JP2011224018A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011224018A5 JP2011224018A5 JP2011171887A JP2011171887A JP2011224018A5 JP 2011224018 A5 JP2011224018 A5 JP 2011224018A5 JP 2011171887 A JP2011171887 A JP 2011171887A JP 2011171887 A JP2011171887 A JP 2011171887A JP 2011224018 A5 JP2011224018 A5 JP 2011224018A5
- Authority
- JP
- Japan
- Prior art keywords
- receptor
- receptor mutant
- mutant
- leu
- ala
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims 22
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims 22
- 102000005962 receptors Human genes 0.000 claims 13
- 108020003175 receptors Proteins 0.000 claims 13
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 5
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 4
- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 claims 4
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 claims 4
- 102000017922 Neurotensin receptor Human genes 0.000 claims 4
- 102000012740 beta Adrenergic Receptors Human genes 0.000 claims 4
- 108010079452 beta Adrenergic Receptors Proteins 0.000 claims 4
- -1 such as an antibody Proteins 0.000 claims 4
- 102000009346 Adenosine receptors Human genes 0.000 claims 3
- 108050000203 Adenosine receptors Proteins 0.000 claims 3
- 239000000556 agonist Substances 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- GJLXVWOMRRWCIB-MERZOTPQSA-N (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanamide Chemical compound C([C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)C1=CC=C(O)C=C1 GJLXVWOMRRWCIB-MERZOTPQSA-N 0.000 claims 2
- 108060003345 Adrenergic Receptor Proteins 0.000 claims 2
- 102000017910 Adrenergic receptor Human genes 0.000 claims 2
- 102000018208 Cannabinoid Receptor Human genes 0.000 claims 2
- 108050007331 Cannabinoid receptor Proteins 0.000 claims 2
- 101000783751 Homo sapiens Adenosine receptor A2a Proteins 0.000 claims 2
- 108060003370 Neurotensin receptor Proteins 0.000 claims 2
- 101500028886 Rattus norvegicus Neurotensin Proteins 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 102000055905 human ADORA2A Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000040125 5-hydroxytryptamine receptor family Human genes 0.000 claims 1
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 claims 1
- 108091008803 APLNR Proteins 0.000 claims 1
- 102000008873 Angiotensin II receptor Human genes 0.000 claims 1
- 108050000824 Angiotensin II receptor Proteins 0.000 claims 1
- 102000008102 Ankyrins Human genes 0.000 claims 1
- 108010049777 Ankyrins Proteins 0.000 claims 1
- 102000016555 Apelin receptors Human genes 0.000 claims 1
- 102000003916 Arrestin Human genes 0.000 claims 1
- 108090000328 Arrestin Proteins 0.000 claims 1
- 108070000005 Bile acid receptors Proteins 0.000 claims 1
- 102000017002 Bile acid receptors Human genes 0.000 claims 1
- 108010073466 Bombesin Receptors Proteins 0.000 claims 1
- 102000010183 Bradykinin receptor Human genes 0.000 claims 1
- 108050001736 Bradykinin receptor Proteins 0.000 claims 1
- 108010001789 Calcitonin Receptors Proteins 0.000 claims 1
- 102100038520 Calcitonin receptor Human genes 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 102000009410 Chemokine receptor Human genes 0.000 claims 1
- 108050000299 Chemokine receptor Proteins 0.000 claims 1
- 102000004859 Cholecystokinin Receptors Human genes 0.000 claims 1
- 108090001085 Cholecystokinin Receptors Proteins 0.000 claims 1
- 102400000739 Corticotropin Human genes 0.000 claims 1
- 101800000414 Corticotropin Proteins 0.000 claims 1
- 102000015554 Dopamine receptor Human genes 0.000 claims 1
- 108050004812 Dopamine receptor Proteins 0.000 claims 1
- 102000010180 Endothelin receptor Human genes 0.000 claims 1
- 108050001739 Endothelin receptor Proteins 0.000 claims 1
- 102000016359 Fibronectins Human genes 0.000 claims 1
- 108010067306 Fibronectins Proteins 0.000 claims 1
- 108070000009 Free fatty acid receptors Proteins 0.000 claims 1
- 102000005915 GABA Receptors Human genes 0.000 claims 1
