BRPI0813273A2 - Síntese catalisada por metal regiosseletivo de benzimidazóis e azabenzimidazóis anelados - Google Patents
Síntese catalisada por metal regiosseletivo de benzimidazóis e azabenzimidazóis aneladosInfo
- Publication number
- BRPI0813273A2 BRPI0813273A2 BRPI0813273-9A2A BRPI0813273A BRPI0813273A2 BR PI0813273 A2 BRPI0813273 A2 BR PI0813273A2 BR PI0813273 A BRPI0813273 A BR PI0813273A BR PI0813273 A2 BRPI0813273 A2 BR PI0813273A2
- Authority
- BR
- Brazil
- Prior art keywords
- ring
- synthesis
- metal
- regioselevel
- benzimidazois
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 229910052751 metal Inorganic materials 0.000 title abstract 2
- 239000002184 metal Substances 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- -1 N-substituted benzimidazoles Chemical class 0.000 abstract 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- 229910052763 palladium Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Measuring Oxygen Concentration In Cells (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07290801 | 2007-06-26 | ||
| PCT/EP2008/004638 WO2009000412A1 (en) | 2007-06-26 | 2008-06-11 | A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0813273A2 true BRPI0813273A2 (pt) | 2014-12-30 |
Family
ID=39720505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0813273-9A2A BRPI0813273A2 (pt) | 2007-06-26 | 2008-06-11 | Síntese catalisada por metal regiosseletivo de benzimidazóis e azabenzimidazóis anelados |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20100216988A1 (enExample) |
| EP (1) | EP2173747B1 (enExample) |
| JP (1) | JP5492769B2 (enExample) |
| KR (1) | KR20100033484A (enExample) |
| CN (1) | CN101687865A (enExample) |
| AT (1) | ATE538120T1 (enExample) |
| AU (1) | AU2008267443A1 (enExample) |
| BR (1) | BRPI0813273A2 (enExample) |
| CA (1) | CA2693142A1 (enExample) |
| IL (1) | IL202822A0 (enExample) |
| WO (1) | WO2009000412A1 (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9512125B2 (en) | 2004-11-19 | 2016-12-06 | The Regents Of The University Of California | Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents |
| KR101499783B1 (ko) | 2006-04-04 | 2015-03-09 | 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 | 키나제 길항물질 |
| US20110160232A1 (en) | 2007-10-04 | 2011-06-30 | Pingda Ren | Certain chemical entities and therapeutic uses thereof |
| AU2009204483B2 (en) | 2008-01-04 | 2014-03-13 | Intellikine, Llc | Certain chemical entities, compositions and methods |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| JP5547099B2 (ja) | 2008-03-14 | 2014-07-09 | インテリカイン， エルエルシー | キナーゼ阻害剤および使用方法 |
| US8993580B2 (en) | 2008-03-14 | 2015-03-31 | Intellikine Llc | Benzothiazole kinase inhibitors and methods of use |
| MX2011000216A (es) | 2008-07-08 | 2011-03-29 | Intellikine Inc | Inhibidores de cinasa y metodos para su uso. |
| US20110224223A1 (en) | 2008-07-08 | 2011-09-15 | The Regents Of The University Of California, A California Corporation | MTOR Modulators and Uses Thereof |
| WO2010036380A1 (en) | 2008-09-26 | 2010-04-01 | Intellikine, Inc. | Heterocyclic kinase inhibitors |
