JP2010540638A5 - - Google Patents
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- Publication number
- JP2010540638A5 JP2010540638A5 JP2010527996A JP2010527996A JP2010540638A5 JP 2010540638 A5 JP2010540638 A5 JP 2010540638A5 JP 2010527996 A JP2010527996 A JP 2010527996A JP 2010527996 A JP2010527996 A JP 2010527996A JP 2010540638 A5 JP2010540638 A5 JP 2010540638A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- haloalkyl
- alkyl
- optionally substituted
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001424 substituent group Chemical group 0.000 claims 31
- 229910052736 halogen Inorganic materials 0.000 claims 30
- 150000002367 halogens Chemical class 0.000 claims 30
- 125000001188 haloalkyl group Chemical group 0.000 claims 24
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 23
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 21
- -1 cyano, hydroxy Chemical group 0.000 claims 20
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- 125000004093 cyano group Chemical group *C#N 0.000 claims 19
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 17
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 16
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 16
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 125000004438 haloalkoxy group Chemical group 0.000 claims 12
- 125000001072 heteroaryl group Chemical group 0.000 claims 12
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 11
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 11
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 10
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 9
- 125000003282 alkyl amino group Chemical group 0.000 claims 9
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 9
- 125000004663 dialkyl amino group Chemical group 0.000 claims 9
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000001931 aliphatic group Chemical group 0.000 claims 4
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 4
- 208000030761 polycystic kidney disease Diseases 0.000 claims 4
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 3
- 125000006832 (C1-C10) alkylene group Chemical group 0.000 claims 2
- 125000002393 azetidinyl group Chemical group 0.000 claims 2
- 125000006161 haloaliphatic group Chemical group 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims 1
- 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 208000010061 Autosomal Dominant Polycystic Kidney Diseases 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 230000001548 androgenic effect Effects 0.000 claims 1
- 208000022185 autosomal dominant polycystic kidney disease Diseases 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99780307P | 2007-10-05 | 2007-10-05 | |
| US60/997,803 | 2007-10-05 | ||
| PCT/US2008/011450 WO2009045503A1 (en) | 2007-10-05 | 2008-10-03 | Method of treating polycystic kidney diseases with ceramide derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013209652A Division JP2014024858A (ja) | 2007-10-05 | 2013-10-04 | セラミド誘導体を用いる多発性嚢胞腎疾患の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010540638A JP2010540638A (ja) | 2010-12-24 |
| JP2010540638A5 true JP2010540638A5 (OSRAM) | 2011-11-17 |
| JP5896601B2 JP5896601B2 (ja) | 2016-03-30 |
Family
ID=40108810
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527996A Expired - Fee Related JP5896601B2 (ja) | 2007-10-05 | 2008-10-03 | セラミド誘導体を用いる多発性嚢胞腎疾患の治療方法 |
| JP2013209652A Pending JP2014024858A (ja) | 2007-10-05 | 2013-10-04 | セラミド誘導体を用いる多発性嚢胞腎疾患の治療方法 |
| JP2015249968A Withdrawn JP2016041761A (ja) | 2007-10-05 | 2015-12-22 | セラミド誘導体を用いる多発性嚢胞腎疾患の治療方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013209652A Pending JP2014024858A (ja) | 2007-10-05 | 2013-10-04 | セラミド誘導体を用いる多発性嚢胞腎疾患の治療方法 |
| JP2015249968A Withdrawn JP2016041761A (ja) | 2007-10-05 | 2015-12-22 | セラミド誘導体を用いる多発性嚢胞腎疾患の治療方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US8912177B2 (OSRAM) |
| EP (2) | EP2550965B1 (OSRAM) |
| JP (3) | JP5896601B2 (OSRAM) |
| KR (3) | KR101640263B1 (OSRAM) |
| CN (2) | CN101888840A (OSRAM) |
| AU (1) | AU2008307516B2 (OSRAM) |
| BR (2) | BRPI0817864A2 (OSRAM) |
| CA (1) | CA2701649C (OSRAM) |
| ES (1) | ES2660690T3 (OSRAM) |
| IL (1) | IL204741A (OSRAM) |
| MX (2) | MX2010003603A (OSRAM) |
| RU (2) | RU2517345C9 (OSRAM) |
| SG (2) | SG184721A1 (OSRAM) |
| WO (1) | WO2009045503A1 (OSRAM) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0517701A8 (pt) | 2004-11-10 | 2018-01-23 | Genzyme Corp | métodos de tratamento de diabetes mellitus |
