JP5492769B2 - 縮環されたベンゾイミダゾール及びアザベンゾイミダゾールの位置選択的金属触媒合成 - Google Patents

縮環されたベンゾイミダゾール及びアザベンゾイミダゾールの位置選択的金属触媒合成 Download PDF

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JP5492769B2
JP5492769B2 JP2010513709A JP2010513709A JP5492769B2 JP 5492769 B2 JP5492769 B2 JP 5492769B2 JP 2010513709 A JP2010513709 A JP 2010513709A JP 2010513709 A JP2010513709 A JP 2010513709A JP 5492769 B2 JP5492769 B2 JP 5492769B2
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bis
unsubstituted
pyridine
alkyl
independently
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JP2010531312A (ja
JP2010531312A5 (enExample
Inventor
ホルヘ・アロンソ
アンドレーアス・リンデンシュミット
マルク・ナツァーレ
オマール・ルカイク
マティーアス・ウルマン
ニス・ハールラント
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Sanofi SA
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Sanofi SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measuring Oxygen Concentration In Cells (AREA)
JP2010513709A 2007-06-26 2008-06-11 縮環されたベンゾイミダゾール及びアザベンゾイミダゾールの位置選択的金属触媒合成 Expired - Fee Related JP5492769B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07290801 2007-06-26
EP07290801.5 2007-06-26
PCT/EP2008/004638 WO2009000412A1 (en) 2007-06-26 2008-06-11 A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles

Publications (3)

Publication Number Publication Date
JP2010531312A JP2010531312A (ja) 2010-09-24
JP2010531312A5 JP2010531312A5 (enExample) 2011-07-07
JP5492769B2 true JP5492769B2 (ja) 2014-05-14

Family

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Application Number Title Priority Date Filing Date
JP2010513709A Expired - Fee Related JP5492769B2 (ja) 2007-06-26 2008-06-11 縮環されたベンゾイミダゾール及びアザベンゾイミダゾールの位置選択的金属触媒合成

Country Status (11)

Country Link
US (1) US20100216988A1 (enExample)
EP (1) EP2173747B1 (enExample)
JP (1) JP5492769B2 (enExample)
KR (1) KR20100033484A (enExample)
CN (1) CN101687865A (enExample)
AT (1) ATE538120T1 (enExample)
AU (1) AU2008267443A1 (enExample)
BR (1) BRPI0813273A2 (enExample)
CA (1) CA2693142A1 (enExample)
IL (1) IL202822A0 (enExample)
WO (1) WO2009000412A1 (enExample)

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WO2009114874A2 (en) 2008-03-14 2009-09-17 Intellikine, Inc. Benzothiazole kinase inhibitors and methods of use
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WO2010006072A2 (en) 2008-07-08 2010-01-14 The Regents Of The University Of California Mtor modulators and uses thereof
EP2346508B1 (en) 2008-09-26 2016-08-24 Intellikine, LLC Heterocyclic kinase inhibitors
ES2570429T3 (es) 2008-10-16 2016-05-18 Univ California Inhibidores de heteroaril quinasa de anillo condensado
US8476282B2 (en) 2008-11-03 2013-07-02 Intellikine Llc Benzoxazole kinase inhibitors and methods of use
JP2010235575A (ja) * 2009-03-09 2010-10-21 Konica Minolta Holdings Inc 含窒素縮合複素環化合物の製造方法
CA2760791C (en) 2009-05-07 2017-06-20 Intellikine, Inc. Heterocyclic compounds and uses thereof
CN105669553A (zh) 2009-08-18 2016-06-15 文蒂雷克斯药品公司 作为toll样受体调节剂的取代的苯并氮杂*
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US8980899B2 (en) 2009-10-16 2015-03-17 The Regents Of The University Of California Methods of inhibiting Ire1
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US8569331B2 (en) 2010-11-01 2013-10-29 Arqule, Inc. Substituted benzo[f]lmidazo[1,2-d]pyrido[2,3-b][1,4]diazepine compounds
EP2637669A4 (en) 2010-11-10 2014-04-02 Infinity Pharmaceuticals Inc Heterocyclic compounds and their use
AR084312A1 (es) 2010-12-16 2013-05-08 Genentech Inc Compuestos triciclicos inhibidores de la pi3k y composiciones farmaceuticas
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JP6027610B2 (ja) 2011-07-19 2016-11-16 インフィニティー ファーマシューティカルズ， インコーポレイテッド 複素環式化合物及びその使用
CN103998442B (zh) 2011-08-29 2016-09-14 无限药品股份有限公司 杂环化合物及其用途
AU2012341028C1 (en) 2011-09-02 2017-10-19 Mount Sinai School Of Medicine Substituted pyrazolo[3,4-D]pyrimidines and uses thereof
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
SG11201502331RA (en) 2012-09-26 2015-04-29 Univ California Modulation of ire1
EP2914296B2 (en) 2012-11-01 2021-09-29 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
UA121104C2 (uk) 2013-10-04 2020-04-10 Інфініті Фармасьютикалз, Інк. Гетероциклічні сполуки і їх застосування
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TWI751548B (zh) * 2019-05-09 2022-01-01 瑞士商赫孚孟拉羅股份公司 經標記之咪唑并[1,2-a]嘧啶之合成
CN110681362B (zh) * 2019-09-26 2020-09-11 浙江大学 以羧基和吲哚基为功能基团的混合模式层析介质
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Also Published As

Publication number Publication date
EP2173747A1 (en) 2010-04-14
EP2173747B1 (en) 2011-12-21
US20100216988A1 (en) 2010-08-26
CN101687865A (zh) 2010-03-31
BRPI0813273A2 (pt) 2014-12-30
KR20100033484A (ko) 2010-03-30
IL202822A0 (en) 2010-06-30
JP2010531312A (ja) 2010-09-24
WO2009000412A1 (en) 2008-12-31
AU2008267443A1 (en) 2008-12-31
ATE538120T1 (de) 2012-01-15
CA2693142A1 (en) 2008-12-31

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