JP2010539970A5 - - Google Patents
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- JP2010539970A5 JP2010539970A5 JP2010527592A JP2010527592A JP2010539970A5 JP 2010539970 A5 JP2010539970 A5 JP 2010539970A5 JP 2010527592 A JP2010527592 A JP 2010527592A JP 2010527592 A JP2010527592 A JP 2010527592A JP 2010539970 A5 JP2010539970 A5 JP 2010539970A5
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- 210000004027 cell Anatomy 0.000 claims 41
- 230000029087 digestion Effects 0.000 claims 10
- 210000000981 epithelium Anatomy 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 8
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 8
- 239000012091 fetal bovine serum Substances 0.000 claims 8
- 239000000243 solution Substances 0.000 claims 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 6
- 210000001519 tissue Anatomy 0.000 claims 6
- 239000001963 growth medium Substances 0.000 claims 5
- 239000006228 supernatant Substances 0.000 claims 5
- 210000003954 umbilical cord Anatomy 0.000 claims 5
- 210000002569 neuron Anatomy 0.000 claims 4
- 230000010261 cell growth Effects 0.000 claims 3
- 230000004663 cell proliferation Effects 0.000 claims 3
- 239000006285 cell suspension Substances 0.000 claims 3
- 238000002659 cell therapy Methods 0.000 claims 3
- 238000005138 cryopreservation Methods 0.000 claims 3
- 230000004069 differentiation Effects 0.000 claims 3
- 238000011084 recovery Methods 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 210000000130 stem cell Anatomy 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- -1 CD31 Proteins 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- 210000001789 adipocyte Anatomy 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 229940088710 antibiotic agent Drugs 0.000 claims 2
- 210000004413 cardiac myocyte Anatomy 0.000 claims 2
- 238000005119 centrifugation Methods 0.000 claims 2
- 210000001612 chondrocyte Anatomy 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 239000005549 deoxyribonucleoside Substances 0.000 claims 2
- 239000008103 glucose Substances 0.000 claims 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
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- 238000009593 lumbar puncture Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 210000004498 neuroglial cell Anatomy 0.000 claims 2
- 239000008196 pharmacological composition Substances 0.000 claims 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 claims 2
- 230000009885 systemic effect Effects 0.000 claims 2
- 230000000699 topical effect Effects 0.000 claims 2
- 210000003462 vein Anatomy 0.000 claims 2
- 102100022464 5'-nucleotidase Human genes 0.000 claims 1
- 102100032912 CD44 antigen Human genes 0.000 claims 1
- 102000019034 Chemokines Human genes 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 102000029816 Collagenase Human genes 0.000 claims 1
- 108060005980 Collagenase Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
- 102100037241 Endoglin Human genes 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 1
- 101000881679 Homo sapiens Endoglin Proteins 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 1
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 1
- 229930182555 Penicillin Natural products 0.000 claims 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 1
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims 1
- 108010067787 Proteoglycans Proteins 0.000 claims 1
- 102000016611 Proteoglycans Human genes 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- 108091028664 Ribonucleotide Proteins 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 1
- 102000004142 Trypsin Human genes 0.000 claims 1
- 108090000631 Trypsin Proteins 0.000 claims 1
- 238000013019 agitation Methods 0.000 claims 1
- 210000001691 amnion Anatomy 0.000 claims 1
- 210000001130 astrocyte Anatomy 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 230000023555 blood coagulation Effects 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 229960002424 collagenase Drugs 0.000 claims 1
