JP2011037904A5 - - Google Patents
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- Publication number
- JP2011037904A5 JP2011037904A5 JP2010264093A JP2010264093A JP2011037904A5 JP 2011037904 A5 JP2011037904 A5 JP 2011037904A5 JP 2010264093 A JP2010264093 A JP 2010264093A JP 2010264093 A JP2010264093 A JP 2010264093A JP 2011037904 A5 JP2011037904 A5 JP 2011037904A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- composition
- gelling agent
- benzoyl peroxide
- penetration enhancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 29
- 239000003349 gelling agent Substances 0.000 claims 8
- 239000004342 Benzoyl peroxide Substances 0.000 claims 7
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims 7
- 235000019400 benzoyl peroxide Nutrition 0.000 claims 7
- 239000003961 penetration enhancing agent Substances 0.000 claims 7
- 238000003756 stirring Methods 0.000 claims 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 6
- 239000007788 liquid Substances 0.000 claims 5
- 239000004094 surface-active agent Substances 0.000 claims 5
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 claims 4
- LZCDAPDGXCYOEH-UHFFFAOYSA-N adapalene Chemical compound C1=C(C(O)=O)C=CC2=CC(C3=CC=C(C(=C3)C34CC5CC(CC(C5)C3)C4)OC)=CC=C21 LZCDAPDGXCYOEH-UHFFFAOYSA-N 0.000 claims 4
- 229960002916 adapalene Drugs 0.000 claims 4
- 239000008346 aqueous phase Substances 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 150000004492 retinoid derivatives Chemical class 0.000 claims 4
- 238000009736 wetting Methods 0.000 claims 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical group CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 239000012071 phase Substances 0.000 claims 3
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 claims 2
- 208000002874 Acne Vulgaris Diseases 0.000 claims 2
- 206010000496 acne Diseases 0.000 claims 2
- 239000002738 chelating agent Substances 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 229920002401 polyacrylamide Polymers 0.000 claims 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 2
- 229940068968 polysorbate 80 Drugs 0.000 claims 2
- 229920000053 polysorbate 80 Polymers 0.000 claims 2
- 239000000080 wetting agent Substances 0.000 claims 2
- 201000004384 Alopecia Diseases 0.000 claims 1
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims 1
- 206010013786 Dry skin Diseases 0.000 claims 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical group C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 1
- 229920002507 Poloxamer 124 Polymers 0.000 claims 1
- WWAZUUULUNZNFE-UHFFFAOYSA-N [Na].NC(=O)C=C Chemical compound [Na].NC(=O)C=C WWAZUUULUNZNFE-UHFFFAOYSA-N 0.000 claims 1
- 239000012072 active phase Substances 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 230000024245 cell differentiation Effects 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000037336 dry skin Effects 0.000 claims 1
- 230000008030 elimination Effects 0.000 claims 1
- 238000003379 elimination reaction Methods 0.000 claims 1
- 208000024963 hair loss Diseases 0.000 claims 1
- 230000003676 hair loss Effects 0.000 claims 1
- 230000009931 harmful effect Effects 0.000 claims 1
- 208000029443 keratinization disease Diseases 0.000 claims 1
