JP2007515471A5 - - Google Patents
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- JP2007515471A5 JP2007515471A5 JP2006546390A JP2006546390A JP2007515471A5 JP 2007515471 A5 JP2007515471 A5 JP 2007515471A5 JP 2006546390 A JP2006546390 A JP 2006546390A JP 2006546390 A JP2006546390 A JP 2006546390A JP 2007515471 A5 JP2007515471 A5 JP 2007515471A5
- Authority
- JP
- Japan
- Prior art keywords
- assembly
- microvesicle
- component
- net charge
- assembly according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000007789 gas Substances 0.000 claims 13
- -1 antibody Proteins 0.000 claims 12
- 239000007900 aqueous suspension Substances 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 9
- 150000003904 phospholipids Chemical class 0.000 claims 9
- 238000004519 manufacturing process Methods 0.000 claims 7
- 239000004094 surface-active agent Substances 0.000 claims 7
- 235000014113 dietary fatty acids Nutrition 0.000 claims 6
- 229930195729 fatty acid Natural products 0.000 claims 6
- 239000000194 fatty acid Substances 0.000 claims 6
- 150000002632 lipids Chemical class 0.000 claims 6
- 239000002243 precursor Substances 0.000 claims 6
- 239000000725 suspension Substances 0.000 claims 6
- 239000000032 diagnostic agent Substances 0.000 claims 5
- 229940039227 diagnostic agent Drugs 0.000 claims 5
- 239000003446 ligand Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 239000012867 bioactive agent Substances 0.000 claims 4
- 239000000693 micelle Substances 0.000 claims 4
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 3
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical class CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 3
- 125000005210 alkyl ammonium group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims 3
- 150000003866 tertiary ammonium salts Chemical class 0.000 claims 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 2
- 108010007979 Glycocholic Acid Proteins 0.000 claims 2
- 239000004698 Polyethylene Substances 0.000 claims 2
- 239000008365 aqueous carrier Substances 0.000 claims 2
- 229940099352 cholate Drugs 0.000 claims 2
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 claims 2
- 229940009976 deoxycholate Drugs 0.000 claims 2
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 claims 2
- 239000000839 emulsion Substances 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- RFDAIACWWDREDC-FRVQLJSFSA-N glycocholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 RFDAIACWWDREDC-FRVQLJSFSA-N 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- 150000008103 phosphatidic acids Chemical class 0.000 claims 2
- 150000008106 phosphatidylserines Chemical class 0.000 claims 2
- 229920000573 polyethylene Polymers 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 150000003431 steroids Chemical class 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 claims 1
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 108010038807 Oligopeptides Proteins 0.000 claims 1
- 102000015636 Oligopeptides Human genes 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 229920002988 biodegradable polymer Polymers 0.000 claims 1
- 239000004621 biodegradable polymer Substances 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 239000010415 colloidal nanoparticle Substances 0.000 claims 1
- 238000002059 diagnostic imaging Methods 0.000 claims 1
- OGQYPPBGSLZBEG-UHFFFAOYSA-N dimethyl(dioctadecyl)azanium Chemical group CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC OGQYPPBGSLZBEG-UHFFFAOYSA-N 0.000 claims 1
- 239000002270 dispersing agent Substances 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003995 emulsifying agent Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 229920000831 ionic polymer Polymers 0.000 claims 1
- 239000002563 ionic surfactant Substances 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 239000002069 magnetite nanoparticle Substances 0.000 claims 1
- 150000002772 monosaccharides Chemical class 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 239000002777 nucleoside Substances 0.000 claims 1
- 125000003835 nucleoside group Chemical group 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 229920001542 oligosaccharide Polymers 0.000 claims 1
- 150000002482 oligosaccharides Chemical class 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 230000005298 paramagnetic effect Effects 0.000 claims 1