- 108010005551 GABA Receptors Proteins 0.000 claims 1
- 102000008924 GPCR kinases Human genes 0.000 claims 1
- 108050000878 GPCR kinases Proteins 0.000 claims 1
- 102000011392 Galanin receptor Human genes 0.000 claims 1
- 108050001605 Galanin receptor Proteins 0.000 claims 1
- 108010016122 Ghrelin Receptors Proteins 0.000 claims 1
- 108010063919 Glucagon Receptors Proteins 0.000 claims 1
- 102100040890 Glucagon receptor Human genes 0.000 claims 1
- 102000017357 Glycoprotein hormone receptor Human genes 0.000 claims 1
- 108050005395 Glycoprotein hormone receptor Proteins 0.000 claims 1
- 102100039256 Growth hormone secretagogue receptor type 1 Human genes 0.000 claims 1
- 102000000543 Histamine Receptors Human genes 0.000 claims 1
- 108010002059 Histamine Receptors Proteins 0.000 claims 1
- 101001060451 Homo sapiens Pyroglutamylated RF-amide peptide receptor Proteins 0.000 claims 1
- 102100030643 Hydroxycarboxylic acid receptor 2 Human genes 0.000 claims 1
- 101710125793 Hydroxycarboxylic acid receptor 2 Proteins 0.000 claims 1
- 101150020170 KISS1R gene Proteins 0.000 claims 1
- 108010093008 Kinins Proteins 0.000 claims 1
- 102000002397 Kinins Human genes 0.000 claims 1
- 102000008238 LHRH Receptors Human genes 0.000 claims 1
- 108010021290 LHRH Receptors Proteins 0.000 claims 1
- 102000016994 Lysolipids receptors Human genes 0.000 claims 1
- 108070000013 Lysolipids receptors Proteins 0.000 claims 1
- 102000029828 Melanin-concentrating hormone receptor Human genes 0.000 claims 1
- 108010047068 Melanin-concentrating hormone receptor Proteins 0.000 claims 1
- 102000004378 Melanocortin Receptors Human genes 0.000 claims 1
- 108090000950 Melanocortin Receptors Proteins 0.000 claims 1
- 108050009605 Melatonin receptor Proteins 0.000 claims 1
- 102000001419 Melatonin receptor Human genes 0.000 claims 1
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 claims 1
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 claims 1
- 102100033818 Motilin receptor Human genes 0.000 claims 1
- 108700040483 Motilin receptors Proteins 0.000 claims 1
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 claims 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 claims 1
- 102100021126 N-formyl peptide receptor 2 Human genes 0.000 claims 1
- 101710091942 N-formyl peptide receptor 2 Proteins 0.000 claims 1
- 102000030937 Neuromedin U receptor Human genes 0.000 claims 1
- 108010002741 Neuromedin U receptor Proteins 0.000 claims 1
- 101800001814 Neurotensin Proteins 0.000 claims 1
- 102400001103 Neurotensin Human genes 0.000 claims 1
- 102000003840 Opioid Receptors Human genes 0.000 claims 1
- 108090000137 Opioid Receptors Proteins 0.000 claims 1
- 108050000742 Orexin Receptor Proteins 0.000 claims 1
- 102000008834 Orexin receptor Human genes 0.000 claims 1
- 108010064032 Pituitary Adenylate Cyclase-Activating Polypeptide Receptors Proteins 0.000 claims 1
- 102000014743 Pituitary Adenylate Cyclase-Activating Polypeptide Receptors Human genes 0.000 claims 1
- 108700023400 Platelet-activating factor receptors Proteins 0.000 claims 1
- 108070000023 Prokineticin receptors Proteins 0.000 claims 1
- 102000056271 Prolactin-releasing peptide receptors Human genes 0.000 claims 1
- 108700024163 Prolactin-releasing peptide receptors Proteins 0.000 claims 1
- 102000002020 Protease-activated receptors Human genes 0.000 claims 1
- 108050009310 Protease-activated receptors Proteins 0.000 claims 1
- 102000002298 Purinergic P2Y Receptors Human genes 0.000 claims 1
- 108010000818 Purinergic P2Y Receptors Proteins 0.000 claims 1
- 102100027888 Pyroglutamylated RF-amide peptide receptor Human genes 0.000 claims 1
- 102000008944 RGS Proteins Human genes 0.000 claims 1
- 108010074020 RGS Proteins Proteins 0.000 claims 1
- 102000004215 Relaxin receptors Human genes 0.000 claims 1
- 108090000728 Relaxin receptors Proteins 0.000 claims 1
- 108050001286 Somatostatin Receptor Proteins 0.000 claims 1
- 102000011096 Somatostatin receptor Human genes 0.000 claims 1
