JP2011501942A5 - - Google Patents
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- Publication number
- JP2011501942A5 JP2011501942A5 JP2010528317A JP2010528317A JP2011501942A5 JP 2011501942 A5 JP2011501942 A5 JP 2011501942A5 JP 2010528317 A JP2010528317 A JP 2010528317A JP 2010528317 A JP2010528317 A JP 2010528317A JP 2011501942 A5 JP2011501942 A5 JP 2011501942A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- amino acid
- terminus
- acid position
- polypeptide fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99839807P | 2007-10-09 | 2007-10-09 | |
| US60/998,398 | 2007-10-09 | ||
| US7079208P | 2008-03-25 | 2008-03-25 | |
| US61/070,792 | 2008-03-25 | ||
| US12345608P | 2008-04-08 | 2008-04-08 | |
| US61/123,456 | 2008-04-08 | ||
| PCT/EP2008/008543 WO2009046983A1 (en) | 2007-10-09 | 2008-10-09 | Soluble fragments of influenza virus pb2 protein capable of binding rna-cap |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014207447A Division JP5937169B2 (ja) | 2007-10-09 | 2014-10-08 | 可溶性ｒｎａキャップ結合ポケット断片、及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011501942A JP2011501942A (ja) | 2011-01-20 |
| JP2011501942A5 true JP2011501942A5 (https=) | 2012-09-27 |
| JP5725861B2 JP5725861B2 (ja) | 2015-05-27 |
Family
ID=40364724
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010528317A Expired - Fee Related JP5725861B2 (ja) | 2007-10-09 | 2008-10-09 | 可溶性ｒｎａキャップ結合ポケット断片、及びその使用 |
| JP2014207447A Expired - Fee Related JP5937169B2 (ja) | 2007-10-09 | 2014-10-08 | 可溶性ｒｎａキャップ結合ポケット断片、及びその使用 |
| JP2016094331A Expired - Fee Related JP6309563B2 (ja) | 2007-10-09 | 2016-05-10 | 可溶性ｒｎａキャップ結合ポケット断片、及びその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014207447A Expired - Fee Related JP5937169B2 (ja) | 2007-10-09 | 2014-10-08 | 可溶性ｒｎａキャップ結合ポケット断片、及びその使用 |
| JP2016094331A Expired - Fee Related JP6309563B2 (ja) | 2007-10-09 | 2016-05-10 | 可溶性ｒｎａキャップ結合ポケット断片、及びその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9045248B2 (https=) |
| EP (2) | EP2197901B1 (https=) |
| JP (3) | JP5725861B2 (https=) |
| KR (1) | KR101672554B1 (https=) |
| CN (1) | CN101970465B (https=) |
| AU (1) | AU2008309939B2 (https=) |
| CA (1) | CA2701362A1 (https=) |
| ES (1) | ES2454773T3 (https=) |
| IL (3) | IL204891A (https=) |
| SG (1) | SG185289A1 (https=) |
| WO (1) | WO2009046983A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2197901B1 (en) * | 2007-10-09 | 2013-12-11 | European Molecular Biology Laboratory (Embl) | Soluble fragments of influenza virus pb2 protein capable of binding rna-cap |
| LT3141252T (lt) | 2009-06-17 | 2018-11-12 | Vertex Pharmaceuticals Inc. | Gripo virusų replikacijos inhibitoriai |
| KR20130075726A (ko) * | 2010-03-16 | 2013-07-05 | 유럽피안 몰레큘러 바이올로지 래보러토리 | 유행성 인플루엔자 바이러스 ａ 2009 ｈ1ｎ1로부터의 ｒｎａ 의존성 ｒｎａ 폴리머라제의 ｐａ 아단위의 단편 및 이의 용도 |
| RU2013132681A (ru) | 2010-12-16 | 2015-01-27 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы репликации вирусов гриппа |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| HK1209140A1 (en) * | 2012-07-19 | 2016-03-24 | Zoetis Services Llc | Bovine influenza c virus compositions |
| JP6618901B2 (ja) | 2013-11-13 | 2019-12-11 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | インフルエンザウイルスの複製の阻害剤を調製する方法 |
