|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4657760A
(en)
|
1979-03-20 |
1987-04-14 |
Ortho Pharmaceutical Corporation |
Methods and compositions using monoclonal antibody to human T cells
|
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
ZA811368B
(en)
|
1980-03-24 |
1982-04-28 |
Genentech Inc |
Bacterial polypedtide expression employing tryptophan promoter-operator
|
|
NZ201705A
(en)
|
1981-08-31 |
1986-03-14 |
Genentech Inc |
Recombinant dna method for production of hepatitis b surface antigen in yeast
|
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
|
US4943529A
(en)
|
1982-05-19 |
1990-07-24 |
Gist-Brocades Nv |
Kluyveromyces as a host strain
|
|
US4713339A
(en)
|
1983-01-19 |
1987-12-15 |
Genentech, Inc. |
Polycistronic expression vector construction
|
|
AU2353384A
(en)
|
1983-01-19 |
1984-07-26 |
Genentech Inc. |
Amplification in eukaryotic host cells
|
|
AU3145184A
(en)
|
1983-08-16 |
1985-02-21 |
Zymogenetics Inc. |
High expression of foreign genes in schizosaccharomyces pombe
|
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
|
US4879231A
(en)
|
1984-10-30 |
1989-11-07 |
Phillips Petroleum Company |
Transformation of yeasts of the genus pichia
|
|
US4965188A
(en)
|
1986-08-22 |
1990-10-23 |
Cetus Corporation |
Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
DE3675588D1
(de)
|
1985-06-19 |
1990-12-20 |
Ajinomoto Kk |
Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
|
|
US5206344A
(en)
|
1985-06-26 |
1993-04-27 |
Cetus Oncology Corporation |
Interleukin-2 muteins and polymer conjugation thereof
|
|
WO1987005330A1
(en)
|
1986-03-07 |
1987-09-11 |
Michel Louis Eugene Bergh |
Method for enhancing glycoprotein stability
|
|
US4849227A
(en)
|
1986-03-21 |
1989-07-18 |
Eurasiam Laboratories, Inc. |
Pharmaceutical compositions
|
|
GB8610600D0
(en)
|
1986-04-30 |
1986-06-04 |
Novo Industri As |
Transformation of trichoderma
|
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
|
US5010182A
(en)
|
1987-07-28 |
1991-04-23 |
Chiron Corporation |
DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides
|
|
KR0154872B1
(ko)
|
1987-12-21 |
1998-10-15 |
로버트 에이. 아미테이지 |
발아하는 식물종자의 아크로박테리움 매개된 형질전환
|
|
AU4005289A
(en)
|
1988-08-25 |
1990-03-01 |
Smithkline Beecham Corporation |
Recombinant saccharomyces
|
|
US5225538A
(en)
|
1989-02-23 |
1993-07-06 |
Genentech, Inc. |
Lymphocyte homing receptor/immunoglobulin fusion proteins
|
|
EP0394538B1
(en)
|
1989-04-28 |
1996-10-16 |
Rhein Biotech Gesellschaft Für Neue Biotechnologische Prozesse Und Produkte Mbh |
A yeast cell of the genus schwanniomyces
|
|
EP0402226A1
(en)
|
1989-06-06 |
1990-12-12 |
Institut National De La Recherche Agronomique |
Transformation vectors for yeast yarrowia
|
|
FR2649120B1
(fr)
|
1989-06-30 |
1994-01-28 |
Cayla |
Nouvelle souche et ses mutants de champignons filamenteux, procede de production de proteines recombinantes a l'aide de ladite souche et souches et proteines obtenues selon ce procede
|
|
US5225212A
(en)
|
1989-10-20 |
1993-07-06 |
Liposome Technology, Inc. |
Microreservoir liposome composition and method
|
|
EP1013270A3
(en)
|
1992-12-02 |
2001-03-28 |
Alkermes Controlled Therapeutics, Inc. |
Controlled release growth hormone containing microspheres
