JP2010531312A5 - - Google Patents

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Publication number
JP2010531312A5
JP2010531312A5 JP2010513709A JP2010513709A JP2010531312A5 JP 2010531312 A5 JP2010531312 A5 JP 2010531312A5 JP 2010513709 A JP2010513709 A JP 2010513709A JP 2010513709 A JP2010513709 A JP 2010513709A JP 2010531312 A5 JP2010531312 A5 JP 2010531312A5
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JP
Japan
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bis
unsubstituted
pyridine
independently
alkyl
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JP2010513709A
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Japanese (ja)
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JP2010531312A (ja
JP5492769B2 (ja
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Priority claimed from PCT/EP2008/004638 external-priority patent/WO2009000412A1/en
Publication of JP2010531312A publication Critical patent/JP2010531312A/ja
Publication of JP2010531312A5 publication Critical patent/JP2010531312A5/ja
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JP2010513709A 2007-06-26 2008-06-11 縮環されたベンゾイミダゾール及びアザベンゾイミダゾールの位置選択的金属触媒合成 Expired - Fee Related JP5492769B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07290801.5 2007-06-26
EP07290801 2007-06-26
PCT/EP2008/004638 WO2009000412A1 (en) 2007-06-26 2008-06-11 A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles

Publications (3)

Publication Number Publication Date
JP2010531312A JP2010531312A (ja) 2010-09-24
JP2010531312A5 true JP2010531312A5 (enExample) 2011-07-07
JP5492769B2 JP5492769B2 (ja) 2014-05-14

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JP2010513709A Expired - Fee Related JP5492769B2 (ja) 2007-06-26 2008-06-11 縮環されたベンゾイミダゾール及びアザベンゾイミダゾールの位置選択的金属触媒合成

Country Status (11)