| WO2010045542A2 (en) | 2008-10-16 | 2010-04-22 | The Regents Of The University Of California | Fused ring heteroaryl kinase inhibitors |
| US8476431B2 (en) | 2008-11-03 | 2013-07-02 | Itellikine LLC | Benzoxazole kinase inhibitors and methods of use |
| JP2010235575A (ja) * | 2009-03-09 | 2010-10-21 | Konica Minolta Holdings Inc | 含窒素縮合複素環化合物の製造方法 |
| WO2010129816A2 (en) | 2009-05-07 | 2010-11-11 | Intellikine, Inc. | Heterocyclic compounds and uses thereof |
| RU2580320C2 (ru) | 2009-08-18 | 2016-04-10 | Вентиркс Фармасьютикалз, Инк. | Замещенные бензоазепины в качестве модуляторов toll-подобного рецептора |
| JP5756804B2 (ja) | 2009-08-18 | 2015-07-29 | ベンティアールエックス ファーマシューティカルズ， インコーポレイテッドＶｅｎｔｉＲｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | Ｔｏｌｌ様レセプターモジュレーターとしての置換ベンゾアゼピン |
| WO2011047384A2 (en) | 2009-10-16 | 2011-04-21 | The Regents Of The University Of California | Methods of inhibiting ire1 |
| JP5951600B2 (ja) | 2010-05-21 | 2016-07-13 | インフィニティー ファーマシューティカルズ， インコーポレイテッド | キナーゼ調節のための、化合物、組成物および方法 |
| TW201307347A (zh) | 2010-11-01 | 2013-02-16 | Arqule Inc | 經取代苯並－咪唑並－吡啶並－二氮呯化合物 |
| US8901133B2 (en) | 2010-11-10 | 2014-12-02 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| CA2820078C (en) * | 2010-12-16 | 2019-02-12 | F. Hoffmann-La Roche Ag | Tricyclic pi3k inhibitor compounds and methods of use |
| KR20180080358A (ko) | 2011-01-10 | 2018-07-11 | 인피니티 파마슈티칼스, 인코포레이티드 | 이소퀴놀린온 및 이의 고체 형태의 제조 방법 |
| JP6130305B2 (ja) | 2011-02-23 | 2017-05-17 | インテリカイン， エルエルシー | キナーゼ阻害剤の組み合わせおよびそれらの使用 |
| CN103930422A (zh) | 2011-07-19 | 2014-07-16 | 无限药品股份有限公司 | 杂环化合物及其用途 |
| EP2734530A1 (en) | 2011-07-19 | 2014-05-28 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| CN103998442B (zh) | 2011-08-29 | 2016-09-14 | 无限药品股份有限公司 | 杂环化合物及其用途 |
| MX370814B (es) | 2011-09-02 | 2020-01-08 | Univ California | Pirazolo[3,4-d]pirimidinas sustituidas y usos de las mismas. |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| WO2014052669A1 (en) | 2012-09-26 | 2014-04-03 | The Regents Of The University Of California | Modulation of ire1 |
| IL291945B2 (en) | 2012-11-01 | 2025-11-01 | Infinity Pharmaceuticals Inc | Treatment of cancers using pi3 kinase isoform modulators |
| US9481667B2 (en) | 2013-03-15 | 2016-11-01 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
| WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| MX389256B (es) | 2013-10-04 | 2025-03-20 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y usos de los mismos. |
| EP4066834A1 (en) | 2014-03-19 | 2022-10-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
| US20150320755A1 (en) | 2014-04-16 | 2015-11-12 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| CN105017257B (zh) * | 2014-04-30 | 2017-05-24 | 华东理工大学 | 四氢茚并吡咯并咪唑的衍生物及其制备方法和用途 |
| WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| KR101540198B1 (ko) * | 2015-01-29 | 2015-07-29 | 성균관대학교산학협력단 | 팔라듐이 함유된 카본 나이트라이드 지지체를 이용한 메탄올과 일산화탄소의 카르보닐레이션 반응으로부터 아세트산을 제조하기 위한 촉매 및 이의 제조방법 |
| KR102654709B1 (ko) * | 2015-03-18 | 2024-04-03 | 브리스톨-마이어스 스큅 컴퍼니 | 치환된 트리시클릭 헤테로시클릭 화합물 |
| CN108349985A (zh) | 2015-09-14 | 2018-07-31 | 无限药品股份有限公司 | 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法 |
