US4109496A
(en)
|
1977-12-20 |
1978-08-29 |
Norris Industries |
Trapped key mechanism
|
US4323546A
(en)
|
1978-05-22 |
1982-04-06 |
Nuc Med Inc. |
Method and composition for cancer detection in humans
|
US4873191A
(en)
|
1981-06-12 |
1989-10-10 |
Ohio University |
Genetic transformation of zygotes
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
US5080891A
(en)
|
1987-08-03 |
1992-01-14 |
Ddi Pharmaceuticals, Inc. |
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
|
US4981785A
(en)
|
1988-06-06 |
1991-01-01 |
Ventrex Laboratories, Inc. |
Apparatus and method for performing immunoassays
|
US4968103A
(en)
|
1988-07-22 |
1990-11-06 |
Photofinish Cosmetics Inc. |
Method of making a brush
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
GB8901778D0
(en)
|
1989-01-27 |
1989-03-15 |
Univ Court Of The University O |
Manipulatory technique
|
US5028205A
(en)
|
1989-12-14 |
1991-07-02 |
Ingersoll-Rand Company |
Oil scavenger system for a seal for a rotary shaft
|
US5614396A
(en)
|
1990-06-14 |
1997-03-25 |
Baylor College Of Medicine |
Methods for the genetic modification of endogenous genes in animal cells by homologous recombination
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
KR100272077B1
(ko)
|
1990-08-29 |
2000-11-15 |
젠팜인터내셔날,인코포레이티드 |
이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
|
CA2405246A1
(en)
|
1990-12-03 |
1992-06-11 |
Genentech, Inc. |
Enrichment method for variant proteins with alterred binding properties
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
EP0552108B1
(de)
|
1992-01-17 |
1999-11-10 |
Lakowicz, Joseph R. |
Phasenmodulationsenergieübertragungsfluoroimmunassay
|
US5376313A
(en)
|
1992-03-27 |
1994-12-27 |
Abbott Laboratories |
Injection molding a plastic assay cuvette having low birefringence
|
US20070124581A1
(en)
|
1992-05-17 |
2007-05-31 |
Reena Khare |
Cell adhesion and extracellular matrix proteins
|
JP3537141B2
(ja)
|
1992-10-30 |
2004-06-14 |
ザ ゼネラル ホスピタル コーポレーション |
新種蛋白質分離のための相互作用を用いる補捉システム
|
CA2156288C
(en)
|
1993-02-19 |
2005-10-18 |
Junichi Yano |
Glycerol derivative, device and pharmaceutical composition
|
US5643765A
(en)
|
1993-04-06 |
1997-07-01 |
University Of Rochester |
Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
|
US5639606A
(en)
|
1993-04-06 |
1997-06-17 |
The University Of Rochester |
Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
|
US5876978A
(en)
|
1993-04-06 |
1999-03-02 |
Medical College Of Ohio |
Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
|
US5538848A
(en)
|
1994-11-16 |
1996-07-23 |
Applied Biosystems Division, Perkin-Elmer Corp. |
Method for detecting nucleic acid amplification using self-quenching fluorescence probe
|
US5599677A
(en)
|
1993-12-29 |
1997-02-04 |
Abbott Laboratories |
Immunoassays for prostate specific antigen
|
US5807522A
(en)
|
1994-06-17 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods for fabricating microarrays of biological samples
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
JP2000502450A
(ja)
|
1995-12-22 |
2000-02-29 |
アボツト・ラボラトリーズ |
蛍光偏光免疫アッセイによる診断法
|
US5994316A
(en)
|
1996-02-21 |
1999-11-30 |
The Immune Response Corporation |
Method of preparing polynucleotide-carrier complexes for delivery to cells
|
US5885529A
(en)
|
1996-06-28 |
1999-03-23 |
Dpc Cirrus, Inc. |
Automated immunoassay analyzer
|
ATE363652T1
(de)
|
1997-03-07 |
2007-06-15 |
Clare Chemical Res Inc |
Fluorometrischer nachweis mit sichtbarem light
|
US6080912A
(en)
|
1997-03-20 |
2000-06-27 |
Wisconsin Alumni Research Foundation |
Methods for creating transgenic animals
|
WO1998049302A1
(en)
|
1997-04-25 |
1998-11-05 |
Genetics Institute, Inc. |
Secreted proteins and polynucleotides encoding them
|
US6004528A
(en)
|
1997-09-18 |
1999-12-21 |
Bergstein; Ivan |
Methods of cancer diagnosis and therapy targeted against the cancer stemline
|
US6083616A
(en)
|
1997-09-19 |
2000-07-04 |
Seal Products, Inc. |
Nontack pressure activated adhesive
|
JP2001517441A
(ja)
*
|
1997-09-24 |
2001-10-09 |
メルク エンド カムパニー インコーポレーテッド |
Gタンパク質共役糖タンパク質ホルモン受容体hg38
|
US20020065394A1
(en)
|
1998-03-18 |
2002-05-30 |
Kenneth Jacobs |
Secreted proteins and polynucleotides encoding them
|
ES2332025T3
(es)
|
1998-03-26 |
2010-01-22 |
The Board Of Trustees Of The Leland Stanford Junior University |
Nuevos receptores de mamiferos acoplados a la proteina g que tienen regiones extracelulares de repeticion ricas en leucina.