- 102000004852 Thyrotropin-releasing hormone receptors Human genes 0.000 claims 1
- 108090001094 Thyrotropin-releasing hormone receptors Proteins 0.000 claims 1
- 108070000027 Trace amine receptors Proteins 0.000 claims 1
- 102000016981 Trace amine receptors Human genes 0.000 claims 1
- 108010075974 Vasoactive Intestinal Peptide Receptors Proteins 0.000 claims 1
- 102000012088 Vasoactive Intestinal Peptide Receptors Human genes 0.000 claims 1
- 102000017937 Vasopressin/oxytocin receptor Human genes 0.000 claims 1
- 108060003373 Vasopressin/oxytocin receptor Proteins 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 238000011948 assay development Methods 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 230000003196 chaotropic effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 claims 1
- 229960000258 corticotropin Drugs 0.000 claims 1
- 238000002425 crystallisation Methods 0.000 claims 1
- 230000008025 crystallization Effects 0.000 claims 1
- 238000007876 drug discovery Methods 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- JCVAGGLLUIBFSY-UHFFFAOYSA-H hexasodium 5-[(1,8-dihydroxy-3,6-disulfonatonaphthalen-2-yl)diazenyl]-4-hydroxy-3-[(8-hydroxy-3,6-disulfonatonaphthalen-1-yl)diazenyl]naphthalene-2,7-disulfonate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].Oc1cc(cc2cc(c(N=Nc3cc(cc4cc(c(N=Nc5cc(cc6cc(cc(O)c56)S([O-])(=O)=O)S([O-])(=O)=O)c(O)c34)S([O-])(=O)=O)S([O-])(=O)=O)c(O)c12)S([O-])(=O)=O)S([O-])(=O)=O JCVAGGLLUIBFSY-UHFFFAOYSA-H 0.000 claims 1
- 108090000146 leukotriene receptors Proteins 0.000 claims 1
- 102000003835 leukotriene receptors Human genes 0.000 claims 1
- 150000002617 leukotrienes Chemical class 0.000 claims 1
- 230000003551 muscarinic effect Effects 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- PCJGZPGTCUMMOT-ISULXFBGSA-N neurotensin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 PCJGZPGTCUMMOT-ISULXFBGSA-N 0.000 claims 1
- 108091008880 orphan GPCRs Proteins 0.000 claims 1
- 239000004031 partial agonist Substances 0.000 claims 1
- 102000014187 peptide receptors Human genes 0.000 claims 1
- 108010011903 peptide receptors Proteins 0.000 claims 1
- 102000030769 platelet activating factor receptor Human genes 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 102000017953 prostanoid receptors Human genes 0.000 claims 1
- 108050007059 prostanoid receptors Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000027426 receptor tyrosine kinases Human genes 0.000 claims 1
- 108091008598 receptor tyrosine kinases Proteins 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108700012359 toxins Proteins 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0705450.5 | 2007-03-22 | ||
| GB0705450A GB0705450D0 (en) | 2007-03-22 | 2007-03-22 | Mutant proteins and method for selecting them |
| GB0724052.6 | 2007-12-08 | ||
| GB0724052A GB0724052D0 (en) | 2007-12-08 | 2007-12-08 | Mutant proteins and methods for selecting them |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010500347A Division JP4842400B2 (ja) | 2007-03-22 | 2008-03-20 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014100213A Division JP2014155502A (ja) | 2007-03-22 | 2014-05-14 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011224018A JP2011224018A (ja) | 2011-11-10 |
| JP2011224018A5 true JP2011224018A5 (cg-RX-API-DMAC7.html) | 2012-11-01 |
Family
ID=39386585
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010500347A Active JP4842400B2 (ja) | 2007-03-22 | 2008-03-20 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2011171887A Pending JP2011224018A (ja) | 2007-03-22 | 2011-08-05 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2014100213A Pending JP2014155502A (ja) | 2007-03-22 | 2014-05-14 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2016129938A Active JP6426661B2 (ja) | 2007-03-22 | 2016-06-30 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2018135756A Pending JP2018164456A (ja) | 2007-03-22 | 2018-07-19 