JP2010532173A5 - - Google Patents
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- JP2010532173A5 JP2010532173A5 JP2010515226A JP2010515226A JP2010532173A5 JP 2010532173 A5 JP2010532173 A5 JP 2010532173A5 JP 2010515226 A JP2010515226 A JP 2010515226A JP 2010515226 A JP2010515226 A JP 2010515226A JP 2010532173 A5 JP2010532173 A5 JP 2010532173A5
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- Prior art keywords
- cells
- pluripotent
- cell
- population
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims description 122
- 238000000034 method Methods 0.000 claims description 60
- 239000007788 liquid Substances 0.000 claims description 26
- 102000035195 Peptidases Human genes 0.000 claims description 25
- 108091005804 Peptidases Proteins 0.000 claims description 25
- 239000002609 medium Substances 0.000 claims description 25
- 239000001963 growth medium Substances 0.000 claims description 22
- 239000003112 inhibitor Substances 0.000 claims description 20
- 238000000926 separation method Methods 0.000 claims description 19
- 108091000080 Phosphotransferase Proteins 0.000 claims description 14
- 102000020233 phosphotransferase Human genes 0.000 claims description 14
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims description 9
- 238000004113 cell culture Methods 0.000 claims description 9
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims description 9
- 238000004891 communication Methods 0.000 claims description 8
- 238000013019 agitation Methods 0.000 claims description 7
- 230000012010 growth Effects 0.000 claims description 6
- 229940122618 Trypsin inhibitor Drugs 0.000 claims description 5
- 101710162629 Trypsin inhibitor Proteins 0.000 claims description 5
- VVBXXVAFSPEIJQ-CVIPOMFBSA-N [(2r)-3-[[(2r)-1-[[(2s,5r,8r,11r,12s,15s,18s,21s)-15-[3-(diaminomethylideneamino)propyl]-21-hydroxy-5-[(4-hydroxyphenyl)methyl]-4,11-dimethyl-2-(2-methylpropyl)-3,6,9,13,16,22-hexaoxo-8-propan-2-yl-10-oxa-1,4,7,14,17-pentazabicyclo[16.3.1]docosan-12-yl]am Chemical compound C([C@@H]1C(=O)N[C@@H](C(=O)O[C@H](C)[C@@H](C(N[C@@H](CCCN=C(N)N)C(=O)N[C@H]2CC[C@H](O)N(C2=O)[C@@H](CC(C)C)C(=O)N1C)=O)NC(=O)[C@H](NC(=O)[C@H](O)COS(O)(=O)=O)CC(C)C)C(C)C)C1=CC=C(O)C=C1 VVBXXVAFSPEIJQ-CVIPOMFBSA-N 0.000 claims description 5
- 230000010261 cell growth Effects 0.000 claims description 5
- 239000002753 trypsin inhibitor Substances 0.000 claims description 5
- 102000004142 Trypsin Human genes 0.000 claims description 4
- 108090000631 Trypsin Proteins 0.000 claims description 4
- 230000004069 differentiation Effects 0.000 claims description 4
- 238000012423 maintenance Methods 0.000 claims description 4
- 230000035755 proliferation Effects 0.000 claims description 4
- 239000012588 trypsin Substances 0.000 claims description 4
- 102000004190 Enzymes Human genes 0.000 claims description 3
- 108090000790 Enzymes Proteins 0.000 claims description 3
- 235000010469 Glycine max Nutrition 0.000 claims description 3
- 244000068988 Glycine max Species 0.000 claims description 3
- 239000004365 Protease Substances 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims description 2
- 210000005260 human cell Anatomy 0.000 claims description 2
- 238000010899 nucleation Methods 0.000 claims description 2
- 210000001778 pluripotent stem cell Anatomy 0.000 claims description 2
- 235000019833 protease Nutrition 0.000 claims description 2
- 235000019419 proteases Nutrition 0.000 claims description 2
- 230000001810 trypsinlike Effects 0.000 claims description 2
- 102000000568 rho-Associated Kinases Human genes 0.000 claims 9
- 108010041788 rho-Associated Kinases Proteins 0.000 claims 9
- ADDJDJQFPKUMAF-SFHVURJKSA-N (4s)-5-amino-5-oxo-4-[[4-(4-phenylthiophen-2-yl)benzoyl]amino]pentanoic acid Chemical compound C1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N)=CC=C1C1=CC(C=2C=CC=CC=2)=CS1 ADDJDJQFPKUMAF-SFHVURJKSA-N 0.000 claims 1
- 229940121649 protein inhibitor Drugs 0.000 claims 1
- 239000012268 protein inhibitor Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000011435 rock Substances 0.000 description 9
- 239000011159 matrix material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94701307P | 2007-06-29 | 2007-06-29 | |
| US60/947,013 | 2007-06-29 | ||
| PCT/US2008/068814 WO2009006422A1 (en) | 2007-06-29 | 2008-06-30 | Automated method and apparatus for embryonic stem cell culture |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014063625A Division JP2014110817A (ja) | 2007-06-29 | 2014-03-26 | 胚性幹細胞培養のための自動化された方法および装置 |
| JP2016125186A Division JP2016168056A (ja) | 2007-06-29 | 2016-06-24 | 胚性幹細胞培養のための自動化された方法および装置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010532173A JP2010532173A (ja) | 2010-10-07 |
