CN101687865A - 稠合的苯并咪唑和氮杂苯并咪唑的区域选择性金属催化合成 - Google Patents

稠合的苯并咪唑和氮杂苯并咪唑的区域选择性金属催化合成 Download PDF

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Publication number
CN101687865A
CN101687865A CN200880022154A CN200880022154A CN101687865A CN 101687865 A CN101687865 A CN 101687865A CN 200880022154 A CN200880022154 A CN 200880022154A CN 200880022154 A CN200880022154 A CN 200880022154A CN 101687865 A CN101687865 A CN 101687865A
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alkyl
base
substituted
pyridine
replacements
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Chinese (zh)
Inventor
J·阿朗索
A·林登施密德
M·纳扎雷
O·勒克亚克
M·乌尔曼
N·哈兰
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Sanofi SRL
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Sanofi Aventis SpA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Measuring Oxygen Concentration In Cells (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN200880022154A 2007-06-26 2008-06-11 稠合的苯并咪唑和氮杂苯并咪唑的区域选择性金属催化合成 Pending CN101687865A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07290801 2007-06-26
EP07290801.5 2007-06-26
PCT/EP2008/004638 WO2009000412A1 (en) 2007-06-26 2008-06-11 A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles

Publications (1)

Publication Number Publication Date
CN101687865A true CN101687865A (zh) 2010-03-31

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CN200880022154A Pending CN101687865A (zh) 2007-06-26 2008-06-11 稠合的苯并咪唑和氮杂苯并咪唑的区域选择性金属催化合成

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US (1) US20100216988A1 (enExample)
EP (1) EP2173747B1 (enExample)
JP (1) JP5492769B2 (enExample)
KR (1) KR20100033484A (enExample)
CN (1) CN101687865A (enExample)
AT (1) ATE538120T1 (enExample)
AU (1) AU2008267443A1 (enExample)
BR (1) BRPI0813273A2 (enExample)
CA (1) CA2693142A1 (enExample)
IL (1) IL202822A0 (enExample)
WO (1) WO2009000412A1 (enExample)

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CN105017257A (zh) * 2014-04-30 2015-11-04 华东理工大学 四氢茚并吡咯并咪唑的衍生物及其制备方法和用途
CN105968044A (zh) * 2016-05-11 2016-09-28 张加明 一种乙氧基喹啉的工业化生产方法
CN107635993A (zh) * 2015-03-18 2018-01-26 百时美施贵宝公司 取代的三环杂环化合物
CN108349987A (zh) * 2015-11-04 2018-07-31 出光兴产株式会社 苯并咪唑稠合杂芳族类
CN110003213A (zh) * 2018-01-04 2019-07-12 南京农业大学 苯并咪唑并三嗪酮类化合物、制备方法及应用
CN111217819A (zh) * 2018-11-27 2020-06-02 杭州科巢生物科技有限公司 乌帕替尼的合成方法
CN112552305A (zh) * 2020-11-26 2021-03-26 广东省测试分析研究所（中国广州分析测试中心） 一种新型苯并环庚烷并咪唑并吡啶类阻燃抗紫外线分子材料及其制备方法与应用
CN114423763A (zh) * 2019-05-09 2022-04-29 豪夫迈·罗氏有限公司 咪唑并[1,2-a]嘧啶的区域选择性合成