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2020193343A Active JP7419217B2 (ja) | 2007-03-22 | 2020-11-20 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010500347A Active JP4842400B2 (ja) | 2007-03-22 | 2008-03-20 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014100213A Pending JP2014155502A (ja) | 2007-03-22 | 2014-05-14 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2016129938A Active JP6426661B2 (ja) | 2007-03-22 | 2016-06-30 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2018135756A Pending JP2018164456A (ja) | 2007-03-22 | 2018-07-19 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2020193343A Active JP7419217B2 (ja) | 2007-03-22 | 2020-11-20 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (7) | US8785135B2 (cg-RX-API-DMAC7.html) |
| EP (4) | EP3926045B1 (cg-RX-API-DMAC7.html) |
| JP (6) | JP4842400B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN103641908A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE544854T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008228085B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2681415C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2121919T3 (cg-RX-API-DMAC7.html) |
| ES (2) | ES3008359T3 (cg-RX-API-DMAC7.html) |
| GB (4) | GB2447786C (cg-RX-API-DMAC7.html) |
| HR (1) | HRP20120336T1 (cg-RX-API-DMAC7.html) |
| PL (1) | PL2121919T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2121919E (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008114020A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008114020A2 (en) * | 2007-03-22 | 2008-09-25 | Heptares Therapeutics Limited | Mutant g-protein coupled receptors and methods for selecting them |
| GB0724051D0 (en) * | 2007-12-08 | 2008-01-16 | Medical Res Council | Mutant proteins and methods for producing them |
| GB0724860D0 (en) | 2007-12-20 | 2008-01-30 | Heptares Therapeutics Ltd | Screening |
| GB0802474D0 (en) | 2008-02-11 | 2008-03-19 | Heptares Therapeutics Ltd | Mutant proteins and methods for selecting them |
| DE08718604T1 (de) * | 2008-03-05 | 2009-12-24 | Medical Research Council | Kristallstruktur |
| GB0910725D0 (en) | 2009-06-22 | 2009-08-05 | Heptares Therapeutics Ltd | Mutant proteins and methods for producing them |
| GB201014715D0 (en) * | 2010-09-06 | 2010-10-20 | Vib Vzw | Nanobodies stabilizing functional conformational states of GPCRS |
| US8900591B2 (en) | 2010-08-20 | 2014-12-02 | Heptares Therapeutics Limited | Vaccines comprising mutant GPCRs with increased conformational stability relative to parent receptors |
| US20140031525A1 (en) | 2011-01-21 | 2014-01-30 | Heptares Therapeutics Limited | Mutant g-protein coupled receptor proteins and methods for producing them |
| CN108752461A (zh) | 2011-02-23 | 2018-11-06 | 麻省理工学院 | 水溶性膜蛋白及其制备和使用方法 |
| WO2012120315A2 (en) | 2011-03-10 | 2012-09-13 | Heptares Therapeutics Limited | Mutant proteins and methods for producing them |
| DK2742066T3 (en) | 2011-08-10 | 2018-03-05 | Heptares Therapeutics Ltd | STABLE PROTEINS |
| JP6251252B2 (ja) * | 2012-06-01 | 2017-12-20 | ヘプタレス セラピューティックス リミテッド | アッセイ |
| CA2899693C (en) | 2013-01-30 | 2023-03-14 | Vib Vzw | Novel chimeric polypeptides for screening and drug discovery purposes |
| EP2970425B1 (en) | 2013-03-15 | 2019-10-30 | United Kingdom Research and Innovation | Mutant membrane proteins and methods for their production |
| US9670264B2 (en) | 2013-04-25 | 2017-06-06 | The Trustees Of The University Of Pennsylvania | Water soluble G-protein coupled receptor |
| US10809222B2 (en) | 2013-04-25 | 2020-10-20 | The Trustees Of The University Of Pennsylvania | Opioid detection based on high quality graphene transistor arrays and a synthetic mu receptor |
| WO2014198528A2 (en) * | 2013-06-11 | 2014-12-18 | Paul Scherrer Institut | Method for determining mutateable ligand-gpcr binding at single amino acid resolution and pairs of mutated ligand and gpcr |
| US10373702B2 (en) | 2014-03-27 | 2019-08-06 | Massachusetts Institute Of Technology | Water-soluble trans-membrane proteins and methods for the preparation and use thereof |