Country Link
US (1) US20100216988A1 (enExample)
EP (1) EP2173747B1 (enExample)
JP (1) JP5492769B2 (enExample)
KR (1) KR20100033484A (enExample)
CN (1) CN101687865A (enExample)
AT (1) ATE538120T1 (enExample)
AU (1) AU2008267443A1 (enExample)
BR (1) BRPI0813273A2 (enExample)
CA (1) CA2693142A1 (enExample)
IL (1) IL202822A0 (enExample)
WO (1) WO2009000412A1 (enExample)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9512125B2 (en) 2004-11-19 2016-12-06 The Regents Of The University Of California Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents
KR101499783B1 (ko) 2006-04-04 2015-03-09 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 키나제 길항물질
US20110160232A1 (en) 2007-10-04 2011-06-30 Pingda Ren Certain chemical entities and therapeutic uses thereof
AU2009204483B2 (en) 2008-01-04 2014-03-13 Intellikine, Llc Certain chemical entities, compositions and methods
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
JP5547099B2 (ja) 2008-03-14 2014-07-09 インテリカイン， エルエルシー キナーゼ阻害剤および使用方法
US8993580B2 (en) 2008-03-14 2015-03-31 Intellikine Llc Benzothiazole kinase inhibitors and methods of use
MX2011000216A (es) 2008-07-08 2011-03-29 Intellikine Inc Inhibidores de cinasa y metodos para su uso.
US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
WO2010036380A1 (en) 2008-09-26 2010-04-01 Intellikine, Inc. Heterocyclic kinase inhibitors
WO2010045542A2 (en) 2008-10-16 2010-04-22 The Regents Of The University Of California Fused ring heteroaryl kinase inhibitors
US8476431B2 (en) 2008-11-03 2013-07-02 Itellikine LLC Benzoxazole kinase inhibitors and methods of use
JP2010235575A (ja) * 2009-03-09 2010-10-21 Konica Minolta Holdings Inc 含窒素縮合複素環化合物の製造方法
WO2010129816A2 (en) 2009-05-07 2010-11-11 Intellikine, Inc. Heterocyclic compounds and uses thereof
RU2580320C2 (ru) 2009-08-18 2016-04-10 Вентиркс Фармасьютикалз, Инк. Замещенные бензоазепины в качестве модуляторов toll-подобного рецептора
JP5756804B2 (ja) 2009-08-18 2015-07-29 ベンティアールエックス ファーマシューティカルズ， インコーポレイテッドＶｅｎｔｉＲｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． Ｔｏｌｌ様レセプターモジュレーターとしての置換ベンゾアゼピン
WO2011047384A2 (en) 2009-10-16 2011-04-21 The Regents Of The University Of California Methods of inhibiting ire1
JP5951600B2 (ja) 2010-05-21 2016-07-13 インフィニティー ファーマシューティカルズ， インコーポレイテッド キナーゼ調節のための、化合物、組成物および方法
TW201307347A (zh) 2010-11-01 2013-02-16 Arqule Inc 經取代苯並－咪唑並－吡啶並－二氮呯化合物
US8901133B2 (en) 2010-11-10 2014-12-02 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CA2820078C (en) * 2010-12-16 2019-02-12 F. Hoffmann-La Roche Ag Tricyclic pi3k inhibitor compounds and methods of use
KR20180080358A (ko) 2011-01-10 2018-07-11 인피니티 파마슈티칼스, 인코포레이티드 이소퀴놀린온 및 이의 고체 형태의 제조 방법
JP6130305B2 (ja) 2011-02-23 2017-05-17 インテリカイン， エルエルシー キナーゼ阻害剤の組み合わせおよびそれらの使用
CN103930422A (zh) 2011-07-19 2014-07-16 无限药品股份有限公司 杂环化合物及其用途
EP2734530A1 (en) 2011-07-19 2014-05-28 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CN103998442B (zh) 2011-08-29 2016-09-14 无限药品股份有限公司 杂环化合物及其用途
MX370814B (es) 2011-09-02 2020-01-08 Univ California Pirazolo[3,4-d]pirimidinas sustituidas y usos de las mismas.
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
WO2014052669A1 (en) 2012-09-26 2014-04-03 The Regents Of The University Of California Modulation of ire1
IL291945B2 (en) 2012-11-01 2025-11-01 Infinity Pharmaceuticals Inc Treatment of cancers using pi3 kinase isoform modulators
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MX389256B (es) 2013-10-04 2025-03-20 Infinity Pharmaceuticals Inc Compuestos heterociclicos y usos de los mismos.
EP4066834A1 (en) 2014-03-19 2022-10-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
US20150320755A1 (en) 2014-04-16 2015-11-12 Infinity Pharmaceuticals, Inc. Combination therapies
CN105017257B (zh) * 2014-04-30 2017-05-24 华东理工大学 四氢茚并吡咯并咪唑的衍生物及其制备方法和用途
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
KR101540198B1 (ko) * 2015-01-29 2015-07-29 성균관대학교산학협력단 팔라듐이 함유된 카본 나이트라이드 지지체를 이용한 메탄올과 일산화탄소의 카르보닐레이션 반응으로부터 아세트산을 제조하기 위한 촉매 및 이의 제조방법
KR102654709B1 (ko) * 2015-03-18 2024-04-03 브리스톨-마이어스 스큅 컴퍼니 치환된 트리시클릭 헤테로시클릭 화합물
CN108349985A (zh) 2015-09-14 2018-07-31 无限药品股份有限公司 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法
CN108349987A (zh) * 2015-11-04 2018-07-31 出光兴产株式会社 苯并咪唑稠合杂芳族类
US10759806B2 (en) 2016-03-17 2020-09-01 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors
CN105968044A (zh) * 2016-05-11 2016-09-28 张加明 一种乙氧基喹啉的工业化生产方法
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CA3028718A1 (en) 2016-06-24 2017-12-28 Infinity Pharmaceuticals, Inc. Combination therapies
CN110003213B (zh) * 2018-01-04 2021-10-08 南京农业大学 苯并咪唑并三嗪酮类化合物、制备方法及应用
CN111217819B (zh) * 2018-11-27 2021-05-14 杭州科巢生物科技有限公司 乌帕替尼的合成方法
WO2020227575A1 (en) * 2019-05-09 2020-11-12 Genentech, Inc. Synthesis of labeled imidazo[1,2-a]pyrimidines
CN110681362B (zh) * 2019-09-26 2020-09-11 浙江大学 以羧基和吲哚基为功能基团的混合模式层析介质
EP4146205A4 (en) 2020-05-05 2024-05-29 Nuvalent, Inc. HETEROAROMATIC MACROCYCLIC ETHERS AS CHEMOTHERAPEUTIC AGENTS
MX2022013657A (es) 2020-05-05 2023-02-01 Nuvalent Inc Quimioterápicos de éter macrocíclico heteroaromático.
CN112552305B (zh) * 2020-11-26 2021-11-30 广东省测试分析研究所（中国广州分析测试中心） 一种苯并环庚烷并咪唑并吡啶类阻燃抗紫外线分子材料及其制备方法与应用
CN113512068B (zh) * 2021-04-13 2022-05-31 山西大学 一种双配体的亚硝酰钌配合物及其制备方法和应用
US20230144528A1 (en) * 2021-09-30 2023-05-11 Prelude Therapeutics Incorporated CDK Inhibitors And Their Use As Pharmaceuticals
CA3231813A1 (en) 2021-10-01 2023-04-06 Sibao CHEN Solid forms, pharmaceutical compositions and preparation of heteroaromatic macrocyclic ether compounds
CN114907421A (zh) * 2022-06-06 2022-08-16 河南师范大学 铑催化6-芳基嘌呤核苷和炔烃合成荧光多环嘌呤盐的方法
CN116943408B (zh) * 2023-06-30 2024-01-30 江苏创新石化有限公司 一种位阻胺复合脱硫剂及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049422A (en) * 1976-03-29 1977-09-20 United States Borax & Chemical Corporation Herbicidal morpholinobenzimidazoles
SU1587052A1 (ru) * 1988-06-27 1990-08-23 Всесоюзный научно-исследовательский институт химических средств защиты растений Способ получени 2,3-дигидро-1Н-пирроло [1,2- @ ]бензимидазол-6-сульфонамидов
EP0627433B1 (en) * 1992-12-07 2003-03-05 Eisai Co., Ltd. Process for producing imidazopyridine derivative and intermediate
WO2003106413A2 (en) * 2001-10-18 2003-12-24 Michigan State University Process for the preparation of oxazolidinones and method of use thereof
WO2006058064A2 (en) 2004-11-29 2006-06-01 Merck & Co., Inc. Fused aminopiperidines as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes

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