JP2011500737A - レスベラトロルおよびペクチンを含有する組成物 - Google Patents
レスベラトロルおよびペクチンを含有する組成物 Download PDFInfo
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- JP2011500737A JP2011500737A JP2010530301A JP2010530301A JP2011500737A JP 2011500737 A JP2011500737 A JP 2011500737A JP 2010530301 A JP2010530301 A JP 2010530301A JP 2010530301 A JP2010530301 A JP 2010530301A JP 2011500737 A JP2011500737 A JP 2011500737A
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- pectin
- composition
- resveratrol
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- Prior art date
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- Granted
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Images
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Abstract
Description
少なくとも95%の粒子は、≦1500μm(好ましくは≦1000μm、より好ましくは≦850μm)の大きさを有するが、多くても35%の粒子は、≦50μm(好ましくは≦100μm、より好ましくは≦150μm)の大きさを有する。
少なくとも95%の粒子は、10μm〜1500μmの範囲(好ましくは10μm〜1000μmの範囲、より好ましくは10μm〜850μmの範囲)の大きさを有するが、多くても35%の粒子は、10μm〜50μmの範囲(好ましくは10μm〜100μmの範囲、より好ましくは10μm〜150μmの範囲)の大きさを有する。
長さ(L):200〜800μm
厚さ(D):5〜100μm
形状因子(L/D):5〜30。
本発明の組成物は、それ自体既知のいずれかの粉末または顆粒の製造方法によって製造されてもよい。好ましい方法は、流動床造粒、高剪断造粒、押出成形、噴霧乾燥および湿式造粒である。本発明は、それらの方法による本発明の組成物の製造方法にも関する。
[実施例1]
796gのレスベラトロルと4gのAerosil 200とを室温で4リットルのDiosna高剪断容器に入れる。インペラーを500rpmで運転しながら、混合物を10分間攪拌し、さらに10分間、1000rpmでインペラーを運転しながら攪拌する。生成物を取り出し、600μmのふるいに通す。
300gのレスベラトロル(製粉せず)をDMR流動床容器に入れ、60℃で30m3/時間の空気を用いる。流動化は得られない。2.5%溶液を噴霧すると、壁上に生成物が固着する。所望の顆粒は得られない。
Claims (14)
- レスベラトロルおよびペクチンを含んでなる組成物。
- 粉末または顆粒の形態であるということを特徴とする請求項1に記載の組成物。
- ペクチンの量が、組成物の全重量に基づき、0.1%〜15重量%、好ましくは0.5%〜7重量%、より好ましくは1.5%〜5重量%の範囲である請求項1または2に記載の組成物。
- 1種以上のフロー調整剤をさらに含有することを特徴とする請求項1〜3のいずれか一項に記載の組成物。
- フロー調整剤(1種以上の化合物)の量が、組成物の全重量に基づき、0.1〜1重量%の範囲であることを特徴とする請求項4に記載の組成物。
- 請求項1〜5のいずれか一項に記載の組成物の製造方法であって、スラリーの全重量に基づき、好ましくは10〜70重量%の固形分を有するレスベラトロルおよびペクチンのスラリーを調製する工程と、それ自体既知の方法でスラリーを噴霧乾燥する工程とを含んでなる方法。
- 請求項1〜5のいずれか一項に記載の組成物の製造方法であって、噴霧器手段を取り付けた流動床乾燥デバイス内で、空気または不活性気体で流動化されるレスベラトロルの流動床を形成することと、所望の顆粒または粉末が得られるまで、ペクチンの水溶液を、霧化された霧の形態で、流動化された粒子上に噴霧することとを含んでなる方法。
- 請求項1〜5のいずれか一項に記載の組成物の製造方法であって、噴霧器手段を取り付けた流動床乾燥デバイス内で、ペクチンと一緒に、空気または不活性気体で流動化されるレスベラトロルの流動床を形成することと、所望の顆粒または粉末が得られるまで、水を、霧化された霧の形態で、流動化された粒子上に噴霧することとを含んでなる方法。
- 流動化工程の前に製粉工程を含んでなることを特徴とする請求項7または8に記載の方法。
- 流動床を形成する前に、1種以上のフロー調整剤を組成物に添加することを特徴とする請求項7〜9のいずれか一項に記載の方法。
- 請求項1〜5のいずれか一項に記載の組成物をベースとする剤形。
- タブレットである請求項11に記載の剤形。
- 請求項1〜5のいずれか一項に記載の組成物を含んでなる食事、医薬品およびパーソナルケア組成物。
- レスベラトロルを含有する粉末の流動性を改善するためのペクチンの使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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EP07021099.2 | 2007-10-29 | ||
EP07021099 | 2007-10-29 | ||
PCT/EP2008/008561 WO2009056212A1 (en) | 2007-10-29 | 2008-10-10 | Compositions containing resveratrol and pectin |
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JP2011500737A true JP2011500737A (ja) | 2011-01-06 |
JP5453693B2 JP5453693B2 (ja) | 2014-03-26 |
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JP2010530301A Active JP5453693B2 (ja) | 2007-10-29 | 2008-10-10 | レスベラトロルおよびペクチンを含有する組成物 |
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US (1) | US8535724B2 (ja) |
EP (1) | EP2214655A1 (ja) |
JP (1) | JP5453693B2 (ja) |
KR (1) | KR20100075960A (ja) |
CN (1) | CN101842091A (ja) |
WO (1) | WO2009056212A1 (ja) |
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US8535724B2 (en) | 2007-10-29 | 2013-09-17 | Dsm Ip Assets B.V. | Compositions containing resveratrol and pectin |
BR112015015272A2 (pt) * | 2013-04-18 | 2017-07-11 | Hershey Co | comestível contendo demulcente finamente moído |
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- 2008-10-10 US US12/740,154 patent/US8535724B2/en active Active
- 2008-10-10 CN CN200880114091A patent/CN101842091A/zh active Pending
- 2008-10-10 KR KR1020107009054A patent/KR20100075960A/ko not_active Application Discontinuation
- 2008-10-10 EP EP08844209A patent/EP2214655A1/en not_active Withdrawn
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Publication number | Publication date |
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US8535724B2 (en) | 2013-09-17 |
US20110039945A1 (en) | 2011-02-17 |
EP2214655A1 (en) | 2010-08-11 |
CN101842091A (zh) | 2010-09-22 |
JP5453693B2 (ja) | 2014-03-26 |
KR20100075960A (ko) | 2010-07-05 |
WO2009056212A1 (en) | 2009-05-07 |
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