JP2011168587A5 - - Google Patents
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- JP2011168587A5 JP2011168587A5 JP2011026718A JP2011026718A JP2011168587A5 JP 2011168587 A5 JP2011168587 A5 JP 2011168587A5 JP 2011026718 A JP2011026718 A JP 2011026718A JP 2011026718 A JP2011026718 A JP 2011026718A JP 2011168587 A5 JP2011168587 A5 JP 2011168587A5
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- Prior art keywords
- salt according
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- Prior art date
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- 150000003839 salts Chemical class 0.000 claims 20
- 238000000634 powder X-ray diffraction Methods 0.000 claims 8
- 239000000126 substance Substances 0.000 claims 8
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 5
- 229910052802 copper Inorganic materials 0.000 claims 5
- 239000010949 copper Substances 0.000 claims 5
- 238000000371 solid-state nuclear magnetic resonance spectroscopy Methods 0.000 claims 5
- 238000001228 spectrum Methods 0.000 claims 5
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 3
- MIOPJNTWMNEORI-UHFFFAOYSA-N camphorsulfonic acid Chemical class C1CC2(CS(O)(=O)=O)C(=O)CC1C2(C)C MIOPJNTWMNEORI-UHFFFAOYSA-N 0.000 claims 2
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 claims 2
- HMABYWSNWIZPAG-UHFFFAOYSA-N rucaparib Chemical compound C1=CC(CNC)=CC=C1C(N1)=C2CCNC(=O)C3=C2C1=CC(F)=C3 HMABYWSNWIZPAG-UHFFFAOYSA-N 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30427710P | 2010-02-12 | 2010-02-12 | |
| US61/304,277 | 2010-02-12 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015086722A Division JP6013551B2 (ja) | 2010-02-12 | 2015-04-21 | ８−フルオロ−２−｛４−［（メチルアミノ）メチル］フェニル｝−１，３，４，５−テトラヒドロ−６Ｈ−アゼピノ［５，４，３−ｃｄ］インドール−６−オンの塩および多形体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011168587A JP2011168587A (ja) | 2011-09-01 |
| JP2011168587A5 true JP2011168587A5 (OSRAM) | 2014-02-20 |
| JP5745283B2 JP5745283B2 (ja) | 2015-07-08 |
Family
ID=43859823
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011026718A Active JP5745283B2 (ja) | 2010-02-12 | 2011-02-10 | ８−フルオロ−２−｛４−［（メチルアミノ）メチル］フェニル｝−１，３，４，５−テトラヒドロ−６Ｈ−アゼピノ［５，４，３−ｃｄ］インドール−６−オンの塩および多形体 |
| JP2015086722A Active JP6013551B2 (ja) | 2010-02-12 | 2015-04-21 | ８−フルオロ−２−｛４−［（メチルアミノ）メチル］フェニル｝−１，３，４，５−テトラヒドロ−６Ｈ−アゼピノ［５，４，３−ｃｄ］インドール−６−オンの塩および多形体 |
| JP2016183846A Active JP6371350B2 (ja) | 2010-02-12 | 2016-09-21 | ８−フルオロ−２−｛４−［（メチルアミノ）メチル］フェニル｝−１，３，４，５−テトラヒドロ−６Ｈ−アゼピノ［５，４，３−ｃｄ］インドール−６−オンの塩および多形体 |
| JP2018132270A Active JP6640931B2 (ja) | 2010-02-12 | 2018-07-12 | ８−フルオロ−２−｛４−［（メチルアミノ）メチル］フェニル｝−１，３，４，５−テトラヒドロ−６Ｈ−アゼピノ［５，４，３−ｃｄ］インドール−６−オンの塩および多形体 |
| JP2019235421A Withdrawn JP2020050671A (ja) | 2010-02-12 | 2019-12-26 | ８−フルオロ−２−｛４−［（メチルアミノ）メチル］フェニル｝−１，３，４，５−テトラヒドロ−６Ｈ−アゼピノ［５，４，３−ｃｄ］インドール−６−オンの塩および多形体 |
| JP2021078485A Pending JP2021107460A (ja) | 2010-02-12 | 2021-05-06 | ８−フルオロ−２−｛４−［（メチルアミノ）メチル］フェニル｝−１，３，４，５−テトラヒドロ−６Ｈ−アゼピノ［５，４，３−ｃｄ］インドール−６−オンの塩および多形体 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015086722A Active JP6013551B2 (ja) | 2010-02-12 | 2015-04-21 | ８−フルオロ−２−｛４−［（メチルアミノ）メチル］フェニル｝−１，３，４，５−テトラヒドロ−６Ｈ−アゼピノ［５，４，３−ｃｄ］インドール−６−オンの塩および多形体 |
| JP2016183846A Active JP6371350B2 (ja) | 2010-02-12 | 2016-09-21 | ８−フルオロ−２−｛４−［（メチルアミノ）メチル］フェニル｝−１，３，４，５−テトラヒドロ−６Ｈ−アゼピノ［５，４，３−ｃｄ］インドール−６−オンの塩および多形体 |
| JP2018132270A Active JP6640931B2 (ja) | 2010-02-12 | 2018-07-12 | ８−フルオロ−２−｛４−［（メチルアミノ）メチル］フェニル｝−１，３，４，５−テトラヒドロ−６Ｈ−アゼピノ［５，４，３−ｃｄ］インドール−６−オンの塩および多形体 |
| JP2019235421A Withdrawn JP2020050671A (ja) | 2010-02-12 | 2019-12-26 | ８−フルオロ−２−｛４−［（メチルアミノ）メチル］フェニル｝−１，３，４，５−テトラヒドロ−６Ｈ−アゼピノ［５，４，３−ｃｄ］インドール−６−オンの塩および多形体 |
| JP2021078485A Pending JP2021107460A (ja) | 2010-02-12 | 2021-05-06 | ８−フルオロ−２−｛４−［（メチルアミノ）メチル］フェニル｝−１，３，４，５−テトラヒドロ−６Ｈ−アゼピノ［５，４，３−ｃｄ］インドール−６−オンの塩および多形体 |
Country Status (32)
| Country | Link |
|---|---|
| US (5) | US8754072B2 (OSRAM) |
| EP (4) | EP3150610B1 (OSRAM) |
| JP (6) | JP5745283B2 (OSRAM) |
| KR (2) | KR102108226B1 (OSRAM) |
| CN (2) | CN102884066B (OSRAM) |
| AR (2) | AR080164A1 (OSRAM) |
| AU (1) | AU2011213944B2 (OSRAM) |
| BR (1) | BR112012019050B1 (OSRAM) |
| CA (2) | CA3024216C (OSRAM) |
| CY (3) | CY1118319T1 (OSRAM) |
| DK (2) | DK3150610T3 (OSRAM) |
| ES (2) | ES2753748T3 (OSRAM) |
| FI (1) | FI2534153T4 (OSRAM) |
| FR (1) | FR18C1049I2 (OSRAM) |
| HR (2) | HRP20161742T4 (OSRAM) |
| HU (3) | HUE030969T4 (OSRAM) |
| IL (1) | IL220921B (OSRAM) |
| LT (3) | LT2534153T (OSRAM) |
| LU (1) | LUC00093I2 (OSRAM) |
| MX (1) | MX343383B (OSRAM) |
| NL (1) | NL300958I2 (OSRAM) |
| NO (1) | NO2018039I1 (OSRAM) |
| NZ (1) | NZ601445A (OSRAM) |
| PL (2) | PL3150610T3 (OSRAM) |
| PT (2) | PT3150610T (OSRAM) |
| RS (2) | RS59494B1 (OSRAM) |
| RU (1) | RU2570198C2 (OSRAM) |
| SG (2) | SG182533A1 (OSRAM) |
| SI (2) | SI2534153T2 (OSRAM) |
| SM (3) | SMT201900634T1 (OSRAM) |
| TW (1) | TWI545123B (OSRAM) |
| WO (1) | WO2011098971A1 (OSRAM) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5745283B2 (ja) | 2010-02-12 | 2015-07-08 | ファイザー・インク | ８−フルオロ−２−｛４−［（メチルアミノ）メチル］フェニル｝−１，３，４，５−テトラヒドロ−６Ｈ−アゼピノ［５，４，３−ｃｄ］インドール−６−オンの塩および多形体 |
| TW201516636A (zh) * | 2013-10-22 | 2015-05-01 | Hon Hai Prec Ind Co Ltd | 電子裝置及其供電方法 |
| RU2705156C2 (ru) * | 2014-08-22 | 2019-11-05 | Кловис Онколоджи, Инк. | Таблетки, содержащие большую дозу рукапариба |
| CA3025049A1 (en) * | 2016-05-16 | 2017-11-23 | Pulmagen Therapeutics (Asthma) Limited | Crystal of quinoline derivative |
| DE102016218772A1 (de) * | 2016-09-28 | 2018-03-29 | Bruker Biospin Gmbh | Verbesserte Temperierung eines NMR-MAS-Rotors |
| US10875870B2 (en) | 2017-01-24 | 2020-12-29 | Assia Chemical Industries Ltd. | Solid state forms of rucaparib and of rucaparib salts |
| CN109651377B (zh) * | 2017-10-12 | 2020-10-20 | 成都海创药业有限公司 | 一种治疗癌症的化合物及其用途 |
| CA3080657A1 (en) * | 2017-11-03 | 2019-05-09 | Sandoz Ag | Crystalline salt of a tricyclic poly(adp-ribose) polymerase inhibitor |
| US11220507B2 (en) | 2017-12-15 | 2022-01-11 | Advitech Advisory And Technologies Sa | Process for the preparation of rucaparib and novel synthesis intermediates |
