JP2011121949A5 - - Google Patents
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- Publication number
- JP2011121949A5 JP2011121949A5 JP2010278550A JP2010278550A JP2011121949A5 JP 2011121949 A5 JP2011121949 A5 JP 2011121949A5 JP 2010278550 A JP2010278550 A JP 2010278550A JP 2010278550 A JP2010278550 A JP 2010278550A JP 2011121949 A5 JP2011121949 A5 JP 2011121949A5
- Authority
- JP
- Japan
- Prior art keywords
- sod1
- ips cell
- cell
- test compound
- ips
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims 8
- 238000000034 method Methods 0.000 claims 6
- 102000008221 Superoxide Dismutase-1 Human genes 0.000 claims 4
- 108010021188 Superoxide Dismutase-1 Proteins 0.000 claims 4
- 238000012216 screening Methods 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 210000001130 astrocyte Anatomy 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 210000000653 nervous system Anatomy 0.000 claims 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000003061 neural cell Anatomy 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28613409P | 2009-12-14 | 2009-12-14 | |
| US61/286,134 | 2009-12-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011121949A JP2011121949A (ja) | 2011-06-23 |
| JP2011121949A5 true JP2011121949A5 (enExample) | 2014-02-06 |
Family
ID=44167440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010278550A Pending JP2011121949A (ja) | 2009-12-14 | 2010-12-14 | 筋萎縮性側索硬化症の予防および治療用医薬組成物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20130115622A1 (enExample) |
| EP (1) | EP2512514B1 (enExample) |
| JP (1) | JP2011121949A (enExample) |
| WO (1) | WO2011074690A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2641086B9 (en) * | 2010-11-18 | 2017-08-16 | Kyoto University | Method for screening drugs for suppressing inflammasome activity |
| JP6335117B2 (ja) * | 2012-03-21 | 2018-05-30 | 国立大学法人京都大学 | アルツハイマー病の治療薬および／または予防薬のスクリーニング方法 |
| WO2014020933A1 (ja) * | 2012-07-31 | 2014-02-06 | アルバイオ株式会社 | 新規蛍光物質 |
| JP6143027B2 (ja) * | 2012-12-28 | 2017-06-07 | 国立大学法人京都大学 | アストロサイトの誘導方法 |
| EP2977449B1 (en) | 2013-03-21 | 2020-02-26 | Kyoto University | Pluripotent stem cell for neuronal differentiation induction |
| JP6856266B2 (ja) * | 2013-12-02 | 2021-04-07 | 国立大学法人京都大学 | Ｆｇｆｒ３病の予防および治療剤ならびにそのスクリーニング方法 |
| US20180000771A1 (en) | 2015-01-13 | 2018-01-04 | Kyoto University | Agent for preventing and/or treating amyotrophic lateral sclerosis |
| US10842822B2 (en) | 2015-10-05 | 2020-11-24 | Orig3N, Inc. | Diagnosis and treatment of parkinson's disease based on identification and amelioration of liver dysfunction |
| CN108624560B (zh) * | 2018-06-01 | 2022-04-08 | 南京艾尔普再生医学科技有限公司 | 一种分化培养基及少突胶质前体细胞的制备方法 |
| CA3152504A1 (en) * | 2019-09-06 | 2021-03-11 | Keio University | Method for producing cell aggregate including glial progenitor cells |
| CN113842449B (zh) * | 2021-09-08 | 2024-02-23 | 乐卫东 | 枸杞糖肽在制备预防和/或治疗肌萎缩侧索硬化的药物中的应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4231938A (en) | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| US4444784A (en) | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| ZA81703B (en) | 1980-02-04 | 1982-09-29 | Merck & Co Inc | New antihypercholesterolemic compounds,intermediates and processes |
| DK149080C (da) | 1980-06-06 | 1986-07-28 | Sankyo Co | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
