CN101687865A - 稠合的苯并咪唑和氮杂苯并咪唑的区域选择性金属催化合成 - Google Patents

稠合的苯并咪唑和氮杂苯并咪唑的区域选择性金属催化合成 Download PDF

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Publication number
CN101687865A
CN101687865A CN200880022154A CN200880022154A CN101687865A CN 101687865 A CN101687865 A CN 101687865A CN 200880022154 A CN200880022154 A CN 200880022154A CN 200880022154 A CN200880022154 A CN 200880022154A CN 101687865 A CN101687865 A CN 101687865A
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alkyl
base
substituted
pyridine
replacements
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Chinese (zh)
Inventor
J·阿朗索
A·林登施密德
M·纳扎雷
O·勒克亚克
M·乌尔曼
N·哈兰
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Sanofi SRL
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Sanofi Aventis SpA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Measuring Oxygen Concentration In Cells (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN200880022154A 2007-06-26 2008-06-11 稠合的苯并咪唑和氮杂苯并咪唑的区域选择性金属催化合成 Pending CN101687865A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07290801 2007-06-26
EP07290801.5 2007-06-26
PCT/EP2008/004638 WO2009000412A1 (en) 2007-06-26 2008-06-11 A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles

Publications (1)

Publication Number Publication Date
CN101687865A true CN101687865A (zh) 2010-03-31

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CN200880022154A Pending CN101687865A (zh) 2007-06-26 2008-06-11 稠合的苯并咪唑和氮杂苯并咪唑的区域选择性金属催化合成

Country Status (11)

Country Link
US (1) US20100216988A1 (enExample)
EP (1) EP2173747B1 (enExample)
JP (1) JP5492769B2 (enExample)
KR (1) KR20100033484A (enExample)
CN (1) CN101687865A (enExample)
AT (1) ATE538120T1 (enExample)
AU (1) AU2008267443A1 (enExample)
BR (1) BRPI0813273A2 (enExample)
CA (1) CA2693142A1 (enExample)
IL (1) IL202822A0 (enExample)
WO (1) WO2009000412A1 (enExample)

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CN105017257A (zh) * 2014-04-30 2015-11-04 华东理工大学 四氢茚并吡咯并咪唑的衍生物及其制备方法和用途
CN105968044A (zh) * 2016-05-11 2016-09-28 张加明 一种乙氧基喹啉的工业化生产方法
CN107635993A (zh) * 2015-03-18 2018-01-26 百时美施贵宝公司 取代的三环杂环化合物
CN108349987A (zh) * 2015-11-04 2018-07-31 出光兴产株式会社 苯并咪唑稠合杂芳族类
CN110003213A (zh) * 2018-01-04 2019-07-12 南京农业大学 苯并咪唑并三嗪酮类化合物、制备方法及应用
CN111217819A (zh) * 2018-11-27 2020-06-02 杭州科巢生物科技有限公司 乌帕替尼的合成方法
CN112552305A (zh) * 2020-11-26 2021-03-26 广东省测试分析研究所（中国广州分析测试中心） 一种新型苯并环庚烷并咪唑并吡啶类阻燃抗紫外线分子材料及其制备方法与应用
CN114423763A (zh) * 2019-05-09 2022-04-29 豪夫迈·罗氏有限公司 咪唑并[1,2-a]嘧啶的区域选择性合成