|
US6485972B1
(en)
|
1998-10-15 |
2002-11-26 |
President And Fellows Of Harvard College |
WNT signalling in reproductive organs
|
US20030166047A1
(en)
|
1999-05-06 |
2003-09-04 |
Millennium Pharmaceuticals, Inc. |
Lgr6 nucleic acids and uses thereof
|
AU6117000A
(en)
|
1999-07-26 |
2001-02-13 |
Genentech Inc. |
Novel polynucleotides and method of use thereof
|
US6824973B2
(en)
|
2000-02-03 |
2004-11-30 |
Kirin Beer Kabushiki Kaisha |
Method of promoting stem cell proliferation or survival by contacting a cell with a stem cell factor-like polypeptide
|
AU2001234944A1
(en)
|
2000-02-03 |
2001-08-14 |
Hyseq, Inc. |
Novel nucleic acids and polypeptides
|
WO2001074164A1
(en)
|
2000-03-31 |
2001-10-11 |
The General Hospital Corporation |
Methods of modulating hair growth
|
CA2405104A1
(en)
|
2000-04-05 |
2001-10-18 |
Kirin Beer Kabushiki Kaisha |
Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides
|
EP1156062A1
(de)
*
|
2000-05-12 |
2001-11-21 |
GPC Biotech AG |
Immunmodulierende an humane MHC Klasse II Antigen bindende Peptide/Proteine
|
AU2001263006A1
(en)
|
2000-05-18 |
2001-11-26 |
Hyseq, Inc. |
Novel nucleic acids and polypeptides
|
AU2001281791A1
(en)
|
2000-05-30 |
2001-12-11 |
Bayer Aktiengesellschaft |
Regulation of human lgr4-like g protein-coupled receptor
|
US6984522B2
(en)
|
2000-08-03 |
2006-01-10 |
Regents Of The University Of Michigan |
Isolation and use of solid tumor stem cells
|
WO2003050502A2
(en)
|
2001-12-07 |
2003-06-19 |
Regents Of The University Of Michigan |
Prospective identification and characterization of breast cancer stem cells
|
US6768004B2
(en)
|
2001-01-11 |
2004-07-27 |
Mueller Sybille |
Nucleotide sequences encoding variable regions of heavy and light chains of monoclonal antibody 1F7, an anti-idiotypic antibody reactive with anti-HIV antibodies
|
US20040077048A1
(en)
|
2002-01-30 |
2004-04-22 |
Warren Bridget A. |
Protein modification and maintenance molecules
|
US7411052B2
(en)
|
2001-03-05 |
2008-08-12 |
Nuvelo, Inc. |
Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides
|
US20030032034A1
(en)
|
2001-03-05 |
2003-02-13 |
Tang Y. Tom |
Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides
|
US20100292155A1
(en)
|
2001-03-05 |
2010-11-18 |
Arca Biopharma, Inc. |
Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides
|
AU2002304249A1
(en)
|
2001-06-11 |
2002-12-23 |
Kirin Beer Kabushiki Kaisha |
Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell and hematopoietic progenitor cell, and dna coding for the same
|
DE60233509D1
(de)
*
|
2001-06-20 |
2009-10-08 |
Fibron Ltd |
Fgfr3 blockierende antikörper, verfahren zum screening darauf und verwendungen davon
|
US20030022217A1
(en)
|
2001-07-02 |
2003-01-30 |
Pe Corporation (Ny) |
Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
|
EP2228443A1
(de)
|
2001-08-30 |
2010-09-15 |
ARCA biopharma, Inc. |
