JP2004520833A5 - - Google Patents

Info

Publication number

JP2004520833A5

JP2004520833A5 JP2002568730A JP2002568730A JP2004520833A5 JP 2004520833 A5 JP2004520833 A5 JP 2004520833A5 JP 2002568730 A JP2002568730 A JP 2002568730A JP 2002568730 A JP2002568730 A JP 2002568730A JP 2004520833 A5 JP2004520833 A5 JP 2004520833A5

Authority

JP

Japan

Prior art keywords

composition

composition according

cell

nucleic acid

promoter

Prior art date

2002-02-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 239000000203 mixture Substances 0.000 claims 45
• 210000004027 cell Anatomy 0.000 claims 16
• 108020004707 nucleic acids Proteins 0.000 claims 15
• 102000039446 nucleic acids Human genes 0.000 claims 15
• 150000007523 nucleic acids Chemical class 0.000 claims 15
• 108090000623 proteins and genes Proteins 0.000 claims 14
• 229920002477 rna polymer Polymers 0.000 claims 9
• 230000014509 gene expression Effects 0.000 claims 7
• 102100034170 Interferon-induced, double-stranded RNA-activated protein kinase Human genes 0.000 claims 6
• 101710089751 Interferon-induced, double-stranded RNA-activated protein kinase Proteins 0.000 claims 6
• 239000013604 expression vector Substances 0.000 claims 6
• 210000004962 mammalian cell Anatomy 0.000 claims 6
• 108020004414 DNA Proteins 0.000 claims 4
• 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 3
• 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 3
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
• 108700008625 Reporter Genes Proteins 0.000 claims 3
• 239000002299 complementary DNA Substances 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 101710152894 ATP-binding cassette sub-family E member 1 Proteins 0.000 claims 2
• 102100020969 ATP-binding cassette sub-family E member 1 Human genes 0.000 claims 2
• 108091023040 Transcription factor Proteins 0.000 claims 2
• 102000040945 Transcription factor Human genes 0.000 claims 2
• 101710114283 Translation initiation factor RLI1 Proteins 0.000 claims 2
• 230000001413 cellular effect Effects 0.000 claims 2
• 210000001671 embryonic stem cell Anatomy 0.000 claims 2
• 230000030279 gene silencing Effects 0.000 claims 2
• 238000012226 gene silencing method Methods 0.000 claims 2
• 239000003112 inhibitor Substances 0.000 claims 2
• 101710095468 Cyclase Proteins 0.000 claims 1
• 102000002464 Galactosidases Human genes 0.000 claims 1
• 108010093031 Galactosidases Proteins 0.000 claims 1
• 108060001084 Luciferase Proteins 0.000 claims 1
• 239000005089 Luciferase Substances 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 108700020796 Oncogene Proteins 0.000 claims 1
• 108700019146 Transgenes Proteins 0.000 claims 1
• SIIZPVYVXNXXQG-KGXOGWRBSA-N [(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-4-[[(3s,4r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-3-hydroxyoxolan-2-yl]methyl [(2r,4r,5r)-2-(6-aminopurin-9-yl)-4-hydroxy-5-(phosphonooxymethyl)oxolan-3-yl] hydrogen phosphate Chemical compound C1=NC2=C(N)N=CN=C2N1[C@@H]1O[C@H](COP(O)(=O)OC2[C@@H](O[C@H](COP(O)(O)=O)[C@H]2O)N2C3=NC=NC(N)=C3N=C2)[C@@H](O)[C@H]1OP(O)(=O)OCC([C@@H](O)[C@H]1O)OC1N1C(N=CN=C2N)=C2N=C1 SIIZPVYVXNXXQG-KGXOGWRBSA-N 0.000 claims 1
• 239000003242 anti bacterial agent Substances 0.000 claims 1
• 230000003115 biocidal effect Effects 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 238000004113 cell culture Methods 0.000 claims 1
• 239000003153 chemical reaction reagent Substances 0.000 claims 1
• 230000000295 complement effect Effects 0.000 claims 1
• 238000004520 electroporation Methods 0.000 claims 1
• 108091006047 fluorescent proteins Proteins 0.000 claims 1
• 102000034287 fluorescent proteins Human genes 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 238000001727 in vivo Methods 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 230000005764 inhibitory process Effects 0.000 claims 1
• 230000000977 initiatory effect Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000001668 nucleic acid synthesis Methods 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 238000003786 synthesis reaction Methods 0.000 claims 1
• 238000013518 transcription Methods 0.000 claims 1
• 230000035897 transcription Effects 0.000 claims 1
• 230000009261 transgenic effect Effects 0.000 claims 1
• 239000013598 vector Substances 0.000 claims 1