JP2012504608A5 - - Google Patents
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- JP2012504608A5 JP2012504608A5 JP2011530057A JP2011530057A JP2012504608A5 JP 2012504608 A5 JP2012504608 A5 JP 2012504608A5 JP 2011530057 A JP2011530057 A JP 2011530057A JP 2011530057 A JP2011530057 A JP 2011530057A JP 2012504608 A5 JP2012504608 A5 JP 2012504608A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- pharmaceutical composition
- halogen
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 150000001875 compounds Chemical class 0.000 claims 20
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 229910052736 halogen Inorganic materials 0.000 claims 13
- 150000002367 halogens Chemical class 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 11
- 125000001424 substituent group Chemical group 0.000 claims 10
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 9
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 9
- -1 cyano, hydroxy Chemical group 0.000 claims 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 6
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 6
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims 6
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 6
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 4
- 125000001931 aliphatic group Chemical group 0.000 claims 4
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 4
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000003282 alkyl amino group Chemical group 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 208000030761 polycystic kidney disease Diseases 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10254108P | 2008-10-03 | 2008-10-03 | |
| US61/102,541 | 2008-10-03 | ||
| PCT/US2009/005435 WO2010039256A1 (en) | 2008-10-03 | 2009-10-02 | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015075248A Division JP6175465B2 (ja) | 2008-10-03 | 2015-04-01 | 2−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012504608A JP2012504608A (ja) | 2012-02-23 |
| JP2012504608A5 true JP2012504608A5 (OSRAM) | 2012-10-25 |
Family
ID=41402426
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011530057A Withdrawn JP2012504608A (ja) | 2008-10-03 | 2009-10-02 | 2−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
| JP2015075248A Expired - Fee Related JP6175465B2 (ja) | 2008-10-03 | 2015-04-01 | 2−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
| JP2017095022A Expired - Fee Related JP6297194B2 (ja) | 2008-10-03 | 2017-05-11 | 2−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
| JP2018028160A Pending JP2018087232A (ja) | 2008-10-03 | 2018-02-20 | 2−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015075248A Expired - Fee Related JP6175465B2 (ja) | 2008-10-03 | 2015-04-01 | 2−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
| JP2017095022A Expired - Fee Related JP6297194B2 (ja) | 2008-10-03 | 2017-05-11 | 2−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
| JP2018028160A Pending JP2018087232A (ja) | 2008-10-03 | 2018-02-20 | 2−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8309593B2 (OSRAM) |
| EP (2) | EP2349255B1 (OSRAM) |
| JP (4) | JP2012504608A (OSRAM) |
| KR (1) | KR101687039B1 (OSRAM) |
| CN (2) | CN107935983A (OSRAM) |
| CA (1) | CA2738768C (OSRAM) |
| IL (2) | IL211946A (OSRAM) |
| MX (1) | MX2011003517A (OSRAM) |
| RU (1) | RU2578947C2 (OSRAM) |