- 229960000502 poloxamer Drugs 0.000 claims 1
- 229920001983 poloxamer Polymers 0.000 claims 1
- 229940093448 poloxamer 124 Drugs 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
- 230000008929 regeneration Effects 0.000 claims 1
- 238000011069 regeneration method Methods 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- LPXFITACVAQQAL-UHFFFAOYSA-M sodium;prop-2-enoylazanide Chemical compound [Na+].[NH-]C(=O)C=C LPXFITACVAQQAL-UHFFFAOYSA-M 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0116747A FR2833841B1 (fr) | 2001-12-21 | 2001-12-21 | Gel comprenant au moins un retinoide et du peroxyde de benzoyle |
| FR0116747 | 2001-12-21 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003556050A Division JP4889922B2 (ja) | 2001-12-21 | 2002-12-09 | 少なくとも一つのレチノイド及び過酸化ベンゾイルを含むゲル組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011037904A JP2011037904A (ja) | 2011-02-24 |
| JP2011037904A5 true JP2011037904A5 (enExample) | 2012-02-23 |
| JP5478468B2 JP5478468B2 (ja) | 2014-04-23 |
Family
ID=8870899
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003556050A Expired - Lifetime JP4889922B2 (ja) | 2001-12-21 | 2002-12-09 | 少なくとも一つのレチノイド及び過酸化ベンゾイルを含むゲル組成物 |
| JP2010264093A Expired - Lifetime JP5478468B2 (ja) | 2001-12-21 | 2010-11-26 | 少なくとも一つのレチノイド及び過酸化ベンゾイルを含むゲル組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003556050A Expired - Lifetime JP4889922B2 (ja) | 2001-12-21 | 2002-12-09 | 少なくとも一つのレチノイド及び過酸化ベンゾイルを含むゲル組成物 |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1458369B1 (enExample) |
| JP (2) | JP4889922B2 (enExample) |
| KR (1) | KR101014586B1 (enExample) |
| CN (1) | CN1329025C (enExample) |
| AR (1) | AR038026A1 (enExample) |
| AT (1) | ATE347354T1 (enExample) |
| AU (2) | AU2002364437B2 (enExample) |
| BR (1) | BRPI0214264B8 (enExample) |
| CA (1) | CA2466321C (enExample) |
| CY (1) | CY1107583T1 (enExample) |
| DE (2) | DE60216634T2 (enExample) |
| DK (1) | DK1458369T3 (enExample) |
| ES (1) | ES2275948T3 (enExample) |
| FR (2) | FR2833841B1 (enExample) |
| HU (1) | HU230439B1 (enExample) |
| MX (1) | MXPA04005918A (enExample) |
| PL (1) | PL220838B1 (enExample) |
| PT (1) | PT1458369E (enExample) |
| RU (1) | RU2320327C2 (enExample) |
| SI (1) | SI1458369T1 (enExample) |
| WO (1) | WO2003055472A1 (enExample) |
| ZA (1) | ZA200403759B (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7820186B2 (en) | 2001-12-21 | 2010-10-26 | Galderma Research & Development | Gel composition for once-daily treatment of common acne comprising a combination of benzoyl peroxide and adapalene and/or adapalene salt |
| FR2833841B1 (fr) * | 2001-12-21 | 2005-07-22 | Galderma Res & Dev | Gel comprenant au moins un retinoide et du peroxyde de benzoyle |
| EP1813312A3 (en) * | 2002-09-05 | 2010-03-24 | Galderma Research & Development | Depigmenting composition for the skin comprising adapalene and at least one depigmenting agent |
| US7544674B2 (en) | 2002-10-25 | 2009-06-09 | Galderma S.A. | Topical skin care composition |
| DE602005021238D1 (de) * | 2004-11-09 | 2010-06-24 | Imaginative Res Associates Inc | Retinoidlösungen und formulierungen daraus |