| CN104151401A (zh) * | 2014-06-05 | 2014-11-19 | 维亚生物科技(上海)有限公司 | 融合表达离子通道蛋白及运输蛋白的方法及其使用的蛋白片断 |
| GB2527286A (en) * | 2014-06-11 | 2015-12-23 | Rsr Ltd | Glycoprotein hormone receptor mutations |
| WO2016070022A1 (en) | 2014-10-31 | 2016-05-06 | Abilita Bio, Inc. | Modified membrane spanning proteins and methods for the preparation and use thereof |
| CA3032514C (en) | 2015-07-31 | 2021-05-04 | Takehiro SHINODA | Method of producing membrane protein and utilization thereof |
| GB201601690D0 (en) | 2016-01-29 | 2016-03-16 | Heptares Therapeutics Ltd | G proteins |
| EP3205450A1 (de) * | 2016-02-09 | 2017-08-16 | Hermes Schleifkörper GmbH | Verfahren zur herstellung eines keramischen formkörpers |
| JP2019527065A (ja) | 2016-05-04 | 2019-09-26 | アビリタ バイオ，インク． | 複数膜貫通型タンパク質を調製する方法とプラットフォーム |
| CN113501881B (zh) * | 2017-09-27 | 2023-07-28 | 北京大学 | 融合蛋白 |
| US12123814B1 (en) * | 2019-06-14 | 2024-10-22 | Pierce Biotechnology, Inc. | G- protein coupled receptor extraction formulations |
| US12371487B2 (en) | 2020-12-23 | 2025-07-29 | Regeneron Pharmaceuticals, Inc. | Methods for obtaining antibodies that bind transmembrane proteins and cells that produce the same |
| CN114038498B (zh) * | 2022-01-06 | 2022-03-18 | 北京晶泰科技有限公司 | Gpcr的热稳定性突变预测方法、结构筛选方法及其装置 |
| CN120948816A (zh) * | 2025-10-20 | 2025-11-14 | 国科大杭州高等研究院 | 一种g蛋白偶联受体的热稳定性突变位点筛选方法及其用途 |
Family Cites Families (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US6780613B1 (en) * | 1988-10-28 | 2004-08-24 | Genentech, Inc. | Growth hormone variants |
| CA2345497A1 (en) | 1988-10-28 | 1990-04-28 | Genentech, Inc. | Growth hormone variants and method for forming growth hormone variants |
| US5750373A (en) | 1990-12-03 | 1998-05-12 | Genentech, Inc. | Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| EP0585287B1 (en) | 1990-07-10 | 1999-10-13 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| AU1545692A (en) | 1991-03-01 | 1992-10-06 | Protein Engineering Corporation | Process for the development of binding mini-proteins |
| JP3147916B2 (ja) * | 1991-03-08 | 2001-03-19 | 森永製菓株式会社 | 体外免疫方法 |
| US5658727A (en) | 1991-04-10 | 1997-08-19 | The Scripps Research Institute | Heterodimeric receptor libraries using phagemids |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| US20030036092A1 (en) * | 1991-11-15 | 2003-02-20 | Board Of Regents, The University Of Texas System | Directed evolution of enzymes and antibodies |
| EP0644935A1 (en) * | 1992-06-12 | 1995-03-29 | Garvan Institute Of Medical Research | DNA SEQUENCES ENCODING THE HUMAN A1, A2a and A2b ADENOSINE RECEPTORS |
| US5585277A (en) * | 1993-06-21 | 1996-12-17 | Scriptgen Pharmaceuticals, Inc. | Screening method for identifying ligands for target proteins |
| JPH10500951A (ja) | 1994-05-23 | 1998-01-27 | スミスクライン・ビーチャム・コーポレイション | コードされた組合せライブラリー |
| US20020028443A1 (en) * | 1999-09-27 | 2002-03-07 | Jay M. Short | Method of dna shuffling with polynucleotides produced by blocking or interrupting a synthesis or amplification process |
| EP0906339A2 (en) | 1996-03-27 | 1999-04-07 | NG, Gordon, Y., K. | Receptor and transporter antagonists |
| AU2728297A (en) * | 1996-04-15 | 1997-11-07 | Board Of Trustees Of The Leland Stanford Junior University | Soluble 7-transmembrane domain G-protein-coupled receptor compositions and me thods |
| US6153410A (en) * | 1997-03-25 | 2000-11-28 | California Institute Of Technology | Recombination of polynucleotide sequences using random or defined primers |
| US6555339B1 (en) * | 1997-04-14 | 2003-04-29 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated human protein-coupled receptors |
| JP2002510505A (ja) * | 1998-04-03 | 2002-04-09 | フィロス インク． | 位置特定可能な蛋白質アレイ |
| US6475733B1 (en) | 1998-04-06 | 2002-11-05 | Lerner Pharmaceuticals, Inc. | Cell surface receptors for the detection and identification of compounds |
| US6692696B1 (en) | 1998-06-18 | 2004-02-17 | ARETé ASSOCIATES | Biosensor |
