JP2011501755A5 - - Google Patents
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- Publication number
- JP2011501755A5 JP2011501755A5 JP2010530290A JP2010530290A JP2011501755A5 JP 2011501755 A5 JP2011501755 A5 JP 2011501755A5 JP 2010530290 A JP2010530290 A JP 2010530290A JP 2010530290 A JP2010530290 A JP 2010530290A JP 2011501755 A5 JP2011501755 A5 JP 2011501755A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- acid
- rooibos
- rooibos extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 11
- 240000006914 Aspalathus linearis Species 0.000 claims 6
- 244000286893 Aspalathus contaminatus Species 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims 2
- 208000012902 Nervous system disease Diseases 0.000 claims 2
- 208000025966 Neurological disease Diseases 0.000 claims 2
- 210000003169 central nervous system Anatomy 0.000 claims 2
- 238000013375 chromatographic separation Methods 0.000 claims 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000000926 neurological effect Effects 0.000 claims 2
- 208000020016 psychiatric disease Diseases 0.000 claims 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 2
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- AAWZDTNXLSGCEK-LNVDRNJUSA-N (3r,5r)-1,3,4,5-tetrahydroxycyclohexane-1-carboxylic acid Chemical compound O[C@@H]1CC(O)(C(O)=O)C[C@@H](O)C1O AAWZDTNXLSGCEK-LNVDRNJUSA-N 0.000 claims 1
- ACEAELOMUCBPJP-UHFFFAOYSA-N (E)-3,4,5-trihydroxycinnamic acid Natural products OC(=O)C=CC1=CC(O)=C(O)C(O)=C1 ACEAELOMUCBPJP-UHFFFAOYSA-N 0.000 claims 1
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 claims 1
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims 1
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 claims 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims 1
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 claims 1
- AAWZDTNXLSGCEK-UHFFFAOYSA-N Cordycepinsaeure Natural products OC1CC(O)(C(O)=O)CC(O)C1O AAWZDTNXLSGCEK-UHFFFAOYSA-N 0.000 claims 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- AAWZDTNXLSGCEK-ZHQZDSKASA-N Quinic acid Natural products O[C@H]1CC(O)(C(O)=O)C[C@H](O)C1O AAWZDTNXLSGCEK-ZHQZDSKASA-N 0.000 claims 1
- 206010039966 Senile dementia Diseases 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- 125000003158 alcohol group Chemical group 0.000 claims 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims 1
- 235000004883 caffeic acid Nutrition 0.000 claims 1
- 229940074360 caffeic acid Drugs 0.000 claims 1
- 208000015114 central nervous system disease Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000001368 chlorogenic acid Nutrition 0.000 claims 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 claims 1
- 229940074393 chlorogenic acid Drugs 0.000 claims 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 claims 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 claims 1
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Natural products OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 235000001785 ferulic acid Nutrition 0.000 claims 1
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 claims 1
- 229940114124 ferulic acid Drugs 0.000 claims 1
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 claims 1
- 229930003935 flavonoid Natural products 0.000 claims 1
- 150000002215 flavonoids Chemical class 0.000 claims 1
- 235000017173 flavonoids Nutrition 0.000 claims 1
- 235000019253 formic acid Nutrition 0.000 claims 1
- 239000000174 gluconic acid Substances 0.000 claims 1
- 229950006191 gluconic acid Drugs 0.000 claims 1
- 235000012208 gluconic acid Nutrition 0.000 claims 1
- 238000000227 grinding Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 235000019260 propionic acid Nutrition 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000001542 size-exclusion chromatography Methods 0.000 claims 1
- 239000001384 succinic acid Substances 0.000 claims 1
- 239000013589 supplement Substances 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07020728A EP2053050B1 (de) | 2007-10-23 | 2007-10-23 | Aspalathin-ähnliches Dihydrochalcon und Verfahren zur Herstellung |
