JP2010501167A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010501167A5 JP2010501167A5 JP2009524883A JP2009524883A JP2010501167A5 JP 2010501167 A5 JP2010501167 A5 JP 2010501167A5 JP 2009524883 A JP2009524883 A JP 2009524883A JP 2009524883 A JP2009524883 A JP 2009524883A JP 2010501167 A5 JP2010501167 A5 JP 2010501167A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- nucleic acid
- acid sequence
- isolated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229920001184 polypeptide Polymers 0.000 claims 25
- 102000004196 processed proteins & peptides Human genes 0.000 claims 25
- 108090000765 processed proteins & peptides Proteins 0.000 claims 25
- 150000007523 nucleic acids Chemical class 0.000 claims 15
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 108020004707 nucleic acids Proteins 0.000 claims 10
- 102000039446 nucleic acids Human genes 0.000 claims 10
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- 230000000295 complement effect Effects 0.000 claims 5
- 230000009261 transgenic effect Effects 0.000 claims 5
- 241001465754 Metazoa Species 0.000 claims 4
- 102000016349 Myosin Light Chains Human genes 0.000 claims 4
- 108010067385 Myosin Light Chains Proteins 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 230000035772 mutation Effects 0.000 claims 3
- 230000000865 phosphorylative effect Effects 0.000 claims 3
- 102000013602 Cardiac Myosins Human genes 0.000 claims 2
- 108010051609 Cardiac Myosins Proteins 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 229930193140 Neomycin Natural products 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 210000004602 germ cell Anatomy 0.000 claims 1
- 230000006801 homologous recombination Effects 0.000 claims 1
- 238000002744 homologous recombination Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229960004927 neomycin Drugs 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
- 241001515965 unidentified phage Species 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83938806P | 2006-08-21 | 2006-08-21 | |
| US92165507P | 2007-04-02 | 2007-04-02 | |
| PCT/CN2007/002531 WO2008028405A1 (en) | 2006-08-21 | 2007-08-21 | Neukinase, a downstream protein of neuregulin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014109644A Division JP6339415B2 (ja) | 2006-08-21 | 2014-05-28 | ニューレグリンの下流タンパク質であるニューキナーゼ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010501167A JP2010501167A (ja) | 2010-01-21 |
| JP2010501167A5 true JP2010501167A5 (enExample) | 2010-11-18 |
Family
ID=39156831
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009524883A Withdrawn JP2010501167A (ja) | 2006-08-21 | 2007-08-21 | ニューレグリンの下流タンパク質であるニューキナーゼ |
| JP2014109644A Expired - Fee Related JP6339415B2 (ja) | 2006-08-21 | 2014-05-28 | ニューレグリンの下流タンパク質であるニューキナーゼ |
| JP2017178155A Pending JP2018074996A (ja) | 2006-08-21 | 2017-09-15 | ニューレグリンの下流タンパク質であるニューキナーゼ |
| JP2019149009A Pending JP2019213550A (ja) | 2006-08-21 | 2019-08-15 | ニューレグリンの下流タンパク質であるニューキナーゼ |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014109644A Expired - Fee Related JP6339415B2 (ja) | 2006-08-21 | 2014-05-28 | ニューレグリンの下流タンパク質であるニューキナーゼ |
| JP2017178155A Pending JP2018074996A (ja) | 2006-08-21 | 2017-09-15 | ニューレグリンの下流タンパク質であるニューキナーゼ |