| LT3068776T (lt) | 2013-11-13 | 2019-08-12 | Vertex Pharmaceuticals Incorporated | Gripo virusų replikacijos inhibitoriai |
| CN105018441A (zh) * | 2014-04-22 | 2015-11-04 | 中国科学院生物物理研究所 | 流感病毒rna聚合酶结晶的方法 |
| CN105002149B (zh) * | 2014-04-22 | 2018-04-06 | 中国科学院生物物理研究所 | 流感病毒rna聚合酶纯化或结晶的方法 |
| EP3294717B1 (en) | 2015-05-13 | 2020-07-29 | Vertex Pharmaceuticals Inc. | Methods of preparing inhibitors of influenza viruses replication |
| EP3294735B8 (en) | 2015-05-13 | 2022-01-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| CN107286044B (zh) | 2016-04-13 | 2021-07-13 | 香港神农有限公司 | 一种能够抑制流感病毒pb2蛋白与rna帽结合的化合物 |
| CL2018003871A1 (es) * | 2018-12-28 | 2021-01-15 | Univ Pontificia Catolica Chile | Anticuerpos monoclonales específicos para el antígeno pb2 del virus de la influenza humana (flu), secuencias nucleotídicas; método y kit de diagnóstico de infección producida por flu |
| WO2020239822A1 (en) | 2019-05-27 | 2020-12-03 | The European Molecular Biology Laboratory | Nucleic acid construct binding to influenza polymerase pb1 rna synthesis active site |
| CN113122596B (zh) * | 2020-08-20 | 2023-01-24 | 深圳市瑞吉生物科技有限公司 | 一种Cap2结构5′帽子类似物及其制备方法和应用 |
| CN114741315B (zh) * | 2022-04-28 | 2023-06-13 | 深圳市紫光同创电子有限公司 | 用例更新方法、装置、电子设备及存储介质 |
| CN116024301B (zh) * | 2023-01-16 | 2025-10-28 | 北京协同创新研究院 | 一种rna依赖性rna聚合酶截短体的筛选方法、截短体及应用 |
| WO2025055169A1 (en) * | 2023-09-12 | 2025-03-20 | The Chinese University Of Hong Kong | A fluorescent probe to measure rna binding and elongation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5837852A (en) * | 1993-10-14 | 1998-11-17 | Bristol-Myers Squibb Company | Capped nucleic acid oligomers that inhibit cap-dependent transcription of the influenza virus endonuclease |
| EP2197901B1 (en) | 2007-10-09 | 2013-12-11 | European Molecular Biology Laboratory (Embl) | Soluble fragments of influenza virus pb2 protein capable of binding rna-cap |
| JP6614523B2 (ja) * | 2014-03-28 | 2019-12-04 | 地方独立行政法人神奈川県立産業技術総合研究所 | インフルエンザウイルスのｒｎａ依存性ｒｎａポリメラーゼのｐｂ２サブユニットに対するモノクローナル抗体 |
-
2008
- 2008-10-09 EP EP08838119.9A patent/EP2197901B1/en not_active Not-in-force
- 2008-10-09 KR KR1020107008765A patent/KR101672554B1/ko not_active Expired - Fee Related
- 2008-10-09 EP EP12175945.0A patent/EP2574619A3/en not_active Withdrawn
- 2008-10-09 US US12/681,974 patent/US9045248B2/en not_active Expired - Fee Related
- 2008-10-09 AU AU2008309939A patent/AU2008309939B2/en not_active Ceased
- 2008-10-09 CA CA2701362A patent/CA2701362A1/en not_active Abandoned
- 2008-10-09 WO PCT/EP2008/008543 patent/WO2009046983A1/en not_active Ceased
- 2008-10-09 JP JP2010528317A patent/JP5725861B2/ja not_active Expired - Fee Related
- 2008-10-09 SG SG2012075354A patent/SG185289A1/en unknown
- 2008-10-09 ES ES08838119.9T patent/ES2454773T3/es active Active
- 2008-10-09 CN CN200880119968.9A patent/CN101970465B/zh not_active Expired - Fee Related
-
2010
- 2010-04-06 IL IL204891A patent/IL204891A/en not_active IP Right Cessation
-
2012
- 2012-11-12 IL IL222997A patent/IL222997A0/en unknown
-
2014
- 2014-10-08 JP JP2014207447A patent/JP5937169B2/ja not_active Expired - Fee Related
-
2015
- 2015-03-23 IL IL237903A patent/IL237903A/en not_active IP Right Cessation
-
2016
- 2016-05-10 JP JP2016094331A patent/JP6309563B2/ja not_active Expired - Fee Related
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