- 239000000816 peptidomimetic Substances 0.000 claims 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 239000010409 thin film Substances 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03079014 | 2003-12-22 | ||
| PCT/IB2004/004233 WO2005063306A1 (en) | 2003-12-22 | 2004-12-21 | Assembly of gas-filled microvesicle with active component for contrast imaging |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007515471A JP2007515471A (ja) | 2007-06-14 |
| JP2007515471A5 true JP2007515471A5 (https=) | 2008-02-14 |
Family
ID=34717205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006546390A Pending JP2007515471A (ja) | 2003-12-22 | 2004-12-21 | 造影イメージング用の活性成分を有する気体封入マイクロベシクルのアセンブリー |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20070081946A1 (https=) |
| EP (1) | EP1696965B1 (https=) |
| JP (1) | JP2007515471A (https=) |
| CN (1) | CN1897978B (https=) |
| AU (1) | AU2004308757B2 (https=) |
| CA (1) | CA2545362C (https=) |
| ES (1) | ES2531751T3 (https=) |
| NO (1) | NO338317B1 (https=) |
| WO (1) | WO2005063306A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4670083B2 (ja) | 2003-02-04 | 2011-04-13 | ブラッコ・シュイス・ソシエテ・アノニム | 超音波造影剤およびその製造方法 |
| CN100563718C (zh) * | 2003-12-22 | 2009-12-02 | 伯拉考开发股份有限公司 | 用于反差成像的充气微囊组件 |
| WO2005070473A1 (en) * | 2004-01-15 | 2005-08-04 | Koninklijke Philips Electronics N.V. | Ultrasound contrast agents for molecular imaging |
| US9248204B2 (en) | 2004-08-18 | 2016-02-02 | Bracco Suisse S.A. | Gas-filled microvesicles composition for contrast imaging |
| CA2633380A1 (en) * | 2005-12-16 | 2007-07-05 | University Of Kansas | Nanoclusters for delivery of therapeutics |
| ATE469660T1 (de) | 2006-09-05 | 2010-06-15 | Bracco Research Sa | Gasgefüllte mikrovesikel mit polymer- modifizierten lipiden |
| US20100041989A1 (en) * | 2006-09-29 | 2010-02-18 | The Trustees Of The University Of Pennsylvania | Use of ultrasound as an antivascular agent |
| US20090234231A1 (en) * | 2008-03-13 | 2009-09-17 | Knight Jon M | Imaging Catheter With Integrated Contrast Agent Injector |
| GB0811856D0 (en) | 2008-06-27 | 2008-07-30 | Ucl Business Plc | Magnetic microbubbles, methods of preparing them and their uses |
| CA2748995C (en) * | 2008-10-07 | 2018-01-16 | Bracco Suisse Sa | Targeting construct comprising anti-polymer antibody and liposomes or microvesicles binding to the same |
| HUE037082T2 (hu) | 2008-11-10 | 2018-08-28 | Arbutus Biopharma Corp | Új lipidek és készítmények terápiás hatóanyagok szállítására |
| CN106362171A (zh) | 2009-02-13 | 2017-02-01 | 华盛顿大学 | 用于磁共振成像的钆表现脂质纳米颗粒 |
| EP2253308A1 (en) | 2009-05-22 | 2010-11-24 | Ludwig-Maximilians-Universität München | Pharmaceutical composition comprising microbubbles for targeted tumor therapy |
| WO2011017524A1 (en) * | 2009-08-05 | 2011-02-10 | The Trustees Of The University Of Pennsylvania | Microfluidic-based generation of functionalized microbubbles for ultrasound imaging and therapy |
| EP2470287A4 (en) | 2009-08-28 | 2015-01-21 | Univ Columbia | SYSTEMS, METHODS AND DEVICES FOR PRODUCING GAS-FILLED MICROBUBBLES |
| US9700640B2 (en) | 2009-09-21 | 2017-07-11 | Drexel University | Stabilized ultrasound contrast agent |
| US8974818B2 (en) * | 2010-01-20 | 2015-03-10 | Henry Wu | Custom-formulated phospholipid microbubbles and methods and uses thereof |
| US9265483B2 (en) | 2010-08-06 | 2016-02-23 | The Trustees Of Columbia University In The City Of New York | Medical imaging contrast devices, methods, and systems |
| TW201208706A (en) | 2010-08-17 | 2012-03-01 | Univ Nat Yang Ming | Ultrasonically-triggered drug vehicle with magnetic resonance imaging function |
| KR101292939B1 (ko) | 2010-12-31 | 2013-08-02 | 삼성전자주식회사 | 엠알유도 고강도집속초음파 치료 및 진단용 인지질 나노입자 및 이의 제조방법 |
| EP2934740B1 (en) | 2012-12-21 | 2019-12-11 | Bracco Suisse SA | Gas-filled microvesicles |
| HUE060034T2 (hu) * | 2013-09-27 | 2023-01-28 | Exact Therapeutics As | Ultrahanggal közvetített hatóanyag leadás |
| JP6202563B2 (ja) * | 2013-10-21 | 2017-09-27 | ネッパジーン株式会社 | 負電荷バブルリポソーム及びカチオン性ペプチドからなる薬物送達キャリア |
| KR101595795B1 (ko) * | 2014-03-19 | 2016-02-22 | (주)아이엠지티 | 약물을 함유한 나노입자가 결합된 이중-목적 paｔ／초음파 조영제 및 이의 제조방법 |
| CA3091952A1 (en) * | 2018-03-07 | 2019-09-12 | Bracco Suisse Sa | Preparation of size-controlled microvesicles |
| ES2984146T3 (es) | 2018-12-21 | 2024-10-29 | Bracco Suisse Sa | Microvesículas llenas de gas con ligando |
