JP2008530099A5 - - Google Patents

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Publication number

JP2008530099A5

JP2008530099A5 JP2007555183A JP2007555183A JP2008530099A5 JP 2008530099 A5 JP2008530099 A5 JP 2008530099A5 JP 2007555183 A JP2007555183 A JP 2007555183A JP 2007555183 A JP2007555183 A JP 2007555183A JP 2008530099 A5 JP2008530099 A5 JP 2008530099A5

Authority

JP

Japan

Prior art keywords

group

alkyl

het

alkylene

aryl

Prior art date

2006-02-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 125000000217 alkyl group Chemical group 0.000 claims 64
• 125000002947 alkylene group Chemical group 0.000 claims 36
• 125000003118 aryl group Chemical group 0.000 claims 35
• 150000001875 compounds Chemical class 0.000 claims 33
• 150000003839 salts Chemical class 0.000 claims 30
• 125000000623 heterocyclic group Chemical group 0.000 claims 29
• 229910052739 hydrogen Inorganic materials 0.000 claims 28
• 239000001257 hydrogen Substances 0.000 claims 28
• 125000003545 alkoxy group Chemical group 0.000 claims 27
• 125000001072 heteroaryl group Chemical group 0.000 claims 27
• 125000001424 substituent group Chemical group 0.000 claims 26
• 229910052736 halogen Inorganic materials 0.000 claims 23
• 150000002367 halogens Chemical group 0.000 claims 23
• 125000004663 dialkyl amino group Chemical group 0.000 claims 21
• -1 nitro, hydroxy Chemical group 0.000 claims 21
• 125000004450 alkenylene group Chemical group 0.000 claims 20
• 125000004419 alkynylene group Chemical group 0.000 claims 20
• 150000002431 hydrogen Chemical class 0.000 claims 19
• 125000003342 alkenyl group Chemical group 0.000 claims 15
• 125000000304 alkynyl group Chemical group 0.000 claims 15
• 125000000732 arylene group Chemical group 0.000 claims 14
• 125000001188 haloalkyl group Chemical group 0.000 claims 14
• 125000005549 heteroarylene group Chemical group 0.000 claims 14
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims 14
• 125000003282 alkyl amino group Chemical group 0.000 claims 13
• 125000004438 haloalkoxy group Chemical group 0.000 claims 13
• 125000004093 cyano group Chemical group *C#N 0.000 claims 12
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 11
• 125000005529 alkyleneoxy group Chemical group 0.000 claims 10
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
• 125000005466 alkylenyl group Chemical group 0.000 claims 9
• 125000004043 oxo group Chemical group O=* 0.000 claims 9
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 9
• 125000004104 aryloxy group Chemical group 0.000 claims 5
• 125000005553 heteroaryloxy group Chemical group 0.000 claims 5
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 5
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 4
• 125000004429 atom Chemical group 0.000 claims 4
• HWYHDWGGACRVEH-UHFFFAOYSA-N n-methyl-n-(4-pyrrolidin-1-ylbut-2-ynyl)acetamide Chemical compound CC(=O)N(C)CC#CCN1CCCC1 HWYHDWGGACRVEH-UHFFFAOYSA-N 0.000 claims 4
• 125000000266 alpha-aminoacyl group Chemical group 0.000 claims 3
• 125000002757 morpholinyl group Chemical group 0.000 claims 3
• 229910052757 nitrogen Inorganic materials 0.000 claims 3
• 125000003386 piperidinyl group Chemical group 0.000 claims 3
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims 3
• JPRPJUMQRZTTED-UHFFFAOYSA-N 1,3-dioxolanyl Chemical group [CH]1OCCO1 JPRPJUMQRZTTED-UHFFFAOYSA-N 0.000 claims 2
• 125000003725 azepanyl group Chemical group 0.000 claims 2
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
• 125000005959 diazepanyl group Chemical group 0.000 claims 2
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
• 125000004193 piperazinyl group Chemical group 0.000 claims 2
• 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 2
• 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 2
• 125000001984 thiazolidinyl group Chemical group 0.000 claims 2
• 125000004568 thiomorpholinyl group Chemical group 0.000 claims 2
• 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 1
• 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
• 125000005988 1,1-dioxo-thiomorpholinyl group Chemical group 0.000 claims 1
• 125000005962 1,4-oxazepanyl group Chemical group 0.000 claims 1
• 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
• 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims 1
• 102000004127 Cytokines Human genes 0.000 claims 1
• 108090000695 Cytokines Proteins 0.000 claims 1
• 150000008575 L-amino acids Chemical class 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 125000002393 azetidinyl group Chemical group 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 229910052799 carbon Inorganic materials 0.000 claims 1
• 230000001419 dependent effect Effects 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 claims 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
• 150000002391 heterocyclic compounds Chemical class 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 230000002452 interceptive effect Effects 0.000 claims 1
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
• 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
• 230000001613 neoplastic effect Effects 0.000 claims 1
• 229910052760 oxygen Inorganic materials 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 1
• 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
• 229910052717 sulfur Inorganic materials 0.000 claims 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
• 230000003612 virological effect Effects 0.000 claims 1