CA2478335C - Amino-methyl substituted tetracycline compounds - Google Patents

Amino-methyl substituted tetracycline compounds Download PDF

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Publication number
CA2478335C
CA2478335C CA2478335A CA2478335A CA2478335C CA 2478335 C CA2478335 C CA 2478335C CA 2478335 A CA2478335 A CA 2478335A CA 2478335 A CA2478335 A CA 2478335A CA 2478335 C CA2478335 C CA 2478335C
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Canada
Prior art keywords
alkyl
aryl
hydrogen
heteroatoms selected
tetracycline compound
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Expired - Fee Related
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CA2478335A
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English (en)
French (fr)
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CA2478335A1 (en
Inventor
Mark L. Nelson
Kwasi Ohemeng
Roger Frechette
Mohamed Y. Ismail
Laura Honeyman
Todd Bowser
Paul Abato
Victor Amoo
Haregewein Assefa
Joel Berniac
Beena Bhatia
Jackson Chen
Oak Kim
Rachid Mechiche
N. Laxma Reddy
Atul K. Verma
Peter Viski
Tadeusz Warchol
Ivan Yanachkov
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Paratek Pharmaceuticals Inc
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Paratek Pharmaceuticals Inc
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Publication of CA2478335C publication Critical patent/CA2478335C/en
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
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    • C07C235/66—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems and singly-bound oxygen atoms, bound to the same carbon skeleton
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