JP2011121949A5 - - Google Patents
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- JP2011121949A5 JP2011121949A5 JP2010278550A JP2010278550A JP2011121949A5 JP 2011121949 A5 JP2011121949 A5 JP 2011121949A5 JP 2010278550 A JP2010278550 A JP 2010278550A JP 2010278550 A JP2010278550 A JP 2010278550A JP 2011121949 A5 JP2011121949 A5 JP 2011121949A5
- Authority
- JP
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- Prior art keywords
- sod1
- ips cell
- cell
- test compound
- ips
- Prior art date
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Claims (5)
- 筋萎縮性側索硬化症の予防および治療薬をスクリーニングする方法であって、以下の工
程を含む方法；
（１）SOD1に変異を有するiPS細胞から分化誘導された神経系細胞と試験化合物を接触させる工程、
（２）該神経系細胞のSOD1の発現量を測定する工程、および
（３）試験化合物と接触させなかった対照と比較して、該SOD1の発現量を減少させる試験化合物を選択する工程。 - 前記のiPS細胞が、筋萎縮性側索硬化症の患者由来のiPS細胞である、請求項１に記載のスクリーニング方法。
- 前記のiPS細胞が、SOD1の106番目のロイシンに変異を有するiPS細胞である、請求項１に記載のスクリーニング方法。
- 前記の神経系細胞が、アストロサイトである、請求項１に記載のスクリーニング方法。
- 前記のアストロサイトが、以下の工程を含む方法で分化誘導された、請求項４に記載の方法；
（１）iPS細胞からニューロスフェアを形成する工程、および
（２）前記ニューロスフェアをLIFとBMPを含有する培地で培養する工程。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28613409P | 2009-12-14 | 2009-12-14 | |
| US61/286,134 | 2009-12-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011121949A JP2011121949A (ja) | 2011-06-23 |
| JP2011121949A5 true JP2011121949A5 (ja) | 2014-02-06 |
Family
ID=44167440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010278550A Pending JP2011121949A (ja) | 2009-12-14 | 2010-12-14 | 筋萎縮性側索硬化症の予防および治療用医薬組成物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20130115622A1 (ja) |
| EP (1) | EP2512514B1 (ja) |
| JP (1) | JP2011121949A (ja) |
| WO (1) | WO2011074690A1 (ja) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2641086B9 (en) | 2010-11-18 | 2017-08-16 | Kyoto University | Method for screening drugs for suppressing inflammasome activity |
| JP6335117B2 (ja) * | 2012-03-21 | 2018-05-30 | 国立大学法人京都大学 | アルツハイマー病の治療薬および／または予防薬のスクリーニング方法 |
| WO2014020933A1 (ja) * | 2012-07-31 | 2014-02-06 | アルバイオ株式会社 | 新規蛍光物質 |
| WO2014104409A1 (en) * | 2012-12-28 | 2014-07-03 | Kyoto University | Method for inducing astrocytes |
| SG11201507829SA (en) | 2013-03-21 | 2015-12-30 | Univ Kyoto | Pluripotent stem cell for neuronal differentiation induction |
| JP6856266B2 (ja) * | 2013-12-02 | 2021-04-07 | 国立大学法人京都大学 | Ｆｇｆｒ３病の予防および治療剤ならびにそのスクリーニング方法 |
| WO2016114322A1 (ja) | 2015-01-13 | 2016-07-21 | 国立大学法人京都大学 | 筋萎縮性側索硬化症の予防及び／又は治療剤 |
| KR20180055901A (ko) | 2015-10-05 | 2018-05-25 | 오리그3엔, 인코포레이티드 | 간 기능장애의 확인 및 개선에 기반한 파킨슨병의 진단 및 치료 |
| CN108624560B (zh) * | 2018-06-01 | 2022-04-08 | 南京艾尔普再生医学科技有限公司 | 一种分化培养基及少突胶质前体细胞的制备方法 |
| CN113842449B (zh) * | 2021-09-08 | 2024-02-23 | 乐卫东 | 枸杞糖肽在制备预防和/或治疗肌萎缩侧索硬化的药物中的应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4231938A (en) | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| US4444784A (en) | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| ZA81703B (en) | 1980-02-04 | 1982-09-29 | Merck & Co Inc | New antihypercholesterolemic compounds,intermediates and processes |
| JPS572240A (en) | 1980-06-06 | 1982-01-07 | Sankyo Co Ltd | Ml-236b derivative |
| MX7065E (es) | 1980-06-06 | 1987-04-10 | Sankyo Co | Un procedimiento microbiologico para preparar derivados de ml-236b |