| CA2344591A1 (en) * | 1998-09-01 | 2000-03-09 | Basf Aktiengesellschaft | Methods for improving the function of heterologous g protein-coupled receptors |
| US7094593B1 (en) * | 1998-09-01 | 2006-08-22 | Basf Aktiengesellschaft | Method for improving the function of heterologous G protein-coupled receptors |
| AU4847600A (en) | 1999-05-14 | 2000-12-05 | Repliscent, Inc. | G-protein coupled receptor (gpcr) based biosensors and sense replication systems |
| WO2001036471A2 (en) * | 1999-11-17 | 2001-05-25 | Arena Pharmaceuticals, Inc. | Endogenous and non-endogenous versions of human g protein-coupled receptors |
| AU2001241463A1 (en) | 2000-02-09 | 2001-08-20 | Human Genome Sciences, Inc. | Human g-protein chemokine receptor (CCR5) HDGNR10 |
| US7678539B2 (en) | 2000-08-10 | 2010-03-16 | Corning Incorporated | Arrays of biological membranes and methods and use thereof |
| WO2002018590A2 (en) * | 2000-08-30 | 2002-03-07 | John Hopkins University School Of Medicine | Identification of activated receptors and ion channels |
| US6448377B1 (en) * | 2000-09-27 | 2002-09-10 | The Board Of Trustees Of The Leland Stanford Junior University | Modified G protein sunbunits |
| WO2002059346A2 (en) | 2000-10-26 | 2002-08-01 | New England Medical Center Hospitals, Inc. | Constitutively active, hypersensitive, and nonfunctional receptors as novel therapeutic agents |
| US20030232331A1 (en) * | 2000-12-05 | 2003-12-18 | Casman Stacie J. | Novel proteins and nucleic acids encoding same |
| CA2438107A1 (en) | 2001-02-14 | 2002-10-24 | Amgen, Inc. | G-protein coupled receptor molecules and uses thereof |
| WO2002068600A2 (en) | 2001-02-26 | 2002-09-06 | Arena Pharmaceuticals, Inc. | Endogenous and non-endogenous versions of human g protein-coupled receptors |
| US7208279B2 (en) * | 2001-03-14 | 2007-04-24 | Caden Biosciences, Inc. | Method for identifying inhibitors of G protein coupled receptor signaling |
| US7294472B2 (en) | 2001-03-14 | 2007-11-13 | Caden Biosciences | Method for identifying modulators of G protein coupled receptor signaling |
| US20070010948A1 (en) | 2001-03-30 | 2007-01-11 | Masaji Ishiguro | G protein-coupled receptor structural model and a method of designing ligand binding to g protein-coupled receptor by using the structural model |
| US20030129649A1 (en) * | 2001-04-24 | 2003-07-10 | Kobilka Brian K. | Conformational assays to detect binding to G protein-coupled receptors |
| US20050009204A1 (en) | 2003-07-11 | 2005-01-13 | Ye Fang | Multiplexed binding assays for receptor arrays |
| DE02770119T1 (de) | 2001-10-25 | 2005-05-04 | Astex Technology Ltd | Kristalle von cytochrome p450 2c9, strukturen und verwendung davon |
| US7115377B2 (en) * | 2001-10-26 | 2006-10-03 | Atto Bioscience, Inc. | Cell-based assays for G-protein-coupled receptor-mediated activities |
| AU2003227268A1 (en) | 2002-03-28 | 2003-10-13 | Takeda Chemical Industries, Ltd. | Novel screening method |
| JP2004238384A (ja) * | 2002-03-28 | 2004-08-26 | Takeda Chem Ind Ltd | 新規スクリーニング方法 |
| JP4344928B2 (ja) | 2002-04-24 | 2009-10-14 | 萬有製薬株式会社 | ヒスタミン受容体ｈ３常活性変異体およびその利用 |
| ATE457728T1 (de) * | 2002-05-01 | 2010-03-15 | Vertex Pharma | Kristallstruktur des aurora-2 proteins und dessen bindungstaschen |
| EP1581648A2 (en) * | 2002-09-09 | 2005-10-05 | Nura, Inc. | G protein coupled receptors and uses thereof |
| AU2002951995A0 (en) * | 2002-10-11 | 2002-10-31 | Alchemia Limited | Classes of compounds that interact with gpcrs |
| US20040096914A1 (en) | 2002-11-20 | 2004-05-20 | Ye Fang | Substrates with stable surface chemistry for biological membrane arrays and methods for fabricating thereof |
| WO2004104041A1 (en) * | 2003-05-20 | 2004-12-02 | The University Court Of The University Of Glasgow | Materials and methods relating to g-protein coupled receptor oligomers |
| US7745161B2 (en) * | 2003-12-19 | 2010-06-29 | Palo Alto Research Center Incorporated | Amplification of enzymatic reactions for use with an enthalpy array |