| EP07020728.7 | 2007-10-23 | ||
| PCT/EP2008/007279 WO2009052895A1 (de) | 2007-10-23 | 2008-09-05 | Aspalathin-ähnliches dihydrochalcon, extrakte aus unfermentiertem rotbusch und verfahren zur herstellung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011501755A JP2011501755A (ja) | 2011-01-13 |
| JP2011501755A5 true JP2011501755A5 (enExample) | 2011-09-29 |
| JP5527900B2 JP5527900B2 (ja) | 2014-06-25 |
Family
ID=38805677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010530290A Expired - Fee Related JP5527900B2 (ja) | 2007-10-23 | 2008-09-05 | アスパラチン様ジヒドロカルコン、未発酵ルイボスからの抽出物およびその調製方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20100222423A1 (enExample) |
| EP (2) | EP2053050B1 (enExample) |
| JP (1) | JP5527900B2 (enExample) |
| AT (2) | ATE522524T1 (enExample) |
| DK (2) | DK2053050T3 (enExample) |
| ES (2) | ES2372203T3 (enExample) |
| HR (1) | HRP20110890T4 (enExample) |
| PL (2) | PL2053050T3 (enExample) |
| PT (2) | PT2053050E (enExample) |
| WO (1) | WO2009052895A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010520913A (ja) | 2007-03-12 | 2010-06-17 | サズセ アーペーエス | ルイボスの抗糖尿病性抽出物 |
| JP6797408B2 (ja) | 2014-11-06 | 2020-12-09 | 国立大学法人 長崎大学 | 新規アルツハイマー病治療薬 |
| JP6735224B2 (ja) | 2016-01-28 | 2020-08-05 | 花王株式会社 | アストロサイトのグルコース代謝活性化剤 |
| JP7244273B2 (ja) * | 2018-12-27 | 2023-03-22 | 株式会社 伊藤園 | ルイボス茶飲料の製造方法 |
| CN109932448A (zh) * | 2019-03-29 | 2019-06-25 | 完美（广东）日用品有限公司 | 一种线叶金雀花及其制品中有效成分的含量测定方法 |
| CN115104730A (zh) * | 2022-06-28 | 2022-09-27 | 北京姿美堂生物技术股份有限公司 | 一种改善睡眠的组合物、线叶金雀花-芦笋睡眠改善液、茶粉的制备方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2895298B2 (ja) * | 1991-12-27 | 1999-05-24 | 株式会社ユニエ | 活性酸素消去・除去剤 |
| JPH05246866A (ja) * | 1992-03-06 | 1993-09-24 | Ruibosuteii Japan:Kk | 脳代謝促進・脳機能改善剤 |
| JPH11116429A (ja) † | 1997-10-13 | 1999-04-27 | Mikimoto Pharmaceut Co Ltd | 化粧品原料および化粧品 |
| JP2001316239A (ja) * | 2000-05-10 | 2001-11-13 | Mikimoto Pharmaceut Co Ltd | 皮膚外用剤 |
| KR100421233B1 (ko) * | 2001-09-10 | 2004-03-11 | 한국원자력연구소 | 식품, 의약품 및 화장품 제조용 천연물의 색도 개선 방법 및 이의 방법에 의해 색도가 개선된 천연물 추출물 |
| ZA200303674B (en) * | 2002-02-20 | 2005-04-26 | Benedict Technology Holdings P | Antioxidant composition. |
| JP4637491B2 (ja) * | 2004-03-01 | 2011-02-23 | 株式会社東洋発酵 | 抗アレルギー用組成物 |
| DE102004052800B4 (de) * | 2004-10-30 | 2017-02-23 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Verbesserte Trägerformulierungen |
| DE102005004438B4 (de) * | 2005-01-31 | 2007-12-20 | Raps Gmbh & Co. Kg | Rooibos-Extrakt mit erhöhtem Aspalathingehalt, Verfahren zur Herstellung eines solchen Rooibos-Extraktes und kosmetisches Mittel enthaltend einen solchen Rooibos-Extrakt |
| JP2007161661A (ja) * | 2005-12-15 | 2007-06-28 | Pola Chem Ind Inc | アドバンスド・グリケーション・エンドプロダクツを分解するための化粧料とその製造法 |
| JP2010520913A (ja) † | 2007-03-12 | 2010-06-17 | サズセ アーペーエス | ルイボスの抗糖尿病性抽出物 |
-
2007
- 2007-10-23 PL PL07020728T patent/PL2053050T3/pl unknown
- 2007-10-23 AT AT07020728T patent/ATE522524T1/de active
- 2007-10-23 DK DK07020728.7T patent/DK2053050T3/da active
- 2007-10-23 EP EP07020728A patent/EP2053050B1/de not_active Not-in-force
- 2007-10-23 ES ES07020728T patent/ES2372203T3/es active Active
- 2007-10-23 PT PT07020728T patent/PT2053050E/pt unknown
-
2008
- 2008-09-05 EP EP08801873.4A patent/EP2069334B2/de not_active Not-in-force
- 2008-09-05 PL PL08801873T patent/PL2069334T5/pl unknown
- 2008-09-05 WO PCT/EP2008/007279 patent/WO2009052895A1/de not_active Ceased
- 2008-09-05 AT AT08801873T patent/ATE533763T1/de active
- 2008-09-05 DK DK08801873.4T patent/DK2069334T4/da active
- 2008-09-05 HR HRP20110890AT patent/HRP20110890T4/hr unknown
- 2008-09-05 PT PT08801873T patent/PT2069334E/pt unknown
- 2008-09-05 JP JP2010530290A patent/JP5527900B2/ja not_active Expired - Fee Related
- 2008-09-05 ES ES08801873.4T patent/ES2373509T5/es active Active
- 2008-09-05 US US12/739,280 patent/US20100222423A1/en not_active Abandoned
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