JP2010525826A5 - - Google Patents
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- JP2010525826A5 JP2010525826A5 JP2010506716A JP2010506716A JP2010525826A5 JP 2010525826 A5 JP2010525826 A5 JP 2010525826A5 JP 2010506716 A JP2010506716 A JP 2010506716A JP 2010506716 A JP2010506716 A JP 2010506716A JP 2010525826 A5 JP2010525826 A5 JP 2010525826A5
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- JP
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- Prior art keywords
- seq
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- nucleotide
- nucleotide sequence
- guide strand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003729 nucleotide group Chemical group 0.000 claims 84
- 239000002773 nucleotide Substances 0.000 claims 78
- 108020004707 nucleic acids Proteins 0.000 claims 24
- 150000007523 nucleic acids Chemical class 0.000 claims 24
- 102000039446 nucleic acids Human genes 0.000 claims 24
- 108700011259 MicroRNAs Proteins 0.000 claims 16
- 239000002679 microRNA Substances 0.000 claims 16
- 230000003278 mimic effect Effects 0.000 claims 11
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 8
- 230000000295 complement effect Effects 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 5
- -1 Aminopropyl Chemical group 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 108091029119 miR-34a stem-loop Proteins 0.000 claims 3
- 108091079013 miR-34b Proteins 0.000 claims 3
- 108091084018 miR-34b stem-loop Proteins 0.000 claims 3
- 108091063470 miR-34b-1 stem-loop Proteins 0.000 claims 3
- 108091049916 miR-34b-2 stem-loop Proteins 0.000 claims 3
- 108091057222 miR-34b-3 stem-loop Proteins 0.000 claims 3
- 108091092639 miR-34b-4 stem-loop Proteins 0.000 claims 3
- 108091090583 miR-34c stem-loop Proteins 0.000 claims 3
- 108091082133 miR-34c-1 stem-loop Proteins 0.000 claims 3
- 229960000549 4-dimethylaminophenol Drugs 0.000 claims 2
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-dimethylaminopyridine Substances CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 claims 2
- 230000015556 catabolic process Effects 0.000 claims 2
- 238000006731 degradation reaction Methods 0.000 claims 2
- 229940124447 delivery agent Drugs 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 230000001293 nucleolytic effect Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 244000089409 Erythrina poeppigiana Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 235000009776 Rathbunia alamosensis Nutrition 0.000 claims 1
- 238000000137 annealing Methods 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92762107P | 2007-05-03 | 2007-05-03 | |
| PCT/US2008/062689 WO2008137867A2 (en) | 2007-05-03 | 2008-05-05 | Compositions comprising mir34 therapeutic agents for treating cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010525826A JP2010525826A (ja) | 2010-07-29 |
| JP2010525826A5 true JP2010525826A5 (enExample) | 2011-06-23 |
Family
ID=39944228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010506716A Pending JP2010525826A (ja) | 2007-05-03 | 2008-05-05 | 癌を治療するためのｍｉｒ３４治療剤を含む組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8399248B2 (enExample) |
| EP (1) | EP2152722B1 (enExample) |
| JP (1) | JP2010525826A (enExample) |
| AU (1) | AU2008247427A1 (enExample) |
| CA (1) | CA2686165A1 (enExample) |