| JP2019149009A Pending JP2019213550A (ja) | 2006-08-21 | 2019-08-15 | ニューレグリンの下流タンパク質であるニューキナーゼ |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US9580515B2 (enExample) |
| EP (4) | EP2059594B1 (enExample) |
| JP (4) | JP2010501167A (enExample) |
| CN (2) | CN101553568B (enExample) |
| CA (1) | CA2661308C (enExample) |
| ES (2) | ES2625316T3 (enExample) |
| WO (1) | WO2008028405A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3211592B2 (ja) | 1994-11-21 | 2001-09-25 | トヨタ自動車株式会社 | 樹脂製品の製造方法 |
| AUPP785098A0 (en) | 1998-12-21 | 1999-01-21 | Victor Chang Cardiac Research Institute, The | Treatment of heart disease |
| AU2002304965A1 (en) * | 2002-05-24 | 2003-12-12 | Zensun (Shanghai) Sci-Tech.Ltd | Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy |
| ES2664086T3 (es) | 2005-12-30 | 2018-04-18 | Zensun (Shanghai) Science & Technology, Co., Ltd. | Liberación extendida de neurregulina para mejorar la función cardíaca |
| US20090156488A1 (en) * | 2007-09-12 | 2009-06-18 | Zensun (Shanghai) Science & Technology Limited | Use of neuregulin for organ preservation |
| JP2009242388A (ja) * | 2008-03-14 | 2009-10-22 | National Cardiovascular Center | 心臓特異的キナーゼの心不全診断および治療への応用 |
| CN102232084B (zh) * | 2008-11-28 | 2014-05-28 | 上海泽生科技开发有限公司 | 纽兰格林及其用途 |
| CN102231987A (zh) * | 2008-11-28 | 2011-11-02 | 上海泽生科技开发有限公司 | 纽兰格林和心脏干细胞 |
| JP6096262B2 (ja) | 2009-08-25 | 2017-03-15 | ゼンサン （シャンハイ） サイエンス アンド テクノロジー，シーオー．，エルティーディー． | ニューレグリンに基づく心不全の治療方法 |
| CN102139095A (zh) | 2010-01-29 | 2011-08-03 | 上海泽生科技开发有限公司 | 神经调节蛋白用于预防、治疗或延迟心脏缺血再灌注损伤的方法和组合物 |
| WO2013053076A1 (en) | 2011-10-10 | 2013-04-18 | Zensun （Shanghai）Science & Technology Limited | Compositions and methods for treating heart failure |
| EP2903632A4 (en) | 2012-10-08 | 2016-07-13 | Zensun Shanghai Science And Technology Ltd | COMPOSITIONS AND METHODS FOR TREATING HEART FAILURE IN DIABETES PATIENTS |
| ES2743617T3 (es) | 2013-05-22 | 2020-02-20 | Zensun Shanghai Science & Tech Co Ltd | Liberación prolongada de neuregulina para tratar la insuficiencia cardíaca |
| CN110946993A (zh) | 2014-01-03 | 2020-04-03 | 上海泽生科技开发股份有限公司 | 纽兰格林制剂的配方 |
| CN105497876B (zh) | 2014-09-24 | 2021-01-15 | 上海泽生科技开发股份有限公司 | 神经调节蛋白用于预防、治疗或延迟心脏室性心律失常的方法和组合物 |
| CN111407882A (zh) | 2014-10-17 | 2020-07-14 | 上海泽生科技开发股份有限公司 | 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物 |
| CN106177992A (zh) * | 2015-05-08 | 2016-12-07 | 上海泽生科技开发有限公司 | cMLCK基因导入 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873191A (en) * | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| US4870009A (en) * | 1982-11-22 | 1989-09-26 | The Salk Institute For Biological Studies | Method of obtaining gene product through the generation of transgenic animals |
| US5272065A (en) * | 1983-10-20 | 1993-12-21 | Research Foundation Of State University Of New York | Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA |
| US4736866A (en) * | 1984-06-22 | 1988-04-12 | President And Fellows Of Harvard College | Transgenic non-human mammals |
| US4980286A (en) * | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