| BRPI0614143A2 (pt) | 2005-08-02 | 2012-11-20 | Sol Gel Technologies Ltd | processo para revestir um material particulado insolével em Água, sàlido, com um àxido metÁlico, material particulado revestido, composiÇço, mÉtodo para o tratamento de uma condiÇço superficial em um induvÍduo, e, uso de material particulado revestido |
| FR2889662B1 (fr) * | 2005-08-11 | 2011-01-14 | Galderma Res & Dev | Emulsion de type huile-dans-eau pour application topique en dermatologie |
| FR2890314B1 (fr) * | 2005-09-02 | 2009-03-20 | Galderma Res & Dev | Compositiondepigmentante de la peau comprenant de l'adapalene au moins un agent depigmentant et au moins un agent anti-inflammatoire |
| EP1926484A2 (en) * | 2005-09-02 | 2008-06-04 | Galderma Research & Development | Depigmenting composition for the skin, comprising adapalene, at least one depigmenting agent and at least one anti-inflammatory agent |
| BRPI0709674A2 (pt) | 2006-03-31 | 2011-12-06 | Stiefel Research Australia Pty Ltd. | gel de suspensão espumante |
| FR2901139B1 (fr) * | 2006-05-17 | 2009-03-20 | Galderma Res & Dev S N C Snc | Compositions comprenant au moins un derive de l'acide naphtoique et du peroxyde de benzoyle, leurs procedes de preparation, et leurs utilisations |
| CA2656451C (en) * | 2006-07-13 | 2015-01-27 | Galderma Research & Development | Composition comprising a retinoid and benzoyl peroxide |
| FR2903603B1 (fr) * | 2006-07-13 | 2009-03-20 | Galderma Res & Dev S N C Snc | Combinaison d'adapalene et de peroxyde de benzole dans le traitement de l'acne |
| FR2903604B1 (fr) * | 2006-07-13 | 2008-09-05 | Galderma Res & Dev S N C Snc | Composition comprenant un retinoide et du peroxyde de benzoyle |
| US8080537B2 (en) | 2006-07-13 | 2011-12-20 | Galderma Research & Development | Combinations of adapalene and benzoyl peroxide for treating acne lesions |
| FR2909000B1 (fr) * | 2006-11-28 | 2009-02-06 | Galderma Res & Dev S N C Snc | Compositions comprenant du peroxyde de benzoyle, au moins un derive de l'acide naphtoique et au moins un compose de type polymeres de polyurethane ou des derives de celui-ci, et leurs utilisations. |
| FR2910321B1 (fr) * | 2006-12-21 | 2009-07-10 | Galderma Res & Dev S N C Snc | Gel creme comprenant au moins un retinoide et du peroxyde de benzole |
| FR2910320B1 (fr) * | 2006-12-21 | 2009-02-13 | Galderma Res & Dev S N C Snc | Emulsion comprenant au moins un retinoide et du peroxyde de benzole |
| EP2114392B1 (en) | 2007-01-30 | 2015-06-10 | Galderma Research & Development | Use of adapalene and benzoyl peroxide for the long term treatment of acne vulgaris |
| EA200970724A1 (ru) * | 2007-02-01 | 2010-02-26 | Сол-Джел Текнолоджиз Лтд. | Композиции для местного применения, содержащие пероксид и ретиноид |
| ES2763829T3 (es) | 2007-02-01 | 2020-06-01 | Sol Gel Tech Ltd | Método para preparar partículas que comprenden un revestimiento de óxido de metal |
| EP1967180A1 (de) * | 2007-03-06 | 2008-09-10 | Almirall Hermal GmbH | Topische Zusammensetzung enthaltend einen Retinoid-Rezeptor-Agonist |
| FR2916966B1 (fr) * | 2007-06-11 | 2011-01-14 | Galderma Res & Dev | Compositions comprenant au moins un compose retinoide, un compose anti-irritant et du peroxyde de benzoyle, et leurs utilisations |
| FR2916975B1 (fr) * | 2007-06-11 | 2009-09-04 | Galderma Res & Dev | Compositions comprenant au moins un compose retinoide, un compose anti-irritant et du peroxyde de benzoyle, et leurs utilisations |