| WO (2) | WO2008137867A2 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2471924A1 (en) | 2004-05-28 | 2012-07-04 | Asuragen, INC. | Methods and compositions involving microRNA |
| ES2534300T3 (es) | 2004-11-12 | 2015-04-21 | Asuragen, Inc. | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
| US8399248B2 (en) | 2007-05-03 | 2013-03-19 | Merck Sharp & Dohme Corp. | Methods of using MIR34 as a biomarker for TP53 functional status |
| AU2008261951A1 (en) * | 2007-06-08 | 2008-12-18 | Asuragen, Inc. | miR-34 regulated genes and pathways as targets for therapeutic intervention |
| US8361714B2 (en) | 2007-09-14 | 2013-01-29 | Asuragen, Inc. | Micrornas differentially expressed in cervical cancer and uses thereof |
| US8188060B2 (en) * | 2008-02-11 | 2012-05-29 | Dharmacon, Inc. | Duplex oligonucleotides with enhanced functionality in gene regulation |
| JP5513375B2 (ja) * | 2008-05-07 | 2014-06-04 | 北海道公立大学法人 札幌医科大学 | 癌の検出方法および検出用キット、ならびに癌治療剤 |
| US8258111B2 (en) | 2008-05-08 | 2012-09-04 | The Johns Hopkins University | Compositions and methods related to miRNA modulation of neovascularization or angiogenesis |
| US9217155B2 (en) | 2008-05-28 | 2015-12-22 | University Of Massachusetts | Isolation of novel AAV'S and uses thereof |
| EP2191834A1 (en) * | 2008-11-26 | 2010-06-02 | Centre National De La Recherche Scientifique (Cnrs) | Compositions and methods for treating retrovirus infections |
| LU91545B1 (en) | 2009-03-27 | 2010-09-28 | Univ Luxembourg | Mirna as a prognostic diagnostic biomarker and therapeutic agent for breast cancer and other human associated pathologies |
| US8734809B2 (en) | 2009-05-28 | 2014-05-27 | University Of Massachusetts | AAV's and uses thereof |
| FR2948687B1 (fr) * | 2009-07-29 | 2015-09-04 | Centre Nat Rech Scient | Utilisation de microarn pour le traitement de pathologies respiratoires chroniques |
| US20120238459A1 (en) * | 2009-09-07 | 2012-09-20 | Yoshiki Murakami | Method for predicting therapeutic effect on chronic hepatitis c |
| US8846631B2 (en) | 2010-01-14 | 2014-09-30 | Regulus Therapeutics Inc. | MicroRNA compositions and methods |
| CA3050894C (en) | 2010-04-23 | 2022-10-18 | University Of Massachusetts | Multicistronic expression constructs |
| CA2833912C (en) | 2010-04-23 | 2021-09-21 | University Of Massachusetts | Aav-based treatment of cholesterol-related disorders |
| WO2011151321A1 (en) * | 2010-05-31 | 2011-12-08 | Institut Curie | Asf1b as a prognosis marker and therapeutic target in human cancer |
| US8933051B2 (en) | 2010-09-30 | 2015-01-13 | University Of Zurich | Treatment of B-cell lymphoma with microRNA |
| CN102031309A (zh) * | 2010-11-30 | 2011-04-27 | 华东师范大学 | miRNA-34c化合物作为脑胶质瘤标志物的应用 |
| AU2012212023B9 (en) * | 2011-02-03 | 2017-01-12 | Mirna Therapeutics, Inc. | Synthetic mimics of miR-34 |
| US9222085B2 (en) | 2011-02-03 | 2015-12-29 | Mirna Therapeutics, Inc. | Synthetic mimics of MIR-124 |
| WO2012145624A2 (en) | 2011-04-21 | 2012-10-26 | University Of Massachusetts | Raav-based compositions and methods for treating alpha-1 anti-trypsin deficiencies |
| US20130028956A1 (en) | 2011-07-29 | 2013-01-31 | Andre Fischer | Method for preventing or treating memory impairment and pharmaceutical compositions useful therefore |
| US9644241B2 (en) | 2011-09-13 | 2017-05-09 | Interpace Diagnostics, Llc | Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease |
| CN105722993A (zh) * | 2011-12-01 | 2016-06-29 | 俄亥俄州国家创新基金会 | 与结肠直肠癌的nsaid化学预防相关的材料和方法 |
| US9334498B2 (en) | 2012-05-10 | 2016-05-10 | Uab Research Foundation | Methods and compositions for modulating MIR-204 activity |
| US9663784B2 (en) | 2012-05-26 | 2017-05-30 | Bonac Corporation | Single-stranded nucleic acid molecule for regulating expression of gene having delivering function |
| DK2872147T3 (da) | 2012-07-13 | 2023-02-20 | Wave Life Sciences Ltd | Fremgangsmåde til fremstilling af kirale oligonukleotider |
| CN105324119A (zh) * | 2013-06-16 | 2016-02-10 | 国立大学法人东京医科齿科大学 | 具有外显子跳跃效应的双链反义核酸 |
| WO2015099122A1 (ja) * | 2013-12-26 | 2015-07-02 | 学校法人東京医科大学 | 遺伝子発現制御のための人工ミミックｍｉＲＮＡおよびその用途 |
| SG10201805087VA (en) * | 2013-12-27 | 2018-07-30 | Bonac Corp | Artificial match-type mirna for controlling gene expression and use therefor |
| US10370432B2 (en) | 2014-10-03 | 2019-08-06 | University Of Massachusetts | Heterologous targeting peptide grafted AAVS |
| WO2016065001A1 (en) | 2014-10-21 | 2016-04-28 | University Of Massachusetts | Recombinant aav variants and uses thereof |
| WO2016104775A1 (ja) | 2014-12-27 | 2016-06-30 | 株式会社ボナック | 遺伝子発現制御のための天然型ｍｉＲＮＡおよびその用途 |
| EP3256170B1 (en) | 2015-02-13 | 2020-09-23 | University of Massachusetts | Compositions and methods for transient delivery of nucleases |
| JP6602847B2 (ja) | 2015-03-27 | 2019-11-06 | 株式会社ボナック | デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子 |
| US11046955B2 (en) | 2015-04-24 | 2021-06-29 | University Of Massachusetts | Modified AAV constructs and uses thereof |
| WO2017070516A1 (en) * | 2015-10-22 | 2017-04-27 | University Of Massachusetts | Prostate-targeting adeno-associated virus serotype vectors |
| CA3012344A1 (en) | 2016-02-12 | 2017-08-17 | University Of Massachusetts | Anti-angiogenic mirna therapeutics for inhibiting corneal neovascularization |
| EP3423581A4 (en) * | 2016-03-04 | 2020-03-04 | Rhode Island Hospital | Targeting microrna for cancer treatment |
| EP3216869B1 (en) | 2016-03-09 | 2019-09-18 | Colizzi, Vittorio | Nutraceutical plant derived microrna elements for treatment of leukemia |
| US10457940B2 (en) | 2016-09-22 | 2019-10-29 | University Of Massachusetts | AAV treatment of Huntington's disease |
| KR20190075964A (ko) | 2016-10-13 | 2019-07-01 | 유니버시티 오브 매사추세츠 | Aav 캡시드 설계 |
| US11584932B2 (en) | 2016-11-01 | 2023-02-21 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
| KR20240158357A (ko) | 2017-11-09 | 2024-11-04 | 가부시키가이샤 팜엑스 테라퓨틱스 | miRNA를 포함하는 암 치료용 의약 조성물 |
| CN107699565B (zh) * | 2017-11-24 | 2020-05-22 | 苏州大学 | 微小rna及其在制备抗肿瘤药物中的应用 |
| CN110791566B (zh) * | 2019-10-29 | 2023-06-27 | 徐州市中心医院 | 人shcbp1基因的用途及相关产品 |
| CN111304327B (zh) * | 2020-02-24 | 2024-04-19 | 宋程 | 人grpel2基因的用途及相关产品 |
| WO2021262919A2 (en) | 2020-06-26 | 2021-12-30 | The Research Foundation For The State University Of New York | 5-halouracil-modified micrornas and their use in the treatment of cancer |
| CN114010523B (zh) * | 2021-11-05 | 2024-04-12 | 天津穗纳生物医药科技有限公司 | 皮肤抗衰剂及其应用 |
| WO2025184661A1 (en) * | 2024-03-01 | 2025-09-04 | Wave Life Sciences Ltd. | Double stranded oligonucleotide compositions and methods relating thereto |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020177568A1 (en) * | 1992-12-07 | 2002-11-28 | Stinchcomb Dan T. | Enzymatic nucleic acid treatment of diseases or conditions related to levels of NF-kappa B |
