CN1897978B - 具有用于反差成像的活性组分的充气微囊组件 - Google Patents

具有用于反差成像的活性组分的充气微囊组件 Download PDF

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Publication number
CN1897978B
CN1897978B CN2004800386181A CN200480038618A CN1897978B CN 1897978 B CN1897978 B CN 1897978B CN 2004800386181 A CN2004800386181 A CN 2004800386181A CN 200480038618 A CN200480038618 A CN 200480038618A CN 1897978 B CN1897978 B CN 1897978B
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China
Prior art keywords
assembly
microcapsules
gas
suspension
components
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Expired - Fee Related
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CN2004800386181A
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English (en)
Chinese (zh)
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CN1897978A (zh
Inventor
M·施奈德
P·比萨
闫锋
A·塞嫩泰
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Bracco Suisse SA
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Bracco Suisse SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6925—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a microcapsule, nanocapsule, microbubble or nanobubble
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN2004800386181A 2003-12-22 2004-12-21 具有用于反差成像的活性组分的充气微囊组件 Expired - Fee Related CN1897978B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03079014.1 2003-12-22
EP03079014 2003-12-22
PCT/IB2004/004233 WO2005063306A1 (en) 2003-12-22 2004-12-21 Assembly of gas-filled microvesicle with active component for contrast imaging

Publications (2)

Publication Number Publication Date
CN1897978A CN1897978A (zh) 2007-01-17
CN1897978B true CN1897978B (zh) 2011-11-23

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN2004800386181A Expired - Fee Related CN1897978B (zh) 2003-12-22 2004-12-21 具有用于反差成像的活性组分的充气微囊组件

Country Status (9)

Country Link
US (2) US20070081946A1 (https=)
EP (1) EP1696965B1 (https=)
JP (1) JP2007515471A (https=)
CN (1) CN1897978B (https=)
AU (1) AU2004308757B2 (https=)
CA (1) CA2545362C (https=)
ES (1) ES2531751T3 (https=)
NO (1) NO338317B1 (https=)
WO (1) WO2005063306A1 (https=)

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CN100563718C (zh) * 2003-12-22 2009-12-02 伯拉考开发股份有限公司 用于反差成像的充气微囊组件
WO2005070473A1 (en) * 2004-01-15 2005-08-04 Koninklijke Philips Electronics N.V. Ultrasound contrast agents for molecular imaging
US9248204B2 (en) 2004-08-18 2016-02-02 Bracco Suisse S.A. Gas-filled microvesicles composition for contrast imaging
CA2633380A1 (en) * 2005-12-16 2007-07-05 University Of Kansas Nanoclusters for delivery of therapeutics
ATE469660T1 (de) 2006-09-05 2010-06-15 Bracco Research Sa Gasgefüllte mikrovesikel mit polymer- modifizierten lipiden
US20100041989A1 (en) * 2006-09-29 2010-02-18 The Trustees Of The University Of Pennsylvania Use of ultrasound as an antivascular agent
US20090234231A1 (en) * 2008-03-13 2009-09-17 Knight Jon M Imaging Catheter With Integrated Contrast Agent Injector
GB0811856D0 (en) 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
CA2748995C (en) * 2008-10-07 2018-01-16 Bracco Suisse Sa Targeting construct comprising anti-polymer antibody and liposomes or microvesicles binding to the same
HUE037082T2 (hu) 2008-11-10 2018-08-28 Arbutus Biopharma Corp Új lipidek és készítmények terápiás hatóanyagok szállítására
CN106362171A (zh) 2009-02-13 2017-02-01 华盛顿大学 用于磁共振成像的钆表现脂质纳米颗粒
EP2253308A1 (en) 2009-05-22 2010-11-24 Ludwig-Maximilians-Universität München Pharmaceutical composition comprising microbubbles for targeted tumor therapy
WO2011017524A1 (en) * 2009-08-05 2011-02-10 The Trustees Of The University Of Pennsylvania Microfluidic-based generation of functionalized microbubbles for ultrasound imaging and therapy
EP2470287A4 (en) 2009-08-28 2015-01-21 Univ Columbia SYSTEMS, METHODS AND DEVICES FOR PRODUCING GAS-FILLED MICROBUBBLES
US9700640B2 (en) 2009-09-21 2017-07-11 Drexel University Stabilized ultrasound contrast agent
US8974818B2 (en) * 2010-01-20 2015-03-10 Henry Wu Custom-formulated phospholipid microbubbles and methods and uses thereof
US9265483B2 (en) 2010-08-06 2016-02-23 The Trustees Of Columbia University In The City Of New York Medical imaging contrast devices, methods, and systems
TW201208706A (en) 2010-08-17 2012-03-01 Univ Nat Yang Ming Ultrasonically-triggered drug vehicle with magnetic resonance imaging function
KR101292939B1 (ko) 2010-12-31 2013-08-02 삼성전자주식회사 엠알유도 고강도집속초음파 치료 및 진단용 인지질 나노입자 및 이의 제조방법
EP2934740B1 (en) 2012-12-21 2019-12-11 Bracco Suisse SA Gas-filled microvesicles
HUE060034T2 (hu) * 2013-09-27 2023-01-28 Exact Therapeutics As Ultrahanggal közvetített hatóanyag leadás
JP6202563B2 (ja) * 2013-10-21 2017-09-27 ネッパジーン株式会社 負電荷バブルリポソーム及びカチオン性ペプチドからなる薬物送達キャリア
KR101595795B1 (ko) * 2014-03-19 2016-02-22 (주)아이엠지티 약물을 함유한 나노입자가 결합된 이중-목적 paｔ／초음파 조영제 및 이의 제조방법
CA3091952A1 (en) * 2018-03-07 2019-09-12 Bracco Suisse Sa Preparation of size-controlled microvesicles
ES2984146T3 (es) 2018-12-21 2024-10-29 Bracco Suisse Sa Microvesículas llenas de gas con ligando
GB2595513B (en) * 2020-05-29 2023-03-29 Act Therapeutics Ltd Treatment of infections
US12233131B2 (en) * 2021-07-14 2025-02-25 Bracco Suisse Sa Cationic calibrated-size gas-filled microvesicles
WO2024059715A2 (en) * 2022-09-14 2024-03-21 Drexel University Microbubbles and methods of making same
NO20221187A1 (en) 2022-11-04 2024-05-06 Exact Therapeutics As Method and system for calculating a point estimate of an ultrasound dose

Citations (2)

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US5562099A (en) * 1990-10-05 1996-10-08 Massachusetts Institute Of Technology Polymeric microparticles containing agents for imaging
CN1234742A (zh) * 1996-10-28 1999-11-10 奈科姆成像有限公司 诊断和/或治疗剂的改进或与其相关的改进

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Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5562099A (en) * 1990-10-05 1996-10-08 Massachusetts Institute Of Technology Polymeric microparticles containing agents for imaging
CN1234742A (zh) * 1996-10-28 1999-11-10 奈科姆成像有限公司 诊断和/或治疗剂的改进或与其相关的改进

Also Published As

Publication number Publication date
JP2007515471A (ja) 2007-06-14
CN1897978A (zh) 2007-01-17
AU2004308757B2 (en) 2010-06-17
AU2004308757A1 (en) 2005-07-14
US20110150778A1 (en) 2011-06-23
NO338317B1 (no) 2016-08-08
EP1696965A1 (en) 2006-09-06
EP1696965B1 (en) 2014-12-10
CA2545362A1 (en) 2005-07-14
ES2531751T3 (es) 2015-03-18
CA2545362C (en) 2013-02-12
US20070081946A1 (en) 2007-04-12
WO2005063306A1 (en) 2005-07-14
NO20063420L (no) 2006-09-22

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Owner name: BRACCO SWITZERLAND SA

Free format text: FORMER OWNER: BRACCO RESEARCH SA

Effective date: 20110905

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Address before: Swiss Pullan Les Waters

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Granted publication date: 20111123

CF01 Termination of patent right due to non-payment of annual fee