JP2011042682A - 水性製剤の増粘剤 - Google Patents
水性製剤の増粘剤 Download PDFInfo
- Publication number
- JP2011042682A JP2011042682A JP2010242734A JP2010242734A JP2011042682A JP 2011042682 A JP2011042682 A JP 2011042682A JP 2010242734 A JP2010242734 A JP 2010242734A JP 2010242734 A JP2010242734 A JP 2010242734A JP 2011042682 A JP2011042682 A JP 2011042682A
- Authority
- JP
- Japan
- Prior art keywords
- hyaluronic acid
- item
- aqueous
- boric acid
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title abstract description 28
- 239000002562 thickening agent Substances 0.000 title abstract description 10
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract description 29
- 229920002674 hyaluronan Polymers 0.000 abstract description 28
- 229960003160 hyaluronic acid Drugs 0.000 abstract description 28
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 abstract description 25
- 239000004327 boric acid Substances 0.000 abstract description 25
- 239000007864 aqueous solution Substances 0.000 abstract description 13
- 238000000034 method Methods 0.000 abstract description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract description 6
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 239000003792 electrolyte Substances 0.000 abstract description 4
- 150000003839 salts Chemical class 0.000 abstract description 4
- 239000000243 solution Substances 0.000 abstract description 4
- 235000011187 glycerol Nutrition 0.000 abstract description 3
- 230000008719 thickening Effects 0.000 abstract description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract description 2
- 239000008103 glucose Substances 0.000 abstract description 2
- 229920002385 Sodium hyaluronate Polymers 0.000 description 10
- 229940010747 sodium hyaluronate Drugs 0.000 description 10
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 239000000203 mixture Substances 0.000 description 6
- 235000002639 sodium chloride Nutrition 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
- 239000008213 purified water Substances 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229910021538 borax Inorganic materials 0.000 description 3
- 159000000000 sodium salts Chemical class 0.000 description 3
- 235000010339 sodium tetraborate Nutrition 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000001103 potassium chloride Substances 0.000 description 2
- 235000011164 potassium chloride Nutrition 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 2
- 229930024421 Adenine Natural products 0.000 description 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 208000002177 Cataract Diseases 0.000 description 1
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 description 1
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 description 1
- 206010013774 Dry eye Diseases 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 208000010412 Glaucoma Diseases 0.000 description 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 1
- DJDFFEBSKJCGHC-UHFFFAOYSA-N Naphazoline Chemical compound Cl.C=1C=CC2=CC=CC=C2C=1CC1=NCCN1 DJDFFEBSKJCGHC-UHFFFAOYSA-N 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229960000643 adenine Drugs 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000000043 antiallergic agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 150000001642 boronic acid derivatives Chemical class 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
- 229940046978 chlorpheniramine maleate Drugs 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- MQRJBSHKWOFOGF-UHFFFAOYSA-L disodium;carbonate;hydrate Chemical compound O.[Na+].[Na+].[O-]C([O-])=O MQRJBSHKWOFOGF-UHFFFAOYSA-L 0.000 description 1
- -1 etc. Substances 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000002955 immunomodulating agent Substances 0.000 description 1
- 229940121354 immunomodulator Drugs 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000007951 isotonicity adjuster Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
- 229960004760 naphazoline hydrochloride Drugs 0.000 description 1
- 229960002362 neostigmine Drugs 0.000 description 1
- LULNWZDBKTWDGK-UHFFFAOYSA-M neostigmine bromide Chemical compound [Br-].CN(C)C(=O)OC1=CC=CC([N+](C)(C)C)=C1 LULNWZDBKTWDGK-UHFFFAOYSA-M 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940108325 retinyl palmitate Drugs 0.000 description 1
- 235000019172 retinyl palmitate Nutrition 0.000 description 1
- 239000011769 retinyl palmitate Substances 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 229940037001 sodium edetate Drugs 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010242734A JP2011042682A (ja) | 1997-05-20 | 2010-10-28 | 水性製剤の増粘剤 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14731597 | 1997-05-20 | ||