| WO2019130229A1 (en) | 2017-12-28 | 2019-07-04 | Mylan Laboratories Ltd | Methods and intermediates for preparing rucaparib |
| MA51524A (fr) | 2018-01-05 | 2020-11-11 | Cybrexa 1 Inc | Composés, compositions et méthodes pour le traitement de maladies impliquant des tissus malades acides ou hypoxiques |
| US10442813B2 (en) | 2018-01-30 | 2019-10-15 | RK Pharma Solutions LLC | Polymorphs of rucaparib camsylate and methods of making same |
| WO2019207596A1 (en) | 2018-04-25 | 2019-10-31 | Mylan Laboratories Limited | Novel crystalline forms of rucaparib (s)-camsylate salt and rucaparib free base |
| WO2019207498A1 (en) * | 2018-04-25 | 2019-10-31 | Biophore India Pharmaceuticals Pvt. Ltd | Solid forms of 8-fluoro-2-{4-[(methylamino)methyl] phenyl}-1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd] indol-6-one ((1s,4r)-7,7dimethyl-2-oxobicyclo [2.2.1] hept-1-yl) methanesulfonic acid salt (rucaparib camsylate) and the prerparation thereof |
| CN108743557A (zh) * | 2018-06-27 | 2018-11-06 | 李莉 | 一种磷酸瑞卡帕布软胶囊及其制备方法 |
| CN109111454A (zh) * | 2018-08-01 | 2019-01-01 | 宁波金未生物科技有限公司 | 一种瑞卡帕布s-樟脑磺酸盐 |
| MX2021005012A (es) | 2018-10-30 | 2021-07-21 | Repare Therapeutics Inc | Compuestos, composiciones farmacéuticas y métodos de preparación de compuestos y de su uso como inhibidores de la cinasa atr. |
| CN111217818A (zh) * | 2018-11-27 | 2020-06-02 | 台耀化学股份有限公司 | 芦卡帕尼樟脑磺酸盐的结晶、及制备三环化合物、芦卡帕尼及其樟脑磺酸盐结晶的方法 |
| CN111542527A (zh) * | 2018-12-06 | 2020-08-14 | 上海诚妙医药科技有限公司 | 芦卡帕利樟脑磺酸盐的新晶型和制备方法及其用途 |
| CN114302744B (zh) | 2019-07-10 | 2025-08-26 | 赛博克萨3公司 | 作为治疗剂的微管靶向剂的肽缀合物 |
| US11634508B2 (en) | 2019-07-10 | 2023-04-25 | Cybrexa 2, Inc. | Peptide conjugates of cytotoxins as therapeutics |
| CN111004244A (zh) * | 2019-12-27 | 2020-04-14 | 重庆市碚圣医药科技股份有限公司 | 一种瑞卡帕布樟脑磺酸盐的合成方法 |
| EP4100125A1 (en) | 2020-02-03 | 2022-12-14 | Sandoz AG | Polymorph of rucaparib mesylate |
| KR20230005270A (ko) * | 2020-04-24 | 2023-01-09 | 아스트라제네카 아베 | 약학적 제형 |
| DK4143182T3 (da) | 2020-04-28 | 2025-03-03 | Rhizen Pharmaceuticals Ag | Nye forbindelser, der er anvendelige som poly(adp-ribose)-polymerase (parp)-hæmmere |
| CN116113406B (zh) | 2020-07-10 | 2025-08-29 | 密歇根大学董事会 | Gas41抑制剂及其使用方法 |
| WO2022015557A1 (en) | 2020-07-14 | 2022-01-20 | Assia Chemical Industries Ltd | Solid state forms of rucaparib salts |
| WO2022090938A1 (en) | 2020-10-31 | 2022-05-05 | Rhizen Pharmaceuticals Ag | Phthalazinone derivatives useful as parp inhibitors |
| MX2023011793A (es) | 2021-04-08 | 2023-10-12 | Rhizen Pharmaceuticals Ag | Inhibidores de poli(adenosin difosfato-ribosa) polimerasa. |
| US20250223295A1 (en) | 2022-01-11 | 2025-07-10 | Assia Chemical Industries Ltd. | Solid state forms of rucaparib tosylate |
| WO2023152754A1 (en) * | 2022-02-08 | 2023-08-17 | Sawant, Mohit Manikrao | Crystalline form of rosuvastatin allyl ester |
| EP4626867A1 (en) * | 2022-11-30 | 2025-10-08 | Ideaya Biosciences, Inc. | 2-oxoquinazoline crystalline forms |