| US5885613A (en) | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
| US5820873A (en) | 1994-09-30 | 1998-10-13 | The University Of British Columbia | Polyethylene glycol modified ceramide lipids and liposome uses thereof |
| US5753613A (en) | 1994-09-30 | 1998-05-19 | Inex Pharmaceuticals Corporation | Compositions for the introduction of polyanionic materials into cells |
| WO2003070918A2 (en) | 2002-02-20 | 2003-08-28 | Ribozyme Pharmaceuticals, Incorporated | Rna interference by modified short interfering nucleic acid |
| US20070032441A1 (en) * | 2001-05-18 | 2007-02-08 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (sina) |
| US20060009409A1 (en) * | 2002-02-01 | 2006-01-12 | Woolf Tod M | Double-stranded oligonucleotides |
| US7250496B2 (en) * | 2002-11-14 | 2007-07-31 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
| US7655785B1 (en) * | 2002-11-14 | 2010-02-02 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof |
| WO2005018534A2 (en) | 2003-05-16 | 2005-03-03 | Rosetta Inpharmatics, Llc | Methods and compositions for rna interference |
| US6882555B2 (en) | 2003-06-18 | 2005-04-19 | Lattice Semiconductor Corporation | Bi-directional buffering for memory data lines |
| EP1670955A2 (en) | 2003-09-22 | 2006-06-21 | Rosetta Inpharmatics LLC. | Synthetic lethal screen using rna interference |
| ATE452188T1 (de) | 2004-02-10 | 2010-01-15 | Sirna Therapeutics Inc | Rna-interferenz-vermittelte hemmung der genexpression unter verwendung multifunktioneller sina (short interfering nucleic acid) |
| US20050182005A1 (en) * | 2004-02-13 | 2005-08-18 | Tuschl Thomas H. | Anti-microRNA oligonucleotide molecules |
| CA2566519C (en) * | 2004-05-14 | 2020-04-21 | Rosetta Genomics Ltd. | Micrornas and uses thereof |
| EP2471924A1 (en) | 2004-05-28 | 2012-07-04 | Asuragen, INC. | Methods and compositions involving microRNA |
| EP1951263A4 (en) | 2005-11-21 | 2009-11-18 | Johnson & Johnson Res Pty Ltd | MULTITARGETING DISTURBING RNAS WITH TWO ACTIVE STRANDS AND DESIGN AND APPLICATION METHODS |
| US7893975B2 (en) * | 2006-10-13 | 2011-02-22 | Apple Inc. | System and method for processing images using predetermined tone reproduction curves |
| US8220277B2 (en) * | 2006-11-07 | 2012-07-17 | Tiax Llc | Dehumidification method having multiple different refrigeration paths between the reheat and cooling coils |
| JP2010516249A (ja) | 2007-01-17 | 2010-05-20 | ザ・ジョンズ・ホプキンス・ユニバーシティ | 腫瘍治療のためのミクロｒｎａに関する組成物及び方法 |
| WO2008104974A2 (en) | 2007-02-27 | 2008-09-04 | Rosetta Genomics Ltd. | Composition and methods for modulating cell proliferation and cell death |
| US8399248B2 (en) | 2007-05-03 | 2013-03-19 | Merck Sharp & Dohme Corp. | Methods of using MIR34 as a biomarker for TP53 functional status |
-
2008
- 2008-05-05 US US12/598,563 patent/US8399248B2/en active Active
- 2008-05-05 US US12/598,590 patent/US8378088B2/en active Active
- 2008-05-05 WO PCT/US2008/062689 patent/WO2008137867A2/en not_active Ceased
- 2008-05-05 EP EP08747666.9A patent/EP2152722B1/en active Active
- 2008-05-05 JP JP2010506716A patent/JP2010525826A/ja active Pending
- 2008-05-05 CA CA 2686165 patent/CA2686165A1/en not_active Abandoned
- 2008-05-05 WO PCT/US2008/062681 patent/WO2008137862A2/en not_active Ceased
- 2008-05-05 AU AU2008247427A patent/AU2008247427A1/en not_active Abandoned
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