| GB2595513B (en) * | 2020-05-29 | 2023-03-29 | Act Therapeutics Ltd | Treatment of infections |
| US12233131B2 (en) * | 2021-07-14 | 2025-02-25 | Bracco Suisse Sa | Cationic calibrated-size gas-filled microvesicles |
| WO2024059715A2 (en) * | 2022-09-14 | 2024-03-21 | Drexel University | Microbubbles and methods of making same |
| NO20221187A1 (en) | 2022-11-04 | 2024-05-06 | Exact Therapeutics As | Method and system for calculating a point estimate of an ultrasound dose |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4276885A (en) * | 1979-05-04 | 1981-07-07 | Rasor Associates, Inc | Ultrasonic image enhancement |
| ATE60340T1 (de) * | 1984-10-19 | 1991-02-15 | Battelle Memorial Institute | Durch mikroorganismen abbaubares polypeptid und seine verwendung fuer die fortschreitende abgabe von medikamenten. |
| US5445813A (en) * | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
| IN172208B (https=) * | 1990-04-02 | 1993-05-01 | Sint Sa | |
| US5556610A (en) * | 1992-01-24 | 1996-09-17 | Bracco Research S.A. | Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method |
| AU636481B2 (en) * | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
| US5562099A (en) * | 1990-10-05 | 1996-10-08 | Massachusetts Institute Of Technology | Polymeric microparticles containing agents for imaging |
| IL104084A (en) * | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them |
| US5464696A (en) * | 1992-08-13 | 1995-11-07 | Bracco International B.V. | Particles for NMR imaging |
| EP1550464A1 (en) * | 1993-07-30 | 2005-07-06 | IMCOR Pharmaceutical Co. | Stabilized microbubble composition for ultrasound |
| NO940711D0 (no) * | 1994-03-01 | 1994-03-01 | Nycomed Imaging As | Preparation of gas-filled microcapsules and contrasts agents for diagnostic imaging |
| US6333021B1 (en) * | 1994-11-22 | 2001-12-25 | Bracco Research S.A. | Microcapsules, method of making and their use |
| IL116328A (en) * | 1994-12-16 | 1999-09-22 | Bracco Research Sa | Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging |
| US6139819A (en) * | 1995-06-07 | 2000-10-31 | Imarx Pharmaceutical Corp. | Targeted contrast agents for diagnostic and therapeutic use |
| ATE238072T1 (de) * | 1996-02-19 | 2003-05-15 | Amersham Health As | Verbesserungen an (oder im bezug auf) kontrastmittel |
| US6331289B1 (en) * | 1996-10-28 | 2001-12-18 | Nycomed Imaging As | Targeted diagnostic/therapeutic agents having more than one different vectors |
| BR9713978A (pt) * | 1996-10-28 | 2000-05-02 | Nycomed Imaging As | Agente diagnóstico alvejável e/ou terapeuticamente ativo, processo para preparação e uso do mesmo, formulação combinada, e, processos para gerar imagens intensificadas de um corpo animal humano ou não-humano e para investigação in vitro de alvejamento por um agente |
| CA2270120A1 (en) * | 1996-10-28 | 1998-05-07 | Pal Rongved | Improvements in or relating to diagnostic/therapeutic agents |
| US6416740B1 (en) * | 1997-05-13 | 2002-07-09 | Bristol-Myers Squibb Medical Imaging, Inc. | Acoustically active drug delivery systems |
| ES2244169T3 (es) * | 1998-02-09 | 2005-12-01 | Bracco International B.V. | Suministro direccionado de medios biologicamente activos. |
| GB9808599D0 (en) * | 1998-04-22 | 1998-06-24 | Nycomed Imaging As | Improvements in or realting to contrast agents |
| JP2002212108A (ja) * | 2001-01-17 | 2002-07-31 | Fuji Photo Film Co Ltd | 超音波散乱体 |
| CA2456988A1 (en) * | 2001-08-16 | 2003-02-27 | Alan P. Carpenter, Jr. | Gas microsphere liposome composites |
| CN100563718C (zh) * | 2003-12-22 | 2009-12-02 | 伯拉考开发股份有限公司 | 用于反差成像的充气微囊组件 |
-
2004
- 2004-12-21 JP JP2006546390A patent/JP2007515471A/ja active Pending
- 2004-12-21 EP EP04806412.5A patent/EP1696965B1/en not_active Expired - Lifetime
- 2004-12-21 US US10/584,382 patent/US20070081946A1/en not_active Abandoned
- 2004-12-21 WO PCT/IB2004/004233 patent/WO2005063306A1/en not_active Ceased
- 2004-12-21 ES ES04806412.5T patent/ES2531751T3/es not_active Expired - Lifetime
- 2004-12-21 CA CA2545362A patent/CA2545362C/en not_active Expired - Fee Related
- 2004-12-21 CN CN2004800386181A patent/CN1897978B/zh not_active Expired - Fee Related
- 2004-12-21 AU AU2004308757A patent/AU2004308757B2/en not_active Ceased
-
2006
- 2006-07-24 NO NO20063420A patent/NO338317B1/no not_active IP Right Cessation
-
2011
- 2011-01-31 US US13/018,290 patent/US20110150778A1/en not_active Abandoned
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