| ES2546181T3 (es) * | 2006-05-09 | 2015-09-21 | Genzyme Corporation | Métodos de tratar la enfermedad del hígado graso mediante inhibición de la síntesis de glucoesfingolípidos |
| EP2594563B1 (en) * | 2007-05-31 | 2018-07-18 | Genzyme Corporation | 2-acylaminopropanol-type glucosylceramide synthase inhibitors |
| CA2701649C (en) * | 2007-10-05 | 2016-05-24 | Genzyme Corporation | Method of treating polycystic kidney diseases with ceramide derivatives |
| CA2731685A1 (en) | 2008-07-28 | 2010-02-04 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
| CN102271678B (zh) * | 2008-10-03 | 2017-06-30 | 简詹姆公司 | 2‑酰胺基丙醇型葡糖神经酰胺合成酶抑制剂 |
| WO2013059119A1 (en) * | 2011-10-17 | 2013-04-25 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
| BR112015003376A8 (pt) | 2012-08-23 | 2018-01-23 | Alios Biopharma Inc | composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica e usos de quantidade eficiente de composto ou sal farmaceuticamente aceitável do mesmo ou composição farmacêutica |
| WO2014150043A1 (en) | 2013-03-15 | 2014-09-25 | Concert Pharmaceuticals Inc. | Inhibitors of the enzyme udp-glucose: n-acyl-sphingosine glucosyltransferase |
| MX2016002199A (es) * | 2013-08-21 | 2016-07-13 | Alios Biopharma Inc | Compuestos antivirales. |
| US9457016B2 (en) | 2013-08-29 | 2016-10-04 | New York University | Methods for treating polycystic kidney disease |
| US10227323B2 (en) * | 2013-09-20 | 2019-03-12 | Biomarin Pharmaceutical Inc. | Glucosylceramide synthase inhibitors for the treatment of diseases |
| MX376685B (es) | 2013-10-29 | 2025-03-07 | Biomarin Pharm Inc | Derivados de n-(1-hidroxi-3-(pirrolidinil)propan-2-il)pirrolidin-3-carboxamida como inhibidores de glucosilceramida sintasa. |
| CN115322089B (zh) * | 2022-07-18 | 2023-10-03 | 中国农业科学院烟草研究所(中国烟草总公司青州烟草研究所) | 一种覆盆子酮半抗原、人工抗原及其制备方法、抗体和应用 |
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| CA2701649C (en) | 2007-10-05 | 2016-05-24 | Genzyme Corporation | Method of treating polycystic kidney diseases with ceramide derivatives |
| WO2009117150A2 (en) | 2008-03-20 | 2009-09-24 | Genzyme Corporation | Method of treating lupus with ceramide derivatives |
| CA2731685A1 (en) | 2008-07-28 | 2010-02-04 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
| CN102271678B (zh) | 2008-10-03 | 2017-06-30 | 简詹姆公司 | 2‑酰胺基丙醇型葡糖神经酰胺合成酶抑制剂 |
-
2008
- 2008-10-03 CA CA2701649A patent/CA2701649C/en not_active Expired - Fee Related
- 2008-10-03 BR BRPI0817864-0A patent/BRPI0817864A2/pt not_active Application Discontinuation
- 2008-10-03 JP JP2010527996A patent/JP5896601B2/ja not_active Expired - Fee Related
- 2008-10-03 BR BRPI0823522-8A2A patent/BRPI0823522A2/pt not_active Application Discontinuation
- 2008-10-03 SG SG2012065983A patent/SG184721A1/en unknown
- 2008-10-03 EP EP12007327.5A patent/EP2550965B1/en not_active Not-in-force
- 2008-10-03 CN CN2008801192139A patent/CN101888840A/zh active Pending
- 2008-10-03 SG SG10201707161PA patent/SG10201707161PA/en unknown
- 2008-10-03 KR KR1020107009935A patent/KR101640263B1/ko not_active Expired - Fee Related
- 2008-10-03 RU RU2010117585/15A patent/RU2517345C9/ru not_active IP Right Cessation
- 2008-10-03 WO PCT/US2008/011450 patent/WO2009045503A1/en not_active Ceased
- 2008-10-03 KR KR1020157018509A patent/KR20150085139A/ko not_active Ceased
- 2008-10-03 KR KR1020167018039A patent/KR20160085917A/ko not_active Ceased
- 2008-10-03 US US12/681,291 patent/US8912177B2/en not_active Expired - Fee Related
- 2008-10-03 MX MX2010003603A patent/MX2010003603A/es active IP Right Grant
- 2008-10-03 MX MX2012003498A patent/MX337396B/es unknown
- 2008-10-03 EP EP08835678.7A patent/EP2209473B1/en not_active Not-in-force
- 2008-10-03 ES ES08835678.7T patent/ES2660690T3/es active Active
- 2008-10-03 AU AU2008307516A patent/AU2008307516B2/en not_active Ceased
- 2008-10-03 CN CN2012104075563A patent/CN102940627A/zh active Pending
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2010
- 2010-03-25 IL IL204741A patent/IL204741A/en active IP Right Grant
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2013
- 2013-10-04 JP JP2013209652A patent/JP2014024858A/ja active Pending
-
2014
- 2014-01-29 RU RU2014102885/15A patent/RU2014102885A/ru not_active Application Discontinuation
- 2014-11-04 US US14/532,432 patent/US20150216872A1/en not_active Abandoned
-
2015
- 2015-12-22 JP JP2015249968A patent/JP2016041761A/ja not_active Withdrawn
-
2017
- 2017-01-25 US US15/414,838 patent/US10220039B2/en not_active Expired - Fee Related
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