| CN108349987A (zh) * | 2015-11-04 | 2018-07-31 | 出光兴产株式会社 | 苯并咪唑稠合杂芳族类 |
| US10759806B2 (en) | 2016-03-17 | 2020-09-01 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors |
| CN105968044A (zh) * | 2016-05-11 | 2016-09-28 | 张加明 | 一种乙氧基喹啉的工业化生产方法 |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| CA3028718A1 (en) | 2016-06-24 | 2017-12-28 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| CN110003213B (zh) * | 2018-01-04 | 2021-10-08 | 南京农业大学 | 苯并咪唑并三嗪酮类化合物、制备方法及应用 |
| CN111217819B (zh) * | 2018-11-27 | 2021-05-14 | 杭州科巢生物科技有限公司 | 乌帕替尼的合成方法 |
| WO2020227575A1 (en) * | 2019-05-09 | 2020-11-12 | Genentech, Inc. | Synthesis of labeled imidazo[1,2-a]pyrimidines |
| CN110681362B (zh) * | 2019-09-26 | 2020-09-11 | 浙江大学 | 以羧基和吲哚基为功能基团的混合模式层析介质 |
| EP4146205A4 (en) | 2020-05-05 | 2024-05-29 | Nuvalent, Inc. | HETEROAROMATIC MACROCYCLIC ETHERS AS CHEMOTHERAPEUTIC AGENTS |
| MX2022013657A (es) | 2020-05-05 | 2023-02-01 | Nuvalent Inc | Quimioterápicos de éter macrocíclico heteroaromático. |
| CN112552305B (zh) * | 2020-11-26 | 2021-11-30 | 广东省测试分析研究所（中国广州分析测试中心） | 一种苯并环庚烷并咪唑并吡啶类阻燃抗紫外线分子材料及其制备方法与应用 |
| CN113512068B (zh) * | 2021-04-13 | 2022-05-31 | 山西大学 | 一种双配体的亚硝酰钌配合物及其制备方法和应用 |
| US20230144528A1 (en) * | 2021-09-30 | 2023-05-11 | Prelude Therapeutics Incorporated | CDK Inhibitors And Their Use As Pharmaceuticals |
| CA3231813A1 (en) | 2021-10-01 | 2023-04-06 | Sibao CHEN | Solid forms, pharmaceutical compositions and preparation of heteroaromatic macrocyclic ether compounds |
| CN114907421A (zh) * | 2022-06-06 | 2022-08-16 | 河南师范大学 | 铑催化6-芳基嘌呤核苷和炔烃合成荧光多环嘌呤盐的方法 |
| CN116943408B (zh) * | 2023-06-30 | 2024-01-30 | 江苏创新石化有限公司 | 一种位阻胺复合脱硫剂及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4049422A (en) * | 1976-03-29 | 1977-09-20 | United States Borax & Chemical Corporation | Herbicidal morpholinobenzimidazoles |
| SU1587052A1 (ru) * | 1988-06-27 | 1990-08-23 | Всесоюзный научно-исследовательский институт химических средств защиты растений | Способ получени 2,3-дигидро-1Н-пирроло [1,2- @ ]бензимидазол-6-сульфонамидов |
| EP0627433B1 (en) * | 1992-12-07 | 2003-03-05 | Eisai Co., Ltd. | Process for producing imidazopyridine derivative and intermediate |
| WO2003106413A2 (en) * | 2001-10-18 | 2003-12-24 | Michigan State University | Process for the preparation of oxazolidinones and method of use thereof |
| WO2006058064A2 (en) | 2004-11-29 | 2006-06-01 | Merck & Co., Inc. | Fused aminopiperidines as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
-
2008
- 2008-06-11 AT AT08759157T patent/ATE538120T1/de active
- 2008-06-11 WO PCT/EP2008/004638 patent/WO2009000412A1/en not_active Ceased
- 2008-06-11 JP JP2010513709A patent/JP5492769B2/ja not_active Expired - Fee Related
- 2008-06-11 BR BRPI0813273-9A2A patent/BRPI0813273A2/pt not_active IP Right Cessation
- 2008-06-11 EP EP08759157A patent/EP2173747B1/en not_active Not-in-force
- 2008-06-11 AU AU2008267443A patent/AU2008267443A1/en not_active Abandoned
- 2008-06-11 KR KR1020097026783A patent/KR20100033484A/ko not_active Withdrawn
- 2008-06-11 CN CN200880022154A patent/CN101687865A/zh active Pending