|
|
WO1996007399A1
(en)
|
1994-09-09 |
1996-03-14 |
Takeda Chemical Industries, Ltd. |
Sustained release preparation containing metal salt of a peptide
|
|
US5951974A
(en)
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
|
US5446090A
(en)
|
1993-11-12 |
1995-08-29 |
Shearwater Polymers, Inc. |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
|
|
AU1684195A
(en)
|
1994-02-22 |
1995-09-04 |
Georgia Tech Research Corporation |
Reduction of friction during wire drawing
|
|
PL184531B1
(pl)
|
1995-06-07 |
2002-11-29 |
Alkermes Inc |
Kompozycja o opóźnionym uwalnianiu ludzkiego hormonu wzrostu do wytwarzania leku do terapii
|
|
ZA965368B
(en)
|
1995-07-14 |
1997-01-14 |
Novo Nordisk As |
A pharmaceutical formulation
|
|
US6551799B2
(en)
*
|
1999-12-07 |
2003-04-22 |
Genentech, Inc. |
Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders
|
|
AU4208799A
(en)
|
1998-05-29 |
1999-12-13 |
Human Genome Sciences, Inc. |
Interleukins-21 and 22
|
|
US20010023070A1
(en)
|
1998-05-29 |
2001-09-20 |
Reinhard Ebner |
Interleukins-21 and 22
|
|
US6274710B1
(en)
|
1998-10-26 |
2001-08-14 |
Ludwig Institute For Cancer Research |
Antibodies which specifically bind T Cell inducible factors (TIFs)
|
|
EP1131333B1
(en)
|
1998-10-26 |
2010-06-02 |
Wyeth a Corporation of the State of Delaware |
ISOLATED NUCLEIC ACID MOLECULES WHICH ENCODE T CELL INDUCIBLE FACTORS (TIFs), THE PROTEINS ENCODED, AND USES THEREOF
|
|
US7307161B1
(en)
|
1999-04-28 |
2007-12-11 |
Genetics Institute, Llc |
Human Gil-19/AE289 polynucleotides
|
|
US7226591B2
(en)
|
2000-05-22 |
2007-06-05 |
Genentech, Inc. |
Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders
|
|
CN1163263C
(zh)
|
2000-01-07 |
2004-08-25 |
华中理工大学 |
一种多肽类药物口腔喷雾剂
|
|
GB0024442D0
(en)
|
2000-10-05 |
2000-11-22 |
Isis Innovation |
Genetic factors affecting the outcome of viral infections
|
|
CN1335182A
(zh)
|
2001-08-08 |
2002-02-13 |
华中科技大学 |
胰岛素口腔喷剂及其制备工艺
|
|
US6797493B2
(en)
|
2001-10-01 |
2004-09-28 |
Lee-Hwei K. Sun |
Fc fusion proteins of human granulocyte colony-stimulating factor with increased biological activities
|
|
AU2002367534A1
(en)
|
2001-11-06 |
2003-11-03 |
Eli Lilly And Company |
Use of il-19, il-22 and il-24 to treat hematopoietic disorders
|
|
AU2002364587A1
(en)
|
2001-12-21 |
2003-07-30 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
CN1176137C
(zh)
|
2002-01-15 |
2004-11-17 |
泛亚生物技术有限公司 |
多臂树杈型功能化聚乙二醇制备方法及它在药物中的应用
|
|
US7597876B2
(en)
|
2007-01-11 |
2009-10-06 |
Immunomedics, Inc. |
Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
|
|
US20030235561A1
(en)
|
2002-06-25 |
2003-12-25 |
Cell Based Delivery Inc. |
Vascularized organized tissues and uses thereof
|
|
US20050148029A1
(en)
|
2003-09-29 |
2005-07-07 |
Biosite, Inc. |
Methods and compositions for determining treatment regimens in systemic inflammatory response syndromes
|
|
CA2544972C
(en)
|
2003-11-05 |
2013-04-23 |
Institut De Recherche Pour Le Developpement (Ird) |
Use of interleukin-22 as a biomarker of resistance to hiv infections in humans and biological applications thereof
|
|
US7651694B2
(en)
|
2004-02-13 |
2010-01-26 |
Nod Pharmaceuticals, Inc. |
Therapeutic calcium phosphate particles and methods of making and using same
