JP5492769B2 - 縮環されたベンゾイミダゾール及びアザベンゾイミダゾールの位置選択的金属触媒合成 - Google Patents

縮環されたベンゾイミダゾール及びアザベンゾイミダゾールの位置選択的金属触媒合成 Download PDF

Info

Publication number
JP5492769B2
JP5492769B2 JP2010513709A JP2010513709A JP5492769B2 JP 5492769 B2 JP5492769 B2 JP 5492769B2 JP 2010513709 A JP2010513709 A JP 2010513709A JP 2010513709 A JP2010513709 A JP 2010513709A JP 5492769 B2 JP5492769 B2 JP 5492769B2
Authority
JP
Japan
Prior art keywords
bis
unsubstituted
pyridine
alkyl
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2010513709A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010531312A5 (enExample
JP2010531312A (ja
Inventor
ホルヘ・アロンソ
アンドレーアス・リンデンシュミット
マルク・ナツァーレ
オマール・ルカイク
マティーアス・ウルマン
ニス・ハールラント
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of JP2010531312A publication Critical patent/JP2010531312A/ja
Publication of JP2010531312A5 publication Critical patent/JP2010531312A5/ja
Application granted granted Critical
Publication of JP5492769B2 publication Critical patent/JP5492769B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Measuring Oxygen Concentration In Cells (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2010513709A 2007-06-26 2008-06-11 縮環されたベンゾイミダゾール及びアザベンゾイミダゾールの位置選択的金属触媒合成 Expired - Fee Related JP5492769B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07290801 2007-06-26
EP07290801.5 2007-06-26
PCT/EP2008/004638 WO2009000412A1 (en) 2007-06-26 2008-06-11 A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles

Publications (3)

Publication Number Publication Date
JP2010531312A JP2010531312A (ja) 2010-09-24
JP2010531312A5 JP2010531312A5 (enExample) 2011-07-07
JP5492769B2 true JP5492769B2 (ja) 2014-05-14

Family

ID=39720505

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010513709A Expired - Fee Related JP5492769B2 (ja) 2007-06-26 2008-06-11 縮環されたベンゾイミダゾール及びアザベンゾイミダゾールの位置選択的金属触媒合成

Country Status (11)