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KR20140099556A (ko) * 2010-12-16 2014-08-12 에프. 호프만-라 로슈 아게 트라이사이클릭 pi3k 억제제 화합물 및 이의 사용 방법
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EP2678018A4 (en) 2011-02-23 2015-09-30 Intellikine Llc COMBINATION OF CHINESE HEMMER AND USES THEREOF
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KR20140063605A (ko) 2011-07-19 2014-05-27 인피니티 파마슈티칼스, 인코포레이티드 헤테로사이클릭 화합물 및 그의 용도
AR091790A1 (es) 2011-08-29 2015-03-04 Infinity Pharmaceuticals Inc Derivados de isoquinolin-1-ona y sus usos
MX370814B (es) 2011-09-02 2020-01-08 Univ California Pirazolo[3,4-d]pirimidinas sustituidas y usos de las mismas.
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
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AU2013323426A1 (en) 2012-09-26 2015-04-23 The Regents Of The University Of California Modulation of ire1
KR102229478B1 (ko) 2012-11-01 2021-03-18 인피니티 파마슈티칼스, 인코포레이티드 Pi3 키나아제 동형단백질 조절인자를 사용하는 암의 치료
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
PL3052485T3 (pl) 2013-10-04 2022-02-28 Infinity Pharmaceuticals, Inc. Związki heterocykliczne i ich zastosowania
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NZ740616A (en) 2015-09-14 2023-05-26 Infinity Pharmaceuticals Inc Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
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IL263680B2 (en) 2016-06-24 2025-10-01 Infinity Pharmaceuticals Inc PI3K inhibitors for use in combination with a second therapeutic agent for the treatment, management or prevention of cancer
CN110681362B (zh) * 2019-09-26 2020-09-11 浙江大学 以羧基和吲哚基为功能基团的混合模式层析介质
BR112022022530A2 (pt) 2020-05-05 2023-02-23 Nuvalent Inc Composto, composição farmacêutica, método de tratamento de câncer, método de inibição seletiva, método de redução de um nível de ros1 ou alk
EP4146626A4 (en) 2020-05-05 2024-05-29 Nuvalent, Inc. CHEMOTHERAPEUTIC AGENTS BASED ON HETEROAROMATIC MACROCYCLIC ETHERS
CN113512068B (zh) * 2021-04-13 2022-05-31 山西大学 一种双配体的亚硝酰钌配合物及其制备方法和应用
US20230144528A1 (en) * 2021-09-30 2023-05-11 Prelude Therapeutics Incorporated CDK Inhibitors And Their Use As Pharmaceuticals
IL311444A (en) 2021-10-01 2024-05-01 Nuvalent Inc Solid forms, pharmaceutical compositions and preparation of heteroaromatic macrocyclic ether compounds
CN114907421A (zh) * 2022-06-06 2022-08-16 河南师范大学 铑催化6-芳基嘌呤核苷和炔烃合成荧光多环嘌呤盐的方法
CN116943408B (zh) * 2023-06-30 2024-01-30 江苏创新石化有限公司 一种位阻胺复合脱硫剂及其制备方法

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105017257A (zh) * 2014-04-30 2015-11-04 华东理工大学 四氢茚并吡咯并咪唑的衍生物及其制备方法和用途
CN105017257B (zh) * 2014-04-30 2017-05-24 华东理工大学 四氢茚并吡咯并咪唑的衍生物及其制备方法和用途
CN107635993A (zh) * 2015-03-18 2018-01-26 百时美施贵宝公司 取代的三环杂环化合物
CN107635993B (zh) * 2015-03-18 2020-05-22 百时美施贵宝公司 取代的三环杂环化合物
CN108349987A (zh) * 2015-11-04 2018-07-31 出光兴产株式会社 苯并咪唑稠合杂芳族类
CN105968044A (zh) * 2016-05-11 2016-09-28 张加明 一种乙氧基喹啉的工业化生产方法
CN110003213A (zh) * 2018-01-04 2019-07-12 南京农业大学 苯并咪唑并三嗪酮类化合物、制备方法及应用
CN110003213B (zh) * 2018-01-04 2021-10-08 南京农业大学 苯并咪唑并三嗪酮类化合物、制备方法及应用
CN111217819A (zh) * 2018-11-27 2020-06-02 杭州科巢生物科技有限公司 乌帕替尼的合成方法
CN114423763A (zh) * 2019-05-09 2022-04-29 豪夫迈·罗氏有限公司 咪唑并[1,2-a]嘧啶的区域选择性合成
CN112552305A (zh) * 2020-11-26 2021-03-26 广东省测试分析研究所（中国广州分析测试中心） 一种新型苯并环庚烷并咪唑并吡啶类阻燃抗紫外线分子材料及其制备方法与应用

Also Published As

Publication number Publication date
IL202822A0 (en) 2010-06-30
KR20100033484A (ko) 2010-03-30
EP2173747B1 (en) 2011-12-21
US20100216988A1 (en) 2010-08-26
EP2173747A1 (en) 2010-04-14
JP2010531312A (ja) 2010-09-24
BRPI0813273A2 (pt) 2014-12-30
ATE538120T1 (de) 2012-01-15
WO2009000412A1 (en) 2008-12-31
CA2693142A1 (en) 2008-12-31
JP5492769B2 (ja) 2014-05-14
AU2008267443A1 (en) 2008-12-31

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