| EP2065032A1 (en) * | 2007-11-27 | 2009-06-03 | Galderma Research & Development | A method for producing adapalene gels |
| CN105287484A (zh) * | 2007-11-30 | 2016-02-03 | 盖尔德马研究及发展公司 | 含有萘甲酸衍生物、过氧化苯甲酰和成膜剂的组合物 |
| ES2773931T3 (es) | 2008-06-05 | 2020-07-15 | Bausch Health Ireland Ltd | Formulaciones farmacéuticas tópicas que contienen una baja concentración de peróxido de benzoílo en suspensión en agua y un solvente orgánico miscible en agua |
| KR20180023070A (ko) | 2008-11-07 | 2018-03-06 | 클록스 테크놀로지스 인크. | 히알루론산, 글루코사민 또는 알란토인을 포함하는 산화성의 광활성화된 피부 회춘용 조성물 |
| US9682031B2 (en) | 2009-10-07 | 2017-06-20 | Tagra Biotechnologies Ltd. | Microcapsules comprising benzoyl peroxide and topical compositions comprising them |
| CA2777489C (en) * | 2009-10-21 | 2018-11-20 | Dow Pharmaceutical Sciences, Inc. | Method for wetting a powder containing benzoyl peroxide |
| BR112012019827A2 (pt) | 2010-02-09 | 2016-05-17 | Galderma Res & Dev | utilização de uma combinação do adapaleno com o peróxido de benzoílo |
| FR2969492B1 (fr) * | 2010-12-23 | 2013-07-05 | Galderma Res & Dev | Mousses dermatologiques obtenues a partir d'un gel ou d'une suspension contenant de l'adapalene |
| FR2969491B1 (fr) * | 2010-12-23 | 2013-07-12 | Galderma Res & Dev | Mousses dermatologiques obtenues a partir d'un gel ou d'une suspension contenant une combinaison d'adapalene et de bpo |
| US8563535B2 (en) | 2011-03-29 | 2013-10-22 | Kamal Mehta | Combination composition comprising benzoyl peroxide and adapalene |
| WO2013175011A1 (en) | 2012-05-25 | 2013-11-28 | Galderma Research & Development | Treatment of preadolescent moderate acne vulgaris |
| DK2919747T3 (en) * | 2012-11-13 | 2019-01-28 | Galderma Sa | BPO VASKEGELSAMMENSÆTNING |
| US9687465B2 (en) | 2012-11-27 | 2017-06-27 | Sol-Gel Technologies Ltd. | Compositions for the treatment of rosacea |
| EP3082785A1 (en) | 2013-12-19 | 2016-10-26 | Galderma Research & Development | Therapy regimen for treating severe acne related diseases |
| KR20160130862A (ko) | 2014-04-01 | 2016-11-14 | 갈데르마 리써어치 앤드 디벨로프먼트 | 여드름 흉터의 치료를 위한 아다팔렌 및 벤조일 퍼옥시드의 조합 |
| MX2017000717A (es) | 2014-07-25 | 2017-05-01 | Galderma Res & Dev | Combinacion de adapaleno y peroxido de benzoilo para el tratamiento del acne grave. |
| JP6526322B2 (ja) * | 2015-08-20 | 2019-06-05 | ソル − ゲル テクノロジーズ リミテッド | 過酸化ベンゾイルおよびアダパレンを含む局所投与用組成物 |
| WO2018080284A1 (ko) * | 2016-10-31 | 2018-05-03 | (주)동구바이오제약 | 여드름 치료용 약물의 생체이용률을 증진시키는 약학적 조성물 |
| CN106729722B (zh) * | 2016-11-21 | 2020-05-12 | 成都山信药业有限公司 | 一种制备稳定复方制剂的方法及复方制剂 |
| HUE073201T2 (hu) | 2017-07-12 | 2026-01-28 | Sol Gel Tech Ltd | Kapszulázott tretinoint tartalmazó készítmények |
| JP2022527549A (ja) * | 2019-04-04 | 2022-06-02 | ガルデルマ ホールディング エスエー | 炭酸イソプロピル過酸化ベンゾイル組成物及び使用の方法 |
| WO2023112664A1 (ja) * | 2021-12-14 | 2023-06-22 | ロート製薬株式会社 | 過酸化ベンゾイルを含有する医薬外用組成物 |
| WO2023177625A1 (en) * | 2022-03-14 | 2023-09-21 | Blue Hill Technologies Llc | Shelf-stable formulations of benzoyl peroxide and methods of producing same |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2378523A1 (fr) * | 1977-01-26 | 1978-08-25 | Grupper Charles | Medicament pour le traitement de l'acne |