Methoden und Materialien basierend auf Stem Cell Growth Factor-ähnlichen Polypeptiden und Polynucleotiden
|
CA2462795A1
(en)
|
2001-10-03 |
2003-04-10 |
Incyte Genomics, Inc. |
Secreted proteins
|
US20040197778A1
(en)
|
2002-12-26 |
2004-10-07 |
Sagres Discovery, Inc. |
Novel compositions and methods in cancer
|
US20070237770A1
(en)
|
2001-11-30 |
2007-10-11 |
Albert Lai |
Novel compositions and methods in cancer
|
AU2002366951A1
(en)
|
2001-12-10 |
2003-07-09 |
Nuvelo,Inc. |
Novel nucleic acids and polypeptides
|
US7193069B2
(en)
|
2002-03-22 |
2007-03-20 |
Research Association For Biotechnology |
Full-length cDNA
|
WO2003091280A1
(en)
|
2002-04-26 |
2003-11-06 |
Kirin Beer Kabushiki Kaisha |
Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell or hematopoietic progenitor cell, and dna coding for the same
|
EP1380644A1
(de)
|
2002-07-08 |
2004-01-14 |
Kylix B.V. |
Verwendung spezifischer TCF Zielgene zur Identifizierung von Medikamenten zur Behandlung von Krebsarten, insbesondere Colorectalkrebs, bei denen TCF/beta-catenin/WNT Signaltransduktion eine zentrale Rolle spielt
|
CA2509568A1
(en)
*
|
2002-12-26 |
2004-07-15 |
Applied Research Systems Ars Holding N.V. |
Spliced variants of lgr6
|
WO2004074436A2
(en)
|
2003-02-19 |
2004-09-02 |
Incyte Corporation |
Methods of use of a gpcr in the diagnosis and treatment of colon and lung cancer
|
US20050003405A1
(en)
|
2003-04-30 |
2005-01-06 |
Hua-Chien Chen |
Treatment and diagnostics of cancer
|
EP2481814A3
(de)
|
2003-06-09 |
2012-10-10 |
The Regents of the University of Michigan |
Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Krebs
|
WO2005110009A2
(en)
|
2003-07-22 |
2005-11-24 |
Immunex Corporation |
COMPOSITIONS AND METHODS RELATING TO TSP-30a, b, c AND d
|
DE10339820A1
(de)
|
2003-08-22 |
2005-03-17 |
Hinzmann, Bernd, Dr. |
Verwendung von an GPR49 bindenden Substanzen zur Diagnose und Behandlung von Krebs
|
US9046537B2
(en)
|
2003-09-22 |
2015-06-02 |
Enzo Biochem, Inc. |
Method for treating inflammation by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain
|
PL2157192T3
(pl)
|
2003-10-10 |
2014-01-31 |
Deutsches Krebsforsch |
Kompozycje do diagnozowania i terapii chorób związanych z nieprawidłową ekspresją futrin (R-spondin)
|
WO2005040828A2
(en)
|
2003-10-24 |
2005-05-06 |
Bayer Healthcare Ag |
Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 49 (gpr49)
|
SG149059A1
(en)
|
2004-01-27 |
2009-01-29 |
Nuvelo Inc |
Gastrointestinal proliferative factor and uses thereof
|
WO2005074633A2
(en)
*
|
2004-02-03 |
2005-08-18 |
The Regents Of The University Of Michigan |
Compositions and methods for characterizing, regulating, diagnosing, and treating cancer
|
MX2007002883A
(es)
|
2004-09-13 |
2007-06-15 |
Macrogenics Inc |
Anticuerpos humanizados contra el virus de nilo occidental y usos terapeuticos y profilacticos del mismo.
