JP2004520833A - 哺乳動物細胞における標的遺伝子発現を阻害する方法 - Google Patents
哺乳動物細胞における標的遺伝子発現を阻害する方法 Download PDFInfo
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- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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Applications Claiming Priority (2)
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| GBGB0104948.5A GB0104948D0 (en) | 2001-02-28 | 2001-02-28 | Novel methods |
| PCT/EP2002/002098 WO2002068635A2 (en) | 2001-02-28 | 2002-02-27 | Methods of inhibiting expression of a target gene in mammalian cells |
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| JP2004520833A true JP2004520833A (ja) | 2004-07-15 |
| JP2004520833A5 JP2004520833A5 (enExample) | 2005-12-22 |
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| JP2002568730A Pending JP2004520833A (ja) | 2001-02-28 | 2002-02-27 | 哺乳動物細胞における標的遺伝子発現を阻害する方法 |
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| US (1) | US20040235764A1 (enExample) |
| EP (1) | EP1385952A2 (enExample) |
| JP (1) | JP2004520833A (enExample) |
| GB (1) | GB0104948D0 (enExample) |
| WO (1) | WO2002068635A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| DE10100586C1 (de) | 2001-01-09 | 2002-04-11 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines Ziegens |
| US7829693B2 (en) | 1999-11-24 | 2010-11-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
| CA2403397A1 (en) | 2000-03-16 | 2001-09-20 | Genetica, Inc. | Methods and compositions for rna interference |
| US8202846B2 (en) | 2000-03-16 | 2012-06-19 | Cold Spring Harbor Laboratory | Methods and compositions for RNA interference |
| US7423142B2 (en) | 2001-01-09 | 2008-09-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of anti-apoptotic genes |
| US8546143B2 (en) | 2001-01-09 | 2013-10-01 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
| US7767802B2 (en) | 2001-01-09 | 2010-08-03 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of anti-apoptotic genes |
| CA2921821A1 (en) | 2001-07-12 | 2003-01-23 | University Of Massachusetts | In vivo production of small interfering rnas that mediate gene silencing |
| DE10163098B4 (de) | 2001-10-12 | 2005-06-02 | Alnylam Europe Ag | Verfahren zur Hemmung der Replikation von Viren |
| US7745418B2 (en) | 2001-10-12 | 2010-06-29 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting viral replication |
| WO2003046186A1 (fr) | 2001-11-28 | 2003-06-05 | Toudai Tlo, Ltd. | Systeme d'expression d'arnsi et procede de production de cellule knockdown a gene fonctionnel ou analogue utilisant ce systeme |
| DE10202419A1 (de) | 2002-01-22 | 2003-08-07 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines durch eine Chromosomen-Aberration entstandenen Zielgens |
| US20040180438A1 (en) * | 2002-04-26 | 2004-09-16 | Pachuk Catherine J. | Methods and compositions for silencing genes without inducing toxicity |
| GB0315401D0 (en) * | 2003-07-01 | 2003-08-06 | Roslin Inst Edinburgh | Disease resistant transgenic non-human animals |
| ME02871B (me) * | 2010-12-03 | 2018-04-20 | Biontech Rna Pharmaceuticals Gmbh | Postupak za ćelijsku ekspresiju rnk |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2163129A1 (en) * | 1993-05-17 | 1994-11-24 | Flossie Wong-Staal | Ribozyme gene therapy for hiv infection and aids |
| US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| DE19956568A1 (de) * | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| EP1354038A2 (en) * | 2000-12-28 | 2003-10-22 | J & J Research Pty Ltd | Double-stranded rna-mediated gene suppression |
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- 2001-02-28 GB GBGB0104948.5A patent/GB0104948D0/en not_active Ceased
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- 2002-02-27 JP JP2002568730A patent/JP2004520833A/ja active Pending
- 2002-02-27 WO PCT/EP2002/002098 patent/WO2002068635A2/en not_active Ceased
- 2002-02-27 EP EP02729941A patent/EP1385952A2/en not_active Withdrawn
- 2002-02-27 US US10/469,447 patent/US20040235764A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20040235764A1 (en) | 2004-11-25 |
| GB0104948D0 (en) | 2001-04-18 |
| EP1385952A2 (en) | 2004-02-04 |
| WO2002068635A3 (en) | 2003-12-04 |
| WO2002068635A2 (en) | 2002-09-06 |
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