| US4189501A (en) * | 1977-10-07 | 1980-02-19 | A. H. C. Pharmacal, Inc. | Composition and method for the treatment of acne |
| LU85849A1 (fr) * | 1985-04-11 | 1986-11-05 | Cird | Derives benzonaphtaleniques,leur procede de preparation et leur application dans les domaines pharmaceutiques et cosmetiques |
| US4792452A (en) * | 1987-07-28 | 1988-12-20 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
| FR2628319B1 (fr) * | 1988-03-09 | 1990-12-07 | Oreal | Compositions pharmaceutiques et cosmetiques a base de peroxyde de benzoyle et de sels d'ammonium quaternaires |
| JP3555762B2 (ja) * | 1991-10-16 | 2004-08-18 | リチャードソン、ビックス、インコーポレーテッド | 非イオン性ポリアクリルアミド誘導体を含有した低ｐＨ水性化粧品ゲル |
| US5470884A (en) * | 1994-05-19 | 1995-11-28 | Procter & Gamble | Anti-acne compositions |
| FR2785284B1 (fr) * | 1998-11-02 | 2000-12-01 | Galderma Res & Dev | Analogues de la vitamine d |
| FR2787322B1 (fr) * | 1998-12-18 | 2002-10-18 | Galderma Res & Dev | Emulsion huile-dans-eau comprenant un agent actif micronise et un systeme emulsionnant approprie |
| WO2001045647A2 (de) * | 1999-12-20 | 2001-06-28 | Henkel Kommanditgesellschaft Auf Aktien | Tablettierung verdickender systeme |
| FR2833841B1 (fr) * | 2001-12-21 | 2005-07-22 | Galderma Res & Dev | Gel comprenant au moins un retinoide et du peroxyde de benzoyle |
-
2001
- 2001-12-21 FR FR0116747A patent/FR2833841B1/fr not_active Expired - Fee Related
-
2002
- 2002-12-09 DE DE60216634T patent/DE60216634T2/de not_active Expired - Lifetime
- 2002-12-09 HU HU0500006A patent/HU230439B1/hu unknown
- 2002-12-09 AT AT02799797T patent/ATE347354T1/de active
- 2002-12-09 AU AU2002364437A patent/AU2002364437B2/en not_active Expired
- 2002-12-09 PT PT02799797T patent/PT1458369E/pt unknown
- 2002-12-09 WO PCT/FR2002/004233 patent/WO2003055472A1/fr not_active Ceased
- 2002-12-09 BR BRPI0214264A patent/BRPI0214264B8/pt not_active IP Right Cessation
- 2002-12-09 EP EP02799797A patent/EP1458369B1/fr not_active Expired - Lifetime
- 2002-12-09 JP JP2003556050A patent/JP4889922B2/ja not_active Expired - Lifetime
- 2002-12-09 CN CNB028258460A patent/CN1329025C/zh not_active Expired - Lifetime
- 2002-12-09 RU RU2004122429/15A patent/RU2320327C2/ru active
- 2002-12-09 CA CA2466321A patent/CA2466321C/fr not_active Expired - Fee Related
- 2002-12-09 MX MXPA04005918A patent/MXPA04005918A/es active IP Right Grant
- 2002-12-09 KR KR1020047008461A patent/KR101014586B1/ko not_active Expired - Lifetime
- 2002-12-09 ES ES02799797T patent/ES2275948T3/es not_active Expired - Lifetime
- 2002-12-09 SI SI200230454T patent/SI1458369T1/sl unknown
- 2002-12-09 DK DK02799797T patent/DK1458369T3/da active
- 2002-12-09 DE DE122008000041C patent/DE122008000041I1/de active Pending
- 2002-12-09 PL PL372270A patent/PL220838B1/pl unknown
- 2002-12-18 AR ARP020104930A patent/AR038026A1/es not_active Application Discontinuation
-
2004
- 2004-05-17 ZA ZA2004/03759A patent/ZA200403759B/en unknown
-
2007
- 2007-01-29 CY CY20071100120T patent/CY1107583T1/el unknown
-
2008
- 2008-06-05 FR FR08C0024C patent/FR08C0024I2/fr active Active
- 2008-11-21 AU AU2008246274A patent/AU2008246274B2/en not_active Expired
-
2010
- 2010-11-26 JP JP2010264093A patent/JP5478468B2/ja not_active Expired - Lifetime
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