| US5225539A (en) * | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5906810A (en) * | 1987-03-17 | 1999-05-25 | Turner; Robert E. | Formulations and uses thereof in the prevention and treatment of oral lesions |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5198346A (en) | 1989-01-06 | 1993-03-30 | Protein Engineering Corp. | Generation and selection of novel DNA-binding proteins and polypeptides |
| US5096815A (en) | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
| FR2646438B1 (fr) | 1989-03-20 | 2007-11-02 | Pasteur Institut | Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration |
| DE69034263D1 (de) | 1989-07-25 | 2009-04-02 | Cell Genesys Inc | Homologe Rekombination für universelle Donorzellen und chimerische Säugetierzellen |
| JP3127158B2 (ja) | 1989-10-05 | 2001-01-22 | オプテイン，インコーポレイティド | 新規の遺伝子及びポリペチドの無細胞合成並びに単離 |
| US5747334A (en) | 1990-02-15 | 1998-05-05 | The University Of North Carolina At Chapel Hill | Random peptide library |
| US5726152A (en) * | 1990-09-21 | 1998-03-10 | Merck & Co., Inc. | Vascular endothelial cell growth factor II |
| US5716930A (en) * | 1991-04-10 | 1998-02-10 | Ludwig Institute For Cancer Research | Glial growth factors |
| US5530109A (en) * | 1991-04-10 | 1996-06-25 | Ludwig Institute For Cancer Research | DNA encoding glial mitogenic factors |
| US5834229A (en) | 1991-05-24 | 1998-11-10 | Genentech, Inc. | Nucleic acids vectors and host cells encoding and expressing heregulin 2-α |
| WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5624902A (en) * | 1995-06-07 | 1997-04-29 | Torrey Pines Institute For Molecular Studies | Peptide inhibitors of calmodulin |
| US5912326A (en) | 1995-09-08 | 1999-06-15 | President And Fellows Of Harvard College | Cerebellum-derived growth factors |
| US5955594A (en) | 1997-04-30 | 1999-09-21 | Mishra; Lopa | Nucleic acids encoding proteins for early liver development |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| EP1073756A4 (en) | 1998-03-26 | 2003-01-22 | Gene Logic Inc | IDENTIFICATION OF A cDNA ASSOCIATED WITH ISCHEMIA IN HUMAN CARDIAC TISSUE |
| US6635249B1 (en) | 1999-04-23 | 2003-10-21 | Cenes Pharmaceuticals, Inc. | Methods for treating congestive heart failure |
| AU1086501A (en) | 1999-10-15 | 2001-04-30 | Carnegie Institution Of Washington | Rna interference pathway genes as tools for targeted genetic interference |
| US7375185B2 (en) | 2000-09-12 | 2008-05-20 | The United States Of America As Represented By The Department Of Health And Human Services | Cardiac myosin light chain kinase polypeptide, encoding nucleic acid, and methods of use |
| US6482624B2 (en) | 2000-11-14 | 2002-11-19 | Pe Corporation (Ny) | Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof |
| US20040142325A1 (en) * | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
| AU2003240688A1 (en) * | 2002-05-24 | 2003-12-12 | Bayer Aktiengesellschaft | Regulation of human kinase |
| WO2004050894A2 (en) | 2002-11-27 | 2004-06-17 | Artesian Therapeutics, Inc. | Heart failure gene determination and therapeutic screening |
| CN1812776A (zh) | 2003-05-21 | 2006-08-02 | 得克萨斯州大学系统董事会 | 抑制蛋白激酶c－mu(pkd)用作心脏肥大和心力衰竭的疗法 |
| JP4792582B2 (ja) | 2003-08-21 | 2011-10-12 | 国立大学法人大阪大学 | 心肥大及びそれに起因する心疾患を予防または治療するための医薬組成物 |
| WO2005063983A1 (en) | 2003-12-29 | 2005-07-14 | Galapagos Genomics N.V. | Modulators of bone homeostasis identified in a high-throughput screen |