Family Cites Families (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4489011A (en) | 1983-05-16 | 1984-12-18 | Merrell Dow Pharmaceuticals Inc. | Hypoglycemic N-(2-substituted-3-dialkylamino-2-propenylidene)-N-alkylalkanaminium camsylate salts |
| GB8607683D0 (en) | 1986-03-27 | 1986-04-30 | Ici Plc | Anti-tumor agents |
| GB8608335D0 (en) | 1986-04-04 | 1986-05-08 | Pfizer Ltd | Pharmaceutically acceptable salts |
| GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| DE4125292A1 (de) * | 1991-07-31 | 1993-02-04 | Kali Chemie Pharma Gmbh | 6-oxo-azepinoindol-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| FI941572A7 (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä |
| DE69334255D1 (de) | 1992-02-06 | 2009-02-12 | Novartis Vaccines & Diagnostic | Marker für Krebs und biosynthetisches Bindeprotein dafür |
| US6177401B1 (en) | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
| US5455258A (en) | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| US5863949A (en) | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
| PT821671E (pt) | 1995-04-20 | 2001-04-30 | Pfizer | Derivados do acido arilsulfonil hidroxamico como inibidores de mmp e tnf |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| GB9520822D0 (en) | 1995-10-11 | 1995-12-13 | Wellcome Found | Therapeutically active compounds |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| ATE225343T1 (de) | 1995-12-20 | 2002-10-15 | Hoffmann La Roche | Matrix-metalloprotease inhibitoren |
| DE69709319T2 (de) | 1996-03-05 | 2002-08-14 | Astrazeneca Ab, Soedertaelje | 4-anilinochinazolin derivate |
| JP3195756B2 (ja) | 1996-07-04 | 2001-08-06 | 公子 吉水 | 潤滑補助体 |
| EP0818442A3 (en) | 1996-07-12 | 1998-12-30 | Pfizer Inc. | Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor |
| EP0912559B1 (en) | 1996-07-13 | 2002-11-06 | Glaxo Group Limited | Fused heterocyclic compounds as protein tyrosine kinase inhibitors |
| HRP970371A2 (en) | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
| WO1998002437A1 (en) | 1996-07-13 | 1998-01-22 | Glaxo Group Limited | Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors |
| EP0923585B1 (en) | 1996-07-18 | 2002-05-08 | Pfizer Inc. | Phosphinate based inhibitors of matrix metalloproteases |
| IL128189A0 (en) | 1996-08-23 | 1999-11-30 | Pfizer | Arylsulfonylamino hydroxamic acid derivatives |
| ID18494A (id) | 1996-10-02 | 1998-04-16 | Novartis Ag | Turunan pirazola leburan dan proses pembuatannya |
| EP0950059B1 (en) | 1997-01-06 | 2004-08-04 | Pfizer Inc. | Cyclic sulfone derivatives |
| ATE248812T1 (de) | 1997-02-03 | 2003-09-15 | Pfizer Prod Inc | Arylsulfonylhydroxamsäurederivate |
| CA2279863A1 (en) | 1997-02-07 | 1998-08-13 | Pfizer Inc. | N-hydroxy-beta-sulfonyl-propionamide derivatives and their use as inhibitors of matrix metalloproteinases |
| TR199901926T2 (xx) | 1997-02-11 | 1999-12-21 | Pfizer Inc. | Arils�lfonil hidroksamik asit t�revleri |
| ATE292623T1 (de) | 1997-05-07 | 2005-04-15 | Sugen Inc | 2-indolinonderivate als modulatoren der proteinkinase-ativität |