|
|
US7670595B2
(en)
|
2004-06-28 |
2010-03-02 |
Merck Patent Gmbh |
Fc-interferon-beta fusion proteins
|
|
CN100515491C
(zh)
*
|
2005-01-04 |
2009-07-22 |
健能隆医药技术（上海）有限公司 |
白介素-22的医药用途
|
|
WO2006088833A2
(en)
|
2005-02-14 |
2006-08-24 |
Wyeth |
Interleukin-17f antibodies and other il-17f signaling antagonists and uses therefor
|
|
US20070099251A1
(en)
*
|
2005-10-17 |
2007-05-03 |
Institute For Systems Biology |
Tissue-and serum-derived glycoproteins and methods of their use
|
|
UA95613C2
(ru)
*
|
2005-11-09 |
2011-08-25 |
Уеллстат Терепьютикс Корпорейшн |
Соединения для лечения расстройсв метаболизма
|
|
WO2007115230A2
(en)
|
2006-03-30 |
2007-10-11 |
University Of Medicine And Dentistry Of New Jersey |
A strategy for homo- or hetero-dimerization of various proteins in solutions and in cells
|
|
WO2007123765A2
(en)
|
2006-03-31 |
2007-11-01 |
Human Genome Sciences Inc. |
Neutrokine-alpha and neutrokine-alpha splice variant
|
|
BRPI0713133A2
(pt)
|
2006-06-19 |
2012-03-27 |
Wyeth Corp |
métodos de modular il-22 e il-17
|
|
WO2008085229A2
(en)
|
2006-11-15 |
2008-07-17 |
Arteriocyte Inc. |
Cell-based therapies for treating liver disease
|
|
CN101361968B
(zh)
|
2007-08-06 |
2011-08-03 |
健能隆医药技术（上海）有限公司 |
白介素-22在治疗脂肪肝中的应用
|
|
WO2009041734A1
(ja)
|
2007-09-26 |
2009-04-02 |
Kyowa Hakko Kirin Co., Ltd. |
ヒトトロンボポエチン受容体に対するアゴニスト抗体
|
|
CN101225110B
(zh)
|
2007-10-23 |
2010-10-20 |
中国人民解放军军事医学科学院基础医学研究所 |
人白细胞介素-22突变体及其构建方法和应用
|
|
CN101168049A
(zh)
*
|
2007-10-23 |
2008-04-30 |
中国人民解放军军事医学科学院基础医学研究所 |
白介素-22在制备治疗肝病药物中的应用及其制备方法
|
|
MX373155B
(es)
|
2007-11-07 |
2020-04-21 |
Genentech Inc |
Composiciones y metodos para el tratamiento de trastornos microbianos.
|
|
CA2748392C
(en)
|
2009-01-12 |
2017-06-27 |
Generon (Shanghai) Corporation |
Use of interleukin-22 for the prevention and/or treatment of multiple organ dysfunction syndrome (mods)
|
|
CA2788096A1
(en)
|
2010-01-13 |
2011-07-21 |
Amgen Inc. |
Il-22-fc and hepcidin activity
|
|
CN102380091A
(zh)
|
2010-08-31 |
2012-03-21 |
健能隆医药技术（上海）有限公司 |
白介素-22在治疗病毒性肝炎中的应用
|
|
CN103182072B
(zh)
|
2011-12-27 |
2017-05-03 |
健能隆医药技术（上海）有限公司 |
白介素‑22在治疗和预防神经损伤疾病或神经退行性疾病中的用途
|
|
BR112015023140A8
(pt)
|
2013-03-15 |
2018-01-23 |
Genentech Inc |
proteínas de fusão, método para a fabricação da proteína de fusão, composições, ácido nucleico,vetor, célula hospedeira, métodos de produção de uma proteína de fusão, de tratamento da doença inflamatória intestinal, de inibição da infecção microbiana, de tratamento da lesão renal, para acelerar ou melhorar a cicatrização, para a prevenção ou tratamento de uma condição cardiovascular, para tratamento da síndrome metabólica e para tratamento da endotoxemia.
|
|
US20160287670A1
(en)
|
2013-11-07 |
2016-10-06 |
Memorial Sloan-Kettering Cancer Center |
Methods of use for il-22 in the treatment of gastrointestinal graft vs. host disease
|
|
CN104623639A
(zh)
|
2013-11-07 |
2015-05-20 |
健能隆医药技术（上海）有限公司 |
白介素22二聚体在制备治疗胰腺炎药物中的应用
|
|
CN104623637A
(zh)
|
2013-11-07 |
2015-05-20 |
健能隆医药技术（上海）有限公司 |
Il-22二聚体在制备静脉注射药物中的应用
|
|
ES2930351T3
(es)
|
2016-04-15 |
2022-12-09 |
Evive Biotechnology Shanghai Ltd |
Un dímero de IL-22 para su uso en el tratamiento de enterocolitis necrosante
|