| US4739073A (en) | 1983-11-04 | 1988-04-19 | Sandoz Pharmaceuticals Corp. | Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof |
| JPS60500015A (ja) | 1982-11-22 | 1985-01-10 | サンド・アクチエンゲゼルシヤフト | メバロラクトン同族体とその誘導体、これらの製造法およびこれらを含有する製薬学的組成物 |
| US5854259A (en) | 1987-08-20 | 1998-12-29 | Nissan Chemical Industries Ltd. | Quinoline type mevalonolactones |
| JP2569746B2 (ja) | 1987-08-20 | 1997-01-08 | 日産化学工業株式会社 | キノリン系メバロノラクトン類 |
| FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| JP2648897B2 (ja) | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
| FR2688138B1 (fr) | 1992-03-06 | 1995-05-05 | Rhone Poulenc Rorer Sa | Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement de la sclerose laterale amyotrophique. |
| US7011828B2 (en) | 2000-03-14 | 2006-03-14 | Es Cell International Pte. Ltd. | Implanting neural progenitor cells derived for human embryonic stem cells |
| EP1302533A4 (en) | 2000-05-16 | 2004-11-17 | Kyowa Hakko Kogyo Kk | NEW METHOD FOR INDUCING DIFFERENTIATION OF EMBRYONIC STEM CELLS IN EECTODERMAL CELLS AND THEIR USE |
| CA2467258A1 (en) | 2001-11-15 | 2003-05-22 | Kyowa Hakko Kogyo Co., Ltd. | Agent for inducing embryonic stem cell to ectodermal cell, method for obtaining the same and use of the same. |
| WO2004000313A2 (fr) * | 2002-06-24 | 2003-12-31 | Exonhit Therapeutics Sa | Traitement de la sclerose laterale amyotrophique avec des composes modulateurs de l’activite de pgc-1 |
| US20050202488A1 (en) * | 2004-03-02 | 2005-09-15 | The General Hospital Corporation | Assay for therapies that inhibit expression of the cytosolic Cu/Zn superoxide dismutase (SOD1) gene |
| JP5141016B2 (ja) | 2004-06-18 | 2013-02-13 | 独立行政法人理化学研究所 | 無血清浮遊培養による胚性幹細胞の神経分化誘導法 |
| EP1871359A1 (en) * | 2005-04-07 | 2008-01-02 | Miso Sabovic | Delaying the ageing process and disorders caused by ageing |
| US20060252775A1 (en) * | 2005-05-03 | 2006-11-09 | Henderson Samuel T | Methods for reducing levels of disease associated proteins |
| EP3418297B1 (en) | 2005-12-13 | 2023-04-05 | Kyoto University | Nuclear reprogramming factor |
| AU2007219615B2 (en) * | 2006-03-03 | 2013-11-28 | Promis Neurosciences Inc. | Methods and compositions to treat and detect misfolded-SOD1 mediated diseases |
| CA2684242C (en) | 2007-03-23 | 2019-11-12 | Wisconsin Alumni Research Foundation | Somatic cell reprogramming |
| WO2008127974A1 (en) * | 2007-04-13 | 2008-10-23 | The Trustees Of Columbia University In The City Of New York | Stem cell-based culture system for drug development |
| JP2009215191A (ja) * | 2008-03-07 | 2009-09-24 | Keio Gijuku | 神経損傷治療剤及び神経損傷治療方法 |
| WO2009146098A2 (en) * | 2008-04-02 | 2009-12-03 | President And Fellows Of Harvard College | Stem cells and uses thereof |
-
2010
- 2010-12-14 JP JP2010278550A patent/JP2011121949A/ja active Pending
- 2010-12-14 US US13/515,897 patent/US20130115622A1/en not_active Abandoned
- 2010-12-14 WO PCT/JP2010/072836 patent/WO2011074690A1/en active Application Filing
- 2010-12-14 EP EP10837714.4A patent/EP2512514B1/en not_active Not-in-force
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