- 230000000112 colonic effect Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000001079 digestive effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 210000003372 endocrine gland Anatomy 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 claims 1
- 210000003560 epithelium corneal Anatomy 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 239000007789 gas Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 230000012010 growth Effects 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 210000000442 hair follicle cell Anatomy 0.000 claims 1
- 230000017525 heat dissipation Effects 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000011534 incubation Methods 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004393 laryngeal mucosa Anatomy 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000004379 membrane Anatomy 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 230000005012 migration Effects 0.000 claims 1
- 238000013508 migration Methods 0.000 claims 1
- 210000000653 nervous system Anatomy 0.000 claims 1
- 210000005155 neural progenitor cell Anatomy 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000002777 nucleoside Substances 0.000 claims 1
- 125000003835 nucleoside group Chemical group 0.000 claims 1
- 235000021238 nutrient digestion Nutrition 0.000 claims 1
- 210000004248 oligodendroglia Anatomy 0.000 claims 1
- 229920001542 oligosaccharide Polymers 0.000 claims 1
- 150000002482 oligosaccharides Chemical class 0.000 claims 1
- 210000000963 osteoblast Anatomy 0.000 claims 1
- 239000008188 pellet Substances 0.000 claims 1
- 229940049954 penicillin Drugs 0.000 claims 1
- 210000003800 pharynx Anatomy 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000002207 retinal effect Effects 0.000 claims 1
- 239000002342 ribonucleoside Substances 0.000 claims 1
- 239000002336 ribonucleotide Substances 0.000 claims 1
- 125000002652 ribonucleotide group Chemical group 0.000 claims 1
- 210000002363 skeletal muscle cell Anatomy 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 claims 1
- 230000003068 static effect Effects 0.000 claims 1
- 239000008174 sterile solution Substances 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 229960005322 streptomycin Drugs 0.000 claims 1
- 239000002344 surface layer Substances 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 210000002435 tendon Anatomy 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 239000012588 trypsin Substances 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT103843A PT103843B (pt) | 2007-10-04 | 2007-10-04 | Método de isolamento de células precursoras a partir do cordão umbilical humano |
| PT103843 | 2007-10-04 | ||
| PCT/IB2008/054067 WO2009044379A2 (en) | 2007-10-04 | 2008-10-03 | Optimised and defined method for isolation and preservation of precursor cells from human umbilical cord |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010539970A JP2010539970A (ja) | 2010-12-24 |
| JP2010539970A5 true JP2010539970A5 (enExample) | 2014-05-22 |
| JP5785394B2 JP5785394B2 (ja) | 2015-09-30 |
Family
ID=40456372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527592A Expired - Fee Related JP5785394B2 (ja) | 2007-10-04 | 2008-10-03 | ヒト臍帯から前駆細胞を単離及び保存するための最適化され、定義された方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9546353B2 (enExample) |
| EP (1) | EP2203555B1 (enExample) |
| JP (1) | JP5785394B2 (enExample) |
| KR (1) | KR20100087705A (enExample) |
| CN (1) | CN101868536B (enExample) |
| AU (1) | AU2008306442B2 (enExample) |
| BR (1) | BRPI0817522A2 (enExample) |
| CA (1) | CA2701907A1 (enExample) |
| EA (1) | EA025532B1 (enExample) |
| ES (1) | ES2582369T3 (enExample) |
| IL (1) | IL204788A (enExample) |
| MX (1) | MX2010003511A (enExample) |
| PT (1) | PT103843B (enExample) |
| WO (1) | WO2009044379A2 (enExample) |