| JP2010532173A5 true JP2010532173A5 (enExample) | 2012-07-26 |
| JP5991796B2 JP5991796B2 (ja) | 2016-09-14 |
Family
ID=39672032
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010515226A Active JP5991796B2 (ja) | 2007-06-29 | 2008-06-30 | 胚性幹細胞培養のための自動化された方法および装置 |
| JP2014063625A Pending JP2014110817A (ja) | 2007-06-29 | 2014-03-26 | 胚性幹細胞培養のための自動化された方法および装置 |
| JP2016125186A Pending JP2016168056A (ja) | 2007-06-29 | 2016-06-24 | 胚性幹細胞培養のための自動化された方法および装置 |
| JP2016217785A Pending JP2017023158A (ja) | 2007-06-29 | 2016-11-08 | 胚性幹細胞培養のための自動化された方法および装置 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014063625A Pending JP2014110817A (ja) | 2007-06-29 | 2014-03-26 | 胚性幹細胞培養のための自動化された方法および装置 |
| JP2016125186A Pending JP2016168056A (ja) | 2007-06-29 | 2016-06-24 | 胚性幹細胞培養のための自動化された方法および装置 |
| JP2016217785A Pending JP2017023158A (ja) | 2007-06-29 | 2016-11-08 | 胚性幹細胞培養のための自動化された方法および装置 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8815585B2 (enExample) |
| EP (2) | EP3293256B1 (enExample) |
| JP (4) | JP5991796B2 (enExample) |
| KR (2) | KR20100059789A (enExample) |
| AU (1) | AU2008272949B2 (enExample) |
| CA (1) | CA2691793A1 (enExample) |
| DK (2) | DK2173863T3 (enExample) |
| WO (1) | WO2009006422A1 (enExample) |
Families Citing this family (81)
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| US8476070B2 (en) | 2005-08-29 | 2013-07-02 | Technion Research & Development Foundation Limited | Media for culturing stem cells |
| ES2704401T3 (es) | 2006-08-02 | 2019-03-18 | Technion Res & Dev Foundation | Métodos de expansión de células madre embrionarias en un cultivo en suspensión |
| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| US9096832B2 (en) | 2007-07-31 | 2015-08-04 | Lifescan, Inc. | Differentiation of human embryonic stem cells |
| CA2959401C (en) | 2008-02-21 | 2021-12-07 | Centocor Ortho Biotech Inc. | Methods, surface modified plates and compositions for cell attachment, cultivation and detachment |
| JP5951254B2 (ja) | 2008-03-17 | 2016-07-13 | ザ スクリプス リサーチ インスティテュート | 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法 |
| US8691569B2 (en) | 2008-03-17 | 2014-04-08 | Agency For Science, Technology And Research | Microcarriers for stem cell culture |
| US8828720B2 (en) | 2008-03-17 | 2014-09-09 | Agency For Science, Technology And Research | Microcarriers for stem cell culture |
| US9458431B2 (en) | 2008-03-17 | 2016-10-04 | Agency For Science, Technology And Research | Microcarriers for stem cell culture |
| SG188918A1 (enExample) | 2008-03-17 | 2013-04-30 | Agency Science Tech & Res | |
| KR101651661B1 (ko) | 2008-06-30 | 2016-08-26 | 얀센 바이오테크 인코포레이티드 | 만능 줄기 세포의 분화 |
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| CN107189979B (zh) | 2010-03-01 | 2021-05-04 | 詹森生物科技公司 | 纯化衍生自多能干细胞的细胞的方法 |
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| DE102004043256B4 (de) * | 2004-09-07 | 2013-09-19 | Rheinische Friedrich-Wilhelms-Universität Bonn | Skalierbarer Prozess zur Kultivierung undifferenzierter Stammzellen in Suspension |
| BRPI0514778B1 (pt) | 2004-09-08 | 2018-07-10 | Wisconsin Alumni Research Foundation | Meio para cultivar células tronco embrionárias |
| WO2006084040A2 (en) | 2005-02-04 | 2006-08-10 | Massachusetts Institute Of Technology | Engineering vascularized muscle tissue |
| US20060199265A1 (en) | 2005-03-02 | 2006-09-07 | Wolf Michael F | Seeding implantable medical devices with cells |
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2008
- 2008-06-30 DK DK08781187.3T patent/DK2173863T3/en active
- 2008-06-30 KR KR1020107002003A patent/KR20100059789A/ko not_active Ceased
- 2008-06-30 US US12/164,969 patent/US8815585B2/en active Active
- 2008-06-30 JP JP2010515226A patent/JP5991796B2/ja active Active
- 2008-06-30 EP EP17192886.4A patent/EP3293256B1/en active Active
- 2008-06-30 WO PCT/US2008/068814 patent/WO2009006422A1/en not_active Ceased
- 2008-06-30 KR KR1020157036767A patent/KR20160005142A/ko not_active Ceased
- 2008-06-30 CA CA2691793A patent/CA2691793A1/en not_active Abandoned
- 2008-06-30 AU AU2008272949A patent/AU2008272949B2/en active Active
- 2008-06-30 DK DK17192886.4T patent/DK3293256T3/da active
- 2008-06-30 EP EP08781187.3A patent/EP2173863B1/en active Active
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2013
- 2013-03-19 US US13/847,349 patent/US20130316445A1/en not_active Abandoned
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2014
- 2014-03-26 JP JP2014063625A patent/JP2014110817A/ja active Pending
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2016
- 2016-06-24 JP JP2016125186A patent/JP2016168056A/ja active Pending
- 2016-11-08 JP JP2016217785A patent/JP2017023158A/ja active Pending
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