JP2011102296A5 - - Google Patents
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- Publication number
- JP2011102296A5 JP2011102296A5 JP2010242947A JP2010242947A JP2011102296A5 JP 2011102296 A5 JP2011102296 A5 JP 2011102296A5 JP 2010242947 A JP2010242947 A JP 2010242947A JP 2010242947 A JP2010242947 A JP 2010242947A JP 2011102296 A5 JP2011102296 A5 JP 2011102296A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- substituted
- alkyl
- arylamino
- tetracycline compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 21
- 239000001257 hydrogen Substances 0.000 claims 21
- -1 tetracycline compound Chemical class 0.000 claims 20
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 19
- 239000004098 Tetracycline Substances 0.000 claims 12
- 229960002180 tetracycline Drugs 0.000 claims 12
- 229930101283 tetracycline Natural products 0.000 claims 12
- 235000019364 tetracycline Nutrition 0.000 claims 12
- 125000001769 aryl amino group Chemical group 0.000 claims 9
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 7
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 5
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 5
- 229910019142 PO4 Inorganic materials 0.000 claims 5
- 125000005110 aryl thio group Chemical group 0.000 claims 5
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 5
- 239000010452 phosphate Substances 0.000 claims 5
- ACVYVLVWPXVTIT-UHFFFAOYSA-M phosphinate Chemical compound [O-][PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-M 0.000 claims 5
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 4
- 125000005199 aryl carbonyloxy group Chemical group 0.000 claims 4
- 125000005200 aryloxy carbonyloxy group Chemical group 0.000 claims 4
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 4
- 150000007942 carboxylates Chemical class 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- GJVFBWCTGUSGDD-UHFFFAOYSA-L pentamethonium bromide Chemical compound [Br-].[Br-].C[N+](C)(C)CCCCC[N+](C)(C)C GJVFBWCTGUSGDD-UHFFFAOYSA-L 0.000 claims 4
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 150000003467 sulfuric acid derivatives Chemical class 0.000 claims 4
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- 125000004442 acylamino group Chemical group 0.000 claims 3
- 125000004104 aryloxy group Chemical group 0.000 claims 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- KWEDUNSJJZVRKR-UHFFFAOYSA-N carbononitridic azide Chemical compound [N-]=[N+]=NC#N KWEDUNSJJZVRKR-UHFFFAOYSA-N 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- 150000003456 sulfonamides Chemical class 0.000 claims 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 1
- 150000003522 tetracyclines Chemical class 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36265402P | 2002-03-08 | 2002-03-08 | |
| US60/362,654 | 2002-03-08 | ||
| US39549502P | 2002-07-12 | 2002-07-12 | |
| US60/395,495 | 2002-07-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003574133A Division JP2005526754A (ja) | 2002-03-08 | 2003-03-10 | アミノメチル置換されたテトラサイクリン化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011102296A JP2011102296A (ja) | 2011-05-26 |
| JP2011102296A5 true JP2011102296A5 (enExample) | 2013-01-24 |
Family
ID=27807973
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003574133A Withdrawn JP2005526754A (ja) | 2002-03-08 | 2003-03-10 | アミノメチル置換されたテトラサイクリン化合物 |
| JP2008104216A Ceased JP2008266330A (ja) | 2002-03-08 | 2008-04-14 | アミノメチル置換されたテトラサイクリン化合物 |
| JP2010069022A Pending JP2010195796A (ja) | 2002-03-08 | 2010-03-25 | アミノメチル置換されたテトラサイクリン化合物 |
| JP2010242947A Pending JP2011102296A (ja) | 2002-03-08 | 2010-10-29 | アミノメチル置換されたテトラサイクリン化合物 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003574133A Withdrawn JP2005526754A (ja) | 2002-03-08 | 2003-03-10 | アミノメチル置換されたテトラサイクリン化合物 |
| JP2008104216A Ceased JP2008266330A (ja) | 2002-03-08 | 2008-04-14 | アミノメチル置換されたテトラサイクリン化合物 |
| JP2010069022A Pending JP2010195796A (ja) | 2002-03-08 | 2010-03-25 | アミノメチル置換されたテトラサイクリン化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7326696B2 (enExample) |
| EP (4) | EP2301534A1 (enExample) |