| JPS572240A (en) | 1980-06-06 | 1982-01-07 | Sankyo Co Ltd | Ml-236b derivative |
| US4739073A (en) | 1983-11-04 | 1988-04-19 | Sandoz Pharmaceuticals Corp. | Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof |
| PH23486A (en) | 1982-11-22 | 1989-08-16 | Sanzoz Inc | Indole analogs of mevalonolactone,pharmaceutical compositions containing the same and method of use thereof |
| JP2569746B2 (ja) | 1987-08-20 | 1997-01-08 | 日産化学工業株式会社 | キノリン系メバロノラクトン類 |
| US5854259A (en) | 1987-08-20 | 1998-12-29 | Nissan Chemical Industries Ltd. | Quinoline type mevalonolactones |
| FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| JP2648897B2 (ja) | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
| FR2688138B1 (fr) | 1992-03-06 | 1995-05-05 | Rhone Poulenc Rorer Sa | Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement de la sclerose laterale amyotrophique. |
| US7011828B2 (en) | 2000-03-14 | 2006-03-14 | Es Cell International Pte. Ltd. | Implanting neural progenitor cells derived for human embryonic stem cells |
| CA2409703A1 (en) | 2000-05-16 | 2001-11-22 | Shin-Ichi Nishikawa | Novel differentiation inducing process of embryonic stem cell to ectodermal cell and its use |
| EP1452594A4 (en) | 2001-11-15 | 2007-01-10 | Kyowa Hakko Kogyo Kk | INDUCTOR FOR DIFFERENTIATING EMBRYOONAL STEM CELLS TO EODODERMAL CELLS, METHOD FOR OBTAINING THEM AND USE THEREOF |
| AU2003260618A1 (en) * | 2002-06-24 | 2004-01-06 | Exonhit Therapeutics Sa | Treatment of amyotrophic lateral sclerosis using pgc-1 activity-modulating compounds |
| US20050202488A1 (en) * | 2004-03-02 | 2005-09-15 | The General Hospital Corporation | Assay for therapies that inhibit expression of the cytosolic Cu/Zn superoxide dismutase (SOD1) gene |
| EP1783205B1 (en) | 2004-06-18 | 2024-02-21 | Riken | Method of inducing the differentiation of embryonic stem cells into nerve by serum-free suspension culture |
| EP1871359A1 (en) * | 2005-04-07 | 2008-01-02 | Miso Sabovic | Delaying the ageing process and disorders caused by ageing |
| US20060252775A1 (en) * | 2005-05-03 | 2006-11-09 | Henderson Samuel T | Methods for reducing levels of disease associated proteins |
| KR101420740B1 (ko) | 2005-12-13 | 2014-07-17 | 교또 다이가꾸 | 핵초기화 인자 |
| AU2007219615B2 (en) * | 2006-03-03 | 2013-11-28 | Promis Neurosciences Inc. | Methods and compositions to treat and detect misfolded-SOD1 mediated diseases |
| EP2137296A2 (en) | 2007-03-23 | 2009-12-30 | Wisconsin Alumni Research Foundation | Somatic cell reprogramming |
| US9765297B2 (en) * | 2007-04-13 | 2017-09-19 | The Trustees Of Columbia University In The City Of New York | Stem cell-based culture system for drug development |
| JP2009215191A (ja) * | 2008-03-07 | 2009-09-24 | Keio Gijuku | 神経損傷治療剤及び神経損傷治療方法 |
| WO2009146098A2 (en) * | 2008-04-02 | 2009-12-03 | President And Fellows Of Harvard College | Stem cells and uses thereof |
-
2010
- 2010-12-14 JP JP2010278550A patent/JP2011121949A/ja active Pending
- 2010-12-14 WO PCT/JP2010/072836 patent/WO2011074690A1/en not_active Ceased
- 2010-12-14 EP EP10837714.4A patent/EP2512514B1/en not_active Not-in-force
- 2010-12-14 US US13/515,897 patent/US20130115622A1/en not_active Abandoned
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