|
AU2005318171B2
(en)
|
2004-12-20 |
2011-09-29 |
Crucell Holland B.V. |
Binding molecules capable of neutralizing West Nile virus and uses thereof
|
US7439327B2
(en)
|
2005-01-18 |
2008-10-21 |
Nuvelo, Inc. |
Stem cell factor-like proteins and uses thereof
|
WO2006110585A2
(en)
|
2005-04-07 |
2006-10-19 |
Novartis Vaccines And Diagnostics Inc. |
Cancer-related genes (prlr)
|
US20090036369A1
(en)
|
2005-07-26 |
2009-02-05 |
Kirin Pharma Kabushiki Kaisha |
Anti-tumor agents comprising r-spondins
|
US7541431B2
(en)
*
|
2005-09-07 |
2009-06-02 |
Maine Medical Center |
Cristin/R-spondin ligands active in the Wnt signaling pathway and methods, compositions and kits relating thereto
|
WO2007100357A2
(en)
|
2005-10-07 |
2007-09-07 |
Nuvelo, Inc. |
Stem cell factor-like protein scfa1 and uses thereof
|
JP5129149B2
(ja)
|
2005-10-31 |
2013-01-23 |
ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン |
癌を処置および診断するための組成物および方法
|
US7723477B2
(en)
|
2005-10-31 |
2010-05-25 |
Oncomed Pharmaceuticals, Inc. |
Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
|
GB0603683D0
(en)
*
|
2006-02-23 |
2006-04-05 |
Novartis Ag |
Organic compounds
|
MX2008015138A
(es)
|
2006-06-02 |
2009-01-28 |
Aveo Pharmaceuticals Inc |
Proteinas de union al factor de crecimiento de hepatocitos (fch).
|
NO345476B1
(no)
|
2006-06-02 |
2021-02-22 |
Xoma Technology Ltd |
Bindingsproteiner for hepatocyttvekstfaktor (HGF)
|
WO2007145840A2
(en)
*
|
2006-06-13 |
2007-12-21 |
Oncomed Pharmaceuticals, Inc. |
Compositions and methods for diagnosing and treating cancer
|
ES2673822T3
(es)
|
2006-07-18 |
2018-06-25 |
Sanofi |
Anticuerpo antagonista contra EphA2 para el tratamiento de cáncer
|
JP2008044926A
(ja)
*
|
2006-08-14 |
2008-02-28 |
Trustees Of Columbia Univ In The City Of New York |
Wnt信号伝達に関係した分泌タンパク質
|
MX2009003229A
(es)
|
2006-09-29 |
2009-06-18 |
Oncomed Pharm Inc |
Composiciones y metodos para diagnosticar y tratar cancer.
|
US8088374B2
(en)
|
2006-10-20 |
2012-01-03 |
Deutsches Krebsforschungszentrum Stiftung Des Offenlichen Rechts |
Methods for inhibition of angiogenesis and vasculogenesis via rspondin antagonists
|
WO2008075796A1
(ja)
|
2006-12-21 |
2008-06-26 |
Kyowa Hakko Kirin Co., Ltd. |
血球回復促進剤
|
WO2008088524A2
(en)
*
|
2006-12-28 |
2008-07-24 |
Nuvelo, Inc. |
Thrombospondin-domain-deficient r-spondin 1 protein as gastrointestinal tract epithelial proliferation factor
|
BRPI0812562A2
(pt)
|
2007-06-12 |
2019-09-24 |
Trubion Pharmaceuticals Inc |
composições terapêuticas anti-cd20 e métodos
|
SI2173379T1
(sl)
|
2007-07-02 |
2015-12-31 |
Oncomed Pharmaceuticals, Inc. |
Sestavki in postopki za zdravljenje in diagnosticiranje raka
|
US20120082659A1
(en)
|
2007-10-02 |
2012-04-05 |
Hartmut Land |
Methods And Compositions Related To Synergistic Responses To Oncogenic Mutations
|
CA2700257A1
(en)
|
2007-10-02 |
2009-04-09 |
Hartmut Land |
Methods and compositions related to synergistic responses to oncogenic mutations
|
JP5676107B2
(ja)
|
2007-11-14 |
2015-02-25 |
中外製薬株式会社 |
抗gpr49抗体を用いる癌の診断および治療
|
EP2313435A4
(de)
|
2008-07-01 |
2012-08-08 |
Aveo Pharmaceuticals Inc |