| JP2010242734A JP2011042682A (ja) | 1997-05-20 | 2010-10-28 | 水性製剤の増粘剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12865898A Division JPH1143446A (ja) | 1997-05-20 | 1998-05-12 | 水性製剤の増粘剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013219722A Division JP5886260B2 (ja) | 1997-05-20 | 2013-10-23 | ヒアルロン酸含有水性製剤の増粘及び粘度低下抑制方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011042682A true JP2011042682A (ja) | 2011-03-03 |
| JP2011042682A5 JP2011042682A5 (enExample) | 2011-12-01 |
Family
ID=43830352
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010242734A Pending JP2011042682A (ja) | 1997-05-20 | 2010-10-28 | 水性製剤の増粘剤 |
| JP2013219722A Expired - Lifetime JP5886260B2 (ja) | 1997-05-20 | 2013-10-23 | ヒアルロン酸含有水性製剤の増粘及び粘度低下抑制方法 |
| JP2015192424A Pending JP2016014053A (ja) | 1997-05-20 | 2015-09-30 | 増粘されたヒアルロン酸含有水性製剤 |
| JP2016211210A Expired - Lifetime JP6156762B2 (ja) | 1997-05-20 | 2016-10-28 | ヒアルロン酸含有水性製剤の増粘及び粘度低下抑制剤 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013219722A Expired - Lifetime JP5886260B2 (ja) | 1997-05-20 | 2013-10-23 | ヒアルロン酸含有水性製剤の増粘及び粘度低下抑制方法 |
| JP2015192424A Pending JP2016014053A (ja) | 1997-05-20 | 2015-09-30 | 増粘されたヒアルロン酸含有水性製剤 |
| JP2016211210A Expired - Lifetime JP6156762B2 (ja) | 1997-05-20 | 2016-10-28 | ヒアルロン酸含有水性製剤の増粘及び粘度低下抑制剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (4) | JP2011042682A (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013112628A (ja) * | 2011-11-28 | 2013-06-10 | Senju Pharmaceut Co Ltd | 動物用眼科組成物 |
| CN117752071A (zh) * | 2023-12-22 | 2024-03-26 | 华熙生物科技股份有限公司 | 一种增稠剂、增稠组件及其制备方法和应用 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6603785B2 (ja) * | 2017-12-08 | 2019-11-06 | 千寿製薬株式会社 | 水溶性高分子を含む水性液剤 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5857319A (ja) * | 1981-09-30 | 1983-04-05 | Green Cross Corp:The | 高粘性ヒアルロン酸製剤 |
| JPH0296531A (ja) * | 1988-08-04 | 1990-04-09 | Ciba Geigy Ag | 眼内溶液の防腐方法及びそのための組成物 |
| SU1623991A1 (ru) * | 1989-05-06 | 1991-01-30 | Всесоюзный научно-исследовательский институт текстильно-галантерейной промышленности | Способ стабилизации гиалуроновой кислоты |
| JPH0469342A (ja) * | 1990-07-06 | 1992-03-04 | Senju Pharmaceut Co Ltd | 水性医薬製剤 |
| JPH1025254A (ja) * | 1996-07-12 | 1998-01-27 | Rohto Pharmaceut Co Ltd | 配合禁忌の防止された水溶性製剤 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5261183A (en) * | 1975-11-15 | 1977-05-20 | Kouji Kobayashi | Manufacture of hydrated gel |
| US4826719A (en) * | 1986-07-15 | 1989-05-02 | H. B. Fuller Company | Fast setting starch-based corrugating adhesive having fully hydrolyzed cold water insoluble polyvinyl alcohol component |
-
2010
- 2010-10-28 JP JP2010242734A patent/JP2011042682A/ja active Pending
-
2013
- 2013-10-23 JP JP2013219722A patent/JP5886260B2/ja not_active Expired - Lifetime
-
2015
- 2015-09-30 JP JP2015192424A patent/JP2016014053A/ja active Pending
-
2016
- 2016-10-28 JP JP2016211210A patent/JP6156762B2/ja not_active Expired - Lifetime
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5857319A (ja) * | 1981-09-30 | 1983-04-05 | Green Cross Corp:The | 高粘性ヒアルロン酸製剤 |
| JPH0296531A (ja) * | 1988-08-04 | 1990-04-09 | Ciba Geigy Ag | 眼内溶液の防腐方法及びそのための組成物 |
| SU1623991A1 (ru) * | 1989-05-06 | 1991-01-30 | Всесоюзный научно-исследовательский институт текстильно-галантерейной промышленности | Способ стабилизации гиалуроновой кислоты |
| JPH0469342A (ja) * | 1990-07-06 | 1992-03-04 | Senju Pharmaceut Co Ltd | 水性医薬製剤 |
| JPH1025254A (ja) * | 1996-07-12 | 1998-01-27 | Rohto Pharmaceut Co Ltd | 配合禁忌の防止された水溶性製剤 |
Non-Patent Citations (5)
| Title |
|---|
| JPN6010010074; 長野浩一他: ポバール 改訂新版, 1981, ｐ．１５２-１５３ * |
| JPN6010010075; 岡野定輔他: 'ホウ酸塩の存在下グアノシン-水分散系のゲル化' 薬学雑誌 Ｖｏｌ．９０， Ｎｏ．１２, 1970, ｐ．１５４２-１５４８ * |
| JPN6010010078; 村上良一: '澱粉-ホウ酸錯体コロイド溶液の粘性挙動' 澱粉科学 Ｖｏｌ．３６， Ｎｏ．４, 1989, ｐ．２７３-２７６ * |
| JPN6010010080; ＭＵＲＡＫＡＭＩ，Ｒ． ｅｔ ａｌ．: 'Ｖｉｓｃｏｓｉｔｙ ｏｆ ａｑｕｅｏｕｓ ｇｌｕｃｏｍａｎｎａｎ-ｂｏｒａｔｅ ｃｏｍｐｌｅｘ ｓｏｌｕｔｉｏｎｓ' ＰＯＬＹＭＥＲ Ｖｏｌ．３３， Ｎｏ．５, 1992, ｐ．１１０８-１１０９ * |
| JPN6011021061; Ｆａｒｍａｋｏｌｏｇｉｙａ ｉ Ｔｏｋｓｉｋｏｌｏｇｉｙａ Ｖｏｌ．３１， Ｉｓｓｕｅ ５, 1968, ｐ．５７４-５７６ * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013112628A (ja) * | 2011-11-28 | 2013-06-10 | Senju Pharmaceut Co Ltd | 動物用眼科組成物 |
| CN117752071A (zh) * | 2023-12-22 | 2024-03-26 | 华熙生物科技股份有限公司 | 一种增稠剂、增稠组件及其制备方法和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6156762B2 (ja) | 2017-07-05 |
| JP2016014053A (ja) | 2016-01-28 |
| JP2017019867A (ja) | 2017-01-26 |
| JP5886260B2 (ja) | 2016-03-16 |
| JP2014012743A (ja) | 2014-01-23 |
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