Country Link
US (1) US20100216988A1 (enExample)
EP (1) EP2173747B1 (enExample)
JP (1) JP5492769B2 (enExample)
KR (1) KR20100033484A (enExample)
CN (1) CN101687865A (enExample)
AT (1) ATE538120T1 (enExample)
AU (1) AU2008267443A1 (enExample)
BR (1) BRPI0813273A2 (enExample)
CA (1) CA2693142A1 (enExample)
IL (1) IL202822A0 (enExample)
WO (1) WO2009000412A1 (enExample)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008520744A (ja) 2004-11-19 2008-06-19 ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 抗炎症性ピラゾロピリミジン
KR20130087054A (ko) 2006-04-04 2013-08-05 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 키나제 길항물질
WO2009046448A1 (en) 2007-10-04 2009-04-09 Intellikine, Inc. Chemical entities and therapeutic uses thereof
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
MX358640B (es) 2008-01-04 2018-08-29 Intellikine Llc Isoquinolin-1 (2h) -onas y tieno [2,3-d]pirimidin-4(3h) -onas substituidas, y metodos de uso de las mismas.
JP5547099B2 (ja) 2008-03-14 2014-07-09 インテリカイン， エルエルシー キナーゼ阻害剤および使用方法
WO2009114874A2 (en) 2008-03-14 2009-09-17 Intellikine, Inc. Benzothiazole kinase inhibitors and methods of use
US9096611B2 (en) 2008-07-08 2015-08-04 Intellikine Llc Kinase inhibitors and methods of use
WO2010006072A2 (en) 2008-07-08 2010-01-14 The Regents Of The University Of California Mtor modulators and uses thereof
US8703778B2 (en) 2008-09-26 2014-04-22 Intellikine Llc Heterocyclic kinase inhibitors
JP5819195B2 (ja) 2008-10-16 2015-11-18 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 融合環ヘテロアリールキナーゼ阻害剤
US8476431B2 (en) 2008-11-03 2013-07-02 Itellikine LLC Benzoxazole kinase inhibitors and methods of use
JP2010235575A (ja) * 2009-03-09 2010-10-21 Konica Minolta Holdings Inc 含窒素縮合複素環化合物の製造方法
JP5789252B2 (ja) 2009-05-07 2015-10-07 インテリカイン， エルエルシー 複素環式化合物およびその使用
RU2016125705A (ru) 2009-08-18 2018-12-04 Вентиркс Фармасьютикалз, Инк. Замещенные бензоазепины в качестве модуляторов тoll-подобных рецепторов
CN102781933B (zh) 2009-08-18 2016-01-20 文蒂雷克斯药品公司 作为toll样受体调节剂的取代的苯并氮杂*
WO2011047384A2 (en) 2009-10-16 2011-04-21 The Regents Of The University Of California Methods of inhibiting ire1
EP2571357B1 (en) 2010-05-21 2016-07-06 Infinity Pharmaceuticals, Inc. Chemical compounds, compositions and methods for kinase modulation
TW201307347A (zh) 2010-11-01 2013-02-16 Arqule Inc 經取代苯並－咪唑並－吡啶並－二氮呯化合物
CN103298474B (zh) 2010-11-10 2016-06-29 无限药品股份有限公司 杂环化合物及其用途
EP3053925A1 (en) 2010-12-16 2016-08-10 F. Hoffmann-La Roche AG Tricyclic pi3k inhibitor compounds and methods of use
TWI546305B (zh) 2011-01-10 2016-08-21 英菲尼提製藥股份有限公司 製備異喹啉酮之方法及異喹啉酮之固體形式
EP2678018A4 (en) 2011-02-23 2015-09-30 Intellikine Llc COMBINATION OF CHINESE HEMMER AND USES THEREOF
AU2012284088B2 (en) 2011-07-19 2015-10-08 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
WO2013012918A1 (en) 2011-07-19 2013-01-24 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
CA2846431A1 (en) 2011-08-29 2013-03-07 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
MX370814B (es) 2011-09-02 2020-01-08 Univ California Pirazolo[3,4-d]pirimidinas sustituidas y usos de las mismas.
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
RU2015115631A (ru) 2012-09-26 2016-11-20 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния Модулирование ire1
CN105102000B (zh) 2012-11-01 2021-10-22 无限药品公司 使用pi3激酶亚型调节剂的癌症疗法
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
US9751888B2 (en) 2013-10-04 2017-09-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MX389256B (es) 2013-10-04 2025-03-20 Infinity Pharmaceuticals Inc Compuestos heterociclicos y usos de los mismos.
EA201691872A1 (ru) 2014-03-19 2017-04-28 Инфинити Фармасьютикалз, Инк. Гетероциклические соединения для применения в лечении pi3k-гамма-опосредованных расстройств
WO2015160975A2 (en) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Combination therapies
CN105017257B (zh) * 2014-04-30 2017-05-24 华东理工大学 四氢茚并吡咯并咪唑的衍生物及其制备方法和用途
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
KR101540198B1 (ko) * 2015-01-29 2015-07-29 성균관대학교산학협력단 팔라듐이 함유된 카본 나이트라이드 지지체를 이용한 메탄올과 일산화탄소의 카르보닐레이션 반응으로부터 아세트산을 제조하기 위한 촉매 및 이의 제조방법
SG11201707469WA (en) * 2015-03-18 2017-10-30 Bristol Myers Squibb Co Substituted tricyclic heterocyclic compounds
CN108349985A (zh) 2015-09-14 2018-07-31 无限药品股份有限公司 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法
US20180319813A1 (en) * 2015-11-04 2018-11-08 Idemitsu Kosan Co., Ltd Benzimidazole fused heteroaryls
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
CN105968044A (zh) * 2016-05-11 2016-09-28 张加明 一种乙氧基喹啉的工业化生产方法
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
EP3474856B1 (en) 2016-06-24 2022-09-14 Infinity Pharmaceuticals, Inc. Combination therapies
CN110003213B (zh) * 2018-01-04 2021-10-08 南京农业大学 苯并咪唑并三嗪酮类化合物、制备方法及应用
CN111217819B (zh) * 2018-11-27 2021-05-14 杭州科巢生物科技有限公司 乌帕替尼的合成方法
CA3138873C (en) * 2019-05-09 2024-01-09 Kyle Bradley Pascual CLAGG Synthesis of labeled imidazo[1,2-a]pyrimidines
CN110681362B (zh) * 2019-09-26 2020-09-11 浙江大学 以羧基和吲哚基为功能基团的混合模式层析介质
WO2021226208A2 (en) 2020-05-05 2021-11-11 Nuvalent, Inc. Heteroaromatic macrocyclic ether chemotherapeutic agents
AU2021268345A1 (en) 2020-05-05 2022-11-10 Nuvalent, Inc. Heteroaromatic macrocyclic ether chemotherapeutic agents
CN112552305B (zh) * 2020-11-26 2021-11-30 广东省测试分析研究所（中国广州分析测试中心） 一种苯并环庚烷并咪唑并吡啶类阻燃抗紫外线分子材料及其制备方法与应用
CN113512068B (zh) * 2021-04-13 2022-05-31 山西大学 一种双配体的亚硝酰钌配合物及其制备方法和应用
US20230144528A1 (en) * 2021-09-30 2023-05-11 Prelude Therapeutics Incorporated CDK Inhibitors And Their Use As Pharmaceuticals
KR20240087788A (ko) 2021-10-01 2024-06-19 뉴베일런트, 아이엔씨. 헤테로방향족 매크로사이클릭 에테르 화합물의 고체 형태, 약학 조성물 및 제조
CN114907421A (zh) * 2022-06-06 2022-08-16 河南师范大学 铑催化6-芳基嘌呤核苷和炔烃合成荧光多环嘌呤盐的方法
CN116943408B (zh) * 2023-06-30 2024-01-30 江苏创新石化有限公司 一种位阻胺复合脱硫剂及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049422A (en) * 1976-03-29 1977-09-20 United States Borax & Chemical Corporation Herbicidal morpholinobenzimidazoles
SU1587052A1 (ru) * 1988-06-27 1990-08-23 Всесоюзный научно-исследовательский институт химических средств защиты растений Способ получени 2,3-дигидро-1Н-пирроло [1,2- @ ]бензимидазол-6-сульфонамидов
DE69332736T2 (de) * 1992-12-07 2004-03-25 Eisai Co., Ltd. Verfahren zur herstellung von imidazopyridinderivaten und zwischenprodukte
AU2002367959A1 (en) * 2001-10-18 2003-12-31 Michigan State University Process for the preparation of oxazolidinones and method of use thereof
ATE527259T1 (de) * 2004-11-29 2011-10-15 Merck Sharp & Dohme Kondensierte aminopiperidine als dipeptidylpeptidase-iv-inhibitoren zur behandlung oder prävention von diabetes