An den fibroblastenwachstumsfaktorrezeptor 3 (fgfr3) bindende proteine
|
WO2010016766A2
(en)
|
2008-08-08 |
2010-02-11 |
Koninklijke Nederlandse Akademie Van Wetenschappen |
Antibodies recognizing endogenous human lgr5 and/or lgr6
|
EP2363471B1
(de)
|
2008-10-31 |
2016-10-12 |
Toray Industries, Inc. |
Immunoassayverfahren für menschliches cxcl1-protein
|
US20120039912A1
(en)
|
2009-04-15 |
2012-02-16 |
Galapagos Sasu |
Rspondin-3 inhibition in bone disorders
|
US20120165270A1
(en)
|
2009-04-27 |
2012-06-28 |
Yeon Sook Choi |
Inhibition of hair follicle growth by the wnt inhibitor dkk1
|
CN102459346B
(zh)
|
2009-04-27 |
2016-10-26 |
昂考梅德药品有限公司 |
制造异源多聚体分子的方法
|
CN102695499A
(zh)
|
2009-06-18 |
2012-09-26 |
惠氏有限责任公司 |
小模块免疫药物的冻干制剂
|
WO2011009090A1
(en)
|
2009-07-16 |
2011-01-20 |
Xoma Technology Ltd. |
Antibodies to high molecular weight melanoma associated antigen
|
WO2011028683A1
(en)
|
2009-09-03 |
2011-03-10 |
Schering Corporation |
Anti-gitr antibodies
|
EP2977060A1
(de)
|
2009-12-23 |
2016-01-27 |
Deutsches Krebsforschungszentrum |
Rspo2- und rspo3-rezeptoren
|
WO2011085289A1
(en)
|
2010-01-11 |
2011-07-14 |
Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University |
Production of a monoclonal antibody therapeutic against west nile virus in plants
|
US9719068B2
(en)
|
2010-05-06 |
2017-08-01 |
Children's Hospital Medical Center |
Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
|
EP2659005A4
(de)
|
2010-12-28 |
2016-08-24 |
Caris Mpi Inc |
Molekulare profilierung von krebs
|
GB201106395D0
(en)
|
2011-04-14 |
2011-06-01 |
Hubrecht Inst |
Compounds
|
PL2702412T3
(pl)
|
2011-04-28 |
2018-01-31 |
Sbi Biotech Co Ltd |
Przeciwciało przeciwko ludzkiej białkowej fosfatazie tyrozynowej typu receptorowego
|
US8802097B2
(en)
|
2011-07-15 |
2014-08-12 |
Oncomed Pharmaceuticals, Inc. |
Anti-RSPO1 antibodies
|
US9296826B2
(en)
|
2011-10-14 |
2016-03-29 |
Novartis Ag |
Antibodies and methods for WNT pathway-related diseases
|
EP2773664A1
(de)
|
2011-11-01 |
2014-09-10 |
Bionomics, Inc. |
Anti-gpr49-antikörper
|
WO2013067055A1
(en)
|
2011-11-01 |
2013-05-10 |
Bionomics, Inc. |
Methods of blocking cancer stem cell growth
|
RU2014133069A
(ru)
|
2012-02-11 |
2016-04-10 |
Дженентек, Инк. |
Транслокации r-спондина и способы с их использованием
|
AR090549A1
(es)
|
2012-03-30 |
2014-11-19 |
Genentech Inc |
Anticuerpos anti-lgr5 e inmunoconjugados
|
WO2014012007A2
(en)
|
2012-07-13 |
2014-01-16 |
Oncomed Pharmaceuticals, Inc. |
Rspo3 binding agents and uses thereof
|
AU2014248568B2
(en)
|
2013-03-12 |
2017-07-13 |
Curegenix, Inc. |
Compounds for treatment of cancer
|
WO2014192974A1
(ja)
|
2013-05-30 |
2014-12-04 |
株式会社オーダーメードメディカルリサーチ |
抗lgr6抗体を含む癌の検出用又は診断用試薬
|
BR112016008477A2
(pt)
|
2013-10-18 |
2017-10-03 |
Genentech Inc |
Corpos, ácido nucleico, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica e usos do anticorpo
|
US9777052B2
(en)
|
2014-12-02 |
2017-10-03 |
The Board Of Regents Of The University Of Oklahoma |
R-spondin variants, compositions, and methods of use
|
MA41123A
(fr)
|
2014-12-02 |
2017-10-10 |
Oncomed Pharm Inc |
Polythérapie pour le traitement du cancer
|