| CA2291709A1 (en) | 1997-05-30 | 1998-12-03 | Merck & Co., Inc. | Novel angiogenesis inhibitors |
| US5835420A (en) | 1997-06-27 | 1998-11-10 | Aplus Flash Technology, Inc. | Node-precise voltage regulation for a MOS memory system |
| PT1003720E (pt) | 1997-08-08 | 2004-07-30 | Pfizer Prod Inc | Derivados de acido ariloxiarilsulfonilamino hidroxamico |
| WO1999010349A1 (en) | 1997-08-22 | 1999-03-04 | Zeneca Limited | Oxindolylquinazoline derivatives as angiogenesis inhibitors |
| AU744939B2 (en) | 1997-09-26 | 2002-03-07 | Merck & Co., Inc. | Novel angiogenesis inhibitors |
| ID23978A (id) | 1997-11-11 | 2000-06-14 | Pfizer Prod Inc | Turunan-turunan tienopirimidin dan tienopiridin yang berguna sebagai zat-zat anti kangker |
| GB9725782D0 (en) | 1997-12-05 | 1998-02-04 | Pfizer Ltd | Therapeutic agents |
| GB9800575D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
| GB9800569D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
| GB9801690D0 (en) | 1998-01-27 | 1998-03-25 | Pfizer Ltd | Therapeutic agents |
| JP4462654B2 (ja) | 1998-03-26 | 2010-05-12 | ソニー株式会社 | 映像素材選択装置及び映像素材選択方法 |
| PA8469401A1 (es) | 1998-04-10 | 2000-05-24 | Pfizer Prod Inc | Derivados biciclicos del acido hidroxamico |
| PA8469501A1 (es) | 1998-04-10 | 2000-09-29 | Pfizer Prod Inc | Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico |
| CO5031249A1 (es) | 1998-05-29 | 2001-04-27 | Sugen Inc | Pirrol substituido-2-indolinonas inhibidoras de proteinci-nasas |
| UA60365C2 (uk) | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця |
| PT1004578E (pt) | 1998-11-05 | 2004-06-30 | Pfizer Prod Inc | Derivados hidroxamida do acido 5-oxo-pirrolidino-2-carboxilico |
| JP2002533404A (ja) | 1998-12-23 | 2002-10-08 | ジー・ディー・サール・アンド・カンパニー | 新生物形成の治療における組合わせ療法としてインテグリン拮抗剤及び放射線治療を使用する方法 |
| US6649645B1 (en) | 1998-12-23 | 2003-11-18 | Pharmacia Corporation | Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia |
| RS50031B (sr) | 1999-01-11 | 2008-11-28 | Agouron Pharmaceuticals Inc., | Triciklični inhibitori poli(adp-riboza)polimeraza |
| KR100452491B1 (ko) | 2001-03-29 | 2004-10-12 | 한미약품 주식회사 | 신규한 결정형 암로디핀 캠실레이트 염 및 그의 제조방법 |
| KR20040011751A (ko) | 2002-07-30 | 2004-02-11 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| PL377533A1 (pl) † | 2002-12-19 | 2006-02-06 | Pfizer Products Inc. | Kompleksy E-2-metoksy-N-(3-{4-[3-metylo-4-(6-metylopirydyn-3-yloksy)-fenyloamino]-chinazolin-6-ylo}-allilo)-acetamidu, sposób ich wytwarzania i zastosowanie |
| WO2004087713A1 (en) | 2003-03-31 | 2004-10-14 | Pfizer Inc. | Salts of tricyclic inhibitors of poly(adp-ribose) polymerases |
| PL1660095T3 (pl) | 2003-07-25 | 2010-07-30 | Cancer Research Tech Ltd | Tricykliczne inhibitory PARP |
| CN101384264B (zh) * | 2004-09-22 | 2012-03-14 | 辉瑞大药厂 | 含有聚（adp-核糖）聚合酶抑制剂的治疗组合物 |
| RU2361592C2 (ru) | 2004-09-22 | 2009-07-20 | Пфайзер Инк. | Терапевтические комбинации, содержащие ингибитор поли(адф-рибоза)полимеразы |
