JP2010532786A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010532786A5 JP2010532786A5 JP2010516035A JP2010516035A JP2010532786A5 JP 2010532786 A5 JP2010532786 A5 JP 2010532786A5 JP 2010516035 A JP2010516035 A JP 2010516035A JP 2010516035 A JP2010516035 A JP 2010516035A JP 2010532786 A5 JP2010532786 A5 JP 2010532786A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical formulation
- here
- hydrophilic
- acid
- irna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- 239000003795 chemical substances by application Substances 0.000 claims 9
- 230000002209 hydrophobic effect Effects 0.000 claims 5
- 239000000693 micelle Substances 0.000 claims 4
- WWZKQHOCKIZLMA-UHFFFAOYSA-N Caprylic acid Natural products CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 3
- 229930186217 Glycolipid Natural products 0.000 claims 3
- 230000015556 catabolic process Effects 0.000 claims 3
- 238000006731 degradation reaction Methods 0.000 claims 3
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 150000003904 phospholipids Chemical class 0.000 claims 3
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 claims 2
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 2
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 2
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 2
- 101710163270 Nuclease Proteins 0.000 claims 2
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims 2
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 claims 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 2
- VKOBVWXKNCXXDE-UHFFFAOYSA-N icosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCC(O)=O VKOBVWXKNCXXDE-UHFFFAOYSA-N 0.000 claims 2
- 230000003834 intracellular effect Effects 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 150000004668 long chain fatty acids Chemical class 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 2
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 2
- 150000003905 phosphatidylinositols Chemical class 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- JSPNNZKWADNWHI-PNANGNLXSA-N (2r)-2-hydroxy-n-[(2s,3r,4e,8e)-3-hydroxy-9-methyl-1-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadeca-4,8-dien-2-yl]heptadecanamide Chemical compound CCCCCCCCCCCCCCC[C@@H](O)C(=O)N[C@H]([C@H](O)\C=C\CC\C=C(/C)CCCCCCCCC)CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O JSPNNZKWADNWHI-PNANGNLXSA-N 0.000 claims 1
- GYSCBCSGKXNZRH-UHFFFAOYSA-N 1-benzothiophene-2-carboxamide Chemical compound C1=CC=C2SC(C(=O)N)=CC2=C1 GYSCBCSGKXNZRH-UHFFFAOYSA-N 0.000 claims 1
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 claims 1
- 235000021357 Behenic acid Nutrition 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 1
- 235000021353 Lignoceric acid Nutrition 0.000 claims 1
- CQXMAMUUWHYSIY-UHFFFAOYSA-N Lignoceric acid Natural products CCCCCCCCCCCCCCCCCCCCCCCC(=O)OCCC1=CC=C(O)C=C1 CQXMAMUUWHYSIY-UHFFFAOYSA-N 0.000 claims 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims 1
- 235000021314 Palmitic acid Nutrition 0.000 claims 1
- 229920002873 Polyethylenimine Polymers 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 claims 1
- 229940116226 behenic acid Drugs 0.000 claims 1
- GONOPSZTUGRENK-UHFFFAOYSA-N benzyl(trichloro)silane Chemical compound Cl[Si](Cl)(Cl)CC1=CC=CC=C1 GONOPSZTUGRENK-UHFFFAOYSA-N 0.000 claims 1
- 229930183167 cerebroside Natural products 0.000 claims 1