| US20050287121A1 (en) * | 2004-05-12 | 2005-12-29 | Merchiers Pascal G | Methods, compositions and compound assays for inhibiting amyloid-beta protein production |
| WO2005121755A1 (en) | 2004-06-14 | 2005-12-22 | Commonwealth Scientific And Industrial Research Organisation | Cell free g-protein coupled receptor and ligand assay |
| US20060188964A1 (en) | 2004-07-28 | 2006-08-24 | Filippo Mancia | Processing for producing and crystallizing G-protein coupled receptors |
| JP2006340717A (ja) * | 2005-05-11 | 2006-12-21 | Sekisui Chem Co Ltd | Ｇタンパク質共役型受容体に対する結合性評価方法及び評価用組成物、融合タンパク質、並びに、遺伝子 |
| FR2890174B1 (fr) | 2005-08-30 | 2009-04-24 | Cis Bio Internat Sa | Procede pour la mise en evidence d'un processus biologique par mesure d'un fret |
| US20070154947A1 (en) * | 2005-08-31 | 2007-07-05 | The Trustees Of Princeton University | Chemical biodiscriminator |
| AU2006338570B2 (en) * | 2005-11-18 | 2013-07-11 | The Ohio State University Research Foundation | Viral gene products and methods for vaccination to prevent viral associated diseases |
| US7495024B2 (en) * | 2006-08-07 | 2009-02-24 | Via Pharmaceuticals, Inc. | Phenylalkyl N-hydroxyureas for combating atherosclerotic plaque |
| WO2008114020A2 (en) | 2007-03-22 | 2008-09-25 | Heptares Therapeutics Limited | Mutant g-protein coupled receptors and methods for selecting them |
| DK2220245T3 (en) | 2007-10-17 | 2015-06-29 | Univ Leland Stanford Junior | Method and composition for the crystallization of G protein coupled receptors |
| EP2203475B1 (en) | 2007-10-22 | 2014-04-16 | The Scripps Research Institute | Methods and compostions for obtaining high-resolution crystals of membrane proteins |
| GB0724051D0 (en) * | 2007-12-08 | 2008-01-16 | Medical Res Council | Mutant proteins and methods for producing them |
| GB0724860D0 (en) | 2007-12-20 | 2008-01-30 | Heptares Therapeutics Ltd | Screening |
| GB0802474D0 (en) * | 2008-02-11 | 2008-03-19 | Heptares Therapeutics Ltd | Mutant proteins and methods for selecting them |
| DE08718604T1 (de) | 2008-03-05 | 2009-12-24 | Medical Research Council | Kristallstruktur |
| GB0910725D0 (en) * | 2009-06-22 | 2009-08-05 | Heptares Therapeutics Ltd | Mutant proteins and methods for producing them |
| US8900591B2 (en) | 2010-08-20 | 2014-12-02 | Heptares Therapeutics Limited | Vaccines comprising mutant GPCRs with increased conformational stability relative to parent receptors |
| DK2611826T3 (en) | 2010-08-30 | 2017-01-09 | Confometrx Inc | A method and composition for the crystallization of a family-C-GPCR |
| US20140031525A1 (en) * | 2011-01-21 | 2014-01-30 | Heptares Therapeutics Limited | Mutant g-protein coupled receptor proteins and methods for producing them |
| JP2014516963A (ja) | 2011-05-13 | 2014-07-17 | レセプトス インコーポレイテッド | Ｇタンパク質共役レセプターを結晶化するための新規融合パートナー |
| DK2742066T3 (en) | 2011-08-10 | 2018-03-05 | Heptares Therapeutics Ltd | STABLE PROTEINS |
| EP2617732A1 (en) | 2012-01-19 | 2013-07-24 | Vib Vzw | Tools and methods for expression of membrane proteins |
| WO2013142278A1 (en) | 2012-03-22 | 2013-09-26 | New York University | Plasmodium vivax vaccine compositions |
| JP6251252B2 (ja) | 2012-06-01 | 2017-12-20 | ヘプタレス セラピューティックス リミテッド | アッセイ |
| WO2014028644A1 (en) | 2012-08-15 | 2014-02-20 | Cyvax, Inc. | Methods and compositions for preventing a condition |
| US20150261911A1 (en) | 2014-03-13 | 2015-09-17 | Heptares Therapeutics Limited | Crystal structure |
-
2008
- 2008-03-20 WO PCT/GB2008/000986 patent/WO2008114020A2/en not_active Ceased
- 2008-03-20 EP EP21171713.7A patent/EP3926045B1/en active Active
- 2008-03-20 CA CA2681415A patent/CA2681415C/en active Active
- 2008-03-20 EP EP08718823A patent/EP2121919B1/en active Active
- 2008-03-20 ES ES21171713T patent/ES3008359T3/es active Active
- 2008-03-20 GB GB0805267A patent/GB2447786C/en active Active
- 2008-03-20 AT AT08718823T patent/ATE544854T1/de active
- 2008-03-20 EP EP11075136A patent/EP2386635A3/en not_active Ceased
- 2008-03-20 EP EP12153522A patent/EP2450445A1/en not_active Ceased
