CN101361968B - 白介素-22在治疗脂肪肝中的应用 - Google Patents

白介素-22在治疗脂肪肝中的应用 Download PDF

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Publication number
CN101361968B
CN101361968B CN2007100445927A CN200710044592A CN101361968B CN 101361968 B CN101361968 B CN 101361968B CN 2007100445927 A CN2007100445927 A CN 2007100445927A CN 200710044592 A CN200710044592 A CN 200710044592A CN 101361968 B CN101361968 B CN 101361968B
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interleukin
fatty liver
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cell
present
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CN101361968A (zh
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黄予良
黄智华
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Yiyi biomedical development (Shanghai) Co.,Ltd.
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Generon Shanghai Corp Ltd
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Priority to CN2007100445927A priority Critical patent/CN101361968B/zh
Application filed by Generon Shanghai Corp Ltd filed Critical Generon Shanghai Corp Ltd
Priority to JP2010520208A priority patent/JP5546453B2/ja
Priority to CA2695734A priority patent/CA2695734C/en
Priority to EP20080797018 priority patent/EP2185202B1/en
Priority to PCT/US2008/071859 priority patent/WO2009020844A1/en
Priority to AU2008284116A priority patent/AU2008284116B2/en
Priority to US12/672,274 priority patent/US20110262385A1/en
Publication of CN101361968A publication Critical patent/CN101361968A/zh
Application granted granted Critical
Publication of CN101361968B publication Critical patent/CN101361968B/zh
Priority to US14/483,175 priority patent/US20140377222A1/en
Priority to US15/694,670 priority patent/US10786551B2/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2007100445927A 2007-08-06 2007-08-06 白介素-22在治疗脂肪肝中的应用 Active CN101361968B (zh)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CN2007100445927A CN101361968B (zh) 2007-08-06 2007-08-06 白介素-22在治疗脂肪肝中的应用
CA2695734A CA2695734C (en) 2007-08-06 2008-08-01 Use of interleukin-22 in the treatment of fatty liver disease
EP20080797018 EP2185202B1 (en) 2007-08-06 2008-08-01 Use of interleukin-22 in the treatment of fatty liver disease
PCT/US2008/071859 WO2009020844A1 (en) 2007-08-06 2008-08-01 Use of interleukin-22 in the treatment of fatty liver disease
JP2010520208A JP5546453B2 (ja) 2007-08-06 2008-08-01 脂肪肝疾患の治療におけるインターロイキン−22の使用
AU2008284116A AU2008284116B2 (en) 2007-08-06 2008-08-01 Use of interleukin-22 in the treatment of fatty liver disease
US12/672,274 US20110262385A1 (en) 2007-08-06 2008-08-01 Use of interleukin-22 in the treatment of fatty liver disease
US14/483,175 US20140377222A1 (en) 2007-08-06 2014-09-11 Use of interleukin-22 in the treatment of fatty liver disease
US15/694,670 US10786551B2 (en) 2007-08-06 2017-09-01 Use of interleukin-22 in the treatment of fatty liver disease

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2007100445927A CN101361968B (zh) 2007-08-06 2007-08-06 白介素-22在治疗脂肪肝中的应用

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CN101361968A CN101361968A (zh) 2009-02-11
CN101361968B true CN101361968B (zh) 2011-08-03