| JP (4) | JP2005526754A (enExample) |
| KR (3) | KR101014918B1 (enExample) |
| CN (3) | CN102531948A (enExample) |
| AU (2) | AU2003220123B2 (enExample) |
| CA (1) | CA2478335C (enExample) |
| EA (3) | EA013819B1 (enExample) |
| IL (3) | IL163931A0 (enExample) |
| WO (1) | WO2003075857A2 (enExample) |
Families Citing this family (64)
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| US6756365B2 (en) * | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| AU753370B2 (en) * | 1998-01-23 | 2002-10-17 | Trustees Of Tufts College | Pharmaceutically active compounds and methods of use thereof |
| US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| CZ301835B6 (cs) * | 1999-09-14 | 2010-07-07 | Trustees Of Tufts College | Zpusob prípravy 7-, 9- nebo 13- substituované tetracyklinové slouceniny, reaktivní tetracyklinový chemický komplex a tetracyklinová sloucenina substituovaná v poloze 7 nebo 9 |
| US6833365B2 (en) * | 2000-01-24 | 2004-12-21 | Trustees Of Tufts College | Tetracycline compounds for treatment of Cryptosporidium parvum related disorders |
| ATE365710T1 (de) * | 2000-03-31 | 2007-07-15 | Tufts College | 7- und 9-carbamat, harnstoff, thioharnstoff, thiocarbamat und heteroaryl-amino substituierte tetracyclinverbindungen |
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| WO2001098236A2 (en) * | 2000-06-16 | 2001-12-27 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
| US20040224927A1 (en) | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
| US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| CZ2003344A3 (cs) | 2000-07-07 | 2003-05-14 | Trustees Of Tufts College | 9-Substituované minocyklinové sloučeniny |
| US7094806B2 (en) * | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| BR0112265A (pt) * | 2000-07-07 | 2003-06-24 | Tufts College | Compostos de tetraciclina substituìda, e de sanciclina 7-substituìda, método para tratar um estado responsivo à tetraciclina em um indivìduo, e, composição farmacêutica |
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-
2003
- 2003-03-10 JP JP2003574133A patent/JP2005526754A/ja not_active Withdrawn
- 2003-03-10 EP EP10184858A patent/EP2301534A1/en not_active Withdrawn
- 2003-03-10 EP EP03716416A patent/EP1482926A4/en not_active Withdrawn
- 2003-03-10 EP EP10184869A patent/EP2311451A1/en not_active Withdrawn
- 2003-03-10 CN CN2011103993027A patent/CN102531948A/zh active Pending
- 2003-03-10 EA EA200401169A patent/EA013819B1/ru not_active IP Right Cessation
- 2003-03-10 AU AU2003220123A patent/AU2003220123B2/en not_active Ceased
- 2003-03-10 KR KR1020047014092A patent/KR101014918B1/ko not_active Expired - Fee Related
- 2003-03-10 KR KR1020107016704A patent/KR101093842B1/ko not_active Expired - Fee Related
- 2003-03-10 EA EA201000491A patent/EA201000491A1/ru unknown
- 2003-03-10 WO PCT/US2003/007229 patent/WO2003075857A2/en not_active Ceased
- 2003-03-10 EA EA200802365A patent/EA200802365A1/ru unknown
- 2003-03-10 CN CNA038099799A patent/CN1649582A/zh active Pending
- 2003-03-10 CN CNA2008100962190A patent/CN101307017A/zh active Pending
- 2003-03-10 IL IL16393103A patent/IL163931A0/xx unknown
- 2003-03-10 CA CA2478335A patent/CA2478335C/en not_active Expired - Fee Related
- 2003-03-10 EP EP10184863A patent/EP2316450A1/en not_active Withdrawn
- 2003-03-10 KR KR1020117006989A patent/KR101163937B1/ko not_active Expired - Fee Related
- 2003-12-15 US US10/737,361 patent/US7326696B2/en not_active Expired - Lifetime
-
2004
- 2004-09-07 IL IL163931A patent/IL163931A/en not_active IP Right Cessation
-
2007
- 2007-06-05 US US11/810,336 patent/US20080015169A1/en not_active Abandoned
-
2008
- 2008-04-14 JP JP2008104216A patent/JP2008266330A/ja not_active Ceased
-
2009
- 2009-08-07 AU AU2009208042A patent/AU2009208042B2/en not_active Expired - Fee Related
-
2010
- 2010-03-25 JP JP2010069022A patent/JP2010195796A/ja active Pending
- 2010-10-29 JP JP2010242947A patent/JP2011102296A/ja active Pending
-
2011
- 2011-05-30 IL IL213220A patent/IL213220A0/en unknown
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