| WO (1) | WO2010039256A1 (OSRAM) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1811991B1 (en) | 2004-11-10 | 2018-11-07 | Genzyme Corporation | Treatment of type 2 diabetes using inhibitors of glycosphingolipid synthesis |
| EP2032134B1 (en) | 2006-05-09 | 2015-06-24 | Genzyme Corporation | Methods of treating fatty liver disease comprising inhibiting glucosphingolipid synthesis |
| EP2594562B1 (en) | 2007-05-31 | 2016-07-20 | Genzyme Corporation | 2-acylaminopropanol-type glucosylceramide synthase inhibitors |
| WO2009045503A1 (en) * | 2007-10-05 | 2009-04-09 | Genzyme Corporation | Method of treating polycystic kidney diseases with ceramide derivatives |
| US8389517B2 (en) * | 2008-07-28 | 2013-03-05 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
| CN107935983A (zh) | 2008-10-03 | 2018-04-20 | 简詹姆公司 | 2‑酰胺基丙醇型葡糖神经酰胺合酶抑制剂 |
| WO2013059119A1 (en) * | 2011-10-17 | 2013-04-25 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
| CN102702010B (zh) * | 2012-05-23 | 2014-09-17 | 北京大学 | 光敏感的功能化固载相及其制备方法和应用 |
| WO2014150043A1 (en) * | 2013-03-15 | 2014-09-25 | Concert Pharmaceuticals Inc. | Inhibitors of the enzyme udp-glucose: n-acyl-sphingosine glucosyltransferase |
| US10227323B2 (en) * | 2013-09-20 | 2019-03-12 | Biomarin Pharmaceutical Inc. | Glucosylceramide synthase inhibitors for the treatment of diseases |
| EP3164128A4 (en) * | 2014-07-03 | 2018-02-28 | Dr. Reddy's Laboratories Ltd. | Amorphous form of eliglustat hemitartarate |
| US10202340B2 (en) | 2015-02-02 | 2019-02-12 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
| EP3268355B1 (en) | 2015-03-11 | 2019-06-12 | BioMarin Pharmaceutical Inc. | Glucosylceramide synthase inhibitors for the treatment of diseases |
| US11116755B2 (en) | 2015-11-18 | 2021-09-14 | Genzyme Corporation | Biomarker of polycystic kidney disease and uses thereof |
| WO2017165766A2 (en) | 2016-03-25 | 2017-09-28 | Genzyme Corporation | Biomarkers of proteopathies and uses thereof |
| WO2017204319A1 (ja) * | 2016-05-27 | 2017-11-30 | 公益財団法人野口研究所 | グルコシルセラミド合成酵素阻害剤 |
| JP2021506920A (ja) | 2017-12-21 | 2021-02-22 | リソソーマル・セラピューティクス・インコーポレイテッドLysosomal Therapeutics Inc. | 結晶性の置換シクロヘキシルピラゾロ[1,5−a]ピリミジニルカルボキサミド化合物およびその治療的使用 |
Family Cites Families (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1555654A (en) * | 1977-06-25 | 1979-11-14 | Exxon Research Engineering Co | Agricultural burner apparatus |
| US4065562A (en) * | 1975-12-29 | 1977-12-27 | Nippon Shinyaku Co., Ltd. | Method and composition for reducing blood glucose levels |
| NO154918C (no) * | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
| GB2020278B (en) * | 1978-05-03 | 1983-02-23 | Nippon Shinyaku Co Ltd | Moranoline dervitives |
| JPS568318A (en) | 1979-06-28 | 1981-01-28 | Janssen Pharmaceutica Nv | Non oral long acting composition of haloperidol and bromperidol derivative |
| GB8311286D0 (en) | 1983-04-26 | 1983-06-02 | Searle & Co | Carboxyalkyl peptide derivatives |
| EP0144290A3 (de) * | 1983-12-01 | 1987-05-27 | Ciba-Geigy Ag | Substituierte Aethylendiaminderivate |
| US5041441A (en) * | 1988-04-04 | 1991-08-20 | The Regents Of The University Of Michigan | Method of chemotherapy using 1-phenyl-2-decanoylamino-3-morpholino-1-propanol |
| JPH0416856A (ja) | 1990-05-10 | 1992-01-21 | Canon Inc | 正帯電性非磁性トナー |
| JPH04140984A (ja) | 1990-10-02 | 1992-05-14 | Canon Inc | スチルビデオカメラ |
| RU2005102C1 (ru) * | 1991-06-21 | 1993-12-30 | Институт геологии Карельского научного центра РАН | Способ получени декоративного стекла |
| US5302609A (en) * | 1992-12-16 | 1994-04-12 | The Regents Of The University Of Michigan | Treatment of diabetic nephropathy |
| US5399567A (en) * | 1993-05-13 | 1995-03-21 | Monsanto Company | Method of treating cholera |
| NZ269847A (en) | 1993-08-13 | 1996-11-26 | Seikagaku Kogyo Co Ltd | 2-alkylamino-3-morpholino-1-propanol derivative in a composition for neuronal disease treatment |
| EP1008342A3 (en) * | 1994-02-02 | 2004-12-29 | The Liposome Company, Inc. | Pharmaceutically active compounds and liposomes, and methods of use thereof |
| WO1995034530A1 (en) | 1994-06-10 | 1995-12-21 | Seikagaku Corporation | 2-acylaminopropanol compound and medicinal composition |
| US6890949B1 (en) * | 1999-07-09 | 2005-05-10 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| WO1997010817A1 (en) * | 1995-09-20 | 1997-03-27 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US6255336B1 (en) | 1995-09-20 | 2001-07-03 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| WO2001004108A1 (en) | 1999-07-09 | 2001-01-18 | Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US20030073680A1 (en) * | 1995-09-20 | 2003-04-17 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| NO965193L (no) * | 1995-12-08 | 1997-06-09 | Seikagaku Kogyo Kk Seikagaku C | Aminalkoholderivat og fremgangsmåte for fremstilling derav |
| JP3993908B2 (ja) | 1995-12-08 | 2007-10-17 | 生化学工業株式会社 | アミノアルコール誘導体及び該誘導体の製造方法 |
| JP4140984B2 (ja) | 1995-12-20 | 2008-08-27 | 生化学工業株式会社 | 分化誘導作用を有する薬剤 |
| US5972928A (en) * | 1997-05-21 | 1999-10-26 | Johns Hopkins University | Methods for treatment of conditions associated with lactosylceramide |
| JP4036500B2 (ja) | 1997-05-23 | 2008-01-23 | 生化学工業株式会社 | アミノアルコール誘導体及びそれを含有する医薬 |
| JP4176170B2 (ja) | 1997-06-06 | 2008-11-05 | 生化学工業株式会社 | アミノアルコール誘導体を含む医薬及び異常増殖性疾患治療薬 |
| US6465488B1 (en) * | 1997-12-11 | 2002-10-15 | Chancellor, Masters & Scholars Of The University Of Oxford | Inhibition of glycolipid biosynthesis |
| CA2336549A1 (en) * | 1998-07-27 | 2000-02-10 | Johns Hopkins University | Methods for treating conditions modulated by lactosylceramide |
| US6610703B1 (en) | 1998-12-10 | 2003-08-26 | G.D. Searle & Co. | Method for treatment of glycolipid storage diseases |
| GB0100889D0 (en) * | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
| AU774960B2 (en) * | 1999-07-09 | 2004-07-15 | Regents Of The University Of Michigan, The | Amino ceramide-like compounds and therapeutic methods of use |
| US6407064B2 (en) * | 1999-12-06 | 2002-06-18 | Seikagaku Corporation | Aminoalcohol derivative and medicament comprising the same |
| JP5009459B2 (ja) * | 1999-12-06 | 2012-08-22 | 生化学工業株式会社 | アミノアルコール誘導体及びそれを含有する医薬 |
| US6235737B1 (en) | 2000-01-25 | 2001-05-22 | Peter Styczynski | Reduction of hair growth |
| NZ522036A (en) | 2000-04-19 | 2004-04-30 | Borody Thomas J | Compositions and therapies for hyperlipidaemia-associated disorders |
| CA2432908A1 (en) | 2000-12-20 | 2002-06-27 | Bristol-Myers Squibb Pharma Company | Diamines as modulators of chemokine receptor activity |
| CN100457719C (zh) | 2000-12-29 | 2009-02-04 | 惠氏公司 | 区域选择性制备取代的苯并[g]喹啉-3-腈和苯并[g]喹唑啉的方法 |
| US20040260099A1 (en) * | 2001-01-10 | 2004-12-23 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US20020198240A1 (en) * | 2001-01-10 | 2002-12-26 | Shayman James A. | Amino ceramide - like compounds and therapeutic methods of use |
| EP1358172B1 (en) | 2001-01-10 | 2009-11-18 | The Regents of The University of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US7148251B2 (en) * | 2001-01-10 | 2006-12-12 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| BR122015016313B8 (pt) * | 2001-07-16 | 2021-05-25 | Genzyme Corp | composto semelhante à ceramida e método de preparar um composto |
| US6835831B2 (en) * | 2001-11-26 | 2004-12-28 | Genzyme Corporation | Diastereoselective synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors |
| GB0229931D0 (en) | 2002-12-21 | 2003-01-29 | Astrazeneca Ab | Therapeutic agents |
| WO2003057874A1 (fr) * | 2001-12-28 | 2003-07-17 | Sumitomo Pharmaceuticals Company, Limited | Marqueurs de maladies pour maladies renales et leur utilisation |
| JP4291696B2 (ja) * | 2002-01-22 | 2009-07-08 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 2−(ピリジン−2−イルアミノ)−ピリド[2,3−d]ピリミジン−7−オン |
| EP1336411A1 (en) | 2002-02-14 | 2003-08-20 | Academisch Medisch Centrum bij de Universiteit van Amsterdam | Compositions and methods for improving enzyme replacement therapy of lysosomal storage diseases |
| JP2003238410A (ja) | 2002-02-21 | 2003-08-27 | Seibutsu Yuki Kagaku Kenkyusho:Kk | インスリン抵抗性解除剤 |
| US6916802B2 (en) * | 2002-04-29 | 2005-07-12 | Genzyme Corporation | Amino ceramide-like compounds and therapeutic methods of use |
| US20060217560A1 (en) * | 2002-04-29 | 2006-09-28 | Shayman James A | Amino ceramide-like compounds and therapeutic methods of use |
| EP1534676B1 (en) * | 2002-07-17 | 2012-09-12 | Actelion Pharmaceuticals Ltd. | Piperidinetriol derivatives as inhibitors of glycosylceramide synthase |
| BR0312947A (pt) | 2002-07-17 | 2007-07-10 | Biogen Idec Inc | terapias para insuficiência renal empregando-se interferon-beta |
| WO2004078194A1 (en) | 2003-02-28 | 2004-09-16 | Intermune, Inc. | Interferon drug therapy for the treatment of viral diseases and liver fibrosis |
| GB0313678D0 (en) * | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compounds |
| EP1528056A1 (en) | 2003-10-29 | 2005-05-04 | Academisch Ziekenhuis bij de Universiteit van Amsterdam | Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors |
| WO2005039578A2 (en) | 2003-10-29 | 2005-05-06 | Macrozyme B.V. | Use of a deoxynojirimycin derivative or a pharmaceutically salt thereof |
| EP1711197A4 (en) | 2003-12-23 | 2008-11-05 | Musc Found For Res Dev | METHOD AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF INFLAMMATORY DISEASES OR CONDITIONS |
| GB0400812D0 (en) | 2004-01-14 | 2004-02-18 | Celltech R&D Ltd | Novel compounds |
| US20070207983A1 (en) | 2004-03-16 | 2007-09-06 | Nieuwenhuizen Willem F | Use of Sphingolipids in the Treatment and Prevention of Type 2 Diabetes Mellitus, Insulin Resistance and Metabolic Syndrome |
| EP1576894A1 (en) | 2004-03-16 | 2005-09-21 | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO | The use of sphingolipids in the treatment and prevention of type 2 diabetes mellitus, insulin resistance and Metabolic Syndrome |
| RU2006143156A (ru) | 2004-05-07 | 2008-06-20 | Мерк Патент ГмбХ (DE) | Gm3 синтаза как терапевтическая мишень при капиллярных осложнениях диабета |
| WO2005123055A2 (en) | 2004-06-14 | 2005-12-29 | Musc Foundation For Research Development | Methods for treating inflammatory disorders |
| KR20070085232A (ko) | 2004-08-20 | 2007-08-27 | 더 존스 홉킨스 유니버시티 | 혈관신생 치료방법 |
| EP1811991B1 (en) | 2004-11-10 | 2018-11-07 | Genzyme Corporation | Treatment of type 2 diabetes using inhibitors of glycosphingolipid synthesis |
| US20090088433A1 (en) * | 2005-01-26 | 2009-04-02 | Bertrand Leblond | Methods of using as analgesics 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds |
| WO2007022518A2 (en) | 2005-08-19 | 2007-02-22 | Amylin Pharmaceuticals, Inc. | New uses of glucoregulatory proteins |
| EP2032134B1 (en) | 2006-05-09 | 2015-06-24 | Genzyme Corporation | Methods of treating fatty liver disease comprising inhibiting glucosphingolipid synthesis |
| WO2008011487A2 (en) | 2006-07-19 | 2008-01-24 | Allergan, Inc. | L-benzyl-l-hydr0xy-2, 3-diamin0-propyl amines and 3-benzyl-3-hydroxy-2-amino-propionicacid amides for chronic pain |
| WO2008011478A2 (en) | 2006-07-19 | 2008-01-24 | Allergan, Inc. | Methods for treating chronic pain using 3-aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds |
| GB0614947D0 (en) | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
| TWI389895B (zh) | 2006-08-21 | 2013-03-21 | Infinity Discovery Inc | 抑制bcl蛋白質與結合夥伴間之交互作用的化合物及方法 |
| EA200901082A1 (ru) * | 2007-02-09 | 2010-02-26 | Айрм Ллк | Соединения и композиции в качестве ингибиторов протеазы, активирующей каналы |
| EP2594562B1 (en) | 2007-05-31 | 2016-07-20 | Genzyme Corporation | 2-acylaminopropanol-type glucosylceramide synthase inhibitors |
| WO2009045503A1 (en) * | 2007-10-05 | 2009-04-09 | Genzyme Corporation | Method of treating polycystic kidney diseases with ceramide derivatives |
| WO2009117150A2 (en) | 2008-03-20 | 2009-09-24 | Genzyme Corporation | Method of treating lupus with ceramide derivatives |
| US8389517B2 (en) * | 2008-07-28 | 2013-03-05 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
| CN107935983A (zh) | 2008-10-03 | 2018-04-20 | 简詹姆公司 | 2‑酰胺基丙醇型葡糖神经酰胺合酶抑制剂 |
-
2009
- 2009-10-02 CN CN201710483611.XA patent/CN107935983A/zh active Pending
- 2009-10-02 US US13/122,135 patent/US8309593B2/en not_active Expired - Fee Related
- 2009-10-02 CA CA2738768A patent/CA2738768C/en not_active Expired - Fee Related
- 2009-10-02 CN CN200980147488.8A patent/CN102271678B/zh not_active Expired - Fee Related
- 2009-10-02 EP EP09741487.4A patent/EP2349255B1/en not_active Not-in-force
- 2009-10-02 JP JP2011530057A patent/JP2012504608A/ja not_active Withdrawn
- 2009-10-02 WO PCT/US2009/005435 patent/WO2010039256A1/en not_active Ceased
- 2009-10-02 EP EP16162074.5A patent/EP3078373A1/en not_active Withdrawn
- 2009-10-02 RU RU2011117028/15A patent/RU2578947C2/ru not_active IP Right Cessation
- 2009-10-02 KR KR1020117010056A patent/KR101687039B1/ko not_active Expired - Fee Related
- 2009-10-02 MX MX2011003517A patent/MX2011003517A/es active IP Right Grant
-
2011
- 2011-03-27 IL IL211946A patent/IL211946A/en not_active IP Right Cessation
-
2012
- 2012-08-27 US US13/595,251 patent/US9272996B2/en not_active Expired - Fee Related
-
2015
- 2015-04-01 JP JP2015075248A patent/JP6175465B2/ja not_active Expired - Fee Related
- 2015-05-03 IL IL238583A patent/IL238583B/en not_active IP Right Cessation
-
2016
- 2016-01-21 US US15/003,207 patent/US9744153B2/en not_active Expired - Fee Related
-
2017
- 2017-05-11 JP JP2017095022A patent/JP6297194B2/ja not_active Expired - Fee Related
-
2018
- 2018-02-20 JP JP2018028160A patent/JP2018087232A/ja active Pending
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