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US (3) US20110262385A1 (enExample)
EP (1) EP2185202B1 (enExample)
JP (1) JP5546453B2 (enExample)
CN (1) CN101361968B (enExample)
AU (1) AU2008284116B2 (enExample)
CA (1) CA2695734C (enExample)
WO (1) WO2009020844A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101361968B (zh) 2007-08-06 2011-08-03 健能隆医药技术(上海)有限公司 白介素-22在治疗脂肪肝中的应用
CN102260343A (zh) 2010-05-25 2011-11-30 健能隆医药技术(上海)有限公司 重组人g-csf二聚体在治疗神经损伤疾病中的用途
CN102380091A (zh) 2010-08-31 2012-03-21 健能隆医药技术(上海)有限公司 白介素-22在治疗病毒性肝炎中的应用
EP2616045B1 (en) 2010-09-15 2017-10-25 Randall J. Mrsny Systems and methods of delivery of bioactive agents using bacterial toxin-derived transport sequences
US11246915B2 (en) 2010-09-15 2022-02-15 Applied Molecular Transport Inc. Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo
WO2013013613A1 (zh) 2011-07-25 2013-01-31 健能隆医药技术(上海)有限公司 G-csf二聚体在制备治疗神经退行性疾病药物中的应用
CN103182072B (zh) 2011-12-27 2017-05-03 健能隆医药技术(上海)有限公司 白介素‑22在治疗和预防神经损伤疾病或神经退行性疾病中的用途
RS57393B1 (sr) 2013-03-15 2018-09-28 Hoffmann La Roche Il-22 polipeptiidi i il-22 fuzioni proteini i metode za njihovu upotrebu
CN104623637A (zh) 2013-11-07 2015-05-20 健能隆医药技术(上海)有限公司 Il-22二聚体在制备静脉注射药物中的应用
SI3139965T1 (sl) 2014-05-07 2022-01-31 Applied Molecular Transport Inc. Fuzijske molekule, izpeljane iz toksina cholix, za peroralno dostavljanje biološko aktivnega tovora
EP3149049B1 (en) * 2014-05-27 2022-10-26 The University Of Queensland Il-22 for use in treating metabolic disorders
WO2016144862A1 (en) 2015-03-09 2016-09-15 Intekrin Therapeutics, Inc. Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy
WO2017181143A1 (en) 2016-04-15 2017-10-19 Generon (Shanghai) Corporation, Ltd. Use of il-22 in treating necrotizing enterocolitis
CN110996951A (zh) 2017-04-03 2020-04-10 科赫罗斯生物科学股份有限公司 治疗进行性核上性麻痹的PPARγ激动剂
IL282986B2 (en) 2018-11-07 2024-01-01 Applied Molecular Transport Inc Colics-derivative carriers for oral administration of heterologous cargo
PL3650037T3 (pl) 2018-11-07 2022-06-06 Applied Molecular Transport Inc. Konstrukty dostarczające do transcytozy i powiązane z nimi sposoby
CA3150859A1 (en) 2019-08-16 2021-02-25 Applied Molecular Transport Inc. Compositions, formulations, and interleukin production and purification
JPWO2022050230A1 (enExample) * 2020-09-03 2022-03-10

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4657760A (en) 1979-03-20 1987-04-14 Ortho Pharmaceutical Corporation Methods and compositions using monoclonal antibody to human T cells
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
NZ201705A (en) 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4943529A (en) 1982-05-19 1990-07-24 Gist-Brocades Nv Kluyveromyces as a host strain
US4713339A (en) 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
AU2353384A (en) 1983-01-19 1984-07-26 Genentech Inc. Amplification in eukaryotic host cells
AU3145184A (en) 1983-08-16 1985-02-21 Zymogenetics Inc. High expression of foreign genes in schizosaccharomyces pombe
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
DE3675588D1 (de) 1985-06-19 1990-12-20 Ajinomoto Kk Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
US5206344A (en) 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
WO1987005330A1 (en) 1986-03-07 1987-09-11 Michel Louis Eugene Bergh Method for enhancing glycoprotein stability
US4849227A (en) 1986-03-21 1989-07-18 Eurasiam Laboratories, Inc. Pharmaceutical compositions
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US5010182A (en) 1987-07-28 1991-04-23 Chiron Corporation DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides
AU633248B2 (en) 1987-12-21 1993-01-28 University Of Toledo, The Agrobacterium mediated transformation of germinating plant seeds
AU4005289A (en) 1988-08-25 1990-03-01 Smithkline Beecham Corporation Recombinant saccharomyces
US5225538A (en) 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
DE394538T1 (de) 1989-04-28 1991-04-11 Rhein Biotech Ges. Fuer Biotechnologische Prozesse Und Produkte Mbh, 4000 Duesseldorf Hefezellen der schwanniomyces-gattung.
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
FR2649120B1 (fr) 1989-06-30 1994-01-28 Cayla Nouvelle souche et ses mutants de champignons filamenteux, procede de production de proteines recombinantes a l'aide de ladite souche et souches et proteines obtenues selon ce procede
US5225212A (en) 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
DE69329295T2 (de) 1992-12-02 2001-03-15 Alkermes Controlled Therapeutics, Inc. Wachstumhormon enthaltende mikrosphaeren mit kontrollierter freisetzung
US5951974A (en) 1993-11-10 1999-09-14 Enzon, Inc. Interferon polymer conjugates
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
AU1684195A (en) 1994-02-22 1995-09-04 Georgia Tech Research Corporation Reduction of friction during wire drawing
PT779806E (pt) 1994-09-09 2001-02-28 Takeda Chemical Industries Ltd Preparacao de libertacao sustentada contendo um sal metalico de um peptido
JPH11506740A (ja) 1995-06-07 1999-06-15 アルカームズ コントロールド セラピューティックス,インコーポレイテッド ヒト成長ホルモンの徐放性組成物
ZA965368B (en) 1995-07-14 1997-01-14 Novo Nordisk As A pharmaceutical formulation
US6551799B2 (en) * 1999-12-07 2003-04-22 Genentech, Inc. Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders
US20010023070A1 (en) 1998-05-29 2001-09-20 Reinhard Ebner Interleukins-21 and 22
AU4208799A (en) 1998-05-29 1999-12-13 Human Genome Sciences, Inc. Interleukins-21 and 22
US6274710B1 (en) 1998-10-26 2001-08-14 Ludwig Institute For Cancer Research Antibodies which specifically bind T Cell inducible factors (TIFs)
AU760224B2 (en) 1998-10-26 2003-05-08 Wyeth Isolated nucleic acid molecules which encode T cell inducible factors (TIFs), the proteins encoded, and uses thereof
US7307161B1 (en) 1999-04-28 2007-12-11 Genetics Institute, Llc Human Gil-19/AE289 polynucleotides
US7226591B2 (en) 2000-05-22 2007-06-05 Genentech, Inc. Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders
CN1163263C (zh) 2000-01-07 2004-08-25 华中理工大学 一种多肽类药物口腔喷雾剂
GB0024442D0 (en) 2000-10-05 2000-11-22 Isis Innovation Genetic factors affecting the outcome of viral infections
CN1335182A (zh) 2001-08-08 2002-02-13 华中科技大学 胰岛素口腔喷剂及其制备工艺
US6797493B2 (en) 2001-10-01 2004-09-28 Lee-Hwei K. Sun Fc fusion proteins of human granulocyte colony-stimulating factor with increased biological activities
JP2005519986A (ja) 2001-11-06 2005-07-07 イーライ・リリー・アンド・カンパニー 造血障害を治療するためのil−19、il−22およびil−24の使用
EP1463752A4 (en) 2001-12-21 2005-07-13 Human Genome Sciences Inc ALBUMIN FUSION PROTEINS
CN1176137C (zh) 2002-01-15 2004-11-17 泛亚生物技术有限公司 多臂树杈型功能化聚乙二醇制备方法及它在药物中的应用
US7597876B2 (en) 2007-01-11 2009-10-06 Immunomedics, Inc. Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
US20030235561A1 (en) 2002-06-25 2003-12-25 Cell Based Delivery Inc. Vascularized organized tissues and uses thereof
US20050148029A1 (en) 2003-09-29 2005-07-07 Biosite, Inc. Methods and compositions for determining treatment regimens in systemic inflammatory response syndromes
DK1748789T3 (da) 2003-11-05 2012-01-23 Inst Rech Developpement Ird IL-22 til forebyggelse af infektionssygdomme
JP5103022B2 (ja) 2004-02-13 2012-12-19 ノッド ファーマシューティカルズ, インコーポレイテッド リン酸カルシウムナノ粒子のコア、生体分子および胆汁酸を含む粒子、ならびにそれらの製造方法および治療用途
US7670595B2 (en) 2004-06-28 2010-03-02 Merck Patent Gmbh Fc-interferon-beta fusion proteins
CN100515491C (zh) * 2005-01-04 2009-07-22 健能隆医药技术(上海)有限公司 白介素-22的医药用途
PE20061391A1 (es) 2005-02-14 2007-01-09 Wyeth Corp Anticuerpos para interleucina-17f y otros antagonistas de la senalizacion de il-17f
WO2007047796A2 (en) * 2005-10-17 2007-04-26 Institute For Systems Biology Tissue-and serum-derived glycoproteins and methods of their use
UA95613C2 (ru) * 2005-11-09 2011-08-25 Уеллстат Терепьютикс Корпорейшн Соединения для лечения расстройсв метаболизма
WO2007115230A2 (en) 2006-03-30 2007-10-11 University Of Medicine And Dentistry Of New Jersey A strategy for homo- or hetero-dimerization of various proteins in solutions and in cells
US8211649B2 (en) 2006-03-31 2012-07-03 Human Genome Sciences, Inc. Methods of diagnosing and prognosing hodgkin's lymphoma
US20080031882A1 (en) 2006-06-19 2008-02-07 Liang Spencer C Methods of modulating IL-22 and IL-17
WO2008085229A2 (en) 2006-11-15 2008-07-17 Arteriocyte Inc. Cell-based therapies for treating liver disease
CN101361968B (zh) 2007-08-06 2011-08-03 健能隆医药技术(上海)有限公司 白介素-22在治疗脂肪肝中的应用
WO2009041734A1 (ja) 2007-09-26 2009-04-02 Kyowa Hakko Kirin Co., Ltd. ヒトトロンボポエチン受容体に対するアゴニスト抗体
CN101168049A (zh) * 2007-10-23 2008-04-30 中国人民解放军军事医学科学院基础医学研究所 白介素-22在制备治疗肝病药物中的应用及其制备方法
CN101225110B (zh) 2007-10-23 2010-10-20 中国人民解放军军事医学科学院基础医学研究所 人白细胞介素-22突变体及其构建方法和应用
CN108815508A (zh) 2007-11-07 2018-11-16 健泰科生物技术公司 用于治疗微生物病症的组合物和方法
EP2385841B1 (en) 2009-01-12 2016-11-16 Generon (Shanghai) Corporation Prevention and/or treatment of multiple organ dysfunction syndrome with interleukin-22
WO2011087986A1 (en) 2010-01-13 2011-07-21 Amgen Inc. Il-22-fc and hepcidin activity
CN102380091A (zh) 2010-08-31 2012-03-21 健能隆医药技术(上海)有限公司 白介素-22在治疗病毒性肝炎中的应用
CN103182072B (zh) 2011-12-27 2017-05-03 健能隆医药技术(上海)有限公司 白介素‑22在治疗和预防神经损伤疾病或神经退行性疾病中的用途
RS57393B1 (sr) 2013-03-15 2018-09-28 Hoffmann La Roche Il-22 polipeptiidi i il-22 fuzioni proteini i metode za njihovu upotrebu
CN104623639A (zh) 2013-11-07 2015-05-20 健能隆医药技术(上海)有限公司 白介素22二聚体在制备治疗胰腺炎药物中的应用
CN104623637A (zh) 2013-11-07 2015-05-20 健能隆医药技术(上海)有限公司 Il-22二聚体在制备静脉注射药物中的应用
US20160287670A1 (en) 2013-11-07 2016-10-06 Memorial Sloan-Kettering Cancer Center Methods of use for il-22 in the treatment of gastrointestinal graft vs. host disease
WO2017181143A1 (en) 2016-04-15 2017-10-19 Generon (Shanghai) Corporation, Ltd. Use of il-22 in treating necrotizing enterocolitis

Also Published As

Publication number Publication date
CA2695734A1 (en) 2009-02-12
CN101361968A (zh) 2009-02-11
JP5546453B2 (ja) 2014-07-09
US10786551B2 (en) 2020-09-29
US20180028614A1 (en) 2018-02-01
AU2008284116B2 (en) 2014-01-09
US20140377222A1 (en) 2014-12-25
US20110262385A1 (en) 2011-10-27
JP2010535786A (ja) 2010-11-25
EP2185202A4 (en) 2013-11-06
EP2185202A1 (en) 2010-05-19
EP2185202B1 (en) 2015-05-06
CA2695734C (en) 2017-02-14
WO2009020844A1 (en) 2009-02-12
AU2008284116A1 (en) 2009-02-12

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