- RIZIAUKTHDLMQX-UHFFFAOYSA-N cerebroside D Natural products CCCCCCCCCCCCCCCCC(O)C(=O)NC(C(O)C=CCCC=C(C)CCCCCCCCC)COC1OC(CO)C(O)C(O)C1O RIZIAUKTHDLMQX-UHFFFAOYSA-N 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- KFEVDPWXEVUUMW-UHFFFAOYSA-N docosanoic acid Natural products CCCCCCCCCCCCCCCCCCCCCC(=O)OCCC1=CC=C(O)C=C1 KFEVDPWXEVUUMW-UHFFFAOYSA-N 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 150000002270 gangliosides Chemical class 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N n-hexanoic acid Natural products CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229920000765 poly(2-oxazolines) Polymers 0.000 claims 1
- 229920002401 polyacrylamide Polymers 0.000 claims 1
- 229920001601 polyetherimide Polymers 0.000 claims 1
- -1 polymorpholine Polymers 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 150000005843 sulfated lipids Chemical class 0.000 claims 1
- QZZGJDVWLFXDLK-UHFFFAOYSA-N tetracosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCCCC(O)=O QZZGJDVWLFXDLK-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94843307P | 2007-07-06 | 2007-07-06 | |
| PCT/US2008/008326 WO2009009025A1 (en) | 2007-07-06 | 2008-07-07 | Mixed micelles including amphipathic conjugates of rna agents, and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010532786A JP2010532786A (ja) | 2010-10-14 |
| JP2010532786A5 true JP2010532786A5 (https=) | 2011-08-25 |
Family
ID=40228904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010516035A Pending JP2010532786A (ja) | 2007-07-06 | 2008-07-07 | Ｒｎａ薬剤の両親媒性接合を含む混合ミセルおよびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110008395A1 (https=) |
| EP (1) | EP2171095A4 (https=) |
| JP (1) | JP2010532786A (https=) |
| KR (1) | KR20100037120A (https=) |
| CA (1) | CA2692748A1 (https=) |
| WO (1) | WO2009009025A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009246321A1 (en) | 2008-05-13 | 2009-11-19 | Phaserx, Inc. | Polymeric carrier |
| EP2285853B1 (en) | 2008-05-13 | 2013-02-27 | University of Washington | Micellic assemblies |
| CA2972694C (en) | 2008-05-13 | 2020-02-11 | University Of Washington | Diblock copolymers and polynucleotide complexes thereof for delivery into cells |
| JP2012500793A (ja) | 2008-08-22 | 2012-01-12 | ユニヴァーシティ オブ ワシントン | 細胞内デリバリーのための異種性ポリマーミセル |
| MX2011004242A (es) | 2008-11-06 | 2011-07-20 | Univ Washington | Copolimeros multibloque. |
| EP2352522A4 (en) | 2008-11-06 | 2014-03-05 | Univ Washington | BISPECIFIC AUXILIARIES FOR INTRA-CELLULAR RELEASE |
| WO2010077678A2 (en) | 2008-12-08 | 2010-07-08 | University Of Washington | Omega-functionalized polymers, junction-functionalized block copolymers, polymer bioconjugates, and radical chain extension polymerization |
| GB0910723D0 (en) * | 2009-06-22 | 2009-08-05 | Sylentis Sau | Novel drugs for inhibition of gene expression |
| WO2011008857A1 (en) | 2009-07-14 | 2011-01-20 | Northeastern University | SiRNA PHOSPHOLIPID CONJUGATE |
| US9415113B2 (en) | 2009-11-18 | 2016-08-16 | University Of Washington | Targeting monomers and polymers having targeting blocks |
| CN102971002B (zh) * | 2010-07-09 | 2019-04-05 | 国立大学法人东京大学 | 核酸递送用组合物及载体组合物、使用其的药物组合物以及核酸递送方法 |
| JP6190132B2 (ja) * | 2013-03-21 | 2017-08-30 | 学校法人近畿大学 | 遺伝子試料導入用基板及び遺伝子試料導入方法 |
| AU2014296278C1 (en) | 2013-07-30 | 2023-02-02 | Genevant Sciences Gmbh | Block copolymers and their conjugates or complexes with oligonucleotides |
| JP2018509387A (ja) | 2015-01-21 | 2018-04-05 | フェーズアールエックス インコーポレイテッド | 細胞に治療および診断剤を送達するための方法、組成物、ならびにシステム |
| JP7249080B2 (ja) * | 2016-08-23 | 2023-03-30 | ディセルナ ファーマシューティカルズ インコーポレイテッド | 可逆的に修飾されたオリゴヌクレオチドを含む組成物及びその使用 |