- 2008-03-20 GB GB0901110A patent/GB2456236B8/en active Active
- 2008-03-20 CN CN201310556727.3A patent/CN103641908A/zh active Pending
- 2008-03-20 GB GB0901111A patent/GB2456237B8/en active Active
- 2008-03-20 HR HRP20120336AT patent/HRP20120336T1/hr unknown
- 2008-03-20 PT PT08718823T patent/PT2121919E/pt unknown
- 2008-03-20 PL PL08718823T patent/PL2121919T3/pl unknown
- 2008-03-20 US US12/450,358 patent/US8785135B2/en active Active
- 2008-03-20 CN CN2008800093780A patent/CN101688203B/zh active Active
- 2008-03-20 DK DK08718823.1T patent/DK2121919T3/da active
- 2008-03-20 JP JP2010500347A patent/JP4842400B2/ja active Active
- 2008-03-20 GB GB0901095A patent/GB2456235B8/en active Active
- 2008-03-20 ES ES08718823T patent/ES2381780T3/es active Active
- 2008-03-20 AU AU2008228085A patent/AU2008228085B2/en active Active
-
2011
- 2011-08-05 JP JP2011171887A patent/JP2011224018A/ja active Pending
-
2012
- 2012-06-11 US US13/493,898 patent/US20120270230A1/en not_active Abandoned
-
2014
- 2014-05-14 JP JP2014100213A patent/JP2014155502A/ja active Pending
-
2015
- 2015-08-26 US US14/836,820 patent/US20160052991A1/en not_active Abandoned
-
2016
- 2016-06-30 JP JP2016129938A patent/JP6426661B2/ja active Active
-
2017
- 2017-09-26 US US15/716,302 patent/US20180086814A1/en not_active Abandoned
-
2018
- 2018-07-19 JP JP2018135756A patent/JP2018164456A/ja active Pending
- 2018-12-10 US US16/215,533 patent/US20190241644A1/en not_active Abandoned
-
2020
- 2020-05-11 US US16/871,254 patent/US11673938B2/en active Active
- 2020-11-20 JP JP2020193343A patent/JP7419217B2/ja active Active
-
2023
- 2023-04-21 US US18/304,801 patent/US20240052017A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011224018A5 (cg-RX-API-DMAC7.html) | ||
| JP2021036901A5 (cg-RX-API-DMAC7.html) | ||
| Tao et al. | Chaperoning G protein-coupled receptors: from cell biology to therapeutics | |
| Wang et al. | Allosteric modulators of g protein-coupled receptors: future therapeutics for complex physiological disorders | |
| Tan et al. | Membrane trafficking of G protein–coupled receptors | |
| Wu et al. | Structure and function of peptide-binding G protein-coupled receptors | |
| Dong et al. | Regulation of G protein-coupled receptor export trafficking | |
| Schöneberg et al. | Mutant G-protein-coupled receptors as a cause of human diseases | |
| Harada et al. | N-Formylated humanin activates both formyl peptide receptor-like 1 and 2 | |
| Girada et al. | Gαs regulates Glucagon-Like Peptide 1 Receptor-mediated cyclic AMP generation at Rab5 endosomal compartment | |
| Springael et al. | Allosteric properties of G protein-coupled receptor oligomers | |
| Lindner et al. | Molecular recognition of the NPY hormone family by their receptors | |
| CN111247163B (zh) | 渐进性糖化终极产物受体(rage)活化的筛选测定法、调节物和调节 | |
| Coleman et al. | The G protein-coupled receptor N-terminus and receptor signalling: N-tering a new era | |
| Rashid et al. | Minireview: diversity and complexity of signaling through peptidergic G protein-coupled receptors | |
| JP2014508763A5 (cg-RX-API-DMAC7.html) | ||
| US6448377B1 (en) | Modified G protein sunbunits | |
| Vischer et al. | G protein‐coupled receptors: walking hand‐in‐hand, talking hand‐in‐hand? | |
| CN101027560A (zh) | 用于治疗高血糖症和相关病症的人类g蛋白偶合受体及其调节物 | |
| TW200804812A (en) | Human g protein-coupled receptor and modulators thereof for the treatment of atherosclerosis and atherosclerotic disease and for the treatment of conditions related to mcp-1 expression | |
| Garcia et al. | Differential determinants for coupling of distinct G proteins with the class B secretin receptor | |
| US20060099646A1 (en) | Bret assay | |
| Bermak et al. | Accessory proteins in the biogenesis of G protein-coupled receptors | |
| Lättig et al. | Structural determinants for selective recognition of peptide ligands for endothelin receptor subtypes ETA and ETB | |
| Yoshida et al. | Orphan GPCRs and methods for identifying their ligands |