Also Published As

Publication number Publication date
ATE538120T1 (de) 2012-01-15
AU2008267443A1 (en) 2008-12-31
EP2173747A1 (en) 2010-04-14
CA2693142A1 (en) 2008-12-31
IL202822A0 (en) 2010-06-30
EP2173747B1 (en) 2011-12-21
WO2009000412A1 (en) 2008-12-31
BRPI0813273A2 (pt) 2014-12-30
JP2010531312A (ja) 2010-09-24
CN101687865A (zh) 2010-03-31
US20100216988A1 (en) 2010-08-26
KR20100033484A (ko) 2010-03-30

Similar Documents

Publication Publication Date Title
JP5492769B2 (ja) 縮環されたベンゾイミダゾール及びアザベンゾイミダゾールの位置選択的金属触媒合成
JP5492770B2 (ja) ベンゾイミダゾール及びアザベンゾイミダゾールの位置選択的銅触媒合成
EP2044033B1 (en) A regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles
EP2134682B1 (en) A transition metal catalyzed synthesis of n-aminoindoles
CA3081790C (en) Macrocyclic compounds as trk kinase inhibitors and uses thereof
HK1142895A (en) A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles
HK1133880A (en) A regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles
HK1142894A (en) A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
CN117460733A (zh) 1,3-二氢咪唑并[4,5-b]吡啶-2-酮和/或其衍生物的合成方法
HK1141287A (en) A transition metal catalyzed synthesis of n-aminoindoles

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110523

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20110523

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130528

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130712

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20140204

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20140303

R150 Certificate of patent or registration of utility model

Ref document number: 5492769

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees