JP2011092194A5 - - Google Patents
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- JP2011092194A5 JP2011092194A5 JP2010262151A JP2010262151A JP2011092194A5 JP 2011092194 A5 JP2011092194 A5 JP 2011092194A5 JP 2010262151 A JP2010262151 A JP 2010262151A JP 2010262151 A JP2010262151 A JP 2010262151A JP 2011092194 A5 JP2011092194 A5 JP 2011092194A5
- Authority
- JP
- Japan
- Prior art keywords
- cytotoxic
- carbon atoms
- alkenyl
- cytotoxic conjugate
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 55
- 125000003342 alkenyl group Chemical group 0.000 claims description 46
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 36
- 239000012634 fragment Substances 0.000 claims description 30
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims description 26
- 125000000623 heterocyclic group Chemical group 0.000 claims description 26
- 125000000217 alkyl group Chemical group 0.000 claims description 22
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 22
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 12
- 125000003107 substituted aryl group Chemical group 0.000 claims description 9
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 5
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 5
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 3
- 125000002228 disulfide group Chemical group 0.000 claims description 3
- 231100000433 cytotoxic Toxicity 0.000 claims 84
- 230000001472 cytotoxic effect Effects 0.000 claims 84
- 239000011230 binding agent Substances 0.000 claims 20
- 239000000126 substance Substances 0.000 claims 18
- 229940127089 cytotoxic agent Drugs 0.000 claims 16
- 239000002254 cytotoxic agent Substances 0.000 claims 16
- 231100000599 cytotoxic agent Toxicity 0.000 claims 16
- 229930126263 Maytansine Natural products 0.000 claims 11
- WKPWGQKGSOKKOO-RSFHAFMBSA-N maytansine Chemical group CO[C@@H]([C@@]1(O)C[C@](OC(=O)N1)([C@H]([C@@H]1O[C@@]1(C)[C@@H](OC(=O)[C@H](C)N(C)C(C)=O)CC(=O)N1C)C)[H])\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 WKPWGQKGSOKKOO-RSFHAFMBSA-N 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 241001529936 Murinae Species 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 8
- 230000002401 inhibitory effect Effects 0.000 claims 7
- 230000001225 therapeutic effect Effects 0.000 claims 7
- 229940123237 Taxane Drugs 0.000 claims 5
- -1 CC-1065 compound Chemical class 0.000 claims 4
- 206010033128 Ovarian cancer Diseases 0.000 claims 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 4
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 3
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 3
- JSHOVKSMJRQOGY-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 4-(pyridin-2-yldisulfanyl)butanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCCSSC1=CC=CC=N1 JSHOVKSMJRQOGY-UHFFFAOYSA-N 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010014733 Endometrial cancer Diseases 0.000 claims 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 208000004354 Vulvar Neoplasms Diseases 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 230000002357 endometrial effect Effects 0.000 claims 2
- 208000023965 endometrium neoplasm Diseases 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 208000024719 uterine cervix neoplasm Diseases 0.000 claims 2
- 201000005102 vulva cancer Diseases 0.000 claims 2
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims 1
- 108010008177 Fd immunoglobulins Proteins 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 230000003013 cytotoxicity Effects 0.000 claims 1
- 231100000135 cytotoxicity Toxicity 0.000 claims 1
- 229960000975 daunorubicin Drugs 0.000 claims 1
- 229930188854 dolastatin Natural products 0.000 claims 1
- 229960004679 doxorubicin Drugs 0.000 claims 1
- AOJJSUZBOXZQNB-TZSSRYMLSA-N doxorubicine Natural products O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 description 6
- 125000001424 substituent group Chemical group 0.000 description 6
- 0 C[C@@](C(O*)=O)N(C)C(*)* Chemical compound C[C@@](C(O*)=O)N(C)C(*)* 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 229910052717 sulfur Inorganic materials 0.000 description 3
- 125000004434 sulfur atom Chemical group 0.000 description 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
- 125000003396 thiol group Chemical group [H]S* 0.000 description 2
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48844703P | 2003-07-21 | 2003-07-21 | |
| US60/488,447 | 2003-07-21 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006521193A Division JP2007503202A (ja) | 2003-07-21 | 2004-07-21 | Ｃａ６抗原特異的な細胞毒性コンジュゲートおよびその使用方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014133794A Division JP5997727B2 (ja) | 2003-07-21 | 2014-06-30 | Ｃａ６抗原特異的な細胞毒性コンジュゲートおよびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011092194A JP2011092194A (ja) | 2011-05-12 |
| JP2011092194A5 true JP2011092194A5 (https=) | 2011-12-01 |
| JP5643619B2 JP5643619B2 (ja) | 2014-12-17 |
Family
ID=34102763
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006521193A Pending JP2007503202A (ja) | 2003-07-21 | 2004-07-21 | Ｃａ６抗原特異的な細胞毒性コンジュゲートおよびその使用方法 |
| JP2010262151A Expired - Fee Related JP5643619B2 (ja) | 2003-07-21 | 2010-11-25 | Ｃａ６抗原特異的な細胞毒性コンジュゲートおよびその使用方法 |
| JP2014133794A Expired - Fee Related JP5997727B2 (ja) | 2003-07-21 | 2014-06-30 | Ｃａ６抗原特異的な細胞毒性コンジュゲートおよびその使用方法 |
| JP2015237469A Expired - Fee Related JP6144749B2 (ja) | 2003-07-21 | 2015-12-04 | Ｃａ６抗原特異的な細胞毒性コンジュゲートおよびその使用方法 |
| JP2017033672A Pending JP2017123857A (ja) | 2003-07-21 | 2017-02-24 | Ｃａ６抗原特異的な細胞毒性コンジュゲートおよびその使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006521193A Pending JP2007503202A (ja) | 2003-07-21 | 2004-07-21 | Ｃａ６抗原特異的な細胞毒性コンジュゲートおよびその使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014133794A Expired - Fee Related JP5997727B2 (ja) | 2003-07-21 | 2014-06-30 | Ｃａ６抗原特異的な細胞毒性コンジュゲートおよびその使用方法 |
| JP2015237469A Expired - Fee Related JP6144749B2 (ja) | 2003-07-21 | 2015-12-04 | Ｃａ６抗原特異的な細胞毒性コンジュゲートおよびその使用方法 |
| JP2017033672A Pending JP2017123857A (ja) | 2003-07-21 | 2017-02-24 | Ｃａ６抗原特異的な細胞毒性コンジュゲートおよびその使用方法 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20050123549A1 (https=) |
| EP (1) | EP1660513B9 (https=) |
| JP (5) | JP2007503202A (https=) |
| KR (5) | KR101565721B1 (https=) |
| CN (3) | CN103145844B (https=) |
| AT (1) | ATE496944T1 (https=) |
| AU (1) | AU2004258955C1 (https=) |
| BR (1) | BRPI0412879A8 (https=) |
| CA (1) | CA2532430C (https=) |
| CR (1) | CR8207A (https=) |
| CY (1) | CY1111938T1 (https=) |
| DE (1) | DE602004031239D1 (https=) |
| DK (1) | DK1660513T5 (https=) |
| EA (1) | EA014640B1 (https=) |
| EC (1) | ECSP066294A (https=) |
| ES (1) | ES2360403T3 (https=) |
| HR (1) | HRP20110302T1 (https=) |
| IL (2) | IL172982A (https=) |
| MX (2) | MXPA06000830A (https=) |
| NO (1) | NO339324B1 (https=) |
| NZ (3) | NZ580855A (https=) |
| PL (1) | PL1660513T3 (https=) |
| PT (1) | PT1660513E (https=) |
| SI (1) | SI1660513T1 (https=) |
| WO (1) | WO2005009369A2 (https=) |
| ZA (1) | ZA200600375B (https=) |
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| US6596503B1 (en) | 2000-08-18 | 2003-07-22 | East Carolina University | Monoclonal antibody DS6, tumor-associated antigen CA6, and methods of use thereof |
| US9539348B2 (en) | 2000-08-18 | 2017-01-10 | East Carolina University | Monoclonal antibody DS6, tumor-associated antigen CA6, and methods of use thereof |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
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| US7834155B2 (en) | 2003-07-21 | 2010-11-16 | Immunogen Inc. | CA6 antigen-specific cytotoxic conjugate and methods of using the same |
| CA2486285C (en) * | 2004-08-30 | 2017-03-07 | Viktor S. Goldmakher | Immunoconjugates targeting syndecan-1 expressing cells and use thereof |
| CA2615761A1 (en) * | 2005-08-22 | 2007-03-01 | Immunogen, Inc. | Humanized anti-ca6 antibodies and methods of using the same |
| CN104804094A (zh) * | 2005-08-22 | 2015-07-29 | 伊缪诺金公司 | Ca6抗原特异性细胞毒性偶联物及其应用方法 |
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| JP6971858B2 (ja) | 2015-06-22 | 2021-11-24 | バイエル ファーマ アクチエンゲゼルシャフト | 酵素開裂性基を有する抗体薬物複合体（ａｄｃ）および抗体プロドラッグ複合体（ａｐｄｃ） |
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2004
- 2004-07-21 AT AT04778714T patent/ATE496944T1/de active
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2006
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2010
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2011
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2014
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2015
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2017
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