- 2008-06-11 CA CA2693142A patent/CA2693142A1/en not_active Abandoned
-
2009
- 2009-12-17 IL IL202822A patent/IL202822A0/en unknown
- 2009-12-22 US US12/644,379 patent/US20100216988A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010531312A (ja) | 2010-09-24 |
| CA2693142A1 (en) | 2008-12-31 |
| US20100216988A1 (en) | 2010-08-26 |
| IL202822A0 (en) | 2010-06-30 |
| EP2173747A1 (en) | 2010-04-14 |
| CN101687865A (zh) | 2010-03-31 |
| AU2008267443A1 (en) | 2008-12-31 |
| KR20100033484A (ko) | 2010-03-30 |
| JP5492769B2 (ja) | 2014-05-14 |
| ATE538120T1 (de) | 2012-01-15 |
| EP2173747B1 (en) | 2011-12-21 |
| WO2009000412A1 (en) | 2008-12-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0813273A2 (pt) | Síntese catalisada por metal regiosseletivo de benzimidazóis e azabenzimidazóis anelados | |
| BRPI0813271A2 (pt) | Síntese regiosseletiva catalisada por cobre de benzimidazóis e azabenzimidazóis | |
| NO20090264L (no) | En regioselektiv palladiumkatalysert syntese av benzimidazoler og azabenzimidazoler | |
| ATE542799T1 (de) | Chinolinonderivate als parp und tank-inhibitoren | |
| SG169989A1 (en) | Aryloazol-2-yl cyanoethylamino compounds, method of making and method of using thereof | |
| CY1110010T1 (el) | Πυριδιναμινοσουλφονυλ υποκατεστημενα βενζαμιδια ως αναστολεις κυτοχρωματος ρ450 3α4 (cyp3a4) | |
| MX2009007713A (es) | Derivados de piridazina, procedimientos para su preparacion y su uso como fungicidas. | |
| MX2012006805A (es) | Indolil-piperidinil bencilaminas como inhibidores de beta-triptasa. | |
| ATE553093T1 (de) | Indazolderivate zur hemmung von trpv1 und verwendungen davon | |
| BRPI0813870A2 (pt) | Síntese catalisada por metal de transição de 2h-indazóis. | |
| NI200900151A (es) | Nuevo procedimiento de síntesis de la agomelatina. | |
| NO20073701L (no) | Nye fremgangsmater for fremstilling av et 2H-kromen | |
| UA97806C2 (ru) | Бензиламины, способ их получения и их применения в качестве противовоспалительных средств | |
| EA200900946A1 (ru) | Новый способ синтеза агомелатина | |
| MY151017A (en) | 5-[(3,3,3-trifluoro-2-hydroxy-1-arylpropyl)amino]-1h-quinolin-2-ones, a process for their production and their use as anti-inflammatory agents | |
| UA94837C2 (ru) | Способ синтеза (7-метокси-1-нафтил)ацетонитрила и применение в синтезе агомелатина | |
| UA107689C2 (xx) | ПОХІДНІ 3,4,4A,10B-ТЕТРАГІДРО-1H-ТІОПІРАНО$4, 3-c]ІЗОХІНОЛІНУ | |
| MX2010004498A (es) | Derivados de ciclohexenoamida y su uso como antagonistas de trpv1. | |
| NL1034604A1 (nl) | Verwijdering van waterstofcyanide uit synthesegas. | |
| BRPI0812829A2 (pt) | Processo para o acoplamento catalisado por paládio de alcinas terminais com tosilatos de arila | |
| EA200900943A1 (ru) | Новый способ синтеза агомелатина | |
| UA85701C2 (ru) | Способ получения ингибиторов триптазы | |
| EA200801549A1 (ru) | Новые производные фенантридина в качестве антагонистов брадикинина | |
| TW200726752A (en) | Process for the production of intermediates for the preparation of tricyclic benzimidazoles | |
| MX2007013872A (es) | Procedimiento para la produccion de 4-bifenililazetidina-2-onas. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |