｔｅｄ Ｐａｒｔｎｅｒｓｈｉｐ Ｐｃｓｋ９の阻害剤としての単一ドメイン抗体
JP2015519050A (ja) * 2012-05-08 2015-07-09 アルダーバイオ・ホールディングズ・エルエルシー 抗ｐｃｓｋ９抗体およびその使用
JP2016528193A (ja) * 2013-06-28 2016-09-15 アムジエン・インコーポレーテツド ホモ接合性家族性高コレステロール血症の治療方法
JP2018076351A (ja) * 2017-12-21 2018-05-17 アムジエン・インコーポレーテツド ホモ接合性家族性高コレステロール血症の治療方法
JP2022518016A (ja) * 2019-01-18 2022-03-11 アストラゼネカ・アクチエボラーグ Ｐｃｓｋ９阻害剤及びその使用方法
JP2022518015A (ja) * 2019-01-18 2022-03-11 アストラゼネカ・アクチエボラーグ Ｐｃｓｋ９阻害剤及びその使用方法
US11306155B2 (en) 2014-07-16 2022-04-19 Sanofi Biotechnology Methods for treating patients with heterozygous familial hypercholesterolemia (heFH) with an anti-PCSK9 antibody
US11673967B2 (en) 2011-07-28 2023-06-13 Regeneron Pharmaceuticals, Inc. Stabilized formulations containing anti-PCSK9 antibodies
US11904017B2 (en) 2015-08-18 2024-02-20 Regeneron Pharmaceuticals, Inc. Methods for reducing or eliminating the need for lipoprotein apheresis in patients with hyperlipidemia by administering alirocumab
US12269897B2 (en) 2008-12-15 2025-04-08 Regeneron Pharmaceuticals, Inc. Anti-PCSK9 antibodies

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