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BRPI0915231A2 (pt) 2008-07-08 2018-06-12 Intellikine Inc compostos inibidores de quinase e métodos de uso
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EP2427195B1 (en) 2009-05-07 2019-05-01 Intellikine, LLC Heterocyclic compounds and uses thereof
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WO2012061342A2 (en) 2010-11-01 2012-05-10 Arqule, Inc. Substituted benzo-imidazo-pyrido-diazepine compounds
AU2011326427B2 (en) 2010-11-10 2016-01-07 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
MX2013006858A (es) * 2010-12-16 2013-07-29 Hoffmann La Roche Compuesto triciclicos inhibidores de la pi3k y metodos de uso.
PE20180318A1 (es) 2011-01-10 2018-02-09 Infinity Pharmaceuticals Inc Procedimiento para preparar isoquinolinonas y formas solidas de isoquinolinonas
JP6130305B2 (ja) 2011-02-23 2017-05-17 インテリカイン， エルエルシー キナーゼ阻害剤の組み合わせおよびそれらの使用
WO2013012918A1 (en) 2011-07-19 2013-01-24 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
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AR091790A1 (es) 2011-08-29 2015-03-04 Infinity Pharmaceuticals Inc Derivados de isoquinolin-1-ona y sus usos
JP6342805B2 (ja) 2011-09-02 2018-06-13 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 置換ピラゾロ［３，４−ｄ］ピリミジンおよびその用途
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KR20150061651A (ko) 2012-09-26 2015-06-04 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 Ire1의 조절
LT2914296T (lt) 2012-11-01 2018-09-25 Infinity Pharmaceuticals, Inc. Vėžio gydymas, panaudojant p13 kinazės izoformos moduliatorius
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
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EP3119397B1 (en) 2014-03-19 2022-03-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
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KR101540198B1 (ko) * 2015-01-29 2015-07-29 성균관대학교산학협력단 팔라듐이 함유된 카본 나이트라이드 지지체를 이용한 메탄올과 일산화탄소의 카르보닐레이션 반응으로부터 아세트산을 제조하기 위한 촉매 및 이의 제조방법
CN114230571B (zh) 2015-09-14 2025-07-08 无限药品股份有限公司 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法
US10759806B2 (en) 2016-03-17 2020-09-01 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
UA125216C2 (uk) 2016-06-24 2022-02-02 Інфініті Фармасьютікалз, Інк. Комбінована терапія
CN110681362B (zh) * 2019-09-26 2020-09-11 浙江大学 以羧基和吲哚基为功能基团的混合模式层析介质
EP4146626A4 (en) 2020-05-05 2024-05-29 Nuvalent, Inc. CHEMOTHERAPEUTIC AGENTS BASED ON HETEROAROMATIC MACROCYCLIC ETHERS
PH12022552787A1 (en) 2020-05-05 2024-03-25 Nuvalent Inc Heteroaromatic macrocyclic ether chemotherapeutic agents
CN113512068B (zh) * 2021-04-13 2022-05-31 山西大学 一种双配体的亚硝酰钌配合物及其制备方法和应用
WO2023056441A1 (en) * 2021-09-30 2023-04-06 Prelude Therapeutics Incorporated Cdk inhibitors and their use as pharmaceuticals
CA3231813A1 (en) 2021-10-01 2023-04-06 Sibao CHEN Solid forms, pharmaceutical compositions and preparation of heteroaromatic macrocyclic ether compounds
CN114907421A (zh) * 2022-06-06 2022-08-16 河南师范大学 铑催化6-芳基嘌呤核苷和炔烃合成荧光多环嘌呤盐的方法
CN116943408B (zh) * 2023-06-30 2024-01-30 江苏创新石化有限公司 一种位阻胺复合脱硫剂及其制备方法

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105017257A (zh) * 2014-04-30 2015-11-04 华东理工大学 四氢茚并吡咯并咪唑的衍生物及其制备方法和用途
CN105017257B (zh) * 2014-04-30 2017-05-24 华东理工大学 四氢茚并吡咯并咪唑的衍生物及其制备方法和用途
CN107635993A (zh) * 2015-03-18 2018-01-26 百时美施贵宝公司 取代的三环杂环化合物
CN107635993B (zh) * 2015-03-18 2020-05-22 百时美施贵宝公司 取代的三环杂环化合物
CN108349987A (zh) * 2015-11-04 2018-07-31 出光兴产株式会社 苯并咪唑稠合杂芳族类
CN105968044A (zh) * 2016-05-11 2016-09-28 张加明 一种乙氧基喹啉的工业化生产方法
CN110003213A (zh) * 2018-01-04 2019-07-12 南京农业大学 苯并咪唑并三嗪酮类化合物、制备方法及应用
CN110003213B (zh) * 2018-01-04 2021-10-08 南京农业大学 苯并咪唑并三嗪酮类化合物、制备方法及应用
CN111217819A (zh) * 2018-11-27 2020-06-02 杭州科巢生物科技有限公司 乌帕替尼的合成方法
CN114423763A (zh) * 2019-05-09 2022-04-29 豪夫迈·罗氏有限公司 咪唑并[1,2-a]嘧啶的区域选择性合成
CN112552305A (zh) * 2020-11-26 2021-03-26 广东省测试分析研究所（中国广州分析测试中心） 一种新型苯并环庚烷并咪唑并吡啶类阻燃抗紫外线分子材料及其制备方法与应用

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IL202822A0 (en) 2010-06-30
EP2173747A1 (en) 2010-04-14
ATE538120T1 (de) 2012-01-15
AU2008267443A1 (en) 2008-12-31
KR20100033484A (ko) 2010-03-30
WO2009000412A1 (en) 2008-12-31
BRPI0813273A2 (pt) 2014-12-30
US20100216988A1 (en) 2010-08-26
EP2173747B1 (en) 2011-12-21
JP5492769B2 (ja) 2014-05-14
CA2693142A1 (en) 2008-12-31
JP2010531312A (ja) 2010-09-24

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