| EP3562510A4 (en) | 2016-12-30 | 2021-01-06 | Genevant Sciences GmbH | BRANCHED PEG MOLECULES AND ASSOCIATED COMPOSITIONS AND PROCEDURES |
| MX2020011570A (es) | 2018-05-07 | 2020-11-24 | Alnylam Pharmaceuticals Inc | Administracion extrahepatica. |
| US20200048305A1 (en) * | 2018-08-10 | 2020-02-13 | South Dakota Board Of Regents | Glutathione-cholesterol derivatives as brain targeting agents |
| BR112023018247A2 (pt) | 2021-03-08 | 2024-01-16 | Extiel Ap Llc | Dispositivo para pirólise de materiais carbonáceos e método |
| CN113633613B (zh) * | 2021-07-20 | 2023-04-25 | 河南大学 | 一种siRNA胶束、制备方法、组合物及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU728176B2 (en) * | 1995-05-04 | 2001-01-04 | Gilead Sciences, Inc. | Nucleic acid ligand complexes |
| US20030147944A1 (en) * | 1999-12-10 | 2003-08-07 | Mayer Lawrence D | Lipid carrier compositions with protected surface reactive functions |
| US8202979B2 (en) * | 2002-02-20 | 2012-06-19 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid |
| WO2004090108A2 (en) * | 2003-04-03 | 2004-10-21 | Alnylam Pharmaceuticals | Irna conjugates |
| ES2702942T3 (es) * | 2003-04-17 | 2019-03-06 | Alnylam Pharmaceuticals Inc | Agentes de ARNi modificados |
| EP3222294A1 (en) * | 2003-04-30 | 2017-09-27 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
-
2008
- 2008-07-07 JP JP2010516035A patent/JP2010532786A/ja active Pending
- 2008-07-07 KR KR1020107001933A patent/KR20100037120A/ko not_active Withdrawn
- 2008-07-07 US US12/667,713 patent/US20110008395A1/en not_active Abandoned
- 2008-07-07 CA CA 2692748 patent/CA2692748A1/en not_active Abandoned
- 2008-07-07 WO PCT/US2008/008326 patent/WO2009009025A1/en not_active Ceased
- 2008-07-07 EP EP08826166A patent/EP2171095A4/en not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010532786A5 (https=) | ||
| Kozubek et al. | Liposomal drug delivery, a novel approach: PLARosomes. | |
| JP2007515470A5 (https=) | ||
| JP7355394B2 (ja) | カロテノイド組成物およびその使用 | |
| Rajera et al. | Niosomes: a controlled and novel drug delivery system | |
| Holland et al. | Poly (ethylene glycol)− lipid conjugates promote bilayer formation in mixtures of non-bilayer-forming lipids | |
| JP2007515471A5 (https=) | ||
| US9452179B2 (en) | Vesicular formulations | |
| KR20010100194A (ko) | 여러 가지 물질의 가용화용 조성물과 제형 및 그들의제조방법 | |
| Tilawat et al. | Nanocochleates: A potential drug delivery system | |
| JP2014521752A (ja) | ステロイドホルモンの送達システムおよびその調製方法 | |
| CN103619325A (zh) | 用于生产脂质体的方法 | |
| JP2014519493A (ja) | ポリマー共役脂質を含むリポソームおよび関連用途 | |
| Negi | Nanolipid materials for drug delivery systems: A comprehensive Review | |
| JP2001502676A (ja) | 障壁を通して活性成分を輸送するための調製物 | |
| JP2020532546A5 (https=) | ||
| CN106456546A (zh) | 用于黏膜递送的脂质体组合物 | |
| Lee et al. | Imaging-based analysis of liposome internalization to macrophage cells: Effects of liposome size and surface modification with PEG moiety | |
| Pattnaik et al. | Lipid vesicles: Potentials as drug delivery systems | |
| KR20200005541A (ko) | 단층 리포좀에서 친수성 화합물의 고효율 캡슐화 | |
| Ali et al. | Bilosomes as soft nanovesicular carriers for ropinirole hydrochloride: Preparation and in-vitro characterization | |
| Gopi et al. | Liposomal nanostructures: Properties and applications | |
| US20060198882A1 (en) | Stable liposomes or micelles comprising a sphinolipid and a peg-lipopolymer | |
| US20130195962A1 (en) | Lipid membrane structure | |
| JP2017513938A (ja) | リポソームムピロシン |