| KR100853601B1 (ko) * | 2004-09-22 | 2008-08-22 | 화이자 인코포레이티드 | 8-플루오로-2-｛4-[(메틸아미노)메틸]페닐｝-1,3,4,5-테트라하이드로-6Ｈ-아제피노[5,4,3-ｃｄ]인돌-6-온의포스페이트 염의 다형성 및 무정형 형태 |
| KR100876520B1 (ko) * | 2004-09-22 | 2008-12-31 | 화이자 인코포레이티드 | 폴리(ａｄｐ-리보오스) 폴리머라제 억제제의 제조 방법 |
| GB0502509D0 (en) | 2005-02-07 | 2005-03-16 | Pfizer Ltd | Novel salt form of a dopamine agonist |
| CA2901244A1 (en) * | 2005-02-23 | 2006-08-31 | Teva Pharmaceutical Industries, Ltd. | Rasagiline formulations of improved content uniformity |
| MX2008016568A (es) * | 2006-07-05 | 2009-01-19 | Teva Pharma | Composiciones farmaceuticas de memantina. |
| KR100843401B1 (ko) | 2006-12-04 | 2008-07-04 | 씨제이제일제당 (주) | 결정성 ｓ-(-)-암로디핀 캠실레이트 무수물 및 이의제조방법 |
| ES2524021T3 (es) * | 2006-12-06 | 2014-12-03 | Conatus Pharmaceuticals, Inc. | Formas cristalinas del ácido (3S)-3-[N-(N'-(2-terc-butilfenil)oxamil)alaninil]amino-5-(2',3',5',6'-tetrafluorofenoxi)-4-oxopentanoico |
| US8983649B2 (en) | 2007-02-16 | 2015-03-17 | Boomerang Systems, Inc. | Automated storage system and transport vehicle |
| WO2008114114A2 (en) | 2007-03-16 | 2008-09-25 | Pfizer Products Inc. | Poly(adp-ribose) polymerases inhibitor for treating ophthalmic condition |
| EP2065385A1 (en) | 2007-11-28 | 2009-06-03 | Laboratorios SALVAT, S.A. | Stable crystalline salt of (R)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabiciyclo [2.2.2]oct-3-yl ester |
| WO2009072915A1 (en) * | 2007-12-05 | 2009-06-11 | Bial - Portela & Ca., S.A. | New salts and crystal forms |
| KR20090060674A (ko) | 2007-12-10 | 2009-06-15 | 씨제이제일제당 (주) | 결정형의 지프라시돈 술폰산염, 그 제조방법, 및 그것를포함하는 약제학적 조성물 |
| NZ586675A (en) | 2008-01-08 | 2012-04-27 | Merck Sharp & Dohme | Pharmaceutically acceptable salts of 2-{ 4-[(3s)-piperidin-3- yl]phenyl} -2h-indazole-7-carboxamide |
| JP5745283B2 (ja) | 2010-02-12 | 2015-07-08 | ファイザー・インク | ８−フルオロ−２−｛４−［（メチルアミノ）メチル］フェニル｝−１，３，４，５−テトラヒドロ−６Ｈ−アゼピノ［５，４，３−ｃｄ］インドール−６−オンの塩および多形体 |
| WO2013044077A1 (en) | 2011-09-23 | 2013-03-28 | Johnson Controls Technology Company | Systems and methods for rear view mirror displays |
| JP5650852B2 (ja) | 2011-12-26 | 2015-01-07 | ウィンテックポリマー株式会社 | ポリブチレンテレフタレート樹脂ペレット、及び当該ポリブチレンテレフタレート樹脂ペレットの製造方法 |
| US9384339B2 (en) | 2012-01-13 | 2016-07-05 | Telecommunication Systems, Inc. | Authenticating cloud computing enabling secure services |
| US9881309B2 (en) | 2012-03-13 | 2018-01-30 | American Express Travel Related Services Company, Inc. | Systems and methods for tailoring marketing |
| KR101984831B1 (ko) | 2013-01-31 | 2019-05-31 | 삼성전자 주식회사 | 반도체 패키지 및 그 제조 방법 |
| CN103309115B (zh) | 2013-05-30 | 2016-03-23 | 京东方科技集团股份有限公司 | 彩色电泳显示面板及其制造方法、显示装置 |
| US9501163B2 (en) | 2014-05-06 | 2016-11-22 | Symbol Technologies, Llc | Apparatus and method for activating a trigger mechanism |
| US10884952B2 (en) | 2016-09-30 | 2021-01-05 | Intel Corporation | Enforcing memory operand types using protection keys |
| JP6943759B2 (ja) | 2017-12-28 | 2021-10-06 | 株式会社東海理化電機製作所 | シフト装置 |
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