| US7341835B2 (en) | 2004-01-13 | 2008-03-11 | Affymetrix, Inc. | Methods of analysis of alternative splicing in mouse |
| WO2008128161A2 (en) | 2007-04-13 | 2008-10-23 | University Of Florida Research Foundation Inc. | Identification of cardiac specific myosin light chain kinase |
-
2007
- 2007-08-20 US US11/894,542 patent/US9580515B2/en active Active
- 2007-08-21 CA CA2661308A patent/CA2661308C/en not_active Expired - Fee Related
- 2007-08-21 WO PCT/CN2007/002531 patent/WO2008028405A1/en not_active Ceased
- 2007-08-21 ES ES13184566.1T patent/ES2625316T3/es active Active
- 2007-08-21 EP EP07800751A patent/EP2059594B1/en active Active
- 2007-08-21 EP EP17155285.4A patent/EP3202904A1/en not_active Withdrawn
- 2007-08-21 ES ES12154752.5T patent/ES2555543T3/es active Active
- 2007-08-21 EP EP13184566.1A patent/EP2730654B1/en active Active
- 2007-08-21 CN CN2007800300485A patent/CN101553568B/zh active Active
- 2007-08-21 CN CN201210072941.7A patent/CN102618562B/zh active Active
- 2007-08-21 EP EP12154752.5A patent/EP2484763B1/en active Active
- 2007-08-21 JP JP2009524883A patent/JP2010501167A/ja not_active Withdrawn
-
2014
- 2014-05-28 JP JP2014109644A patent/JP6339415B2/ja not_active Expired - Fee Related
-
2017
- 2017-01-05 US US15/399,506 patent/US10227418B2/en active Active
- 2017-09-15 JP JP2017178155A patent/JP2018074996A/ja active Pending
-
2019
- 2019-02-08 US US16/271,716 patent/US20200207870A1/en not_active Abandoned
- 2019-08-15 JP JP2019149009A patent/JP2019213550A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010501167A5 (enExample) | ||
| KR102021585B1 (ko) | 두 개의 벡터로부터 발현된 Cas9 단백질을 이용한 유전자 발현 조절 방법 | |
| JP2009148257A5 (enExample) | ||
| JP2021502085A5 (enExample) | ||
| JP2006512921A5 (enExample) | ||
| JP2009529877A5 (enExample) | ||
| AR014653A1 (es) | Genes y promotores de la familia del maiz pr1, molecula de acido nucleico aislada, construccion de adn, vector, celula huesped, metodo para inducir laexpresion de una secuencia nucleotidica heterologa en una planta, metodo para expresar en forma constituyente una secuencia nucleotidica heterologa en | |
| CA3154384A1 (en) | Modified bacterial retroelement with enhanced dna production | |
| JP2019524140A5 (enExample) | ||
| JP5336676B2 (ja) | 新規な部位特異的組換え酵素によって認識される配列及びその認識配列を用いた部位特異的組換え方法 | |
| JP2018521630A5 (enExample) | ||
| RU2011147121A (ru) | Промотор целого семени | |
| CN110643636B (zh) | 一种团头鲂MSTNa&b基因敲除方法与应用 | |
| JP2005509420A5 (enExample) | ||
| US20200115706A1 (en) | Method of Recording Multiplexed Biological Information into a CRISPR Array Using a Retron | |
| JP2020515248A5 (enExample) | ||
| JP2004520833A5 (enExample) | ||
| CN104328116A (zh) | 一种与牙鲆耐热性相关的snp位点及其应用 | |
| RU2019139045A (ru) | Способы и композиции для модификации гена регулятора трансмембранной проводимости при кистозном фиброзе (cftr) | |
| WO2009052687A1 (en) | Genes for improving salt tolerance and drought tolerance of plant and the uses thereof | |
| CN112626122B (zh) | hKDR人源化小鼠模型及其建立方法和应用 | |
| JP2013531967A5 (enExample) | ||
| CN103626851A (zh) | 一种镉离子结合多肽及其编码序列 | |
| AU2007208928A8 (en) | Transgenic plant transformed with stress-responsive gene | |
| CN111801103A (zh) | 猪异种抗原的鉴定 |