| ZA (1) | ZA201002260B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2634545T3 (es) | 2010-06-01 | 2017-09-28 | Auxocell Laboratories, Inc. | Células madre nativas de la gelatina de Wharton y su purificación |
| US9234177B2 (en) | 2010-10-18 | 2016-01-12 | Sunshine Life Science & Technology Corp. | Human multipotent embryonic stem cell-like progenitor cells |
| TWI535377B (zh) * | 2011-09-01 | 2016-06-01 | Storage, culture and application of umbilical cord tissue and its derived cells | |
| ES2890126T3 (es) * | 2011-12-30 | 2022-01-17 | Amit Patel | Métodos y composiciones para la obtención clínica de una célula alogénica y usos terapéuticos |
| CN102550543B (zh) * | 2012-02-10 | 2014-04-16 | 四川新生命干细胞科技股份有限公司 | 用于保存脐带组织的液体 |
| CN103461322B (zh) * | 2012-06-07 | 2016-08-03 | 西比曼生物科技（上海）有限公司 | 用于冻存复苏后的细胞的保存液 |
| EP2756754B1 (de) | 2013-01-17 | 2017-01-04 | Vita 34 Ag | Verfahren zur Behandlung von Nabelschnurgewebe, insbesondere im Zusammenhang mit der Konservierung des Gewebes |
| WO2015181831A2 (en) * | 2014-05-24 | 2015-12-03 | Venkataramanaa Neelamkrishnan | A method for targettingglioblastoma with wharton jelly-mesenchymal stem cells (wj-msc) derived from human umbilical cord |
| JP2017533917A (ja) * | 2014-11-05 | 2017-11-16 | ティッシュテック，インク． | 神経成長および再生を促進するための組成物および方法 |
| WO2017004460A1 (en) * | 2015-06-30 | 2017-01-05 | Surgenex, LLC | Compositions and methods for flowable allograft tissue |
| WO2017096611A1 (zh) * | 2015-12-11 | 2017-06-15 | 郭镭 | 一种从脐带华通氏胶组织中分离培养脐带间充质干细胞的方法 |
| WO2019175773A1 (en) | 2018-03-12 | 2019-09-19 | Universidade Do Porto | Compositions for use in the treatment of musculoskeletal conditions and methods for producing the same leveraging the synergistic activity of two different types of mesenchymal stromal/stem cells |
| CN112342191A (zh) * | 2019-08-07 | 2021-02-09 | 路春光 | hMSC生产试剂盒开发和质量管理标准优化和体系建立 |
| CN111893092A (zh) * | 2020-06-28 | 2020-11-06 | 国大生命科学产业集团(深圳)有限公司 | 一种人脐带来源的间充质干细胞及其制备方法 |
| CN113025567A (zh) * | 2021-03-31 | 2021-06-25 | 中国人民解放军陆军特色医学中心 | 一种椎间盘单细胞的分离方法 |
| DE102021116694B4 (de) * | 2021-06-29 | 2023-03-09 | Promocell Gmbh | Wässrige Lösung zur Zellkonservierung |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT402890B (de) * | 1994-03-16 | 1997-09-25 | Berbi Gmbh | Verwendung von notoginsenosid r1 zur herstellung von arzneimitteln |
| JPWO2003080822A1 (ja) * | 2002-03-27 | 2005-07-28 | ニプロ株式会社 | 胎盤由来の間葉系細胞およびその医学的用途 |
| CA2633980A1 (en) * | 2005-12-29 | 2007-07-12 | Anthrogenesis Corporation | Improved composition for collecting and preserving placental stem cells and methods of using the composition |
| ES2524443T3 (es) * | 2006-11-13 | 2014-12-09 | DePuy Synthes Products, LLC | Expansión in vitro de células postparto usando microportadores |
-
2007
- 2007-10-04 PT PT103843A patent/PT103843B/pt active IP Right Grant
-
2008
- 2008-10-03 CA CA2701907A patent/CA2701907A1/en not_active Abandoned
- 2008-10-03 KR KR1020107009850A patent/KR20100087705A/ko not_active Ceased
- 2008-10-03 MX MX2010003511A patent/MX2010003511A/es active IP Right Grant
- 2008-10-03 JP JP2010527592A patent/JP5785394B2/ja not_active Expired - Fee Related
- 2008-10-03 WO PCT/IB2008/054067 patent/WO2009044379A2/en not_active Ceased
- 2008-10-03 US US12/680,604 patent/US9546353B2/en not_active Expired - Fee Related
- 2008-10-03 EP EP08807881.1A patent/EP2203555B1/en not_active Not-in-force
- 2008-10-03 ES ES08807881.1T patent/ES2582369T3/es active Active
- 2008-10-03 EA EA201000425A patent/EA025532B1/ru not_active IP Right Cessation
- 2008-10-03 BR BRPI0817522-5A2A patent/BRPI0817522A2/pt not_active Application Discontinuation
- 2008-10-03 AU AU2008306442A patent/AU2008306442B2/en not_active Ceased
- 2008-10-03 CN CN200880114557.0A patent/CN101868536B/zh not_active Expired - Fee Related
-
2010
- 2010-03-28 IL IL204788A patent/IL204788A/en not_active IP Right Cessation
- 2010-03-30 ZA ZA2010/02260A patent/ZA201002260B/en unknown
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